Uridine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.253347
COL6A3 collagen, type VI, alpha 3 0.196304
PRSS23 protease, serine, 23 0.13169
B2M beta-2-microglobulin 0.126407
ADM adrenomedullin 0.0983643
STC1 stanniocalcin 1 0.0923659
ERRFI1 ERBB receptor feedback inhibitor 1 0.0792906
CDH13 cadherin 13 0.075119
FMNL2 formin-like 2 0.069379
DSCAM Down syndrome cell adhesion molecule 0.0634612
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0621386
COL5A1 collagen, type V, alpha 1 0.0600682
SAMD4A sterile alpha motif domain containing 4A 0.0574441
COL6A1 collagen, type VI, alpha 1 0.0572687
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0570497
PLEC plectin 0.0559781
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0535356
RBM25 RNA binding motif protein 25 0.0526218
TGFBI transforming growth factor, beta-induced, 68kDa 0.052032
TRIO trio Rho guanine nucleotide exchange factor 0.0519329
ANO6 anoctamin 6 0.0512483
ARRDC3 arrestin domain containing 3 0.0509278
CAVIN1 caveolae associated protein 1 0.0506108
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0504248
KMT2C lysine (K)-specific methyltransferase 2C 0.050054
COL6A2 collagen, type VI, alpha 2 0.0487341
TNIP1 TNFAIP3 interacting protein 1 0.0482916
RAI14 retinoic acid induced 14 0.0481754
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0474072
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.047033
FRMD6 FERM domain containing 6 0.0466115
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0451357
MYO10 myosin X 0.0437132
JUN jun proto-oncogene 0.0436419
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0436133
CALU calumenin 0.0429396
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0421702
ATP13A3 ATPase type 13A3 0.0417402
PGK1 phosphoglycerate kinase 1 0.0414493
CXCL8 chemokine (C-X-C motif) ligand 8 0.0404958
CALD1 caldesmon 1 0.0400315
AKAP12 A kinase (PRKA) anchor protein 12 0.0398107
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0397126
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0396755
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.0395388
MAML2 mastermind-like 2 (Drosophila) 0.0394898
EIF1 eukaryotic translation initiation factor 1 0.0391441
ZEB2 zinc finger E-box binding homeobox 2 0.0385146
LGALS1 lectin, galactoside-binding, soluble, 1 0.037981
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0378526
CALR calreticulin 0.037603
LOXL2 lysyl oxidase-like 2 0.037475
TM4SF1 transmembrane 4 L six family member 1 0.0374141
TFG TRK-fused gene 0.0373212
IL6 interleukin 6 0.0368597
AK1 adenylate kinase 1 0.0367157
SDC4 syndecan 4 0.0364584
COL5A2 collagen, type V, alpha 2 0.0361415
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0361333
MSN moesin 0.0357171
GLIS3 GLIS family zinc finger 3 0.0356197
IGFBP7 insulin-like growth factor binding protein 7 0.0352488
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0349209
PRELID2 PRELI domain containing 2 0.0346973
SLC38A2 solute carrier family 38, member 2 0.0344879
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0344397
IL6ST interleukin 6 signal transducer 0.0341709
TUBB tubulin, beta class I 0.0338661
MACF1 microtubule-actin crosslinking factor 1 0.0338461
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0336207
AHNAK AHNAK nucleoprotein 0.0332073
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0326656
TPM4 tropomyosin 4 0.0326482
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0323726
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0319821
TMED9 transmembrane emp24 protein transport domain containing 9 0.031898
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.03187
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0316536
RPL3 ribosomal protein L3 0.0316489
PRICKLE2 prickle homolog 2 (Drosophila) 0.0314111
WNT5A wingless-type MMTV integration site family, member 5A 0.0309166
ANKRD36 ankyrin repeat domain 36 0.0308987
SMAD3 SMAD family member 3 0.0306898
TMSB4X thymosin beta 4, X-linked 0.0306763
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0305995
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0303496
APP amyloid beta (A4) precursor protein 0.0303038
VEGFA vascular endothelial growth factor A 0.0298235
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0296571
AKAP13 A kinase (PRKA) anchor protein 13 0.0296253
RAB8B RAB8B, member RAS oncogene family 0.0296092
ANXA1 annexin A1 0.0292859
ACTN4 actinin, alpha 4 0.0292269
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0291822
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.029071
TPM2 tropomyosin 2 (beta) 0.0289789
HDLBP high density lipoprotein binding protein 0.028938
EXT1 exostosin glycosyltransferase 1 0.0289239
EIF4H eukaryotic translation initiation factor 4H 0.0287226
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0286856

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.292036
NDRG1 N-myc downstream regulated 1 -0.133307
FTH1 ferritin, heavy polypeptide 1 -0.0810063
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.067881
POTEF POTE ankyrin domain family, member F -0.0604192
VIM vimentin -0.0581973
RTN4 reticulon 4 -0.056575
JMJD1C jumonji domain containing 1C -0.0506362
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0495511
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0469301
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0436435
MEF2A myocyte enhancer factor 2A -0.043528
FN1 fibronectin 1 -0.0434815
ASPH aspartate beta-hydroxylase -0.0414189
FNDC3A fibronectin type III domain containing 3A -0.0405154
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0402202
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0377493
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0361583
RLF rearranged L-myc fusion -0.0358643
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0348395
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0346644
RPL28 ribosomal protein L28 -0.0342292
HDAC9 histone deacetylase 9 -0.033699
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0329006
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0328246
HIP1 huntingtin interacting protein 1 -0.0327
RBM33 RNA binding motif protein 33 -0.0325189
MBD5 methyl-CpG binding domain protein 5 -0.0322772
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0318128
PKM pyruvate kinase, muscle -0.0316123
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0301846
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0300191
FTL ferritin, light polypeptide -0.0299907
GRB10 growth factor receptor-bound protein 10 -0.0297232
DPYSL2 dihydropyrimidinase-like 2 -0.0289985
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0284954
TSC22D2 TSC22 domain family, member 2 -0.0281752
MATR3 matrin 3 -0.0280645
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0280112
CENPF centromere protein F, 350/400kDa -0.0279597
ACER3 alkaline ceramidase 3 -0.0279293
INSIG1 insulin induced gene 1 -0.027738
EGFR epidermal growth factor receptor -0.0276652
TET2 tet methylcytosine dioxygenase 2 -0.0273322
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0272261
CUL3 cullin 3 -0.0271495
HELZ helicase with zinc finger -0.0269717
ATP5F1B ATP synthase F1 subunit beta -0.0262979
ZBTB20 zinc finger and BTB domain containing 20 -0.0260711
NAV2 neuron navigator 2 -0.0259992
RAB31 RAB31, member RAS oncogene family -0.0259438
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0259313
CLASP1 cytoplasmic linker associated protein 1 -0.0258789
SOD2 superoxide dismutase 2, mitochondrial -0.0257395
USP34 ubiquitin specific peptidase 34 -0.025679
ACBD6 acyl-CoA binding domain containing 6 -0.0250685
RPLP1 ribosomal protein, large, P1 -0.0250658
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0249744
PTBP2 polypyrimidine tract binding protein 2 -0.0249309
WASHC4 WASH complex subunit 4 -0.0246802
SEPTIN2 septin 2 -0.0245537
ANKRD33B ankyrin repeat domain 33B -0.0245462
UBAP2 ubiquitin associated protein 2 -0.0244018
ITM2B integral membrane protein 2B -0.024227
CDC27 cell division cycle 27 -0.0241986
TIMP1 TIMP metallopeptidase inhibitor 1 -0.024173
TENT4A terminal nucleotidyltransferase 4A -0.0241118
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0240629
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0238819
ATF6 activating transcription factor 6 -0.0238532
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0238095
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0237862
CDK19 cyclin-dependent kinase 19 -0.0237426
ENO2 enolase 2 (gamma, neuronal) -0.0237056
SLC25A51 solute carrier family 25, member 51 -0.023478
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0233749
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0233381
RPL11 ribosomal protein L11 -0.0232613
KPNB1 karyopherin (importin) beta 1 -0.0231603
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0231073
CLEC1B C-type lectin domain family 1, member B -0.0230567
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0228722
JARID2 jumonji, AT rich interactive domain 2 -0.0228329
IRF1 interferon regulatory factor 1 -0.022765
FKBP10 FK506 binding protein 10, 65 kDa -0.0226903
SEPTIN7 septin 7 -0.0225972
NEMF nuclear export mediator factor -0.0225543
RAP1A RAP1A, member of RAS oncogene family -0.0224923
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0224597
FMR1 fragile X mental retardation 1 -0.0223401
GPBP1 GC-rich promoter binding protein 1 -0.022299
IGFBP3 insulin-like growth factor binding protein 3 -0.0222073
RAI1 retinoic acid induced 1 -0.0221095
LMO7 LIM domain 7 -0.022095
MAGT1 magnesium transporter 1 -0.022056
WDFY3 WD repeat and FYVE domain containing 3 -0.0220028
VCAM1 vascular cell adhesion molecule 1 -0.0219848
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0218635
STRN3 striatin, calmodulin binding protein 3 -0.021662
XPO1 exportin 1 -0.0216471