Uridine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Uridine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Uridine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.139463
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0928031
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0834735
CANX calnexin 0.0834698
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0823613
AHNAK AHNAK nucleoprotein 0.0735938
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0710476
DSCAM Down syndrome cell adhesion molecule 0.069972
DST dystonin 0.0695589
BASP1 brain abundant, membrane attached signal protein 1 0.0684614
PKM pyruvate kinase, muscle 0.0658229
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0649756
CEP250 centrosomal protein 250kDa 0.0604668
LDHA lactate dehydrogenase A 0.0600362
CUL4B cullin 4B 0.059946
MSN moesin 0.0597466
NUP58 nucleoporin 58 0.0586193
BIRC3 baculoviral IAP repeat containing 3 0.0584549
RBM39 RNA binding motif protein 39 0.0555142
CAPRIN2 caprin family member 2 0.0544184
EIF1 eukaryotic translation initiation factor 1 0.0542518
PTMA prothymosin, alpha 0.0542123
VIM vimentin 0.0532518
FNDC3B fibronectin type III domain containing 3B 0.0530512
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0506149
GOLGA4 golgin A4 0.0498357
NKTR natural killer cell triggering receptor 0.0490249
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0486897
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0485323
NUMA1 nuclear mitotic apparatus protein 1 0.048322
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0478677
ANXA1 annexin A1 0.0478132
PGK1 phosphoglycerate kinase 1 0.0476542
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0474958
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0473389
YBX3 Y box binding protein 3 0.0471626
RAD23B RAD23 homolog B (S. cerevisiae) 0.0467385
HILPDA hypoxia inducible lipid droplet-associated 0.046614
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0459444
PHF3 PHD finger protein 3 0.0448128
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0444059
CPNE1 copine I 0.0443954
HMGB2 high mobility group box 2 0.0440912
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0440148
PHF20 PHD finger protein 20 0.0439558
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0430951
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0426206
NAMPT nicotinamide phosphoribosyltransferase 0.0423112
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0416053
ATP13A3 ATPase type 13A3 0.04144
B2M beta-2-microglobulin 0.0412935
OGA O-GlcNAcase 0.0403553
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0403416
PYGL phosphorylase, glycogen, liver 0.0402009
CALR calreticulin 0.0401952
ANLN anillin, actin binding protein 0.0400417
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0393773
SRRM2 serine/arginine repetitive matrix 2 0.0390807
LOC112694756 uncharaterized LOC112694756 0.038725
XPO1 exportin 1 0.0387131
ERRFI1 ERBB receptor feedback inhibitor 1 0.0384944
MARCHF6 membrane associated ring-CH-type finger 6 0.0383917
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0382303
NONO non-POU domain containing, octamer-binding 0.0376639
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.037302
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0371211
IGFBP3 insulin-like growth factor binding protein 3 0.0370069
YAP1 Yes-associated protein 1 0.0366515
ITSN2 intersectin 2 0.0366395
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0359805
ANKHD1 ankyrin repeat and KH domain containing 1 0.0355366
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0354516
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0354442
ARRDC3 arrestin domain containing 3 0.0354228
TNIP1 TNFAIP3 interacting protein 1 0.0352058
ANKRD36 ankyrin repeat domain 36 0.035131
MACF1 microtubule-actin crosslinking factor 1 0.0350668
FMNL2 formin-like 2 0.0349049
SMYD3 SET and MYND domain containing 3 0.0348135
HSPA8 heat shock 70kDa protein 8 0.0347416
SET SET nuclear proto-oncogene 0.0347142
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0344164
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.032839
EEF2 eukaryotic translation elongation factor 2 0.0322935
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0319168
NCOR1 nuclear receptor corepressor 1 0.0317812
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0317029
RPL3 ribosomal protein L3 0.0316149
SRSF11 serine/arginine-rich splicing factor 11 0.03138
NDRG1 N-myc downstream regulated 1 0.0313368
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0313201
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0312126
CEP295 centrosomal protein 295kDa 0.0308449
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0307994
ENO1 enolase 1, (alpha) 0.0306518
RAD21 RAD21 homolog (S. pombe) 0.0303989
NAP1L1 nucleosome assembly protein 1-like 1 0.0303902
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0302575
ATXN1 ataxin 1 0.0301731
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0300253

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0681368
RAB7A RAB7A, member RAS oncogene family -0.0479192
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0451496
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.044963
NLK nemo-like kinase -0.0395267
RIN2 Ras and Rab interactor 2 -0.0349958
OSMR oncostatin M receptor -0.0336949
MORF4L1 mortality factor 4 like 1 -0.033587
NALCN sodium leak channel, non selective -0.0329643
CCDC14 coiled-coil domain containing 14 -0.0326777
NCEH1 neutral cholesterol ester hydrolase 1 -0.0316287
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0314667
BSG basigin (Ok blood group) -0.0309184
CCDC91 coiled-coil domain containing 91 -0.0298441
THSD4 thrombospondin, type I, domain containing 4 -0.0297451
TAOK3 TAO kinase 3 -0.0294862
POTEF POTE ankyrin domain family, member F -0.0291462
NAV2 neuron navigator 2 -0.0289633
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0283495
EFL1 elongation factor like GTPase 1 -0.0281866
HJURP Holliday junction recognition protein -0.0276699
BPTF bromodomain PHD finger transcription factor -0.0272715
RIGI RNA sensor RIG-I -0.02711
FTH1 ferritin, heavy polypeptide 1 -0.0269916
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0266154
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0265782
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0265061
PCNX4 pecanex 4 -0.0263305
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0261654
RPS25 ribosomal protein S25 -0.0260492
LAMA5 laminin, alpha 5 -0.0257282
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0252834
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0249541
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0249318
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0248829
CHSY1 chondroitin sulfate synthase 1 -0.0242121
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0240542
ATF6 activating transcription factor 6 -0.0238612
HBS1L HBS1-like translational GTPase -0.023601
PRH1 proline-rich protein HaeIII subfamily 1 -0.0235555
ZC3H12C zinc finger CCCH-type containing 12C -0.0228298
DNER delta/notch-like EGF repeat containing -0.0228172
SMAD3 SMAD family member 3 -0.0226589
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0222318
OASL 2'-5'-oligoadenylate synthetase-like -0.022228
SS18 synovial sarcoma translocation, chromosome 18 -0.0222118
CAPN7 calpain 7 -0.0221813
FBXL7 F-box and leucine-rich repeat protein 7 -0.0218779
MYO5A myosin VA (heavy chain 12, myoxin) -0.0217745
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0216166
PIAS1 protein inhibitor of activated STAT, 1 -0.021512
MICU1 mitochondrial calcium uptake 1 -0.0214984
FNDC3A fibronectin type III domain containing 3A -0.0213239
ATXN3 ataxin 3 -0.0212458
SPAG9 sperm associated antigen 9 -0.0212055
SCFD1 sec1 family domain containing 1 -0.0211041
SVIL supervillin -0.0210987
DOCK4 dedicator of cytokinesis 4 -0.0210435
PDE8A phosphodiesterase 8A -0.0210087
KIAA1328 KIAA1328 -0.0208784
ETV6 ets variant 6 -0.0208762
SNED1 sushi, nidogen and EGF-like domains 1 -0.0207988
MTMR3 myotubularin related protein 3 -0.0207966
PTBP2 polypyrimidine tract binding protein 2 -0.0207781
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0207298
SMAD2 SMAD family member 2 -0.0205683
RPLP1 ribosomal protein, large, P1 -0.0205656
SIK2 salt-inducible kinase 2 -0.0205591
SAP30BP SAP30 binding protein -0.0205509
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.020216
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0201986
TMSB10 thymosin beta 10 -0.0201355
IL31RA interleukin 31 receptor A -0.020036
ARMH4 armadillo like helical domain containing 4 -0.0200146
ZNF609 zinc finger protein 609 -0.0200033
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.019936
PSD3 pleckstrin and Sec7 domain containing 3 -0.0198663
HMGA1 high mobility group AT-hook 1 -0.0197567
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0196981
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0196341
MECP2 methyl CpG binding protein 2 -0.0195398
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0195024
RFC3 replication factor C (activator 1) 3, 38kDa -0.0193874
SLC39A11 solute carrier family 39, member 11 -0.0192058
MCC mutated in colorectal cancers -0.0190122
NHLRC2 NHL repeat containing 2 -0.0189948
EFCAB14 EF-hand calcium binding domain 14 -0.0189033
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0187968
RBM27 RNA binding motif protein 27 -0.0187302
ZBTB20 zinc finger and BTB domain containing 20 -0.0187087
PEX14 peroxisomal biogenesis factor 14 -0.0186727
WWTR1 WW domain containing transcription regulator 1 -0.0186501
STAT5B signal transducer and activator of transcription 5B -0.0186253
CKAP2 cytoskeleton associated protein 2 -0.018443
RREB1 ras responsive element binding protein 1 -0.0184232
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0184127
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.018406
ADIPOR2 adiponectin receptor 2 -0.0183236
STXBP1 syntaxin binding protein 1 -0.0183208
SDCCAG8 serologically defined colon cancer antigen 8 -0.0182557