Urolithiasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description presence of calculi in any part of the urinary system (Mammalian Phenotype Ontology, MP_0005360)
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Genes

274 genes co-occuring with the disease Urolithiasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
AGXT alanine-glyoxylate aminotransferase 3.152
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.973
GRHPR glyoxylate reductase/hydroxypyruvate reductase 2.858
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.793
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.791
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.78
PTH parathyroid hormone 2.76
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.753
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.733
SPP1 secreted phosphoprotein 1 2.677
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.668
UMOD uromodulin 2.574
XDH xanthine dehydrogenase 2.482
ALB albumin 2.37
CASR calcium-sensing receptor 2.37
MOCOS molybdenum cofactor sulfurase 2.306
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.218
CLDN14 claudin 14 2.213
NUMA1 nuclear mitotic apparatus protein 1 2.201
CHRM3 cholinergic receptor, muscarinic 3 2.155
AMBP alpha-1-microglobulin/bikunin precursor 2.145
PHC3 polyhomeotic homolog 3 (Drosophila) 2.14
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.139
APRT adenine phosphoribosyltransferase 2.123
CRP C-reactive protein, pentraxin-related 2.117
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.101
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.093
HAVCR1 hepatitis A virus cellular receptor 1 2.073
CLCN5 chloride channel, voltage-sensitive 5 2.061
REN renin 1.959
INS insulin 1.958
OGA O-GlcNAcase 1.954
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.946
SLC26A7 solute carrier family 26 (anion exchanger), member 7 1.943
CLDN16 claudin 16 1.939
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.939
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.912
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.911
LCN2 lipocalin 2 1.906
MEN1 multiple endocrine neoplasia I 1.892
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 1.883
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.878
FGF23 fibroblast growth factor 23 1.876
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.858
MGP matrix Gla protein 1.844
F2 coagulation factor II (thrombin) 1.836
OAT ornithine aminotransferase 1.819
ACE angiotensin I converting enzyme 1.808
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 1.807
IL6 interleukin 6 1.803
CST3 cystatin C 1.791
IL1B interleukin 1, beta 1.784
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.782
KL klotho 1.768
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 1.768
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.754
DGKH diacylglycerol kinase, eta 1.744
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 1.728
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.718
TNF tumor necrosis factor 1.716
SLC26A8 solute carrier family 26 (anion exchanger), member 8 1.707
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 1.699
AVP arginine vasopressin 1.692
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.692
BGLAP bone gamma-carboxyglutamate (gla) protein 1.682
AHSG alpha-2-HS-glycoprotein 1.676
PREPL prolyl endopeptidase-like 1.653
ADRA1A adrenoceptor alpha 1A 1.645
CCL2 chemokine (C-C motif) ligand 2 1.636
AQP2 aquaporin 2 (collecting duct) 1.636
CLDN19 claudin 19 1.626
B2M beta-2-microglobulin 1.625
SLC26A9 solute carrier family 26 (anion exchanger), member 9 1.621
CDC73 cell division cycle 73 1.599
EMP1 epithelial membrane protein 1 1.599
PDILT protein disulfide isomerase-like, testis expressed 1.588
AOX1 aldehyde oxidase 1 1.575
RGS14 regulator of G-protein signaling 14 1.57
KLK3 kallikrein-related peptidase 3 1.569
RIMBP3 RIMS binding protein 3 1.561
OCRL oculocerebrorenal syndrome of Lowe 1.551
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.537
GPX6 glutathione peroxidase 6 1.532
GPX2 glutathione peroxidase 2 1.532
GPX5 glutathione peroxidase 5 1.531
GPX8 glutathione peroxidase 8 (putative) 1.531
GPX3 glutathione peroxidase 3 1.53
GPX7 glutathione peroxidase 7 1.528
POMC proopiomelanocortin 1.521
PRODH2 proline dehydrogenase (oxidase) 2 1.515
PTHLH parathyroid hormone-like hormone 1.512
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.5
TGFB1 transforming growth factor, beta 1 1.498
CALCR calcitonin receptor 1.488
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.477
IL18 interleukin 18 1.473
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.472
ADRA1D adrenoceptor alpha 1D 1.47
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.464
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.455
CXCL8 chemokine (C-X-C motif) ligand 8 1.443
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.441
FN1 fibronectin 1 1.439
UPK3A uroplakin 3A 1.435
ALPL alkaline phosphatase, liver/bone/kidney 1.434
WNK4 WNK lysine deficient protein kinase 4 1.43
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 1.417
TSPY10 testis specific protein, Y-linked 10 1.416
MINDY4 MINDY lysine 48 deubiquitinase 4 1.415
ORAI1 ORAI calcium release-activated calcium modulator 1 1.41
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.408
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.396
SUOX sulfite oxidase 1.39
PPARG peroxisome proliferator-activated receptor gamma 1.379
TSPY3 testis specific protein, Y-linked 3 1.379
PDZK1 PDZ domain containing 1 1.377
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.363
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.363
GPN1 GPN-loop GTPase 1 1.359
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 1.355
UPK2 uroplakin 2 1.35
AGXT2 alanine--glyoxylate aminotransferase 2 1.346
LYZL1 lysozyme-like 1 1.345
UPK1B uroplakin 1B 1.344
UPK1A uroplakin 1A 1.341
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.336
NOX4 NADPH oxidase 4 1.326
KHK ketohexokinase (fructokinase) 1.316
CHRM4 cholinergic receptor, muscarinic 4 1.315
S100A9 S100 calcium binding protein A9 1.315
CKB creatine kinase, brain 1.31
STAP2 signal transducing adaptor family member 2 1.308
GC group-specific component (vitamin D binding protein) 1.302
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.3
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.295
CKMT1B creatine kinase, mitochondrial 1B 1.294
WDR72 WD repeat domain 72 1.292
CKM creatine kinase, muscle 1.289
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.289
CA9 carbonic anhydrase IX 1.282
F3 coagulation factor III (thromboplastin, tissue factor) 1.281
LMAN2 lectin, mannose-binding 2 1.277
ZNF446 zinc finger protein 446 1.277
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.274
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.27
SLC26A5 solute carrier family 26 (anion exchanger), member 5 1.266
KRT20 keratin 20, type I 1.264
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.263
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 1.261
GCG glucagon 1.256
MMP10 matrix metallopeptidase 10 1.253
NLRP3 NLR family, pyrin domain containing 3 1.253
PPARA peroxisome proliferator-activated receptor alpha 1.246
PHEX phosphate regulating endopeptidase homolog, X-linked 1.245
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.245
GGCX gamma-glutamyl carboxylase 1.244
DNAH8 dynein, axonemal, heavy chain 8 1.239
CCDC121 coiled-coil domain containing 121 1.236
HMOX1 heme oxygenase 1 1.236
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.232
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.229
PXDNL peroxidasin-like 1.226
CA2 carbonic anhydrase II 1.225
PXDN peroxidasin 1.225
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.224
CD44 CD44 molecule (Indian blood group) 1.22
SAYSD1 SAYSVFN motif domain containing 1 1.22
IL1A interleukin 1, alpha 1.218
NOS3 nitric oxide synthase 3 (endothelial cell) 1.216
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.215
EVI5L ecotropic viral integration site 5-like 1.205
COL4A4 collagen, type IV, alpha 4 1.204
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.202
ADIPOQ adiponectin, C1Q and collagen domain containing 1.202
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 1.195
ENO1 enolase 1, (alpha) 1.194
ACTB actin, beta 1.192
PDE5A phosphodiesterase 5A, cGMP-specific 1.19
MMP9 matrix metallopeptidase 9 1.188
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.186
MPO myeloperoxidase 1.185
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.184
EPO erythropoietin 1.183
MEPE matrix extracellular phosphoglycoprotein 1.18
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 1.179
PNLIP pancreatic lipase 1.175
SHBG sex hormone-binding globulin 1.17
GSR glutathione reductase 1.17
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.166
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.166
SOX3 SRY (sex determining region Y)-box 3 1.162
FABP1 fatty acid binding protein 1, liver 1.161
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.16
IGF1 insulin-like growth factor 1 (somatomedin C) 1.158
MB myoglobin 1.154
IFNG interferon, gamma 1.154
GCM2 glial cells missing homolog 2 (Drosophila) 1.149
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.148
KRT7 keratin 7, type II 1.147
S100A12 S100 calcium binding protein A12 1.147
AMY2B amylase, alpha 2B (pancreatic) 1.145
KNG1 kininogen 1 1.142
AMY2A amylase, alpha 2A (pancreatic) 1.141
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.141
TLR4 toll-like receptor 4 1.14
FAM43A family with sequence similarity 43, member A 1.137
CD4 CD4 molecule 1.133
NOX1 NADPH oxidase 1 1.133
ADSL adenylosuccinate lyase 1.132
CYBB cytochrome b-245, beta polypeptide 1.127
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.126
LYZ lysozyme 1.125
LDHA lactate dehydrogenase A 1.124
SLC16A9 solute carrier family 16, member 9 1.123
WNK1 WNK lysine deficient protein kinase 1 1.121
GAST gastrin 1.118
APOE apolipoprotein E 1.117
BCAS3 breast carcinoma amplified sequence 3 1.117
CP ceruloplasmin (ferroxidase) 1.116
IL10 interleukin 10 1.116
PAQR6 progestin and adipoQ receptor family member VI 1.115
PRPS1 phosphoribosyl pyrophosphate synthetase 1 1.113
CAPG capping protein (actin filament), gelsolin-like 1.112
LRP2 low density lipoprotein receptor-related protein 2 1.11
RUNX2 runt-related transcription factor 2 1.105
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 1.103
LTF lactotransferrin 1.102
AMY1B amylase, alpha 1B (salivary) 1.099
PRL prolactin 1.096
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.092
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.092
APEH acylaminoacyl-peptide hydrolase 1.09
PNP purine nucleoside phosphorylase 1.089
CAV1 caveolin 1, caveolae protein, 22kDa 1.088
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 1.086
BMP2 bone morphogenetic protein 2 1.085
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.082
HLA-B major histocompatibility complex, class I, B 1.075
AVPR2 arginine vasopressin receptor 2 1.071
TP53 tumor protein p53 1.068
PROZ protein Z, vitamin K-dependent plasma glycoprotein 1.063
ANXA1 annexin A1 1.062
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 1.062
MGAM maltase-glucoamylase 1.058
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 1.058
IL1RN interleukin 1 receptor antagonist 1.056
NGF nerve growth factor (beta polypeptide) 1.049
BSND barttin CLCNK-type chloride channel accessory beta subunit 1.048
ACE2 angiotensin I converting enzyme 2 1.046
EGF epidermal growth factor 1.043
F12 coagulation factor XII (Hageman factor) 1.041
LEP leptin 1.039
LCTL lactase-like 1.038
BCL2 B-cell CLL/lymphoma 2 1.035
OR9A2 olfactory receptor, family 9, subfamily A, member 2 1.032
DMP1 dentin matrix acidic phosphoprotein 1 1.03
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.028
JUN jun proto-oncogene 1.02
ESPN espin 1.018
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.017
KCNK5 potassium channel, two pore domain subfamily K, member 5 1.013
IBSP integrin-binding sialoprotein 1.011
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 1.011
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.01
FGFR3 fibroblast growth factor receptor 3 1.01
CTRB2 chymotrypsinogen B2 1.009
ASB12 ankyrin repeat and SOCS box containing 12 1.009
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.009
LDHAL6B lactate dehydrogenase A-like 6B 1.005
ZNF512 zinc finger protein 512 1.004
CTRB1 chymotrypsinogen B1 1.003
CFH complement factor H 1.002
SST somatostatin 1.001
SI sucrase-isomaltase (alpha-glucosidase) 1.001