Urothelial Carcinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C2145472
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Genes

406 genes associated with the disease Urothelial Carcinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALK anaplastic lymphoma receptor tyrosine kinase
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
ANGPTL4 angiopoietin-like 4
ANKRD36B ankyrin repeat domain 36B
ANXA10 annexin A10
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
AR androgen receptor
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARID1A AT rich interactive domain 1A (SWI-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ASCC1 activating signal cointegrator 1 complex subunit 1
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AXIN2 axin 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BCAM basal cell adhesion molecule (Lutheran blood group)
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BGN biglycan
BOK BCL2-related ovarian killer
BRCA2 breast cancer 2, early onset
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C17ORF97 chromosome 17 open reading frame 97
CA2 carbonic anhydrase II
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CBX8 chromobox homolog 8
CCAR2 cell cycle and apoptosis regulator 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCN2 cellular communication network factor 2
CCND1 cyclin D1
CCNE1 cyclin E1
CD163 CD163 molecule
CD24 CD24 molecule
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CISH cytokine inducible SH2-containing protein
CKAP4 cytoskeleton-associated protein 4
CKS1B CDC28 protein kinase regulatory subunit 1B
CLDN5 claudin 5
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNR1 cannabinoid receptor 1 (brain)
COX2
CREBBP CREB binding protein
CRYZ crystallin, zeta (quinone reductase)
CSAG2 CSAG family, member 2
CSAG3 CSAG family, member 3
CST3 cystatin C
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
CTAG1A cancer/testis antigen 1A
CTAG1B cancer/testis antigen 1B
CTHRC1 collagen triple helix repeat containing 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DACH2 dachshund family transcription factor 2
DAPK1 death-associated protein kinase 1
DCN decorin
DCTN6 dynactin 6
DDIT3 DNA-damage-inducible transcript 3
DDR2 discoidin domain receptor tyrosine kinase 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEDD death effector domain containing
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DLL1 delta-like 1 (Drosophila)
DNER delta/notch-like EGF repeat containing
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOC2A double C2-like domains, alpha
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A2 eukaryotic translation initiation factor 5A2
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELK1 ELK1, member of ETS oncogene family
EMP2 epithelial membrane protein 2
EMP3 epithelial membrane protein 3
ENG endoglin
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP2 fatty acid binding protein 2, intestinal
FASN fatty acid synthase
FGF19 fibroblast growth factor 19
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FGF7 fibroblast growth factor 7
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FHIT fragile histidine triad
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXM1 forkhead box M1
GAB1 GRB2-associated binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA3 GATA binding protein 3
GDE1 glycerophosphodiester phosphodiesterase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GFRA3 GDNF family receptor alpha 3
GLS2 glutaminase 2 (liver, mitochondrial)
GPBAR1 G protein-coupled bile acid receptor 1
GPR87 G protein-coupled receptor 87
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX2 glutathione peroxidase 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GSN gelsolin
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GYLTL1B glycosyltransferase-like 1B
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAMP hepcidin antimicrobial peptide
HAS3 hyaluronan synthase 3
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC6 histone deacetylase 6
HDAC8 histone deacetylase 8
HDAC9 histone deacetylase 9
HEPACAM hepatic and glial cell adhesion molecule
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-DMA major histocompatibility complex, class II, DM alpha
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HNF1B HNF1 homeobox B
HOXB13 homeobox B13
HPGDS hematopoietic prostaglandin D synthase
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNL2 interferon, lambda 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INHBA inhibin, beta A
IRF3 interferon regulatory factor 3
ISYNA1 inositol-3-phosphate synthase 1
JAK1 Janus kinase 1
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KCNK17 potassium channel, two pore domain subfamily K, member 17
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KDM6A lysine (K)-specific demethylase 6A
KDR kinase insert domain receptor
KIF20B kinesin family member 20B
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT5 keratin 5, type II
L1CAM L1 cell adhesion molecule
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS9 lectin, galactoside-binding, soluble, 9
LMLN leishmanolysin-like (metallopeptidase M8 family)
LMNA lamin A/C
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEC2 melanoma antigen family C2
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MBD2 methyl-CpG binding domain protein 2
MCM10 minichromosome maintenance complex component 10
MET MET proto-oncogene, receptor tyrosine kinase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MMUT methylmalonyl-CoA mutase
MPO myeloperoxidase
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
MST1 macrophage stimulating 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOG myogenin (myogenic factor 4)
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NAIP NLR family, apoptosis inhibitory protein
NCAM1 neural cell adhesion molecule 1
NCOA3 nuclear receptor coactivator 3
NDN necdin, melanoma antigen (MAGE) family member
NECTIN4 nectin cell adhesion molecule 4
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NID2 nidogen 2 (osteonidogen)
NKX2-1 NK2 homeobox 1
NLRP4 NLR family, pyrin domain containing 4
NLRP9 NLR family, pyrin domain containing 9
NME5 NME/NM23 family member 5
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUMA1 nuclear mitotic apparatus protein 1
OGG1 8-oxoguanine DNA glycosylase
OPN1LW opsin 1 (cone pigments), long-wave-sensitive
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAX8 paired box 8
PCBP4 poly(rC) binding protein 4
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PHB prohibitin
PIAS1 protein inhibitor of activated STAT, 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PKM pyruvate kinase, muscle
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEK pleckstrin
PLK1 polo-like kinase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POU5F1 POU class 5 homeobox 1
PPL periplakin
PRAME preferentially expressed antigen in melanoma
PRMT5 protein arginine methyltransferase 5
PSG2 pregnancy specific beta-1-glycoprotein 2
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTOV1 prostate tumor overexpressed 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
REN renin
RING1 ring finger protein 1
RNF2 ring finger protein 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RORA RAR-related orphan receptor A
RPE65 retinal pigment epithelium-specific protein 65kDa
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSF1 remodeling and spacing factor 1
S100A1 S100 calcium binding protein A1
S100A4 S100 calcium binding protein A4
S100B S100 calcium binding protein B
SATB2 SATB homeobox 2
SDC1 syndecan 1
SFXN1 sideroflexin 1
SGSM3 small G protein signaling modulator 3
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SH3GL2 SH3-domain GRB2-like 2
SIRT6 sirtuin 6
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SLITRK6 SLIT and NTRK-like family, member 6
SMAD3 SMAD family member 3
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAG2 stromal antigen 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYP synaptophysin
TARBP2 TAR (HIV-1) RNA binding protein 2
TERT telomerase reverse transcriptase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
THBS1 thrombospondin 1
TICAM2 toll-like receptor adaptor molecule 2
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TMEM67 transmembrane protein 67
TMPRSS13 transmembrane protease, serine 13
TMSB4X thymosin beta 4, X-linked
TMX1 thioredoxin-related transmembrane protein 1
TNC tenascin C
TNF tumor necrosis factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM34 translocase of outer mitochondrial membrane 34
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TRAP triiodothyronine receptor auxiliary protein
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSC2 tuberous sclerosis 2
TUG1 taurine up-regulated 1 (non-protein coding)
TWIST1 twist family bHLH transcription factor 1
UBQLN2 ubiquilin 2
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
UPK2 uroplakin 2
UPK3A uroplakin 3A
USP28 ubiquitin specific peptidase 28
UVRAG UV radiation resistance associated
VEGFA vascular endothelial growth factor A
VIM vimentin
WISP1 WNT1 inducible signaling pathway protein 1
WNT5A wingless-type MMTV integration site family, member 5A
WWOX WW domain containing oxidoreductase
XPO5 exportin 5
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF654 zinc finger protein 654
ZNF671 zinc finger protein 671