VAMP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vesicle-associated membrane protein 1 (synaptobrevin 1)|Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 6843)
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Genes

333 genes differentially expressed following the VAMP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SYN2 synapsin II 2.48508
AHSG alpha-2-HS-glycoprotein 2.48508
ZNF521 zinc finger protein 521 2.48508
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.48508
ADAM29 ADAM metallopeptidase domain 29 2.48508
IL18 interleukin 18 2.48508
SPATA22 spermatogenesis associated 22 2.48508
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.48508
SLFN12L schlafen family member 12-like 2.48508
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.48508
HPX hemopexin 2.48508
C2ORF66 chromosome 2 open reading frame 66 2.48508
DES desmin 2.48508
LOC124900192 uncharacterized LOC124900192 2.48508
LRTM2 leucine-rich repeats and transmembrane domains 2 2.48508
AMH anti-Mullerian hormone 2.48508
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.48508
MUSK muscle, skeletal, receptor tyrosine kinase 2.48508
GOLGA8N golgin A8 family, member N 2.48508
PLN phospholamban 2.48508
KCNIP3 Kv channel interacting protein 3, calsenilin 2.48508
ADAT3 adenosine deaminase, tRNA-specific 3 2.48508
SIX6 SIX homeobox 6 2.41042
MISP mitotic spindle positioning 2.41042
MUC22 mucin 22 2.41042
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.41042
SRPX2 sushi-repeat containing protein, X-linked 2 2.41042
KRT25 keratin 25, type I 2.41042
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.41042
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 2.41042
MRPL21 mitochondrial ribosomal protein L21 2.41042
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.41042
NRN1 neuritin 1 2.41042
SYCP2 synaptonemal complex protein 2 2.41042
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.41042
ACOT1 acyl-CoA thioesterase 1 2.41042
LAPTM5 lysosomal protein transmembrane 5 2.41042
CEMP1 cementum protein 1 2.41042
SSTR1 somatostatin receptor 1 2.41042
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.41042
MYBPC1 myosin binding protein C, slow type 2.41042
PCDHB8 protocadherin beta 8 2.41042
MCM2 minichromosome maintenance complex component 2 2.41042
TRIM73 tripartite motif containing 73 2.41042
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 2.41042
TRIM10 tripartite motif containing 10 2.41042
TRIM77 tripartite motif containing 77 2.41042
TMEM176A transmembrane protein 176A 2.41042
AVPR2 arginine vasopressin receptor 2 2.41042
CABP4 calcium binding protein 4 2.41042
SPINK6 serine peptidase inhibitor, Kazal type 6 2.41042
ASPDH aspartate dehydrogenase domain containing 2.41042
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.41042
BTN1A1 butyrophilin, subfamily 1, member A1 2.41042
SLC46A2 solute carrier family 46, member 2 2.41042
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.41042
LOC107986837 uncharacterized LOC107986837 2.41042
SMIM40 small integral membrane protein 40 2.41042
CFAP65 cilia and flagella associated protein 65 2.41042
CES4A carboxylesterase 4A 2.41042
C3AR1 complement component 3a receptor 1 2.41042
YIPF7 Yip1 domain family, member 7 2.41042
CD300LF CD300 molecule-like family member f 2.41042
HTRA4 HtrA serine peptidase 4 2.41042
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.41042
LORICRIN loricrin cornified envelope precursor protein 2.41042
TBXT T-box transcription factor T 2.41042
RTL9 retrotransposon Gag like 9 2.41042
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.41042
EPCIP exosomal polycystin 1 interacting protein 2.41042
TMDD1 transmembrane and death domain 1 2.41042
C17ORF113 chromosome 17 open reading frame 113 2.41042
CFAP97D2 CFAP97 domain containing 2 2.41042
PEAK3 PEAK family member 3 2.41042
CATSPERZ catsper channel auxiliary subunit zeta 2.41042
H2BC3 H2B clustered histone 3 2.41042
OTOR otoraplin 2.41042
STX11 syntaxin 11 2.41042
GLP2R glucagon-like peptide 2 receptor 2.41042
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.41042
SLAMF6 SLAM family member 6 2.41042
CDK7 cyclin-dependent kinase 7 2.41042
SCRT1 scratch family zinc finger 1 2.41042
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.41042
C10ORF67 chromosome 10 open reading frame 67 2.41042
GAST gastrin 2.41042
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.41042
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.41042
TACR2 tachykinin receptor 2 2.41042
ZNF705B zinc finger protein 705B 2.41042
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.41042
GATA3 GATA binding protein 3 2.41042
GATA6 GATA binding protein 6 2.41042
CSAG3 CSAG family, member 3 2.41042
TINAG tubulointerstitial nephritis antigen 2.41042
GDF7 growth differentiation factor 7 2.41042
RAI14 retinoic acid induced 14 2.41042
ZSWIM2 zinc finger, SWIM-type containing 2 2.41042
EDN1 endothelin 1 2.41042
CALML5 calmodulin-like 5 2.41042
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.41042
LMOD3 leiomodin 3 (fetal) 2.41042
MUC17 mucin 17, cell surface associated 2.41042
NUTM2B NUT family member 2B 2.41042
MRGPRE MAS-related GPR, member E 2.41042
SAMD7 sterile alpha motif domain containing 7 2.41042
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.41042
CALR3 calreticulin 3 2.41042
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.41042
ALLC allantoicase 2.41042
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.41042
TEX36 testis expressed 36 2.41042
BARHL2 BarH-like homeobox 2 2.41042
RPS21 ribosomal protein S21 2.41042
GP5 glycoprotein V (platelet) 2.41042
PLBD1 phospholipase B domain containing 1 2.41042
C6ORF163 chromosome 6 open reading frame 163 2.41042
BRDT bromodomain, testis-specific 2.41042
ADNP2 ADNP homeobox 2 2.41042
KLF2 Kruppel-like factor 2 2.41042
EWSR1 EWS RNA-binding protein 1 2.41042
CTBP1 C-terminal binding protein 1 2.41042
TREH trehalase (brush-border membrane glycoprotein) 2.41042
FNDC9 fibronectin type III domain containing 9 2.41042
CGB2 chorionic gonadotropin, beta polypeptide 2 2.41042
CCDC154 coiled-coil domain containing 154 2.41042
NOSIP nitric oxide synthase interacting protein 2.41042
PRR35 proline rich 35 2.41042
GREM1 gremlin 1, DAN family BMP antagonist 2.41042
SOST sclerostin 2.41042
LHX6 LIM homeobox 6 2.41042
MOBP myelin-associated oligodendrocyte basic protein 2.41042
EFCC1 EF-hand and coiled-coil domain containing 1 2.41042
NKX6-2 NK6 homeobox 2 2.41042
PMCH pro-melanin-concentrating hormone 2.41042
CASQ2 calsequestrin 2 (cardiac muscle) 2.41042
FKBP1C FK506 binding protein 1C 2.41042
C22ORF31 chromosome 22 open reading frame 31 2.41042
HIC1 hypermethylated in cancer 1 2.41042
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.41042
STRC stereocilin 2.41042
FRMPD1 FERM and PDZ domain containing 1 2.41042
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.41042
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.41042
ASCL1 achaete-scute family bHLH transcription factor 1 2.41042
DMRT1 doublesex and mab-3 related transcription factor 1 2.41042
TG thyroglobulin 2.41042
APOA1 apolipoprotein A-I 2.41042
VAV1 vav 1 guanine nucleotide exchange factor 2.41042
CTSF cathepsin F 2.41042
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.41042
SLC38A8 solute carrier family 38, member 8 2.41042
BCL2L15 BCL2-like 15 2.41042
ZPLD1 zona pellucida-like domain containing 1 2.41042
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.41042
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.36548
C21ORF91 chromosome 21 open reading frame 91 2.36445
NUTM2E NUT family member 2E 2.35284
ERCC2 excision repair cross-complementation group 2 2.34217
ATP5MGL ATP synthase membrane subunit g like 2.34217
RIBC2 RIB43A domain with coiled-coils 2 2.34217
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.34217
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.34217
HEPACAM hepatic and glial cell adhesion molecule 2.34217
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 2.34217
FAM229B family with sequence similarity 229, member B 2.34217
ARGFX arginine-fifty homeobox 2.34217
ARF6 ADP-ribosylation factor 6 2.34217
CCM2L cerebral cavernous malformation 2-like 2.34217
GSPT2 G1 to S phase transition 2 2.34217
FKBP10 FK506 binding protein 10, 65 kDa 2.33156
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.30837
RNFT2 ring finger protein, transmembrane 2 2.30301
PDZD11 PDZ domain containing 11 2.30301
MIGA2 mitoguardin 2 2.28231
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.28231
TSBP1 testis expressed basic protein 1 2.27252
MARCHF3 membrane associated ring-CH-type finger 3 2.2661
GAL galanin/GMAP prepropeptide 2.26279
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.25887
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 2.25393
INTS4 integrator complex subunit 4 2.25139
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.24478
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.23162
SH3BGR SH3 domain binding glutamate-rich protein 2.21938
LYRM9 LYR motif containing 9 2.21794
PHF3 PHD finger protein 3 2.19853
ATG14 autophagy related 14 2.19289
JOSD1 Josephin domain containing 1 2.19289
CHIC2 cysteine-rich hydrophobic domain 2 2.16505
GPR173 G protein-coupled receptor 173 2.16505
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.16505
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.15937
SUGP1 SURP and G patch domain containing 1 2.15937
ZFP14 ZFP14 zinc finger protein 2.14493
LAMP1 lysosomal-associated membrane protein 1 2.14493
ZFHX2 zinc finger homeobox 2 2.12595
ZNF555 zinc finger protein 555 2.09115
ETFRF1 electron transfer flavoprotein regulatory factor 1 2.09093
BRCA2 breast cancer 2, early onset 2.09088
WDR4 WD repeat domain 4 2.08828
SAMD10 sterile alpha motif domain containing 10 2.08828
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.0879
RND2 Rho family GTPase 2 2.07463
MARS1 methionyl-tRNA synthetase 1 2.06914
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.06466
LZTS2 leucine zipper, putative tumor suppressor 2 2.06161
SORBS3 sorbin and SH3 domain containing 3 2.06161
ZNF385D zinc finger protein 385D 2.05733
PEMT phosphatidylethanolamine N-methyltransferase 2.05606
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 2.04028
SMIM24 small integral membrane protein 24 2.04028
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 2.02867
STPG2 sperm-tail PG-rich repeat containing 2 2.02341
DZIP1L DAZ interacting zinc finger protein 1-like 2.01789
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 2.00825
CST3 cystatin C 2.00783
TMEM223 transmembrane protein 223 2.00384
VAT1 vesicle amine transport 1 2.00013
DLL3 delta-like 3 (Drosophila) 2.00013
MICU1 mitochondrial calcium uptake 1 2.00013

decreased expression

Symbol Name Standardized Value
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -2.48508
CERCAM cerebral endothelial cell adhesion molecule -2.48508
NLRC5 NLR family, CARD domain containing 5 -2.41042
MARCHF10 membrane associated ring-CH-type finger 10 -2.41042
RCAN1 regulator of calcineurin 1 -2.41042
SRPX sushi-repeat containing protein, X-linked -2.41042
C2CD2L C2CD2-like -2.41042
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.41042
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.41042
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.41042
TMEM236 transmembrane protein 236 -2.41042
KIFC2 kinesin family member C2 -2.41042
DDIT3 DNA-damage-inducible transcript 3 -2.41042
SYT5 synaptotagmin V -2.41042
GGCT gamma-glutamylcyclotransferase -2.41042
CRYAB crystallin, alpha B -2.41042
RBMS2 RNA binding motif, single stranded interacting protein 2 -2.41042
TRIM2 tripartite motif containing 2 -2.41042
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.41042
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.36548
SNPH syntaphilin -2.34217
TMEM215 transmembrane protein 215 -2.34217
REN renin -2.34217
ANKRD34A ankyrin repeat domain 34A -2.34217
SUSD2 sushi domain containing 2 -2.34217
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.34217
PLK5 polo-like kinase 5 -2.34217
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.34217
C7ORF57 chromosome 7 open reading frame 57 -2.34217
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.34217
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -2.34217
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.34217
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.34217
NPTX1 neuronal pentraxin I -2.34217
ZNF341 zinc finger protein 341 -2.34217
PRRT4 proline-rich transmembrane protein 4 -2.34217
AGBL4 ATP/GTP binding protein-like 4 -2.34217
PIH1D2 PIH1 domain containing 2 -2.34217
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -2.34217
KCNK4 potassium channel, two pore domain subfamily K, member 4 -2.34217
BAIAP3 BAI1-associated protein 3 -2.34217
CFAP157 cilia and flagella associated protein 157 -2.34217
MAEL maelstrom spermatogenic transposon silencer -2.34217
ACTL8 actin-like 8 -2.34217
PCDHGA1 protocadherin gamma subfamily A, 1 -2.34217
PDGFA platelet-derived growth factor alpha polypeptide -2.34217
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.34217
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.34217
CSP2 CS pseudogene 2 -2.34217
SAAL1 serum amyloid A-like 1 -2.34217
AGMO alkylglycerol monooxygenase -2.34217
RIPK4 receptor-interacting serine-threonine kinase 4 -2.33981
ZNF780B zinc finger protein 780B -2.33449
RAB1A RAB1A, member RAS oncogene family -2.33232
CHRM3 cholinergic receptor, muscarinic 3 -2.31003
RCAN2 regulator of calcineurin 2 -2.30866
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -2.30744
H2BC8 H2B clustered histone 8 -2.30301
ANGPT1 angiopoietin 1 -2.30301
FSD2 fibronectin type III and SPRY domain containing 2 -2.30301
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -2.30301
NR2C1 nuclear receptor subfamily 2, group C, member 1 -2.29308
KLK1 kallikrein 1 -2.28231
ARGLU1 arginine and glutamate rich 1 -2.28231
TPH2 tryptophan hydroxylase 2 -2.2661
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.26279
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.24077
UNC5A unc-5 homolog A (C. elegans) -2.21794
NKD2 naked cuticle homolog 2 (Drosophila) -2.21794
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.21794
ZNF536 zinc finger protein 536 -2.21794
FBXL12 F-box and leucine-rich repeat protein 12 -2.21141
TLR2 toll-like receptor 2 -2.20287
ZNF792 zinc finger protein 792 -2.20287
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.19936
NOTCH1 notch 1 -2.19593
ADHFE1 alcohol dehydrogenase, iron containing, 1 -2.1808
PITPNM3 PITPNM family member 3 -2.17836
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -2.1773
PGBD2 piggyBac transposable element derived 2 -2.1773
KIAA2026 KIAA2026 -2.13801
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -2.13566
ATRNL1 attractin-like 1 -2.12595
NOD1 nucleotide-binding oligomerization domain containing 1 -2.12292
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.11498
GADD45B growth arrest and DNA-damage-inducible, beta -2.11498
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.1058
MAP1A microtubule-associated protein 1A -2.1058
VLDLR very low density lipoprotein receptor -2.1054
AARD alanine and arginine rich domain containing protein -2.10274
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.10274
STYX serine/threonine/tyrosine interacting protein -2.08828
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.073
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.06596
WDR26 WD repeat domain 26 -2.06596
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -2.06596
SLC66A3 solute carrier family 66 member 3 -2.06466
TCL1B T-cell leukemia/lymphoma 1B -2.05452
ZNF57 zinc finger protein 57 -2.05452
CMYA5 cardiomyopathy associated 5 -2.04028
TMEM35B transmembrane protein 35B -2.04028
FBP2 fructose-1,6-bisphosphatase 2 -2.02919
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 -2.02236
CENPA centromere protein A -2.01789
EMC1 ER membrane protein complex subunit 1 -2.01789
B3GAT2 beta-1,3-glucuronyltransferase 2 -2.00825
RUNX3 runt-related transcription factor 3 -2.00825
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.00825
MORN1 MORN repeat containing 1 -2.00258
ASL argininosuccinate lyase -2.00013
RBM15B RNA binding motif protein 15B -2.00013
NHSL3 NHS like 3 -2.00013