VAMP2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vesicle-associated membrane protein 2 (synaptobrevin 2)|The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6844)
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Genes

334 genes differentially expressed following the VAMP2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PBOV1 prostate and breast cancer overexpressed 1 3.07787
KCNIP3 Kv channel interacting protein 3, calsenilin 3.07787
PARP10 poly (ADP-ribose) polymerase family, member 10 3.07787
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.07787
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.07787
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.07787
MISP mitotic spindle positioning 3.07787
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.07787
OR2G6 olfactory receptor, family 2, subfamily G, member 6 3.07787
TFEC transcription factor EC 3.07787
OVOL3 ovo-like zinc finger 3 3.07787
TMEM235 transmembrane protein 235 3.07787
PECAM1 platelet/endothelial cell adhesion molecule 1 3.07787
C11ORF86 chromosome 11 open reading frame 86 3.07787
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 3.07787
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.07787
CXCL2 chemokine (C-X-C motif) ligand 2 3.07787
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.07787
DRP2 dystrophin related protein 2 3.07787
CLDN22 claudin 22 3.07787
KLLN killin, p53-regulated DNA replication inhibitor 3.07787
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.07787
IL1RN interleukin 1 receptor antagonist 3.07787
FXYD3 FXYD domain containing ion transport regulator 3 3.07787
ABRA actin binding Rho activating protein 3.07787
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.07787
ZAR1L zygote arrest 1-like 3.07787
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.07787
LOXL4 lysyl oxidase-like 4 3.07787
LTB lymphotoxin beta (TNF superfamily, member 3) 3.07787
BLNK B-cell linker 3.07787
SCIN scinderin 3.07787
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.07787
RNF39 ring finger protein 39 3.07787
LOC105378220 macrophage receptor MARCO-like 3.07787
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.07787
OPLAH 5-oxoprolinase (ATP-hydrolysing) 3.07787
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.07787
CAMK1G calcium/calmodulin-dependent protein kinase IG 3.07787
FGF7 fibroblast growth factor 7 3.07787
POPDC2 popeye domain containing 2 3.07787
MFAP5 microfibrillar associated protein 5 3.07787
EFHB EF-hand domain family, member B 3.07787
OR5H1 olfactory receptor, family 5, subfamily H, member 1 3.07787
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.07787
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.07787
FAM167A family with sequence similarity 167, member A 3.07787
ACOT1 acyl-CoA thioesterase 1 3.07787
AKAP14 A kinase (PRKA) anchor protein 14 3.07787
POMC proopiomelanocortin 3.07787
GGT6 gamma-glutamyltransferase 6 3.07787
SOX1 SRY (sex determining region Y)-box 1 3.07787
TMEM229A transmembrane protein 229A 3.07787
RLBP1 retinaldehyde binding protein 1 3.07787
FAM3D family with sequence similarity 3, member D 3.07787
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.07787
TSSK4 testis-specific serine kinase 4 3.07787
CFHR3 complement factor H-related 3 3.07787
SIX1 SIX homeobox 1 3.07787
HRH1 histamine receptor H1 3.07787
RNF17 ring finger protein 17 3.07787
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.07787
FBXL8 F-box and leucine-rich repeat protein 8 3.07787
ALOX15 arachidonate 15-lipoxygenase 3.07787
TKTL2 transketolase-like 2 3.07787
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 3.07787
PDE7B phosphodiesterase 7B 3.07787
PTH2 parathyroid hormone 2 3.07787
PTGDR2 prostaglandin D2 receptor 2 3.07787
OLIG3 oligodendrocyte transcription factor 3 3.07787
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.07787
LRG1 leucine-rich alpha-2-glycoprotein 1 3.07787
SH2D6 SH2 domain containing 6 3.07787
SLC25A45 solute carrier family 25, member 45 3.07787
CELF6 CUGBP, Elav-like family member 6 3.07787
SPINK4 serine peptidase inhibitor, Kazal type 4 3.07787
TMEM176B transmembrane protein 176B 3.07787
TRIM15 tripartite motif containing 15 3.07787
TMIE transmembrane inner ear 3.07787
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 3.07787
CFAP99 cilia and flagella associated protein 99 3.07787
PEAR1 platelet endothelial aggregation receptor 1 3.07787
RSPO1 R-spondin 1 3.07787
ARR3 arrestin 3, retinal (X-arrestin) 3.07787
CALHM5 calcium homeostasis modulator family member 5 3.07787
PLPP7 phospholipid phosphatase 7 (inactive) 3.07787
GARIN6 golgi associated RAB2 interactor family member 6 3.07787
FAM90A12 family with sequence similarity 90 member A12 3.07787
THBD thrombomodulin 3.07787
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.07787
EMILIN1 elastin microfibril interfacer 1 3.07787
SIRPG signal-regulatory protein gamma 3.07787
PCDHGA3 protocadherin gamma subfamily A, 3 3.07787
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.07787
CLEC4C C-type lectin domain family 4, member C 3.07787
CXCR6 chemokine (C-X-C motif) receptor 6 3.07787
CIMAP1D CIMAP1 family member D 3.07787
CCDC9B coiled-coil domain containing 9B 3.07787
CDHR4 cadherin-related family member 4 3.07787
CALHM3 calcium homeostasis modulator 3 3.07787
HKDC1 hexokinase domain containing 1 3.07787
CCDC198 coiled-coil domain containing 198 3.07787
APOC4 apolipoprotein C-IV 3.07787
HK3 hexokinase 3 (white cell) 3.07787
MINDY4B MINDY family member 4B 3.07787
H3C14 H3 clustered histone 14 3.07787
LAMB4 laminin, beta 4 3.07787
CPNE8-AS1 CPNE8 antisense RNA 1 3.07787
GBX2 gastrulation brain homeobox 2 3.07787
WNT2 wingless-type MMTV integration site family member 2 3.07787
TEX26 testis expressed 26 3.07787
GJC2 gap junction protein, gamma 2, 47kDa 3.07787
GOLGA8J golgin A8 family, member J 3.07787
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.07787
DEFB109B defensin beta 109B 3.07787
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.07787
SPAAR small regulatory polypeptide of amino acid response 3.07787
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.07787
SPHKAP SPHK1 interactor, AKAP domain containing 3.07787
PRSS33 protease, serine, 33 3.07787
OTOP2 otopetrin 2 3.07787
INSM1 insulinoma-associated 1 3.07787
PRTN3 proteinase 3 3.07787
NYX nyctalopin 3.07787
RBBP8NL RBBP8 N-terminal like 3.07787
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.07787
DYNLRB2 dynein, light chain, roadblock-type 2 3.07787
TMEM86B transmembrane protein 86B 3.07787
MT1M metallothionein 1M 3.07787
VTCN1 V-set domain containing T cell activation inhibitor 1 3.07787
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.07787
ADRB1 adrenoceptor beta 1 3.07787
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.07787
SUN3 Sad1 and UNC84 domain containing 3 3.07787
TBC1D28 TBC1 domain family, member 28 3.07787
TMEM40 transmembrane protein 40 3.07787
CD80 CD80 molecule 3.07787
ZNF705A zinc finger protein 705A 3.07787
AMDHD1 amidohydrolase domain containing 1 3.07787
SYT15 synaptotagmin XV 3.07787
TBX10 T-box 10 3.07787
ADRA1B adrenoceptor alpha 1B 3.07787
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.07787
FOXC1 forkhead box C1 3.07787
CD8B CD8b molecule 3.07787
AGR2 anterior gradient 2 3.07787
MAGEB17 melanoma antigen family B17 3.07787
RAD21L1 RAD21-like 1 (S. pombe) 3.07787
SELE selectin E 3.07787
PLG plasminogen 3.07787
H2BC1 H2B clustered histone 1 3.07787
POF1B premature ovarian failure, 1B 3.07787
KRT3 keratin 3, type II 3.07787
OTOF otoferlin 3.07787
FATE1 fetal and adult testis expressed 1 3.07787
ERICH3 glutamate-rich 3 3.07787
PKD2L1 polycystic kidney disease 2-like 1 3.07787
SCEL sciellin 3.07787
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.07787
EBF4 early B-cell factor 4 3.07787
FAM222A family with sequence similarity 222, member A 3.02653
LAMA4 laminin, alpha 4 3.02653
PCDH19 protocadherin 19 2.99049
SERF1B small EDRK-rich factor 1B (centromeric) 2.99049
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.99049
ZSCAN20 zinc finger and SCAN domain containing 20 2.93252
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.89684
PEX19 peroxisomal biogenesis factor 19 2.87601
ANKRD10 ankyrin repeat domain 10 2.85115
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 2.84736
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.77699
CHMP2A charged multivesicular body protein 2A 2.70234
FZD6 frizzled class receptor 6 2.69003
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.67417
MTFR1 mitochondrial fission regulator 1 2.59128
NSUN4 NOP2/Sun domain family, member 4 2.58088
FLCN folliculin 2.57987
FAM149A family with sequence similarity 149, member A 2.56775
ADRB2 adrenoceptor beta 2, surface 2.53722
ELAC2 elaC ribonuclease Z 2 2.53722
TECPR1 tectonin beta-propeller repeat containing 1 2.51673
TAS2R30 taste receptor, type 2, member 30 2.51497
KLF10 Kruppel-like factor 10 2.50036
WDR27 WD repeat domain 27 2.49291
CSRNP3 cysteine-serine-rich nuclear protein 3 2.48177
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.46719
GRSF1 G-rich RNA sequence binding factor 1 2.45133
PCDHGB1 protocadherin gamma subfamily B, 1 2.372
ATP5MC1 ATP synthase membrane subunit c locus 1 2.369
DDHD2 DDHD domain containing 2 2.31641
PRSS23 protease, serine, 23 2.30571
PKNOX1 PBX/knotted 1 homeobox 1 2.2941
ZNF484 zinc finger protein 484 2.29317
CHURC1 churchill domain containing 1 2.2864
NALF2 NALCN channel auxiliary factor 2 2.2795
EMC8 ER membrane protein complex subunit 8 2.25794
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.25794
ATG5 autophagy related 5 2.25032
SYPL1 synaptophysin-like 1 2.2503
NOL10 nucleolar protein 10 2.21869
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.20644
KLHDC2 kelch domain containing 2 2.20345
PIERCE2 piercer of microtubule wall 2 2.18552
ODAD4 outer dynein arm docking complex subunit 4 2.18552
NLRC3 NLR family, CARD domain containing 3 2.18552
TM4SF18 transmembrane 4 L six family member 18 2.18552
KAT6B K(lysine) acetyltransferase 6B 2.18552
XKRX XK, Kell blood group complex subunit-related, X-linked 2.18552
NOTO notochord homeobox 2.18552
OTX1 orthodenticle homeobox 1 2.18552
ELMO3 engulfment and cell motility 3 2.18552
MID2 midline 2 2.18552
FRMD5 FERM domain containing 5 2.18552
HRC histidine rich calcium binding protein 2.18552
CORIN corin, serine peptidase 2.18552
FASTKD2 FAST kinase domains 2 2.18552
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 2.18401
PRCC papillary renal cell carcinoma (translocation-associated) 2.18353
GPN2 GPN-loop GTPase 2 2.16344
GOLGA7 golgin A7 2.12096
HNRNPR heterogeneous nuclear ribonucleoprotein R 2.11777
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2.11442
KIAA0319 KIAA0319 2.09862
GFM1 G elongation factor, mitochondrial 1 2.09027
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.08345
GABPB2 GA binding protein transcription factor, beta subunit 2 2.06747
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.06747
POM121C POM121 transmembrane nucleoporin C 2.0363
ASPNAT aspartate N-acetyltransferase 2.03222
SACK1B scaffolding CK1 anchoring protein B 2.02776
ZNF407 zinc finger protein 407 2.02694
PCDH15 protocadherin-related 15 2.01946
ZNF217 zinc finger protein 217 2.01185
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.00967

decreased expression

Symbol Name Standardized Value
PLIN5 perilipin 5 -3.07787
CCDC177 coiled-coil domain containing 177 -3.07787
SPOCD1 SPOC domain containing 1 -3.07787
DUSP28 dual specificity phosphatase 28 -3.07787
LOX lysyl oxidase -3.07787
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.94822
SEPTIN4 septin 4 -2.93338
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.87601
WNK4 WNK lysine deficient protein kinase 4 -2.87601
IRX3 iroquois homeobox 3 -2.87601
GREM2 gremlin 2, DAN family BMP antagonist -2.87601
SYTL5 synaptotagmin-like 5 -2.87601
NPPA natriuretic peptide A -2.87601
ZMYND15 zinc finger, MYND-type containing 15 -2.87601
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.87601
TMEM171 transmembrane protein 171 -2.87601
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 -2.87601
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.87601
ANO3 anoctamin 3 -2.87601
GJD3 gap junction protein, delta 3, 31.9kDa -2.87601
TACSTD2 tumor-associated calcium signal transducer 2 -2.87601
ZNF582 zinc finger protein 582 -2.87601
SACK1A scaffolding CK1 anchoring protein A -2.87601
NOD2 nucleotide-binding oligomerization domain containing 2 -2.87601
ADAMTSL2 ADAMTS-like 2 -2.87601
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.87601
TDRD6 tudor domain containing 6 -2.87601
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.87601
TSNAXIP1 translin-associated factor X interacting protein 1 -2.87601
CLRN1 clarin 1 -2.87601
TRHR thyrotropin-releasing hormone receptor -2.87601
KLK8 kallikrein-related peptidase 8 -2.87601
ANKRD65 ankyrin repeat domain 65 -2.87601
FBXO15 F-box protein 15 -2.87601
CRYBA4 crystallin, beta A4 -2.87601
CRYBA1 crystallin, beta A1 -2.87601
TSLP thymic stromal lymphopoietin -2.87601
CALY calcyon neuron-specific vesicular protein -2.87601
C11ORF91 chromosome 11 open reading frame 91 -2.87601
LRRC3 leucine rich repeat containing 3 -2.87601
LCNL1 lipocalin-like 1 -2.87601
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.87601
TOM1L1 target of myb1 (chicken)-like 1 -2.87179
CABP1 calcium binding protein 1 -2.8478
TPBG trophoblast glycoprotein -2.84429
CUL7 cullin 7 -2.83966
ZNF2 zinc finger protein 2 -2.76396
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.68367
GJA9 gap junction protein, alpha 9, 59kDa -2.63259
CCDC60 coiled-coil domain containing 60 -2.63259
CMKLR2 chemerin chemokine-like receptor 2 -2.62403
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.62068
MAGEH1 melanoma antigen family H1 -2.59128
SMIM11 small integral membrane protein 11 -2.57609
PDCD2L programmed cell death 2-like -2.56051
ZNF821 zinc finger protein 821 -2.52277
COPS2 COP9 signalosome subunit 2 -2.48877
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.48172
MXD1 MAX dimerization protein 1 -2.46719
LIG4 ligase IV, DNA, ATP-dependent -2.46719
CNOT10 CCR4-NOT transcription complex, subunit 10 -2.46653
HIPK1 homeodomain interacting protein kinase 1 -2.4196
RAB9A RAB9A, member RAS oncogene family -2.35831
IGFBP6 insulin-like growth factor binding protein 6 -2.35831
HSF2BP heat shock transcription factor 2 binding protein -2.35831
EXOSC5 exosome component 5 -2.35585
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.34642
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.32422
SOX8 SRY (sex determining region Y)-box 8 -2.29772
XG Xg blood group -2.29772
FANCI Fanconi anemia, complementation group I -2.27899
POLR1G RNA polymerase I subunit G -2.2546
CDK19 cyclin-dependent kinase 19 -2.2387
MARCHF4 membrane associated ring-CH-type finger 4 -2.22646
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.21432
MARCHF11 membrane associated ring-CH-type finger 11 -2.21432
TMEM141 transmembrane protein 141 -2.20795
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.18552
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.18552
SPRY3 sprouty homolog 3 (Drosophila) -2.18552
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.18533
SLC35E2B solute carrier family 35, member E2B -2.18401
TMEM231 transmembrane protein 231 -2.12096
GALK2 galactokinase 2 -2.11777
RBIS ribosomal biogenesis factor -2.11679
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.10678
PRKG1 protein kinase, cGMP-dependent, type I -2.10341
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 -2.09211
PLXDC1 plexin domain containing 1 -2.09168
FAM43A family with sequence similarity 43, member A -2.09168
PDZD8 PDZ domain containing 8 -2.0751
DRAM2 DNA-damage regulated autophagy modulator 2 -2.05291
ANKRD52 ankyrin repeat domain 52 -2.05016
WDCP WD repeat and coiled coil containing -2.05016
AAMDC adipogenesis associated, Mth938 domain containing -2.01746
AIF1L allograft inflammatory factor 1-like -2.01496
SERINC5 serine incorporator 5 -2.00671
MELTF melanotransferrin -2.00671
CDCA2 cell division cycle associated 2 -2.00464
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.0032