VAMP3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vesicle-associated membrane protein 3|Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9341)
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Genes

349 genes differentially expressed following the VAMP3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 3.59693
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.59693
SLC46A3 solute carrier family 46, member 3 3.59693
PTX3 pentraxin 3, long 3.59693
TEX13B testis expressed 13B 3.59693
PCDHB6 protocadherin beta 6 3.59693
PCDHB1 protocadherin beta 1 3.59693
MBLAC1 metallo-beta-lactamase domain containing 1 3.59693
SSTR1 somatostatin receptor 1 3.59693
MAP7D1 MAP7 domain containing 1 3.59693
IZUMO3 IZUMO family member 3 3.59693
ZNF492 zinc finger protein 492 3.59693
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.59693
RAET1G retinoic acid early transcript 1G 3.59693
RNF151 ring finger protein 151 3.59693
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.59693
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.59693
CCDC116 coiled-coil domain containing 116 3.59693
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.59693
AGTR1 angiotensin II receptor, type 1 3.59693
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.59693
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.59693
SKOR2 SKI family transcriptional corepressor 2 3.59693
LRRC52 leucine rich repeat containing 52 3.59693
S100A9 S100 calcium binding protein A9 3.59693
MUC22 mucin 22 3.59693
BMP5 bone morphogenetic protein 5 3.59693
GALR3 galanin receptor 3 3.59693
SP6 Sp6 transcription factor 3.59693
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.59693
SPACA3 sperm acrosome associated 3 3.59693
SPACA7 sperm acrosome associated 7 3.59693
FAM9C family with sequence similarity 9, member C 3.59693
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.59693
SPNS2 spinster homolog 2 (Drosophila) 3.59693
LCN12 lipocalin 12 3.59693
FOXR1 forkhead box R1 3.59693
ASB10 ankyrin repeat and SOCS box containing 10 3.59693
MT1HL1 metallothionein 1H-like 1 3.59693
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.59693
SLC9C2 solute carrier family 9, member C2 (putative) 3.59693
ADGB androglobin 3.59693
PTGFR prostaglandin F receptor (FP) 3.59693
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.59693
NLRP10 NLR family, pyrin domain containing 10 3.59693
PLA2G10 phospholipase A2, group X 3.59693
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.59693
SPATS1 spermatogenesis associated, serine-rich 1 3.59693
ROPN1B rhophilin associated tail protein 1B 3.59693
DUSP8 dual specificity phosphatase 8 3.59693
DUSP9 dual specificity phosphatase 9 3.59693
KRT86 keratin 86, type II 3.59693
SMLR1 small leucine-rich protein 1 3.59693
PROX2 prospero homeobox 2 3.59693
OR51M1 olfactory receptor, family 51, subfamily M, member 1 3.59693
OSTN osteocrin 3.59693
NECTIN4 nectin cell adhesion molecule 4 3.59693
STYXL2 serine/threonine/tyrosine interacting like 2 3.59693
CCDC198 coiled-coil domain containing 198 3.59693
SPMIP1 sperm microtubule inner protein 1 3.59693
LY6S-AS1 LY6S antisense RNA 1 3.59693
IRF2-DT IRF2 divergent transcript 3.59693
MAP3K4-AS1 MAP3K4 antisense RNA 1 3.59693
C1ORF232 chromosome 1 open reading frame 230 3.59693
CPHXL cytoplasmic polyadenylated homeobox like 3.59693
RTL5 retrotransposon Gag like 5 3.59693
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.59693
DNAAF8 dynein axonemal assembly factor 8 3.59693
MROH5 maestro heat-like repeat family member 5 3.59693
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 3.59693
MEOX1 mesenchyme homeobox 1 3.59693
LOC124900192 uncharacterized LOC124900192 3.59693
IL31RA interleukin 31 receptor A 3.59693
WNT11 wingless-type MMTV integration site family, member 11 3.59693
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.59693
IRF8 interferon regulatory factor 8 3.59693
ARL5C ADP-ribosylation factor-like 5C 3.59693
ACTL10 actin-like 10 3.59693
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 3.59693
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.59693
ZNF575 zinc finger protein 575 3.59693
TLR7 toll-like receptor 7 3.59693
WDR93 WD repeat domain 93 3.59693
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.59693
GPR84 G protein-coupled receptor 84 3.59693
PLEK2 pleckstrin 2 3.59693
ARMC12 armadillo repeat containing 12 3.59693
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.59693
EXOC3L4 exocyst complex component 3-like 4 3.59693
C1QL2 complement component 1, q subcomponent-like 2 3.59693
TBX3 T-box 3 3.59693
LOC390937 Ets2 repressor factor-like 3.59693
NPAS4 neuronal PAS domain protein 4 3.59693
PCDHGB1 protocadherin gamma subfamily B, 1 3.59693
IL17REL interleukin 17 receptor E-like 3.59693
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.59693
AKR1B15 aldo-keto reductase family 1, member B15 3.59693
PSG3 pregnancy specific beta-1-glycoprotein 3 3.59693
EDN2 endothelin 2 3.59693
EDN3 endothelin 3 3.59693
DYDC1 DPY30 domain containing 1 3.59693
PGR progesterone receptor 3.59693
TBPL2 TATA box binding protein like 2 3.59693
OR3A2 olfactory receptor, family 3, subfamily A, member 2 3.59693
LST1 leukocyte specific transcript 1 3.59693
EPX eosinophil peroxidase 3.59693
NUTM2E NUT family member 2E 3.59693
BPIFB1 BPI fold containing family B, member 1 3.59693
CCNI2 cyclin I family, member 2 3.59693
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.59693
ZMYND10 zinc finger, MYND-type containing 10 3.59693
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.59693
PLA2G4E phospholipase A2, group IVE 3.59693
CST4 cystatin S 3.59693
CERKL ceramide kinase-like 3.59693
LMOD3 leiomodin 3 (fetal) 3.59693
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.59693
VWA3B von Willebrand factor A domain containing 3B 3.59693
PLA1A phospholipase A1 member A 3.59693
PRDM9 PR domain containing 9 3.59693
DCDC2B doublecortin domain containing 2B 3.59693
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.59693
FBXO40 F-box protein 40 3.59693
KLK5 kallikrein-related peptidase 5 3.59693
SAMD5 sterile alpha motif domain containing 5 3.59693
C16ORF78 chromosome 16 open reading frame 78 3.59693
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.59693
FATE1 fetal and adult testis expressed 1 3.59693
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.59693
NOX3 NADPH oxidase 3 3.59693
PRSS37 protease, serine, 37 3.59693
BPI bactericidal/permeability-increasing protein 3.59693
NTN5 netrin 5 3.59693
DMRT1 doublesex and mab-3 related transcription factor 1 3.59693
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.59693
LENEP lens epithelial protein 3.59693
LAMP3 lysosomal-associated membrane protein 3 3.59693
INSL4 insulin-like 4 (placenta) 3.59693
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.59693
WFDC13 WAP four-disulfide core domain 13 3.59693
PHOX2A paired-like homeobox 2a 3.59693
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.59693
FCAR Fc fragment of IgA receptor 3.59693
OTP orthopedia homeobox 3.59693
WFDC11 WAP four-disulfide core domain 11 3.59693
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.59693
ADAM29 ADAM metallopeptidase domain 29 3.59693
PGPEP1L pyroglutamyl-peptidase I-like 3.59693
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.59693
CLCNKB chloride channel, voltage-sensitive Kb 3.59693
CD34 CD34 molecule 3.59693
CLEC1A C-type lectin domain family 1, member A 3.59693
IRX4 iroquois homeobox 4 3.59693
GGN gametogenetin 3.59693
RTN4RL1 reticulon 4 receptor-like 1 3.59693
FGF9 fibroblast growth factor 9 3.59693
PRSS22 protease, serine, 22 3.59693
FXYD2 FXYD domain containing ion transport regulator 2 3.59693
NPIPA6 nuclear pore complex interacting protein family, member A6 3.46367
DPF3 D4, zinc and double PHD fingers, family 3 3.46367
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase 3.33911
NCOA7 nuclear receptor coactivator 7 3.31451
RIMKLA ribosomal modification protein rimK-like family member A 3.18685
BHMT2 betaine--homocysteine S-methyltransferase 2 3.18608
ZNF32 zinc finger protein 32 3.04139
NICN1 nicolin 1 2.92627
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.83098
EFCAB14 EF-hand calcium binding domain 14 2.81649
C2ORF72 chromosome 2 open reading frame 72 2.80627
RBM45 RNA binding motif protein 45 2.64948
RALB v-ral simian leukemia viral oncogene homolog B 2.6322
PACRG PARK2 co-regulated 2.55446
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.54838
RADIL Ras association and DIL domains 2.49235
RHCG Rh family, C glycoprotein 2.49235
FRMPD1 FERM and PDZ domain containing 1 2.49235
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.46823
PRMT8 protein arginine methyltransferase 8 2.46823
TIMCC TIM double twin CX3C motif chaperone 2.46464
PAQR9 progestin and adipoQ receptor family member IX 2.43636
TTLL13 tubulin tyrosine ligase like 13 2.43037
BMP8A bone morphogenetic protein 8a 2.43037
BRICD5 BRICHOS domain containing 5 2.43037
CD1D CD1d molecule 2.43037
FGF4 fibroblast growth factor 4 2.43037
JPH2 junctophilin 2 2.43037
PROKR1 prokineticin receptor 1 2.43037
APRT adenine phosphoribosyltransferase 2.43037
NAP1L5 nucleosome assembly protein 1-like 5 2.43037
PRB3 proline-rich protein BstNI subfamily 3 2.43037
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.43037
PTCH2 patched 2 2.43037
SEMG1 semenogelin I 2.43037
H4C13 H4 clustered histone 13 2.43037
PDCL2 phosducin-like 2 2.43037
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.43037
RECQL5 RecQ protein-like 5 2.41448
SEPTIN11 septin 11 2.41349
DEPDC5 DEP domain containing 5 2.37986
AAK1 AP2 associated kinase 1 2.36568
ARL5A ADP-ribosylation factor-like 5A 2.36568
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.3346
B2M beta-2-microglobulin 2.33237
CDK11A cyclin-dependent kinase 11A 2.32165
ZNF783 zinc finger family member 783 2.31379
WASF3 WAS protein family, member 3 2.3074
LAMP5 lysosomal-associated membrane protein family, member 5 2.28689
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.28689
NPB neuropeptide B 2.28689
TMEM88 transmembrane protein 88 2.28689
BORCS8 BLOC-1 related complex subunit 8 2.28165
GOLIM4 golgi integral membrane protein 4 2.26481
UBE2C ubiquitin-conjugating enzyme E2C 2.17625
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.15697
REEP1 receptor accessory protein 1 2.15348
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.1507
LBP lipopolysaccharide binding protein 2.14851
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2.14614
HMOX1 heme oxygenase 1 2.14428
BEX5 brain expressed, X-linked 5 2.12016
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.09869
DTX3L deltex 3 like, E3 ubiquitin ligase 2.07432
DNAH3 dynein, axonemal, heavy chain 3 2.06955
LINC02610 long intergenic non-protein coding RNA 2610 2.06681
NINJ2 ninjurin 2 2.06063
LGALSL lectin, galactoside-binding-like 2.04239
IGFLR1 IGF-like family receptor 1 2.02848
PTTG1 pituitary tumor-transforming 1 2.02107
ATOX1 antioxidant 1 copper chaperone 2.02084
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2.02084
SCN10A sodium channel, voltage gated, type X alpha subunit 2.00417

decreased expression

Symbol Name Standardized Value
TMEM151A transmembrane protein 151A -3.59693
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -3.59693
GPRC5A G protein-coupled receptor, class C, group 5, member A -3.59693
POU5F2 POU domain class 5, transcription factor 2 -3.59693
AGBL1 ATP/GTP binding protein-like 1 -3.59693
C10ORF90 chromosome 10 open reading frame 90 -3.59693
BBS12 Bardet-Biedl syndrome 12 -3.59693
BIN2 bridging integrator 2 -3.59693
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -3.59693
CDKN2A cyclin-dependent kinase inhibitor 2A -3.59693
POU3F4 POU class 3 homeobox 4 -3.59693
ZAR1L zygote arrest 1-like -3.59693
ONECUT2 one cut homeobox 2 -3.59693
ICAM5 intercellular adhesion molecule 5, telencephalin -3.59693
SPINT4 serine peptidase inhibitor, Kunitz type 4 -3.59693
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -3.59693
MRPL53 mitochondrial ribosomal protein L53 -3.59693
CXORF65 chromosome X open reading frame 65 -3.59693
ELF4 E74-like factor 4 (ets domain transcription factor) -3.59693
SERF1A small EDRK-rich factor 1A (telomeric) -3.59693
RAPSN receptor-associated protein of the synapse -3.59693
TMEM82 transmembrane protein 82 -3.59693
ABI3BP ABI family, member 3 (NESH) binding protein -3.59693
IL2RB interleukin 2 receptor, beta -3.59693
TTC6 tetratricopeptide repeat domain 6 -3.59693
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -3.59693
SPAG6 sperm associated antigen 6 -3.59693
SLC10A4 solute carrier family 10, member 4 -3.59693
CLIC2 chloride intracellular channel 2 -3.59693
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -3.59693
OR1C1 olfactory receptor, family 1, subfamily C, member 1 -3.59693
ITGA10 integrin, alpha 10 -3.59693
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -3.59693
RRH retinal pigment epithelium-derived rhodopsin homolog -3.59693
GBX2 gastrulation brain homeobox 2 -3.59693
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -3.59693
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -3.59693
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.59693
IL21R interleukin 21 receptor -3.59693
H2BC14 H2B clustered histone 14 -3.59693
GFY golgi-associated, olfactory signaling regulator -3.59693
EFCAB12 EF-hand calcium binding domain 12 -3.59693
EMILIN3 elastin microfibril interfacer 3 -3.59693
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -3.59693
ADAP1 ArfGAP with dual PH domains 1 -3.59693
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.59693
UBQLN4 ubiquilin 4 -3.31973
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -3.1107
C16ORF89 chromosome 16 open reading frame 89 -3.1107
MANF mesencephalic astrocyte-derived neurotrophic factor -3.03042
AFAP1 actin filament associated protein 1 -2.96899
DPP3 dipeptidyl-peptidase 3 -2.9612
GUCA1B guanylate cyclase activator 1B (retina) -2.92056
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -2.79602
CEP57 centrosomal protein 57kDa -2.76357
SENP1 SUMO1/sentrin specific peptidase 1 -2.60874
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.57708
ANGPTL4 angiopoietin-like 4 -2.57708
C11ORF86 chromosome 11 open reading frame 86 -2.57708
TLR5 toll-like receptor 5 -2.57708
CCNL2 cyclin L2 -2.56105
IGSF1 immunoglobulin superfamily, member 1 -2.53803
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.50938
RMP64 ribonuclease MRP subunit p64 -2.46823
CCPG1 cell cycle progression 1 -2.46823
POMK protein-O-mannose kinase -2.46114
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.44872
ZNRF3 zinc and ring finger 3 -2.43945
C2CD4C C2 calcium-dependent domain containing 4C -2.43037
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.43037
CNFN cornifelin -2.42122
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.399
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 -2.39415
ARMC8 armadillo repeat containing 8 -2.37986
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -2.35782
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -2.35261
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.35081
PCDHA9 protocadherin alpha 9 -2.3419
GPR139 G protein-coupled receptor 139 -2.3419
TSPAN5 tetraspanin 5 -2.33752
MTNAP1 mitochondrial nucleoid associated protein 1 -2.33691
FIGNL1 fidgetin-like 1 -2.3346
PCDHB12 protocadherin beta 12 -2.32165
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.32165
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.32165
KLF9 Kruppel-like factor 9 -2.32165
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -2.32165
MYO1H myosin IH -2.32165
SPN sialophorin -2.32165
ZNF234 zinc finger protein 234 -2.31655
FANCC Fanconi anemia, complementation group C -2.31529
ANAPC1 anaphase promoting complex subunit 1 -2.31007
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.26393
PUDP pseudouridine 5'-phosphatase -2.26033
RMDN2 regulator of microtubule dynamics 2 -2.22417
NOMO3 NODAL modulator 3 -2.22417
WAPL WAPL cohesin release factor -2.20657
ANO4 anoctamin 4 -2.2007
STXBP5L syntaxin binding protein 5-like -2.19912
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.19705
STARD9 StAR-related lipid transfer (START) domain containing 9 -2.17579
IFT38 intraflagellar transport 38 -2.15135
CUEDC2 CUE domain containing 2 -2.1507
CCND2 cyclin D2 -2.14364
SCN2A sodium channel, voltage gated, type II alpha subunit -2.13637
NAGS N-acetylglutamate synthase -2.13637
ZNF25 zinc finger protein 25 -2.13637
RNF114 ring finger protein 114 -2.12207
PRKX protein kinase, X-linked -2.09364
BTBD1 BTB (POZ) domain containing 1 -2.08535
POLN polymerase (DNA directed) nu -2.06524
ZNF566 zinc finger protein 566 -2.06246
CCDC60 coiled-coil domain containing 60 -2.05415
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.0365
UBXN4 UBX domain protein 4 -2.02107
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 -2.02107
SFT2D3 SFT2 domain containing 3 -2.0072
STXBP3 syntaxin binding protein 3 -2.0023