VAMP4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vesicle-associated membrane protein 4|Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8674)
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Genes

286 genes differentially expressed following the VAMP4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMPRSS11E transmembrane protease, serine 11E 2.82427
EGFL6 EGF-like-domain, multiple 6 2.82427
PCDHB7 protocadherin beta 7 2.82427
SLC35G5 solute carrier family 35, member G5 2.82427
HGD homogentisate 1,2-dioxygenase 2.82427
CCNB3 cyclin B3 2.82427
CLEC19A C-type lectin domain family 19, member A 2.82427
GJB1 gap junction protein, beta 1, 32kDa 2.82427
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.82427
FFAR4 free fatty acid receptor 4 2.82427
TRIM33 tripartite motif containing 33 2.82427
SCN2B sodium channel, voltage gated, type II beta subunit 2.82427
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.82427
HRH4 histamine receptor H4 2.82427
LAPTM5 lysosomal protein transmembrane 5 2.82427
CCKAR cholecystokinin A receptor 2.82427
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.82427
LY86 lymphocyte antigen 86 2.82427
EGFLAM EGF-like, fibronectin type III and laminin G domains 2.82427
ZNF492 zinc finger protein 492 2.82427
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.82427
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.82427
CSTL1 cystatin-like 1 2.82427
PTH2 parathyroid hormone 2 2.82427
ZNF556 zinc finger protein 556 2.82427
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.82427
KANTR KDM5C adjacent non-coding transcript 2.82427
GMFG glia maturation factor, gamma 2.82427
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.82427
CRH corticotropin releasing hormone 2.82427
FABP12 fatty acid binding protein 12 2.82427
COPZ2 coatomer protein complex, subunit zeta 2 2.82427
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.82427
DRP2 dystrophin related protein 2 2.82427
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.82427
CA9 carbonic anhydrase IX 2.82427
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.82427
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.82427
C19ORF67 chromosome 19 open reading frame 67 2.82427
LYNX1 Ly6/neurotoxin 1 2.82427
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.82427
NRROS negative regulator of reactive oxygen species 2.82427
AVPR2 arginine vasopressin receptor 2 2.82427
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.82427
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.82427
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.82427
OR56B2 olfactory receptor family 56 subfamily B member 2 2.82427
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.82427
STAT4 signal transducer and activator of transcription 4 2.82427
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.82427
ZC3H7B zinc finger CCCH-type containing 7B 2.82427
RAG2 recombination activating gene 2 2.82427
VN1R1 vomeronasal 1 receptor 1 2.82427
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.82427
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.82427
TREX2 three prime repair exonuclease 2 2.82427
SQOR sulfide quinone oxidoreductase 2.82427
ANGPTL8 angiopoietin like 8 2.82427
CCN3 cellular communication network factor 3 2.82427
FAM240C family with sequence similarity 240 member C 2.82427
H2BK1 H2B.K variant histone 1 2.82427
C1ORF202 chromosome 1 open reading frame 202 2.82427
H3-7 H3.7 histone (putative) 2.82427
H3C3 H3 clustered histone 3 2.82427
AKR1C8 aldo-keto reductase family 1 member C8 2.82427
VXN vexin 2.82427
RTL5 retrotransposon Gag like 5 2.82427
INKA1 inka box actin regulator 1 2.82427
RAB36 RAB36, member RAS oncogene family 2.82427
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.82427
TLE6 transducin-like enhancer of split 6 2.82427
FPR2 formyl peptide receptor 2 2.82427
FAM3D family with sequence similarity 3, member D 2.82427
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.82427
PLVAP plasmalemma vesicle associated protein 2.82427
TSSK6 testis-specific serine kinase 6 2.82427
FOXL1 forkhead box L1 2.82427
GJA9 gap junction protein, alpha 9, 59kDa 2.82427
SIX3 SIX homeobox 3 2.82427
LGALS7B lectin, galactoside-binding, soluble, 7B 2.82427
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.82427
CALCA calcitonin-related polypeptide alpha 2.82427
KL klotho 2.82427
LRRC70 leucine rich repeat containing 70 2.82427
EXOC3L1 exocyst complex component 3-like 1 2.82427
LENG9 leukocyte receptor cluster (LRC) member 9 2.82427
PIWIL4 piwi-like RNA-mediated gene silencing 4 2.82427
FAM186B family with sequence similarity 186, member B 2.82427
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.82427
UBL4B ubiquitin-like 4B 2.82427
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.82427
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.82427
CLCN1 chloride channel, voltage-sensitive 1 2.82427
CD177 CD177 molecule 2.82427
CTAGE9 CTAGE family, member 9 2.82427
KLF2 Kruppel-like factor 2 2.82427
RPL8 ribosomal protein L8 2.82427
ADAM2 ADAM metallopeptidase domain 2 2.82427
TNNI3K TNNI3 interacting kinase 2.82427
C16ORF78 chromosome 16 open reading frame 78 2.82427
IRGC immunity-related GTPase family, cinema 2.82427
EMP1 epithelial membrane protein 1 2.82427
ODF1 outer dense fiber of sperm tails 1 2.82427
C11ORF91 chromosome 11 open reading frame 91 2.82427
UBQLNL ubiquilin-like 2.82427
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.82427
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.82427
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.82427
SMIM22 small integral membrane protein 22 2.82427
CTF1 cardiotrophin 1 2.82427
RBMXL2 RNA binding motif protein, X-linked-like 2 2.82427
CLDN34 claudin 34 2.82427
PSG8 pregnancy specific beta-1-glycoprotein 8 2.82427
HCRT hypocretin (orexin) neuropeptide precursor 2.82427
ALOXE3 arachidonate lipoxygenase 3 2.82427
OCIAD2 OCIA domain containing 2 2.82427
SPMIP9 sperm microtubule inner protein 9 2.82427
SLC38A3 solute carrier family 38, member 3 2.82427
LGALS12 lectin, galactoside-binding, soluble, 12 2.82427
FAIM2 Fas apoptotic inhibitory molecule 2 2.82427
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.82427
LAMB4 laminin, beta 4 2.82427
C10ORF105 chromosome 10 open reading frame 105 2.82427
MB myoglobin 2.82427
EVI2A ecotropic viral integration site 2A 2.82427
GJC2 gap junction protein, gamma 2, 47kDa 2.82427
UBXN10 UBX domain protein 10 2.82427
PGR progesterone receptor 2.82427
EGR3 early growth response 3 2.82427
RELN reelin 2.82427
PRPH peripherin 2.82427
FGR FGR proto-oncogene, Src family tyrosine kinase 2.82427
SMIM17 small integral membrane protein 17 2.82427
SPHKAP SPHK1 interactor, AKAP domain containing 2.82427
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.82427
SDS serine dehydratase 2.82427
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.82427
GOLGA8H golgin A8 family, member H 2.82427
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.82427
BOLA2 bolA family member 2 2.82427
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.82427
CYGB cytoglobin 2.82427
FXYD3 FXYD domain containing ion transport regulator 3 2.82427
CHAD chondroadherin 2.82427
WFDC13 WAP four-disulfide core domain 13 2.82427
PITX3 paired-like homeodomain 3 2.82427
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.82427
UNC13C unc-13 homolog C (C. elegans) 2.82427
IL33 interleukin 33 2.82427
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.82427
TAS2R46 taste receptor, type 2, member 46 2.82427
EPN3 epsin 3 2.82427
SPAG8 sperm associated antigen 8 2.82427
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.82427
SLITRK6 SLIT and NTRK-like family, member 6 2.82427
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.82427
THSD1 thrombospondin, type I, domain containing 1 2.82427
EFCAB9 EF-hand calcium binding domain 9 2.82427
TBC1D28 TBC1 domain family, member 28 2.82427
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.82427
NMUR1 neuromedin U receptor 1 2.82427
ANKRD33 ankyrin repeat domain 33 2.82427
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.82427
PRR15L proline rich 15-like 2.82427
AOC3 amine oxidase, copper containing 3 2.82427
EPX eosinophil peroxidase 2.82427
AMER2 APC membrane recruitment protein 2 2.82427
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.82427
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.81548
BCAS1 breast carcinoma amplified sequence 1 2.69232
FUNDC2 FUN14 domain containing 2 2.55665
TMBIM4 transmembrane BAX inhibitor motif containing 4 2.55639
ZNF493 zinc finger protein 493 2.52812
CALD1 caldesmon 1 2.50003
FURIN furin (paired basic amino acid cleaving enzyme) 2.45192
MSS51 MSS51 mitochondrial translational activator 2.37466
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.3537
C16ORF54 chromosome 16 open reading frame 54 2.32358
ANXA9 annexin A9 2.32358
C3 complement component 3 2.32126
RERE arginine-glutamic acid dipeptide (RE) repeats 2.31535
MAPK10 mitogen-activated protein kinase 10 2.29596
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 2.29444
UBXN1 UBX domain protein 1 2.28285
TBX6 T-box 6 2.25659
PINK1 PTEN induced putative kinase 1 2.23234
WNT11 wingless-type MMTV integration site family, member 11 2.22197
UST uronyl-2-sulfotransferase 2.21288
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 2.20938
RPL14 ribosomal protein L14 2.19323
XKR7 XK, Kell blood group complex subunit-related family, member 7 2.18437
UVRAG UV radiation resistance associated 2.17815
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.17423
PRPF19 pre-mRNA processing factor 19 2.1699
ZBTB26 zinc finger and BTB domain containing 26 2.13189
CDH23 cadherin-related 23 2.1138
ZNF804A zinc finger protein 804A 2.07786
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.07786
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 2.07786
HIF3A hypoxia inducible factor 3, alpha subunit 2.06784
MYL9 myosin, light chain 9, regulatory 2.06221
IL7 interleukin 7 2.02695
HEXD hexosaminidase D 2.01668

decreased expression

Symbol Name Standardized Value
LIPT2-AS1 LIPT2 antisense RNA 1 -2.82427
RGPD1 RANBP2-like and GRIP domain containing 1 -2.82427
MROH6 maestro heat-like repeat family member 6 -2.82427
HIPK4 homeodomain interacting protein kinase 4 -2.82427
AGFG2 ArfGAP with FG repeats 2 -2.82427
LGALS1 lectin, galactoside-binding, soluble, 1 -2.82427
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -2.82427
UPP2 uridine phosphorylase 2 -2.82427
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.82427
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.82427
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.82427
TNS2 tensin 2 -2.82427
GADL1 glutamate decarboxylase-like 1 -2.82427
EPPIN epididymal peptidase inhibitor -2.82427
FGF22 fibroblast growth factor 22 -2.82427
TENT5C terminal nucleotidyltransferase 5C -2.82427
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.82427
EFNB1 ephrin-B1 -2.82427
STX11 syntaxin 11 -2.82427
REP15 RAB15 effector protein -2.82427
TEP1 telomerase-associated protein 1 -2.82427
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.82427
REC114 REC114 meiotic recombination protein -2.82427
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.82427
ANGPT4 angiopoietin 4 -2.82427
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.82427
A1CF APOBEC1 complementation factor -2.82427
WNT4 wingless-type MMTV integration site family, member 4 -2.82427
LYPD1 LY6/PLAUR domain containing 1 -2.82427
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.82427
ANKRD65 ankyrin repeat domain 65 -2.82427
RAD51B RAD51 paralog B -2.82427
C19ORF84 chromosome 19 open reading frame 84 -2.82427
MPV17L MPV17 mitochondrial membrane protein-like -2.82427
DRD4 dopamine receptor D4 -2.82427
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.82427
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled -2.82427
TRIM24 tripartite motif containing 24 -2.82427
SRCIN1 SRC kinase signaling inhibitor 1 -2.76494
FAAH fatty acid amide hydrolase -2.75922
ZNF875 zinc finger protein 875 -2.73893
GBA1 glucosylceramidase beta 1 -2.7305
H2BC21 H2B clustered histone 21 -2.6945
ARID5A AT rich interactive domain 5A (MRF1-like) -2.64276
CILP2 cartilage intermediate layer protein 2 -2.61382
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.50003
BRWD3 bromodomain and WD repeat domain containing 3 -2.41582
CIB1 calcium and integrin binding 1 (calmyrin) -2.36148
LMF1 lipase maturation factor 1 -2.3537
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -2.32358
ZNF8 zinc finger protein 8 -2.31535
H2AC20 H2A clustered histone 20 -2.29596
BAMBI BMP and activin membrane-bound inhibitor -2.29444
KATNBL1 katanin p80 subunit B-like 1 -2.24701
CDC37 cell division cycle 37 -2.23152
FAAP24 FA core complex associated protein 24 -2.22197
CCDC14 coiled-coil domain containing 14 -2.21847
PTPRM protein tyrosine phosphatase, receptor type, M -2.20435
EIF3C eukaryotic translation initiation factor 3, subunit C -2.19323
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -2.19192
MT1F metallothionein 1F -2.19192
ZNF747 zinc finger protein 747 -2.19192
CCDC74B coiled-coil domain containing 74B -2.19192
H2AC12 H2A clustered histone 12 -2.18839
RTL10 retrotransposon Gag like 10 -2.1445
VAMP4 vesicle-associated membrane protein 4 -2.14392
CCDC142 coiled-coil domain containing 142 -2.13874
E4F1 E4F transcription factor 1 -2.13874
MAP6D1 MAP6 domain containing 1 -2.13189
SLC35E4 solute carrier family 35, member E4 -2.13051
GPR183 G protein-coupled receptor 183 -2.1242
TLL1 tolloid-like 1 -2.10271
ULK4 unc-51 like kinase 4 -2.1026
LARP1B La ribonucleoprotein domain family, member 1B -2.0964
KRABD5 KRAB domain containing 5 -2.09511
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -2.07491
CGREF1 cell growth regulator with EF-hand domain 1 -2.06347
STON2 stonin 2 -2.06347
RNF6 ring finger protein (C3H2C3 type) 6 -2.05928
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.05601
ZNF718 zinc finger protein 718 -2.042
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13 -2.04098
SFXN5 sideroflexin 5 -2.00542