VAMP8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vesicle-associated membrane protein 8|This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 8673)
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Genes

362 genes differentially expressed following the VAMP8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCRG1 stimulator of chondrogenesis 1 3.38192
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.38192
MUC1 mucin 1, cell surface associated 3.38192
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.38192
PKP1 plakophilin 1 3.38192
HORMAD1 HORMA domain containing 1 3.38192
OSGIN1 oxidative stress induced growth inhibitor 1 3.38192
RIMBP2 RIMS binding protein 2 3.38192
ERN2 endoplasmic reticulum to nucleus signaling 2 3.38192
CCNB3 cyclin B3 3.38192
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 3.38192
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.38192
ANKRD22 ankyrin repeat domain 22 3.38192
ISM2 isthmin 2 3.38192
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.38192
NRN1 neuritin 1 3.38192
HLX H2.0-like homeobox 3.38192
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.38192
CD274 CD274 molecule 3.38192
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.38192
PROKR1 prokineticin receptor 1 3.38192
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.38192
PI16 peptidase inhibitor 16 3.38192
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 3.38192
TAL2 T-cell acute lymphocytic leukemia 2 3.38192
GIMAP4 GTPase, IMAP family member 4 3.38192
CPLX1 complexin 1 3.38192
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.38192
HMX3 H6 family homeobox 3 3.38192
GYS2 glycogen synthase 2 (liver) 3.38192
LDHC lactate dehydrogenase C 3.38192
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.38192
LOC105378220 macrophage receptor MARCO-like 3.38192
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.38192
THEMIS thymocyte selection associated 3.38192
TDO2 tryptophan 2,3-dioxygenase 3.38192
TSHZ1 teashirt zinc finger homeobox 1 3.38192
LGALS2 lectin, galactoside-binding, soluble, 2 3.38192
BIRC3 baculoviral IAP repeat containing 3 3.38192
GCKR glucokinase (hexokinase 4) regulator 3.38192
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.38192
GADL1 glutamate decarboxylase-like 1 3.38192
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.38192
CRX cone-rod homeobox 3.38192
RLN1 relaxin 1 3.38192
PLK5 polo-like kinase 5 3.38192
LRRC63 leucine rich repeat containing 63 3.38192
MPL MPL proto-oncogene, thrombopoietin receptor 3.38192
FAM9B family with sequence similarity 9, member B 3.38192
LOC124906892 uncharacterized LOC124906892 3.38192
ITPRID1 ITPR interacting domain containing 1 3.38192
GARIN1A golgi associated RAB2 interactor 1A 3.38192
H1-6 H1.6 linker histone, cluster member 3.38192
GBP4 guanylate binding protein 4 3.38192
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.38192
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.38192
TMPRSS6 transmembrane protease, serine 6 3.38192
SAG S-antigen; retina and pineal gland (arrestin) 3.38192
ASB4 ankyrin repeat and SOCS box containing 4 3.38192
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 3.38192
SPEM2 SPEM family member 2 3.38192
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.38192
EPCIP exosomal polycystin 1 interacting protein 3.38192
ERLN endoregulin 3.38192
LIPT2-AS1 LIPT2 antisense RNA 1 3.38192
NOTCH2NLB notch 2 N-terminal like B 3.38192
CIMAP1D CIMAP1 family member D 3.38192
CFAP97D2 CFAP97 domain containing 2 3.38192
GREP1 glycine rich extracellular protein 1 3.38192
SMIM35 small integral membrane protein 35 3.38192
ARMH2 armadillo like helical domain containing 2 3.38192
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.38192
RAB36 RAB36, member RAS oncogene family 3.38192
ZNF441 zinc finger protein 441 3.38192
SPATA22 spermatogenesis associated 22 3.38192
TLR6 toll-like receptor 6 3.38192
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.38192
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 3.38192
CKM creatine kinase, muscle 3.38192
OLAH oleoyl-ACP hydrolase 3.38192
OR6C1 olfactory receptor, family 6, subfamily C, member 1 3.38192
WNT11 wingless-type MMTV integration site family, member 11 3.38192
TEX101 testis expressed 101 3.38192
CCDC17 coiled-coil domain containing 17 3.38192
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.38192
ZAN zonadhesin (gene/pseudogene) 3.38192
PGLYRP2 peptidoglycan recognition protein 2 3.38192
GCSAM germinal center-associated, signaling and motility 3.38192
SELL selectin L 3.38192
ZNF705D zinc finger protein 705D 3.38192
LEKR1 leucine, glutamate and lysine rich 1 3.38192
DLK1 delta-like 1 homolog (Drosophila) 3.38192
LGSN lengsin, lens protein with glutamine synthetase domain 3.38192
LRRC73 leucine rich repeat containing 73 3.38192
PLEK2 pleckstrin 2 3.38192
FMR1NB fragile X mental retardation 1 neighbor 3.38192
LRRC3C leucine rich repeat containing 3C 3.38192
CAPN14 calpain 14 3.38192
GOLGA6C golgin A6 family, member C 3.38192
RUFY4 RUN and FYVE domain containing 4 3.38192
ANKRD33 ankyrin repeat domain 33 3.38192
PRAM1 PML-RARA regulated adaptor molecule 1 3.38192
PDZRN4 PDZ domain containing ring finger 4 3.38192
MLIP muscular LMNA-interacting protein 3.38192
ACTB actin, beta 3.38192
CFAP47 cilia and flagella associated protein 47 3.38192
CLCA4 chloride channel accessory 4 3.38192
ITPKA inositol-trisphosphate 3-kinase A 3.38192
CFAP61 cilia and flagella associated protein 61 3.38192
CD8B CD8b molecule 3.38192
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 3.38192
OR10G4 olfactory receptor, family 10, subfamily G, member 4 3.38192
MAGEA12 melanoma antigen family A12 3.38192
AICDA activation-induced cytidine deaminase 3.38192
RIPPLY2 ripply transcriptional repressor 2 3.38192
AGXT2 alanine--glyoxylate aminotransferase 2 3.38192
PDCD1 programmed cell death 1 3.38192
ZCCHC12 zinc finger, CCHC domain containing 12 3.38192
SCT secretin 3.38192
HKDC1 hexokinase domain containing 1 3.38192
RTBDN retbindin 3.38192
CLRN1 clarin 1 3.38192
AQP7 aquaporin 7 3.38192
AQP4 aquaporin 4 3.38192
RESP18 regulated endocrine-specific protein 18 3.38192
PSKH2 protein serine kinase H2 3.38192
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.38192
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.38192
GAL3ST2 galactose-3-O-sulfotransferase 2 3.38192
SHISA8 shisa family member 8 3.38192
GOLGA6B golgin A6 family, member B 3.38192
KRT86 keratin 86, type II 3.38192
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.38192
CLEC7A C-type lectin domain family 7, member A 3.38192
IL11 interleukin 11 3.38192
ALLC allantoicase 3.38192
RBM24 RNA binding motif protein 24 3.38192
BTG4 B-cell translocation gene 4 3.38192
SOST sclerostin 3.38192
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.38192
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 3.38192
SH2D1B SH2 domain containing 1B 3.38192
BTBD16 BTB (POZ) domain containing 16 3.38192
OPRK1 opioid receptor, kappa 1 3.38192
FXYD3 FXYD domain containing ion transport regulator 3 3.38192
C5ORF46 chromosome 5 open reading frame 46 3.38192
C22ORF31 chromosome 22 open reading frame 31 3.38192
MAGEC3 melanoma antigen family C3 3.38192
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.38192
SHISA3 shisa family member 3 3.38192
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.38192
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.38192
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.38192
ACAN aggrecan 3.38192
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.38192
CTSF cathepsin F 3.38192
ZPLD1 zona pellucida-like domain containing 1 3.38192
IRX4 iroquois homeobox 4 3.38192
PRTN3 proteinase 3 3.38192
CFP complement factor properdin 3.38192
RPL35A ribosomal protein L35a 3.38192
TRAF3IP3 TRAF3 interacting protein 3 3.38192
HPCAL4 hippocalcin like 4 3.38192
DIPK1A divergent protein kinase domain 1A 3.30623
ZFP42 ZFP42 zinc finger protein 3.29023
NOS2 nitric oxide synthase 2, inducible 3.25137
MMD2 monocyte to macrophage differentiation-associated 2 3.1667
RPL15 ribosomal protein L15 3.15104
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 3.0111
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 2.99618
RPL38 ribosomal protein L38 2.98947
SHOC1 shortage in chiasmata 1 2.98842
POLR1H RNA polymerase I subunit H 2.90162
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.88287
TUBB tubulin, beta class I 2.86698
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.85786
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.81283
TOR2A torsin family 2, member A 2.7992
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.7726
TEP1 telomerase-associated protein 1 2.7481
MYNN myoneurin 2.7481
ARHGAP27 Rho GTPase activating protein 27 2.7481
FNDC5 fibronectin type III domain containing 5 2.7481
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.73822
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.66317
FAAP20 FA core complex associated protein 20 2.6613
IGSF5 immunoglobulin superfamily, member 5 2.6455
DMAC1 distal membrane arm assembly component 1 2.62457
PARP1 poly (ADP-ribose) polymerase 1 2.60497
VCAN versican 2.59966
BMP7 bone morphogenetic protein 7 2.5967
CD59 CD59 molecule, complement regulatory protein 2.5373
SRSF2 serine/arginine-rich splicing factor 2 2.52447
EIF4A1 eukaryotic translation initiation factor 4A1 2.51384
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.51384
MFAP3L microfibrillar-associated protein 3-like 2.46515
ZNF37A zinc finger protein 37A 2.46229
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 2.46229
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.46229
CENPM centromere protein M 2.4564
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.40496
FBL fibrillarin 2.40402
IQCE IQ motif containing E 2.3815
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.36706
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.3544
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.30354
LOC114841035 uncharacterized LOC114841035 2.30354
HPSE heparanase 2.30354
CCDC178 coiled-coil domain containing 178 2.30354
EVI2A ecotropic viral integration site 2A 2.30354
SAP25 Sin3A-associated protein, 25kDa 2.28897
MANSC4 MANSC domain containing 4 2.28897
PROX1 prospero homeobox 1 2.28897
PROM2 prominin 2 2.28897
DRC3 dynein regulatory complex subunit 3 2.28897
HARS1 histidyl-tRNA synthetase 1 2.28897
OVCH2 ovochymase 2 (gene/pseudogene) 2.28897
GRPR gastrin-releasing peptide receptor 2.27134
MEX3C mex-3 RNA binding family member C 2.26097
SFSWAP splicing factor, suppressor of white-apricot family 2.25418
POLQ polymerase (DNA directed), theta 2.24662
ACP2 acid phosphatase 2, lysosomal 2.24086
NR2C1 nuclear receptor subfamily 2, group C, member 1 2.23908
TP53 tumor protein p53 2.23546
LIMD1 LIM domains containing 1 2.22517
FBXO27 F-box protein 27 2.19982
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.18811
RPL24 ribosomal protein L24 2.17226
SIK1 salt-inducible kinase 1 2.15018
RPL10 ribosomal protein L10 2.1338
RPA1 replication protein A1, 70kDa 2.12608
TPK1 thiamin pyrophosphokinase 1 2.12088
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 2.11319
UBE2S ubiquitin-conjugating enzyme E2S 2.09274
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.09095
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.08415
ZMYM2 zinc finger, MYM-type 2 2.07767
CREB3L4 cAMP responsive element binding protein 3-like 4 2.07327
SH2B2 SH2B adaptor protein 2 2.0682
CCDC86 coiled-coil domain containing 86 2.06298
RPL28 ribosomal protein L28 2.06298
DRG1 developmentally regulated GTP binding protein 1 2.05446
OSBPL1A oxysterol binding protein-like 1A 2.03045
XKR9 XK, Kell blood group complex subunit-related family, member 9 2.02727
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.01643
FXYD5 FXYD domain containing ion transport regulator 5 2.00491

decreased expression

Symbol Name Standardized Value
RGPD1 RANBP2-like and GRIP domain containing 1 -3.38192
SCN3B sodium channel, voltage gated, type III beta subunit -3.38192
AOC3 amine oxidase, copper containing 3 -3.38192
BOLL boule-like RNA-binding protein -3.38192
C1ORF167 chromosome 1 open reading frame 167 -3.38192
TCF24 transcription factor 24 -3.38192
RBM46 RNA binding motif protein 46 -3.38192
LRCOL1 leucine rich colipase-like 1 -3.38192
CCDC152 coiled-coil domain containing 152 -3.38192
ANPEP alanyl (membrane) aminopeptidase -3.38192
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -3.38192
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -3.38192
IKZF3 IKAROS family zinc finger 3 (Aiolos) -3.38192
BMP2 bone morphogenetic protein 2 -3.38192
SBK2 SH3 domain binding kinase family, member 2 -3.38192
MEP1B meprin A, beta -3.38192
MED13L mediator complex subunit 13-like -3.38192
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -3.38192
TMEM184A transmembrane protein 184A -3.38192
ACTL8 actin-like 8 -3.38192
NRG4 neuregulin 4 -3.38192
CALCA calcitonin-related polypeptide alpha -3.38192
VIPR2 vasoactive intestinal peptide receptor 2 -3.38192
KLF5 Kruppel-like factor 5 (intestinal) -3.38192
HJURP Holliday junction recognition protein -3.38192
KISS1 KiSS-1 metastasis-suppressor -3.38192
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -3.38192
C1ORF74 chromosome 1 open reading frame 74 -3.38192
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -3.38192
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -3.38192
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -3.38192
RANBP3L RAN binding protein 3-like -3.38192
CYS1 cystin 1 -3.38192
ART3 ADP-ribosyltransferase 3 -3.38192
CTSO cathepsin O -3.38192
AGER advanced glycosylation end product-specific receptor -3.38192
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -3.35341
TRAF1 TNF receptor-associated factor 1 -3.24369
VAMP8 vesicle-associated membrane protein 8 -3.09147
CTNND2 catenin (cadherin-associated protein), delta 2 -2.9786
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.83861
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.7992
PLXNA4 plexin A4 -2.79868
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -2.79779
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.79779
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.77279
AKAP7 A kinase (PRKA) anchor protein 7 -2.71862
MBTPS1 membrane-bound transcription factor peptidase, site 1 -2.62358
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.62358
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.61873
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.60946
EVA1B eva-1 homolog B (C. elegans) -2.60946
SMYD2 SET and MYND domain containing 2 -2.59049
CRACD capping protein inhibiting regulator of actin dynamics -2.57744
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.56477
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.5373
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.53232
JPH2 junctophilin 2 -2.53232
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.53232
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.53232
TSPAN9 tetraspanin 9 -2.50531
ASB18 ankyrin repeat and SOCS box containing 18 -2.45503
CNR1 cannabinoid receptor 1 (brain) -2.45503
WDR62 WD repeat domain 62 -2.45166
BCHE butyrylcholinesterase -2.45166
RGN regucalcin -2.4121
PRDM10 PR domain containing 10 -2.40363
TRNP1 TMF1-regulated nuclear protein 1 -2.3624
DUSP3 dual specificity phosphatase 3 -2.35688
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) -2.3501
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -2.3501
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.34333
SNRPC small nuclear ribonucleoprotein polypeptide C -2.3079
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils -2.30459
CEP126 centrosomal protein 126kDa -2.30354
TXNL1 thioredoxin-like 1 -2.30354
C16ORF54 chromosome 16 open reading frame 54 -2.28897
SDC3 syndecan 3 -2.28897
ERO1B endoplasmic reticulum oxidoreductase 1 beta -2.28897
SMAD9 SMAD family member 9 -2.28897
ZNF233 zinc finger protein 233 -2.28897
NUP37 nucleoporin 37kDa -2.27751
AP3B1 adaptor-related protein complex 3, beta 1 subunit -2.27196
TRMO tRNA methyltransferase O -2.25625
THSD4 thrombospondin, type I, domain containing 4 -2.25625
SLC25A48 solute carrier family 25, member 48 -2.25625
KLK10 kallikrein-related peptidase 10 -2.25399
RFC1 replication factor C (activator 1) 1, 145kDa -2.24639
CTXN1 cortexin 1 -2.21448
CHGB chromogranin B -2.21026
FN1 fibronectin 1 -2.20598
NEK3 NIMA-related kinase 3 -2.1958
RILPL1 Rab interacting lysosomal protein-like 1 -2.18811
FAM217A family with sequence similarity 217, member A -2.18811
GOLGA3 golgin A3 -2.17906
LPCAT2 lysophosphatidylcholine acyltransferase 2 -2.17906
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.16245
ETNK1 ethanolamine kinase 1 -2.15767
RTL4 retrotransposon Gag like 4 -2.15767
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.15387
ZNF613 zinc finger protein 613 -2.15151
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.15151
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -2.14183
DSG2 desmoglein 2 -2.12608
ZNF554 zinc finger protein 554 -2.1213
FMNL3 formin-like 3 -2.1213
MYO1H myosin IH -2.1213
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.09274
LCORL ligand dependent nuclear receptor corepressor-like -2.08415
GPR155 G protein-coupled receptor 155 -2.06915
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -2.0682
LY75 lymphocyte antigen 75 -2.06434
TMEM150C transmembrane protein 150C -2.05889
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.05118
TSPEAR thrombospondin-type laminin G domain and EAR repeats -2.02452
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -2.01502