VAV1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vav 1 guanine nucleotide exchange factor|This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 7409)
Similar Terms
Downloads & Tools

Genes

325 genes differentially expressed following the VAV1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
EBI3 Epstein-Barr virus induced 3 3.08002
PGBDF plakoglobin binding and degradation factor 3.08002
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 3.08002
DDN dendrin 3.08002
SIRPB2 signal-regulatory protein beta 2 3.08002
GJA10 gap junction protein, alpha 10, 62kDa 3.08002
FETUB fetuin B 3.08002
ASB17 ankyrin repeat and SOCS box containing 17 3.08002
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.08002
TMEM151A transmembrane protein 151A 3.08002
DNASE1L2 deoxyribonuclease I-like 2 3.08002
TXLNB taxilin beta 3.08002
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.08002
TREM2 triggering receptor expressed on myeloid cells 2 3.08002
CDH5 cadherin 5, type 2 (vascular endothelium) 3.08002
FAM180A family with sequence similarity 180, member A 3.08002
NPM3 nucleophosmin/nucleoplasmin 3 3.08002
ALOX15 arachidonate 15-lipoxygenase 3.08002
CD1D CD1d molecule 3.08002
LYZL6 lysozyme-like 6 3.08002
C12ORF71 chromosome 12 open reading frame 71 3.08002
HMX1 H6 family homeobox 1 3.08002
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.08002
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.08002
EVPL envoplakin 3.08002
IL18R1 interleukin 18 receptor 1 3.08002
STAP1 signal transducing adaptor family member 1 3.08002
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.08002
CCDC83 coiled-coil domain containing 83 3.08002
GALR2 galanin receptor 2 3.08002
TRPC5OS TRPC5 opposite strand 3.08002
RGPD4 RANBP2-like and GRIP domain containing 4 3.08002
PRSS36 protease, serine, 36 3.08002
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.08002
S100A1 S100 calcium binding protein A1 3.08002
PNOC prepronociceptin 3.08002
IDUA iduronidase, alpha-L- 3.08002
TREML1 triggering receptor expressed on myeloid cells-like 1 3.08002
PRG4 proteoglycan 4 3.08002
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.08002
HLX H2.0-like homeobox 3.08002
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.08002
ROPN1L rhophilin associated tail protein 1-like 3.08002
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.08002
RDH8 retinol dehydrogenase 8 (all-trans) 3.08002
GPR37L1 G protein-coupled receptor 37 like 1 3.08002
OSTN osteocrin 3.08002
HNF1A HNF1 homeobox A 3.08002
ASIC4 acid sensing (proton gated) ion channel family member 4 3.08002
LRRC73 leucine rich repeat containing 73 3.08002
RAB6D RAB6D, member RAS oncogene family 3.08002
CCDC187 coiled-coil domain containing 187 3.08002
LRTM3 leucine rich repeat transmembrane protein 3 3.08002
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.08002
LOC124903372 uncharacterized LOC124903372 3.08002
INSYN1 inhibitory synaptic factor 1 3.08002
CIBAR2 CBY1 interacting BAR domain containing 2 3.08002
SEPTIN12 septin 12 3.08002
ODAPH odontogenesis associated phosphoprotein 3.08002
CATSPERZ catsper channel auxiliary subunit zeta 3.08002
UTS2 urotensin 2 3.08002
CDKN2A cyclin-dependent kinase inhibitor 2A 3.08002
OASL 2'-5'-oligoadenylate synthetase-like 3.08002
PCDHA3 protocadherin alpha 3 3.08002
PCDHA2 protocadherin alpha 2 3.08002
IL12RB1 interleukin 12 receptor, beta 1 3.08002
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 3.08002
SLC22A10 solute carrier family 22, member 10 3.08002
COL19A1 collagen, type XIX, alpha 1 3.08002
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.08002
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.08002
KIAA2026 KIAA2026 3.08002
EXOC3L4 exocyst complex component 3-like 4 3.08002
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.08002
CFAP45 cilia and flagella associated protein 45 3.08002
MIA melanoma inhibitory activity 3.08002
NHLRC4 NHL repeat containing 4 3.08002
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.08002
GOLGA6L2 golgin A6 family-like 2 3.08002
AKR1D1 aldo-keto reductase family 1, member D1 3.08002
LOC128125816 uncharacterized LOC128125816 3.08002
G6PC2 glucose-6-phosphatase, catalytic, 2 3.08002
CPA2 carboxypeptidase A2 (pancreatic) 3.08002
BAHCC1 BAH domain and coiled-coil containing 1 3.08002
THBD thrombomodulin 3.08002
ZCCHC12 zinc finger, CCHC domain containing 12 3.08002
PRDM9 PR domain containing 9 3.08002
OR4D10 olfactory receptor, family 4, subfamily D, member 10 3.08002
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.08002
PRAM1 PML-RARA regulated adaptor molecule 1 3.08002
EPGN epithelial mitogen 3.08002
PRRX1 paired related homeobox 1 3.08002
BCL2L15 BCL2-like 15 3.08002
DEFB135 defensin, beta 135 3.08002
KLK7 kallikrein-related peptidase 7 3.08002
C2CD4B C2 calcium-dependent domain containing 4B 3.08002
MRLN myoregulin 3.08002
CBX8 chromobox homolog 8 3.08002
SPINK9 serine peptidase inhibitor, Kazal type 9 3.08002
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.08002
GPR61 G protein-coupled receptor 61 3.08002
WDR44 WD repeat domain 44 3.08002
ANKRD63 ankyrin repeat domain 63 3.08002
ESYT1 extended synaptotagmin-like protein 1 3.08002
ADGRA1 adhesion G protein-coupled receptor A1 3.08002
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.08002
POF1B premature ovarian failure, 1B 3.08002
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.08002
OPRK1 opioid receptor, kappa 1 3.08002
CHRM4 cholinergic receptor, muscarinic 4 3.08002
TSPAN19 tetraspanin 19 3.08002
AMDHD1 amidohydrolase domain containing 1 3.08002
NPY2R neuropeptide Y receptor Y2 3.08002
DRC1 dynein regulatory complex subunit 1 3.08002
CD22 CD22 molecule 3.08002
SPATA31E1 SPATA31 subfamily E, member 1 3.08002
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.08002
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.08002
TAS2R46 taste receptor, type 2, member 46 3.08002
PLA2G1B phospholipase A2, group IB (pancreas) 3.08002
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 3.08002
LKAAEAR1 LKAAEAR motif containing 1 3.08002
ICAM2 intercellular adhesion molecule 2 3.08002
UNC13C unc-13 homolog C (C. elegans) 3.08002
ADAM18 ADAM metallopeptidase domain 18 3.08002
FAM151A family with sequence similarity 151, member A 3.08002
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.08002
ANKRD55 ankyrin repeat domain 55 3.08002
TBPL2 TATA box binding protein like 2 3.08002
PRSS38 protease, serine, 38 3.08002
SNTN sentan, cilia apical structure protein 3.08002
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.08002
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.08002
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.08002
CLCNKB chloride channel, voltage-sensitive Kb 3.08002
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.08002
WLS wntless Wnt ligand secretion mediator 3.06564
EIF3G eukaryotic translation initiation factor 3, subunit G 3.03571
CRYGD crystallin, gamma D 2.92885
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.85324
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.79714
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.79162
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 2.75022
UNC45A unc-45 homolog A (C. elegans) 2.68067
KDM4B lysine (K)-specific demethylase 4B 2.62172
PCYOX1 prenylcysteine oxidase 1 2.60901
TMEM37 transmembrane protein 37 2.60367
GATAD1 GATA zinc finger domain containing 1 2.596
CFAP57 cilia and flagella associated protein 57 2.59455
TCTN2 tectonic family member 2 2.57605
AFTPH aftiphilin 2.52786
ZMYND15 zinc finger, MYND-type containing 15 2.52001
HOOK1 hook microtubule-tethering protein 1 2.50647
TMC8 transmembrane channel-like 8 2.48883
PRELID3A PRELI domain containing 3A 2.48054
SCEL sciellin 2.44746
RRH retinal pigment epithelium-derived rhodopsin homolog 2.44746
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.44746
PGAM1 phosphoglycerate mutase 1 (brain) 2.41893
DCAF16 DDB1 and CUL4 associated factor 16 2.41626
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.39771
SSBP1 single-stranded DNA binding protein 1, mitochondrial 2.39771
MX2 MX dynamin-like GTPase 2 2.39074
KLF10 Kruppel-like factor 10 2.30684
PDGFB platelet-derived growth factor beta polypeptide 2.29773
PCDHB14 protocadherin beta 14 2.28943
IPO5 importin 5 2.28367
PTPRU protein tyrosine phosphatase, receptor type, U 2.28367
PWWP2A PWWP domain containing 2A 2.27928
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.27838
CD163L1 CD163 molecule-like 1 2.27838
SOCS5 suppressor of cytokine signaling 5 2.26799
L3HYPDH L-3-hydroxyproline dehydratase (trans-) 2.25671
ASMT acetylserotonin O-methyltransferase 2.21785
MPPED2 metallophosphoesterase domain containing 2 2.19703
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.19126
INTS14 integrator complex subunit 14 2.17841
PCID2 PCI domain containing 2 2.17841
VRK2 vaccinia related kinase 2 2.16893
LYRM2 LYR motif containing 2 2.15565
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.15542
LOC112694756 uncharaterized LOC112694756 2.15542
PMP22 peripheral myelin protein 22 2.15542
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.13409
SVIL supervillin 2.10419
ANKRD36 ankyrin repeat domain 36 2.1028
CCDC25 coiled-coil domain containing 25 2.08601
GNAS GNAS complex locus 2.08516
YIPF4 Yip1 domain family, member 4 2.08107
GPC1 glypican 1 2.07875
AK3 adenylate kinase 3 2.07624
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 2.07489
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.0506
TRIM5 tripartite motif containing 5 2.0506
BAK1 BCL2-antagonist/killer 1 2.04823
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.04676
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.04131
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.04098
SYT2 synaptotagmin II 2.03565
ZNF136 zinc finger protein 136 2.0229

decreased expression

Symbol Name Standardized Value
ANXA1 annexin A1 -3.08002
BTLA B and T lymphocyte associated -3.08002
KREMEN2 kringle containing transmembrane protein 2 -3.08002
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.08002
CCDC152 coiled-coil domain containing 152 -3.08002
WDR87 WD repeat domain 87 -3.08002
HHAT hedgehog acyltransferase -3.08002
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -3.08002
MR1 major histocompatibility complex, class I-related -3.08002
ALK anaplastic lymphoma receptor tyrosine kinase -3.08002
BTNL9 butyrophilin-like 9 -3.08002
IZUMO4 IZUMO family member 4 -3.08002
ZNF823 zinc finger protein 823 -3.08002
SYCE3 synaptonemal complex central element protein 3 -3.08002
TAS2R19 taste receptor, type 2, member 19 -3.08002
TNS2 tensin 2 -3.08002
SYTL3 synaptotagmin-like 3 -3.08002
NLRP6 NLR family, pyrin domain containing 6 -3.08002
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -3.08002
PPP1R3C protein phosphatase 1, regulatory subunit 3C -3.08002
TSKS testis-specific serine kinase substrate -3.08002
FXYD2 FXYD domain containing ion transport regulator 2 -3.08002
PRSS21 protease, serine, 21 (testisin) -3.08002
NGDN neuroguidin, EIF4E binding protein -3.08002
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -3.08002
RHBG Rh family, B glycoprotein (gene/pseudogene) -3.08002
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -3.08002
IL6ST-DT IL6ST divergent transcript -3.08002
FMO3 flavin containing monooxygenase 3 -3.08002
CCER2 coiled-coil glutamate-rich protein 2 -3.08002
SLC7A14 solute carrier family 7, member 14 -3.08002
NECTIN4 nectin cell adhesion molecule 4 -3.08002
INSL6 insulin-like 6 -3.08002
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -3.08002
LOC124903233 uncharacterized LOC124903233 -3.08002
HLA-DMB major histocompatibility complex, class II, DM beta -3.08002
CEND1 cell cycle exit and neuronal differentiation 1 -3.08002
MAP1A microtubule-associated protein 1A -3.08002
SPMIP8 sperm microtubule inner protein 8 -3.08002
PHLDA2 pleckstrin homology-like domain, family A, member 2 -3.08002
MORN5 MORN repeat containing 5 -3.08002
TMEM196 transmembrane protein 196 -3.08002
IL19 interleukin 19 -3.08002
PRB4 proline-rich protein BstNI subfamily 4 -3.08002
TMIE transmembrane inner ear -3.08002
IRF5 interferon regulatory factor 5 -3.08002
LIX1 Lix1 homolog (chicken) -3.08002
BEST2 bestrophin 2 -3.08002
PRDM7 PR domain containing 7 -3.08002
CMKLR1 chemerin chemokine-like receptor 1 -3.08002
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -3.08002
ARMC9 armadillo repeat containing 9 -3.08002
DRICH1 aspartate-rich 1 -3.08002
RBM20 RNA binding motif protein 20 -3.08002
UPK2 uroplakin 2 -3.00506
CCDC51 coiled-coil domain containing 51 -2.93023
ZUP1 zinc finger containing ubiquitin peptidase 1 -2.75022
PHTF1 putative homeodomain transcription factor 1 -2.68067
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.64313
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.63461
EXT2 exostosin glycosyltransferase 2 -2.63461
CDK14 cyclin-dependent kinase 14 -2.62614
TRIM3 tripartite motif containing 3 -2.6085
CEMIP cell migration inducing protein, hyaluronan binding -2.60367
APOL2 apolipoprotein L, 2 -2.57338
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.48277
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -2.47389
SAXO4 stabilizer of axonemal microtubules 4 -2.47389
NCKAP5 NCK-associated protein 5 -2.47389
AADAT aminoadipate aminotransferase -2.47337
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.44746
HPD 4-hydroxyphenylpyruvate dioxygenase -2.43623
SLC45A1 solute carrier family 45, member 1 -2.43623
RAB3C RAB3C, member RAS oncogene family -2.40283
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.39771
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.39771
AK7 adenylate kinase 7 -2.3551
COG7 component of oligomeric golgi complex 7 -2.31554
ADNP activity-dependent neuroprotector homeobox -2.31021
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.30413
UBXN11 UBX domain protein 11 -2.30245
ZNF385D zinc finger protein 385D -2.29846
FBXL17 F-box and leucine-rich repeat protein 17 -2.28059
SYNGR1 synaptogyrin 1 -2.28059
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.28059
SDHAF4 succinate dehydrogenase complex assembly factor 4 -2.2793
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.26422
KRCC1 lysine-rich coiled-coil 1 -2.25082
ANKRD31 ankyrin repeat domain 31 -2.24035
MEIS1 Meis homeobox 1 -2.24035
DNAH6 dynein, axonemal, heavy chain 6 -2.24035
MMD monocyte to macrophage differentiation-associated -2.21271
ERRFI1 ERBB receptor feedback inhibitor 1 -2.1977
THOC5 THO complex 5 -2.19432
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.19154
TWF2 twinfilin actin binding protein 2 -2.19154
ADGRV1 adhesion G protein-coupled receptor V1 -2.19022
THRA thyroid hormone receptor, alpha -2.18221
CD38 CD38 molecule -2.18036
GPR87 G protein-coupled receptor 87 -2.18036
SPATA18 spermatogenesis associated 18 -2.17733
SKIDA1 SKI/DACH domain containing 1 -2.17437
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.1652
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.14512
GSTO2 glutathione S-transferase omega 2 -2.13744
RABL3 RAB, member of RAS oncogene family-like 3 -2.13409
RICTOR RPTOR independent companion of MTOR, complex 2 -2.12572
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.11188
LARP1 La ribonucleoprotein domain family, member 1 -2.08601
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.08516
CNTNAP5 contactin associated protein-like 5 -2.07533
MACC1 metastasis associated in colon cancer 1 -2.04949
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -2.04345
MORN1 MORN repeat containing 1 -2.02769
MBNL1 muscleblind-like splicing regulator 1 -2.02769
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.0252
C20ORF203 chromosome 20 open reading frame 203 -2.01182
CD7 CD7 molecule -2.01182
SAMD15 sterile alpha motif domain containing 15 -2.01182
PKD1L3 polycystic kidney disease 1-like 3 -2.01182
PROK2 prokineticin 2 -2.01182
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.01182
WASF3 WAS protein family, member 3 -2.01182
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.0055
DOLPP1 dolichyldiphosphatase 1 -2.00167