| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | vav 1 guanine nucleotide exchange factor|This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 7409) |
| External Link | https://ncbi.nlm.nih.gov/gene/7409 |
| Similar Terms | |
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499 genes differentially expressed following the VAV1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 0.0182607 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.0174378 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.0168221 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0165772 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0160238 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.0144008 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0131751 |
| MDFIC | MyoD family inhibitor domain containing | 0.0129231 |
| CD200 | CD200 molecule | 0.012847 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.0118693 |
| OLFM1 | olfactomedin 1 | 0.0117494 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.0117149 |
| FTO | fat mass and obesity associated | 0.01165 |
| S100A7 | S100 calcium binding protein A7 | 0.0115447 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.0113821 |
| PDZK1 | PDZ domain containing 1 | 0.0112456 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.0108933 |
| PTK2 | protein tyrosine kinase 2 | 0.0108913 |
| CDC20 | cell division cycle 20 | 0.0108775 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.0107504 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0106998 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 0.0104229 |
| LTA4H | leukotriene A4 hydrolase | 0.0103858 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.0101891 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.010159 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.010151 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | 0.010123 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.0100336 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.0100327 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00979415 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00979136 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00977522 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.00974152 |
| HMGB2 | high mobility group box 2 | 0.00972981 |
| XPO7 | exportin 7 | 0.00956131 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00954346 |
| TFDP1 | transcription factor Dp-1 | 0.00951239 |
| PRC1 | protein regulator of cytokinesis 1 | 0.0094589 |
| KIF20A | kinesin family member 20A | 0.00939838 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00929945 |
| SUMO3 | small ubiquitin-like modifier 3 | 0.00928354 |
| HMGB3 | high mobility group box 3 | 0.0092817 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00926365 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00922781 |
| TSPAN7 | tetraspanin 7 | 0.00916922 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 0.00914102 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00911239 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.009051 |
| TRH | thyrotropin-releasing hormone | 0.00903487 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00893686 |
| OIP5 | Opa interacting protein 5 | 0.00889881 |
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | 0.0088178 |
| TMEM14A | transmembrane protein 14A | 0.00878979 |
| NTS | neurotensin | 0.00878171 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.00877122 |
| FABP7 | fatty acid binding protein 7, brain | 0.00868995 |
| ENO1 | enolase 1, (alpha) | 0.00867956 |
| KIF5C | kinesin family member 5C | 0.00864092 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00860545 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.00857789 |
| L1TD1 | LINE-1 type transposase domain containing 1 | 0.00853842 |
| ANXA6 | annexin A6 | 0.00844226 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | 0.00843815 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00843408 |
| CDCA4 | cell division cycle associated 4 | 0.00842255 |
| PXDN | peroxidasin | 0.00834489 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | 0.00833793 |
| SFRP1 | secreted frizzled-related protein 1 | 0.008312 |
| ALPL | alkaline phosphatase, liver/bone/kidney | 0.00823484 |
| SNCAIP | synuclein, alpha interacting protein | 0.00821129 |
| CCNA2 | cyclin A2 | 0.00820789 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00816653 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00816149 |
| SLC2A4RG | SLC2A4 regulator | 0.00811786 |
| CRIP2 | cysteine-rich protein 2 | 0.00809662 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00809495 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00808979 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.00804367 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00804231 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00802125 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 0.00800507 |
| RBBP4 | retinoblastoma binding protein 4 | 0.00798392 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 0.0079658 |
| SALL2 | spalt-like transcription factor 2 | 0.00793256 |
| PBK | PDZ binding kinase | 0.007929 |
| RPA3 | replication protein A3, 14kDa | 0.00790367 |
| PLP1 | proteolipid protein 1 | 0.00790337 |
| LMNB1 | lamin B1 | 0.00789386 |
| GPI | glucose-6-phosphate isomerase | 0.00787686 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00787555 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00786304 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00784963 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00783174 |
| CHEK2 | checkpoint kinase 2 | 0.00783119 |
| COMMD10 | COMM domain containing 10 | 0.00782012 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | 0.00774257 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.00774039 |
| TYRP1 | tyrosinase-related protein 1 | 0.0077269 |
| APOBEC3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 0.00771938 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 0.00768503 |
| TFF1 | trefoil factor 1 | 0.00767844 |
| TPI1 | triosephosphate isomerase 1 | 0.0076471 |
| SLC17A3 | solute carrier family 17 (organic anion transporter), member 3 | 0.0076461 |
| HBB | hemoglobin, beta | 0.00764374 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00763368 |
| PDGFD | platelet derived growth factor D | 0.00760427 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.0075985 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00759201 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 0.00754791 |
| SET | SET nuclear proto-oncogene | 0.00751839 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00745961 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.00745256 |
| PRDX2 | peroxiredoxin 2 | 0.00743278 |
| MATN2 | matrilin 2 | 0.00742965 |
| TK1 | thymidine kinase 1, soluble | 0.00741457 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00739632 |
| KRT13 | keratin 13, type I | 0.00739535 |
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 0.00737286 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.00736704 |
| MCM5 | minichromosome maintenance complex component 5 | 0.007355 |
| RHOA | ras homolog family member A | 0.00733725 |
| PIMREG | PICALM interacting mitotic regulator | 0.00732989 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.00732819 |
| HMGB1 | high mobility group box 1 | 0.00732409 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.00730103 |
| LY86 | lymphocyte antigen 86 | 0.00727334 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00724687 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00724432 |
| RAD51AP1 | RAD51 associated protein 1 | 0.00722732 |
| MPO | myeloperoxidase | 0.00721949 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00719843 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.00718552 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.00717067 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00716593 |
| KIF15 | kinesin family member 15 | 0.00716076 |
| TTN | titin | 0.00715512 |
| PTH2R | parathyroid hormone 2 receptor | 0.00714263 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00710601 |
| CETN2 | centrin, EF-hand protein, 2 | 0.0070952 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.00708007 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | 0.00707021 |
| CEP170 | centrosomal protein 170kDa | 0.00706917 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00706544 |
| VBP1 | von Hippel-Lindau binding protein 1 | 0.00703947 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00703383 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00701272 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.00697448 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00696746 |
| PRMT2 | protein arginine methyltransferase 2 | 0.00693423 |
| CAPNS1 | calpain, small subunit 1 | 0.00693417 |
| GPA33 | glycoprotein A33 (transmembrane) | 0.00692743 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00689704 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.00689001 |
| IL17RB | interleukin 17 receptor B | 0.00687402 |
| TRMT5 | tRNA methyltransferase 5 | 0.00687196 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00686877 |
| SELENOT | selenoprotein T | 0.00685833 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.00684881 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.00684803 |
| PCLAF | PCNA clamp associated factor | 0.00684606 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00683251 |
| FBXO11 | F-box protein 11 | 0.00683042 |
| CDK2 | cyclin-dependent kinase 2 | 0.00680272 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00679986 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.00677986 |
| APOA1 | apolipoprotein A-I | 0.00677191 |
| DZIP1 | DAZ interacting zinc finger protein 1 | 0.00674372 |
| CDCA3 | cell division cycle associated 3 | 0.00672969 |
| PLK1 | polo-like kinase 1 | 0.00671075 |
| ITM2A | integral membrane protein 2A | 0.00670994 |
| TPM4 | tropomyosin 4 | 0.00669404 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00669092 |
| NREP | neuronal regeneration related protein | 0.00665912 |
| NES | nestin | 0.00664964 |
| CLCA4 | chloride channel accessory 4 | 0.00664565 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.00664432 |
| RPL10 | ribosomal protein L10 | 0.0066419 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.006595 |
| IFT52 | intraflagellar transport 52 | 0.00658748 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00658465 |
| SIRT3 | sirtuin 3 | 0.00658043 |
| TATDN2 | TatD DNase domain containing 2 | 0.00657251 |
| EMP2 | epithelial membrane protein 2 | 0.00656344 |
| STMN1 | stathmin 1 | 0.00655552 |
| PRKD3 | protein kinase D3 | 0.00654736 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00654256 |
| NUP37 | nucleoporin 37kDa | 0.00651879 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.00651785 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0065164 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.00651383 |
| FBL | fibrillarin | 0.00650005 |
| C8ORF33 | chromosome 8 open reading frame 33 | 0.00649973 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00648812 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.00644818 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.00643082 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00642705 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.0064196 |
| CENPX | centromere protein X | 0.00639729 |
| ZDHHC13 | zinc finger, DHHC-type containing 13 | 0.00639665 |
| EAPP | E2F-associated phosphoprotein | 0.00639627 |
| EMC2 | ER membrane protein complex subunit 2 | 0.00639468 |
| FBXO5 | F-box protein 5 | 0.006386 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00637714 |
| AURKB | aurora kinase B | 0.00637341 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.00637146 |
| BNC2 | basonuclin 2 | 0.00636621 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00635672 |
| CHMP2B | charged multivesicular body protein 2B | 0.00634998 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 0.00634969 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.00632564 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0063223 |
| GPM6B | glycoprotein M6B | 0.00630999 |
| OGN | osteoglycin | 0.00630756 |
| PARPBP | PARP1 binding protein | 0.00630177 |
| TPBG | trophoblast glycoprotein | 0.0062816 |
| CALML4 | calmodulin-like 4 | 0.00627551 |
| ACE2 | angiotensin I converting enzyme 2 | 0.00626343 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00626197 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.00625667 |
| SKA1 | spindle and kinetochore associated complex subunit 1 | 0.00624649 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.00624617 |
| GPC4 | glypican 4 | 0.00623551 |
| CYC1 | cytochrome c-1 | 0.00623077 |
| SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 0.00622772 |
| SNRNP25 | small nuclear ribonucleoprotein 25kDa (U11/U12) | 0.00622436 |
| SLC35A5 | solute carrier family 35, member A5 | 0.00621996 |
| NPR3 | natriuretic peptide receptor 3 | 0.00621721 |
| LASP1 | LIM and SH3 protein 1 | 0.0062116 |
| PGD | phosphogluconate dehydrogenase | 0.00621157 |
| FOXM1 | forkhead box M1 | 0.00620233 |
| TMEM38B | transmembrane protein 38B | 0.00618446 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.0061593 |
| CCNF | cyclin F | 0.00615754 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.00615707 |
| WDR61 | WD repeat domain 61 | 0.00614374 |
| ABHD10 | abhydrolase domain containing 10 | 0.00613182 |
| FXYD1 | FXYD domain containing ion transport regulator 1 | 0.00612782 |
| RANBP1 | RAN binding protein 1 | 0.00609249 |
| SF3B3 | splicing factor 3b, subunit 3, 130kDa | 0.0060877 |
| MCM2 | minichromosome maintenance complex component 2 | 0.0060836 |
| ARMT1 | acidic residue methyltransferase 1 | 0.0060811 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 0.00607754 |
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 0.00607164 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.00606013 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00605018 |
| WDHD1 | WD repeat and HMG-box DNA binding protein 1 | 0.00604285 |
| UGT2A3 | UDP glucuronosyltransferase 2 family, polypeptide A3 | 0.00603691 |
| ACADM | acyl-CoA dehydrogenase, C-4 to C-12 straight chain | 0.00602986 |
| ADGRE1 | adhesion G protein-coupled receptor E1 | 0.00602969 |
| ILF2 | interleukin enhancer binding factor 2 | 0.0060265 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0259482 |
| GNAS | GNAS complex locus | -0.0248522 |
| XIC | X chromosome inactivation center | -0.0227769 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0191172 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.0160238 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0156437 |
| PERP | PERP, TP53 apoptosis effector | -0.0154433 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0151212 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0148595 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.0148555 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.0144545 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0144394 |
| APOD | apolipoprotein D | -0.0138971 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0138827 |
| JAG1 | jagged 1 | -0.0131234 |
| PEG10 | paternally expressed 10 | -0.0126658 |
| RND3 | Rho family GTPase 3 | -0.0125352 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.0124003 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0122623 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0121336 |
| BLNK | B-cell linker | -0.0121215 |
| MRPS16 | mitochondrial ribosomal protein S16 | -0.0120742 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.0119931 |
| TUFT1 | tuftelin 1 | -0.0119433 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0117161 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0116578 |
| MXRA5 | matrix-remodelling associated 5 | -0.0115328 |
| KRT7 | keratin 7, type II | -0.0115244 |
| HIST1H2BD | histone cluster 1, H2bd | -0.011477 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0113255 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0113199 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0112504 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0112084 |
| HIST1H2BK | histone cluster 1, H2bk | -0.0111693 |
| DEFB1 | defensin, beta 1 | -0.0111498 |
| NVL | nuclear VCP-like | -0.0111391 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.0109572 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0108855 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.01078 |
| EFNA1 | ephrin-A1 | -0.0106788 |
| PXDC1 | PX domain containing 1 | -0.0106436 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0106181 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.0106113 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0105889 |
| HMOX1 | heme oxygenase 1 | -0.0105787 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0105688 |
| IRS2 | insulin receptor substrate 2 | -0.0105621 |
| RRAGC | Ras-related GTP binding C | -0.0105232 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.0103878 |
| GLOD4 | glyoxalase domain containing 4 | -0.0103577 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.01035 |
| INAVA | innate immunity activator | -0.0103285 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0103219 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.0103192 |
| THBS2 | thrombospondin 2 | -0.0102003 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0101488 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.0101093 |
| ATF3 | activating transcription factor 3 | -0.0100804 |
| JUNB | jun B proto-oncogene | -0.010071 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.0100326 |
| ITGB4 | integrin, beta 4 | -0.010024 |
| IFI44L | interferon-induced protein 44-like | -0.00999388 |
| ANXA1 | annexin A1 | -0.00999301 |
| NXN | nucleoredoxin | -0.0098604 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00983424 |
| HTRA1 | HtrA serine peptidase 1 | -0.00982449 |
| SNAI2 | snail family zinc finger 2 | -0.00978499 |
| RIN2 | Ras and Rab interactor 2 | -0.00974644 |
| CTSD | cathepsin D | -0.00966865 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00959154 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00956321 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00952948 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00952556 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0094206 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00941033 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00940959 |
| KRT14 | keratin 14, type I | -0.00930863 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | -0.00929729 |
| LAMC2 | laminin, gamma 2 | -0.00929567 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00928183 |
| WASL | Wiskott-Aldrich syndrome-like | -0.00927891 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0092754 |
| IER5 | immediate early response 5 | -0.00924592 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00916429 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.009147 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00910658 |
| PSAP | prosaposin | -0.00910405 |
| H1-2 | H1.2 linker histone, cluster member | -0.00908333 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00903756 |
| MGLL | monoglyceride lipase | -0.00900763 |
| CD4 | CD4 molecule | -0.00895151 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00892639 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00892575 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00891989 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.00884886 |
| ITGAV | integrin, alpha V | -0.0088374 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00882918 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.00882826 |
| KLHL24 | kelch-like family member 24 | -0.00881496 |
| GPX3 | glutathione peroxidase 3 | -0.00873162 |
| IPO13 | importin 13 | -0.00872446 |
| CD163 | CD163 molecule | -0.00872369 |
| APOL1 | apolipoprotein L, 1 | -0.0086706 |
| INTS6 | integrator complex subunit 6 | -0.00866952 |
| AMOTL2 | angiomotin like 2 | -0.00866203 |
| EHD1 | EH-domain containing 1 | -0.00865219 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00863765 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00862812 |
| PDGFC | platelet derived growth factor C | -0.00859664 |
| NKX3-1 | NK3 homeobox 1 | -0.00854267 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.00849795 |
| LAMB3 | laminin, beta 3 | -0.00847808 |
| S100A11 | S100 calcium binding protein A11 | -0.00845893 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00845419 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | -0.00843651 |
| FN1 | fibronectin 1 | -0.00843119 |
| VNN1 | vanin 1 | -0.00842766 |
| SYNGR3 | synaptogyrin 3 | -0.00841879 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00838261 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00837155 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00835971 |
| OSBPL2 | oxysterol binding protein-like 2 | -0.00835363 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00835217 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00830175 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00826655 |
| PRSS21 | protease, serine, 21 (testisin) | -0.00826509 |
| BBX | bobby sox homolog (Drosophila) | -0.00824877 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00823555 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00821817 |
| RRBP1 | ribosome binding protein 1 | -0.00820813 |
| MIR22HG | MIR22 host gene | -0.00820303 |
| RGCC | regulator of cell cycle | -0.0081968 |
| SSX1 | synovial sarcoma, X breakpoint 1 | -0.00818292 |
| EFNB2 | ephrin-B2 | -0.00817443 |
| NELL1 | NEL-like 1 (chicken) | -0.00815424 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00814989 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0081426 |
| C1ORF54 | chromosome 1 open reading frame 54 | -0.00814156 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00812062 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.00809216 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.00807935 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00806909 |
| HMGA1 | high mobility group AT-hook 1 | -0.00801953 |
| EGR1 | early growth response 1 | -0.00801866 |
| C6ORF48 | chromosome 6 open reading frame 48 | -0.00797921 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.00795631 |
| RPS27L | ribosomal protein S27-like | -0.00795099 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -0.00794597 |
| PRSS8 | protease, serine, 8 | -0.00793307 |
| MX1 | MX dynamin-like GTPase 1 | -0.00789571 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00788985 |
| EPHA2 | EPH receptor A2 | -0.00787406 |
| GRN | granulin | -0.00786553 |
| IL1B | interleukin 1, beta | -0.0078596 |
| PLD3 | phospholipase D family, member 3 | -0.00785733 |
| G0S2 | G0/G1 switch 2 | -0.0078568 |
| PLK2 | polo-like kinase 2 | -0.00784426 |
| DUSP10 | dual specificity phosphatase 10 | -0.00784186 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00780096 |
| GPR137B | G protein-coupled receptor 137B | -0.00776402 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.00775823 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.00775505 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00774043 |
| HDAC9 | histone deacetylase 9 | -0.00773192 |
| GOLGA8A | golgin A8 family, member A | -0.00771297 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.00769687 |
| SNX11 | sorting nexin 11 | -0.00768136 |
| USP47 | ubiquitin specific peptidase 47 | -0.00767184 |
| MVP | major vault protein | -0.00766263 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.00766205 |
| CNTN1 | contactin 1 | -0.0076344 |
| LY75 | lymphocyte antigen 75 | -0.00762225 |
| ABHD2 | abhydrolase domain containing 2 | -0.00760831 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.00758002 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00755653 |
| ANKRD12 | ankyrin repeat domain 12 | -0.00754834 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00754363 |
| DGKA | diacylglycerol kinase, alpha 80kDa | -0.00753588 |
| BRD2 | bromodomain containing 2 | -0.00745277 |
| MAOA | monoamine oxidase A | -0.00742113 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -0.00741006 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.00736526 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.00734326 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.00732156 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00728626 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00727011 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.00726861 |
| PLXNA1 | plexin A1 | -0.00726137 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00725911 |
| ZNF91 | zinc finger protein 91 | -0.00725018 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00724061 |
| DUSP4 | dual specificity phosphatase 4 | -0.00723327 |
| KLK11 | kallikrein-related peptidase 11 | -0.00721721 |
| TGM2 | transglutaminase 2 | -0.00721384 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.00721027 |
| KMT5B | lysine methyltransferase 5B | -0.00721014 |
| CCN2 | cellular communication network factor 2 | -0.00718364 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00717737 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00717028 |
| C2 | complement component 2 | -0.00713133 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00710943 |
| KLK10 | kallikrein-related peptidase 10 | -0.00710631 |
| TOB1 | transducer of ERBB2, 1 | -0.00709568 |
| LAMB1 | laminin, beta 1 | -0.00709528 |
| CLGN | calmegin | -0.0070909 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00708193 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -0.00706592 |
| TSPAN1 | tetraspanin 1 | -0.00704457 |
| MNT | MAX network transcriptional repressor | -0.00703224 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.0070287 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00699537 |
| TGFA | transforming growth factor, alpha | -0.00699501 |
| LIMK2 | LIM domain kinase 2 | -0.00698389 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.00698251 |
| IRF7 | interferon regulatory factor 7 | -0.00697546 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00696546 |
| MAP9 | microtubule-associated protein 9 | -0.0069647 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0069587 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.00694536 |
| ZNF281 | zinc finger protein 281 | -0.00694041 |
| HIST3H2A | histone cluster 3, H2a | -0.00692922 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.00691605 |
| KLHL21 | kelch-like family member 21 | -0.00690018 |
| SQSTM1 | sequestosome 1 | -0.00689438 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.0068874 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00687451 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.00687095 |
| TXNIP | thioredoxin interacting protein | -0.00685602 |
| FNTA | farnesyltransferase, CAAX box, alpha | -0.00682564 |
| MSLN | mesothelin | -0.00681102 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00680359 |
| PLBD1 | phospholipase B domain containing 1 | -0.00680351 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00680205 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.0067922 |
| BAD | BCL2-associated agonist of cell death | -0.00678406 |
| C1QB | complement component 1, q subcomponent, B chain | -0.00677798 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00677413 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00676965 |
| CDCP1 | CUB domain containing protein 1 | -0.00676153 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00675886 |
| TPD52 | tumor protein D52 | -0.00672657 |
| LIMA1 | LIM domain and actin binding 1 | -0.00672269 |
| MMP7 | matrix metallopeptidase 7 | -0.00669425 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.00669259 |
| GPX4 | glutathione peroxidase 4 | -0.00669243 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | -0.0066787 |
| GDF15 | growth differentiation factor 15 | -0.00667768 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00667661 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00667522 |
