VAV1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description vav 1 guanine nucleotide exchange factor|This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 7409)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_VAV1
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Genes

79 co-expressed genes for VAV1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AIP aryl hydrocarbon receptor interacting protein
ARHGAP4 Rho GTPase activating protein 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
CAPRIN1 cell cycle associated protein 1
CCR9 chemokine (C-C motif) receptor 9
CD48 CD48 molecule
CD53 CD53 molecule
CLCN7 chloride channel, voltage-sensitive 7
CORO1A coronin, actin binding protein, 1A
CORO7 coronin 7
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CSK c-src tyrosine kinase
CYBA cytochrome b-245, alpha polypeptide
CYTIP cytohesin 1 interacting protein
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DGCR6 DiGeorge syndrome critical region gene 6
DOCK2 dedicator of cytokinesis 2
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DRG2 developmentally regulated GTP binding protein 2
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ELF4 E74-like factor 4 (ets domain transcription factor)
FANCC Fanconi anemia, complementation group C
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLA galactosidase, alpha
GPSM3 G-protein signaling modulator 3
GRK6 G protein-coupled receptor kinase 6
GRM4 glutamate receptor, metabotropic 4
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HNRNPL heterogeneous nuclear ribonucleoprotein L
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
LAPTM5 lysosomal protein transmembrane 5
LYST lysosomal trafficking regulator
MADD MAP-kinase activating death domain
MPV17 MpV17 mitochondrial inner membrane protein
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NMI N-myc (and STAT) interactor
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OSTF1 osteoclast stimulating factor 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PHF11 PHD finger protein 11
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTPRC protein tyrosine phosphatase, receptor type, C
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RENBP renin binding protein
RGS19 regulator of G-protein signaling 19
SASH3 SAM and SH3 domain containing 3
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SP110 SP110 nuclear body protein
SPN sialophorin
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TRIM22 tripartite motif containing 22
TRIM38 tripartite motif containing 38
TRIP13 thyroid hormone receptor interactor 13
TTF1 transcription termination factor, RNA polymerase I
VAV1 vav 1 guanine nucleotide exchange factor
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
ZNF134 zinc finger protein 134
ZNF76 zinc finger protein 76