VCL Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description vinculin|Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7414)
External Link http://www.ncbi.nlm.nih.gov/gene/7414
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107 interacting proteins for hub protein VCL from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABI2 abl-interactor 2
ACTA1 actin, alpha 1, skeletal muscle
ACTB actin, beta
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTN4 actinin, alpha 4
ALS2CR11 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
ANXA2 annexin A2
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
B2M beta-2-microglobulin
BCAR1 breast cancer anti-estrogen resistance 1
C14ORF166 chromosome 14 open reading frame 166
C19ORF57 chromosome 19 open reading frame 57
CALML5 calmodulin-like 5
CBX2 chromobox homolog 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEP350 centrosomal protein 350kDa
CIRBP cold inducible RNA binding protein
CLTC clathrin, heavy chain (Hc)
COL8A1 collagen, type VIII, alpha 1
CORO2B coronin, actin binding protein, 2B
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYCS cytochrome c, somatic
DCT dopachrome tautomerase
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4E eukaryotic translation initiation factor 4E
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GSN gelsolin
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSPA8 heat shock 70kDa protein 8
IL7R interleukin 7 receptor
LETM2 leucine zipper-EF-hand containing transmembrane protein 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRN2 leucine rich repeat neuronal 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MYH9 myosin, heavy chain 9, non-muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NONO non-POU domain containing, octamer-binding
NRAP nebulin-related anchoring protein
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
PARK2 parkin RBR E3 ubiquitin protein ligase
PDIA3 protein disulfide isomerase family A, member 3
PFN1 profilin 1
PGAM2 phosphoglycerate mutase 2 (muscle)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTK2 protein tyrosine kinase 2
PXN paxillin
RAVER1 ribonucleoprotein, PTB-binding 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RIT2 Ras-like without CAAX 2
RPS19 ribosomal protein S19
RPS21 ribosomal protein S21
RPS24 ribosomal protein S24
RPSA ribosomal protein SA
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
S100A13 S100 calcium binding protein A13
SCFD1 sec1 family domain containing 1
SELE selectin E
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPG small nuclear ribonucleoprotein polypeptide G
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX3 syntaxin 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLN1 talin 1
TLN2 talin 2
TRIP6 thyroid hormone receptor interactor 6
TUBB2A tubulin, beta 2A class IIa
U2AF1 U2 small nuclear RNA auxiliary factor 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C
VASP vasodilator-stimulated phosphoprotein
VCL vinculin
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
XIRP1 xin actin binding repeat containing 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta