VDR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vitamin D (1,25- dihydroxyvitamin D3) receptor|This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 7421)
Similar Terms
Downloads & Tools

Genes

275 genes differentially expressed following the VDR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HRG histidine-rich glycoprotein 2.73972
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.73972
CIITA class II, major histocompatibility complex, transactivator 2.73972
SIGLEC9 sialic acid binding Ig-like lectin 9 2.73972
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.73972
PAX4 paired box 4 2.73972
DSG3 desmoglein 3 2.73972
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.73972
SLC25A41 solute carrier family 25, member 41 2.73972
SOX18 SRY (sex determining region Y)-box 18 2.73972
CARD16 caspase recruitment domain family, member 16 2.73972
NAPSA napsin A aspartic peptidase 2.73972
TMEM212 transmembrane protein 212 2.73972
SBK3 SH3 domain binding kinase family, member 3 2.73972
LOC390937 Ets2 repressor factor-like 2.73972
RLBP1 retinaldehyde binding protein 1 2.73972
OR4N2 olfactory receptor, family 4, subfamily N, member 2 2.73972
SECTM1 secreted and transmembrane 1 2.73972
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.73972
TRIM74 tripartite motif containing 74 2.73972
FAM81B family with sequence similarity 81, member B 2.73972
OR56A5 olfactory receptor, family 56, subfamily A, member 5 2.73972
TDO2 tryptophan 2,3-dioxygenase 2.73972
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.73972
ETV7 ets variant 7 2.73972
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.73972
ATOH7 atonal homolog 7 (Drosophila) 2.73972
BHMT2 betaine--homocysteine S-methyltransferase 2 2.73972
GIMD1 GIMAP family P-loop NTPase domain containing 1 2.73972
TREML2 triggering receptor expressed on myeloid cells-like 2 2.73972
DLX4 distal-less homeobox 4 2.73972
UMODL1 uromodulin-like 1 2.73972
SPP2 secreted phosphoprotein 2, 24kDa 2.73972
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.73972
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.73972
OTUD6A OTU deubiquitinase 6A 2.73972
TCAF2 TRPM8 channel-associated factor 2 2.73972
PCDHA3 protocadherin alpha 3 2.73972
PTPRH protein tyrosine phosphatase, receptor type, H 2.73972
TEX101 testis expressed 101 2.73972
TRIM31 tripartite motif containing 31 2.73972
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.73972
PKD2L1 polycystic kidney disease 2-like 1 2.73972
SPRR2B small proline-rich protein 2B 2.73972
FRG2C FSHD region gene 2 family, member C 2.73972
SCEL sciellin 2.73972
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.73972
EIF4H eukaryotic translation initiation factor 4H 2.73972
GBP4 guanylate binding protein 4 2.73972
ERVW-1 endogenous retrovirus group W, member 1 2.73972
LORICRIN loricrin cornified envelope precursor protein 2.73972
FREY1 Frey regulator of sperm-oocyte fusion 1 2.73972
H3C3 H3 clustered histone 3 2.73972
ZNF593OS ZNF593 opposite strand 2.73972
C1ORF232 chromosome 1 open reading frame 230 2.73972
RBM33-DT RBM33 divergent transcript 2.73972
GNG14 G protein subunit gamma 14 2.73972
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.73972
GC group-specific component (vitamin D binding protein) 2.73972
DSG1 desmoglein 1 2.73972
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.73972
C3ORF80 chromosome 3 open reading frame 80 2.73972
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.73972
DMBX1 diencephalon/mesencephalon homeobox 1 2.73972
IL4 interleukin 4 2.73972
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.73972
SLAMF1 signaling lymphocytic activation molecule family member 1 2.73972
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.73972
C12ORF54 chromosome 12 open reading frame 54 2.73972
FGFBP2 fibroblast growth factor binding protein 2 2.73972
WNT9B wingless-type MMTV integration site family, member 9B 2.73972
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.73972
HNF1A HNF1 homeobox A 2.73972
LRRN4CL LRRN4 C-terminal like 2.73972
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.73972
TBX10 T-box 10 2.73972
CIMIP2C ciliary microtubule inner protein 2C 2.73972
TEX19 testis expressed 19 2.73972
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.73972
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.73972
C7ORF33 chromosome 7 open reading frame 33 2.73972
PRH2 proline-rich protein HaeIII subfamily 2 2.73972
CCL27 chemokine (C-C motif) ligand 27 2.73972
CGB7 chorionic gonadotropin, beta polypeptide 7 2.73972
CTSW cathepsin W 2.73972
F13B coagulation factor XIII, B polypeptide 2.73972
LRRC46 leucine rich repeat containing 46 2.73972
VHLL von Hippel-Lindau tumor suppressor-like 2.73972
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.73972
KRT13 keratin 13, type I 2.73972
EDN2 endothelin 2 2.73972
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.73972
GP5 glycoprotein V (platelet) 2.73972
DSC1 desmocollin 1 2.73972
C20ORF144 chromosome 20 open reading frame 144 2.73972
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.73972
NPBWR1 neuropeptides B/W receptor 1 2.73972
TEX12 testis expressed 12 2.73972
WFDC5 WAP four-disulfide core domain 5 2.73972
SPATA31A1 SPATA31 subfamily A, member 1 2.73972
ZC3H11D zinc finger CCCH-type containing 11D 2.73972
C11ORF97 chromosome 11 open reading frame 97 2.73972
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.73972
FGG fibrinogen gamma chain 2.73972
CST1 cystatin SN 2.73972
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.73972
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.73972
KIF4B kinesin family member 4B 2.73972
IL21 interleukin 21 2.73972
EOMES eomesodermin 2.73972
PGPEP1L pyroglutamyl-peptidase I-like 2.73972
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.73972
FOXG1 forkhead box G1 2.73972
NPC1L1 NPC1-like 1 2.73972
TMEM52B transmembrane protein 52B 2.73972
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.73972
R3HDML R3H domain containing-like 2.73972
WFDC11 WAP four-disulfide core domain 11 2.73972
ANXA2R annexin A2 receptor 2.73972
MB myoglobin 2.73972
BTG4 B-cell translocation gene 4 2.73972
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.73972
ORM2 orosomucoid 2 2.73972
TMPRSS15 transmembrane protease, serine 15 2.73972
PATE1 prostate and testis expressed 1 2.73972
RNF224 ring finger protein 224 2.73972
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.73972
PLA2G12B phospholipase A2, group XIIB 2.73972
DCT dopachrome tautomerase 2.73972
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.73972
CLCA4 chloride channel accessory 4 2.73972
TRIM7 tripartite motif containing 7 2.73972
NUTM2A NUT family member 2A 2.73972
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.73972
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 2.73972
RRP1 ribosomal RNA processing 1 2.72972
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 2.68168
C1ORF74 chromosome 1 open reading frame 74 2.60259
TMEM222 transmembrane protein 222 2.59177
HLA-C major histocompatibility complex, class I, C 2.58855
WDR5 WD repeat domain 5 2.51706
NEGR1 neuronal growth regulator 1 2.47655
CEP112 centrosomal protein 112kDa 2.43603
HSPA1A heat shock 70kDa protein 1A 2.37207
YIPF6 Yip1 domain family, member 6 2.37109
BAHCC1 BAH domain and coiled-coil containing 1 2.35754
BBS9 Bardet-Biedl syndrome 9 2.34204
GPI glucose-6-phosphate isomerase 2.3368
EIF3B eukaryotic translation initiation factor 3, subunit B 2.27985
LOC102723564 uncharacterized LOC102723564 2.27985
ANKRD34B ankyrin repeat domain 34B 2.27985
TXNDC9 thioredoxin domain containing 9 2.27805
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.27576
RPL12 ribosomal protein L12 2.26031
RPL39L ribosomal protein L39-like 2.25464
PLPP5 phospholipid phosphatase 5 2.24176
VIT vitrin 2.23826
IL23A interleukin 23, alpha subunit p19 2.2226
IFITM1 interferon induced transmembrane protein 1 2.21676
NME1 NME/NM23 nucleoside diphosphate kinase 1 2.20941
NMT1 N-myristoyltransferase 1 2.20494
RPS3 ribosomal protein S3 2.16325
MAST4 microtubule associated serine/threonine kinase family member 4 2.10308
RCC2 regulator of chromosome condensation 2 2.09896
GUK1 guanylate kinase 1 2.09735
NAMPT nicotinamide phosphoribosyltransferase 2.09043
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 2.08475
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 2.08283
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 2.08089
TTC14 tetratricopeptide repeat domain 14 2.07533
ZNF71 zinc finger protein 71 2.07533
TM2D2 TM2 domain containing 2 2.06818
TXN2 thioredoxin 2 2.06499
MRPL9 mitochondrial ribosomal protein L9 2.06416
LURAP1 leucine rich adaptor protein 1 2.05668
GUCA1A guanylate cyclase activator 1A (retina) 2.05668
COQ9 coenzyme Q9 2.04796
GK5 glycerol kinase 5 (putative) 2.03877
ARHGAP24 Rho GTPase activating protein 24 2.01404

decreased expression

Symbol Name Standardized Value
OPRL1 opiate receptor-like 1 -2.73972
PF4V1 platelet factor 4 variant 1 -2.73972
TGM1 transglutaminase 1 -2.73972
SYCP2 synaptonemal complex protein 2 -2.73972
FAM3D family with sequence similarity 3, member D -2.73972
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.73972
TMEM40 transmembrane protein 40 -2.73972
CCR6 chemokine (C-C motif) receptor 6 -2.73972
KCNK9 potassium channel, two pore domain subfamily K, member 9 -2.73972
EXTL1 exostosin-like glycosyltransferase 1 -2.73972
ZC2HC1B zinc finger, C2HC-type containing 1B -2.73972
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.73972
CSNK2A3 casein kinase 2, alpha 3 polypeptide -2.73972
ARSI arylsulfatase family, member I -2.73972
PNMA5 paraneoplastic Ma antigen family member 5 -2.73972
BAAT bile acid CoA:amino acid N-acyltransferase -2.73972
PRELP proline/arginine-rich end leucine-rich repeat protein -2.73972
TCP11 t-complex 11, testis-specific -2.73972
BMP3 bone morphogenetic protein 3 -2.73972
SPHK1 sphingosine kinase 1 -2.73972
KLLN killin, p53-regulated DNA replication inhibitor -2.73972
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -2.73972
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) -2.73972
IDO2 indoleamine 2,3-dioxygenase 2 -2.73972
KLK15 kallikrein-related peptidase 15 -2.73972
AMIGO1 adhesion molecule with Ig-like domain 1 -2.73972
ZAR1L zygote arrest 1-like -2.73972
ASB9 ankyrin repeat and SOCS box containing 9 -2.73972
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -2.73972
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -2.73972
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A -2.73972
OPRM1 opioid receptor, mu 1 -2.73972
HAO2 hydroxyacid oxidase 2 (long chain) -2.73972
DRC1 dynein regulatory complex subunit 1 -2.73972
H4C12 H4 clustered histone 12 -2.73972
FAM131C family with sequence similarity 131, member C -2.73972
LIME1 Lck interacting transmembrane adaptor 1 -2.73972
GZMM granzyme M (lymphocyte met-ase 1) -2.73972
CLRN1 clarin 1 -2.73972
TDRD10 tudor domain containing 10 -2.73972
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.73972
CDH19 cadherin 19, type 2 -2.73972
ANKRD44 ankyrin repeat domain 44 -2.69699
FCRL5 Fc receptor-like 5 -2.68678
SLC46A3 solute carrier family 46, member 3 -2.68168
LMNTD2 lamin tail domain containing 2 -2.68168
BBS1 Bardet-Biedl syndrome 1 -2.67996
HCK HCK proto-oncogene, Src family tyrosine kinase -2.67295
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.61764
SH3PXD2A SH3 and PX domains 2A -2.58855
MEP1B meprin A, beta -2.58224
AXL AXL receptor tyrosine kinase -2.58224
CHRM5 cholinergic receptor, muscarinic 5 -2.57217
INO80C INO80 complex subunit C -2.53965
USP39 ubiquitin specific peptidase 39 -2.53286
CFAP126 cilia and flagella associated protein 126 -2.52625
CEP19 centrosomal protein 19kDa -2.48878
CC2D2B coiled-coil and C2 domain containing 2B -2.45001
DCDC2C doublecortin domain containing 2C -2.43797
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -2.43603
PTBP3 polypyrimidine tract binding protein 3 -2.41439
STPG4 sperm-tail PG-rich repeat containing 4 -2.40439
FUBP3 far upstream element (FUSE) binding protein 3 -2.3923
MIIP migration and invasion inhibitory protein -2.35754
TLE6 transducin-like enhancer of split 6 -2.3368
DEPP1 DEPP autophagy regulator 1 -2.3368
CSMD2 CUB and Sushi multiple domains 2 -2.31761
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.30189
RAD51C RAD51 paralog C -2.30157
SLC35G2 solute carrier family 35, member G2 -2.29278
ANAPC10 anaphase promoting complex subunit 10 -2.27908
ZNF471 zinc finger protein 471 -2.27805
CD83 CD83 molecule -2.22101
NLRC4 NLR family, CARD domain containing 4 -2.21676
IRAK3 interleukin-1 receptor-associated kinase 3 -2.21427
SFTPD surfactant protein D -2.21427
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -2.19509
RIPOR3 RIPOR family member 3 -2.1924
SMC2 structural maintenance of chromosomes 2 -2.15537
TRIM11 tripartite motif containing 11 -2.15187
PRKG1 protein kinase, cGMP-dependent, type I -2.1414
IL21R interleukin 21 receptor -2.11851
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.10308
SHISAL2B shisa like 2B -2.09896
TEAD4 TEA domain family member 4 -2.09735
TOP6BL TOP6B like initiator of meiotic double strand breaks -2.07584
PSTK phosphoseryl-tRNA kinase -2.07124
DENND1B DENN/MADD domain containing 1B -2.06818
ACAD10 acyl-CoA dehydrogenase family, member 10 -2.05813
TMEM225B transmembrane protein 225B -2.04857
TMEM255A transmembrane protein 255A -2.04857
SPRYD4 SPRY domain containing 4 -2.04334
SPRED1 sprouty-related, EVH1 domain containing 1 -2.04219
WRNIP1 Werner helicase interacting protein 1 -2.03713
CNTD1 cyclin N-terminal domain containing 1 -2.00813
ICOSLG inducible T-cell co-stimulator ligand -2.00272