VEGFA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description vascular endothelial growth factor A|This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7422)
Similar Terms
Downloads & Tools

Genes

360 genes differentially expressed following the VEGFA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LBHD1 LBH domain containing 1 3.47288
OR5B12 olfactory receptor, family 5, subfamily B, member 12 3.47288
ADGRE3 adhesion G protein-coupled receptor E3 3.47288
IZUMO3 IZUMO family member 3 3.47288
IGFL3 IGF-like family member 3 3.47288
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.47288
TRIM10 tripartite motif containing 10 3.47288
FGL2 fibrinogen-like 2 3.47288
MGAM2 maltase-glucoamylase 2 (putative) 3.47288
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.47288
WT1 Wilms tumor 1 3.47288
CTRL chymotrypsin-like 3.47288
CTRC chymotrypsin C (caldecrin) 3.47288
ZNF99 zinc finger protein 99 3.47288
TPBGL trophoblast glycoprotein-like 3.47288
GJA3 gap junction protein, alpha 3, 46kDa 3.47288
SIX2 SIX homeobox 2 3.47288
CD6 CD6 molecule 3.47288
CD5 CD5 molecule 3.47288
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.47288
ZNF503 zinc finger protein 503 3.47288
ZNF492 zinc finger protein 492 3.47288
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.47288
PAX6 paired box 6 3.47288
LRG1 leucine-rich alpha-2-glycoprotein 1 3.47288
BATF basic leucine zipper transcription factor, ATF-like 3.47288
IL2RB interleukin 2 receptor, beta 3.47288
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.47288
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.47288
CRYAA crystallin, alpha A 3.47288
ZNF804B zinc finger protein 804B 3.47288
KRTAP5-1 keratin associated protein 5-1 3.47288
TRIB2 tribbles pseudokinase 2 3.47288
TPH1 tryptophan hydroxylase 1 3.47288
OR4E1 olfactory receptor, family 4, subfamily E, member 1 (gene/pseudogene) 3.47288
SPDEF SAM pointed domain containing ETS transcription factor 3.47288
CRYGA crystallin, gamma A 3.47288
MUC22 mucin 22 3.47288
GIMAP4 GTPase, IMAP family member 4 3.47288
SLC23A3 solute carrier family 23, member 3 3.47288
BIRC7 baculoviral IAP repeat containing 7 3.47288
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.47288
NRROS negative regulator of reactive oxygen species 3.47288
AVPR2 arginine vasopressin receptor 2 3.47288
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.47288
LRRC10B leucine rich repeat containing 10B 3.47288
APOBR apolipoprotein B receptor 3.47288
MUC20 mucin 20, cell surface associated 3.47288
MNX1 motor neuron and pancreas homeobox 1 3.47288
PVRIG poliovirus receptor related immunoglobulin domain containing 3.47288
LOC124909439 uncharacterized LOC124909439 3.47288
CES4A carboxylesterase 4A 3.47288
GIPC3 GIPC PDZ domain containing family, member 3 3.47288
PTH1R parathyroid hormone 1 receptor 3.47288
GPR35 G protein-coupled receptor 35 3.47288
PNLIPRP1 pancreatic lipase-related protein 1 3.47288
SRGN serglycin 3.47288
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.47288
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.47288
TRIM31 tripartite motif containing 31 3.47288
SAG S-antigen; retina and pineal gland (arrestin) 3.47288
CCDC198 coiled-coil domain containing 198 3.47288
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.47288
LOC114841035 uncharacterized LOC114841035 3.47288
CIMIP2A ciliary microtubule inner protein 2A 3.47288
ANKRD42-DT ANKRD42 divergent transcript 3.47288
NOTCH2NLB notch 2 N-terminal like B 3.47288
C1ORF232 chromosome 1 open reading frame 230 3.47288
CIMIP3 ciliary microtubule inner protein 3 3.47288
AKAIN1 A-kinase anchor inhibitor 1 3.47288
H2AC1 H2A clustered histone 1 3.47288
CGB3 chorionic gonadotropin subunit beta 3 3.47288
AJM1 apical junction component 1 homolog 3.47288
FOXC1 forkhead box C1 3.47288
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.47288
LY6H lymphocyte antigen 6 complex, locus H 3.47288
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.47288
BHLHA9 basic helix-loop-helix family, member a9 3.47288
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.47288
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.47288
CBLN3 cerebellin 3 precursor 3.47288
CD79A CD79a molecule, immunoglobulin-associated alpha 3.47288
GOLGA6L4 golgin A6 family-like 4 3.47288
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.47288
CLDN2 claudin 2 3.47288
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.47288
RGS21 regulator of G-protein signaling 21 3.47288
SAA1 serum amyloid A1 3.47288
LY6K lymphocyte antigen 6 complex, locus K 3.47288
ZNF705D zinc finger protein 705D 3.47288
C15ORF62 chromosome 15 open reading frame 62 3.47288
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.47288
GATA2 GATA binding protein 2 3.47288
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.47288
GPR83 G protein-coupled receptor 83 3.47288
LRRC73 leucine rich repeat containing 73 3.47288
BLNK B-cell linker 3.47288
C9 complement component 9 3.47288
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.47288
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.47288
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.47288
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.47288
EFCAB3 EF-hand calcium binding domain 3 3.47288
BTNL3 butyrophilin-like 3 3.47288
RETNLB resistin like beta 3.47288
CLRN1 clarin 1 3.47288
IL21R interleukin 21 receptor 3.47288
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.47288
TDRD10 tudor domain containing 10 3.47288
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.47288
C16ORF78 chromosome 16 open reading frame 78 3.47288
NPBWR1 neuropeptides B/W receptor 1 3.47288
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.47288
ARHGAP20 Rho GTPase activating protein 20 3.47288
WDFY4 WDFY family member 4 3.47288
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.47288
DMTN dematin actin binding protein 3.47288
ELANE elastase, neutrophil expressed 3.47288
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.47288
KRT15 keratin 15, type I 3.47288
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 3.47288
MORC1 MORC family CW-type zinc finger 1 3.47288
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.47288
APOD apolipoprotein D 3.47288
LRRC46 leucine rich repeat containing 46 3.47288
CDH10 cadherin 10, type 2 (T2-cadherin) 3.47288
POU2AF1 POU class 2 associating factor 1 3.47288
LHX5 LIM homeobox 5 3.47288
C1ORF105 chromosome 1 open reading frame 105 3.47288
TSPAN19 tetraspanin 19 3.47288
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.47288
HPGDS hematopoietic prostaglandin D synthase 3.47288
CXORF58 chromosome X open reading frame 58 3.47288
DRC7 dynein regulatory complex subunit 7 3.47288
BTG4 B-cell translocation gene 4 3.47288
GOLGA8N golgin A8 family, member N 3.47288
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.47288
FOXS1 forkhead box S1 3.47288
UBXN10 UBX domain protein 10 3.47288
CTSW cathepsin W 3.47288
C2CD4A C2 calcium-dependent domain containing 4A 3.47288
GPR50 G protein-coupled receptor 50 3.47288
IL19 interleukin 19 3.47288
IL1A interleukin 1, alpha 3.47288
SST somatostatin 3.47288
MUC7 mucin 7, secreted 3.47288
OCM oncomodulin 3.47288
ANKRD55 ankyrin repeat domain 55 3.47288
GFRAL GDNF family receptor alpha like 3.47288
SIGLEC15 sialic acid binding Ig-like lectin 15 3.47288
DLX5 distal-less homeobox 5 3.47288
TRHR thyrotropin-releasing hormone receptor 3.47288
CHRDL2 chordin-like 2 3.47288
APOL6 apolipoprotein L, 6 3.47288
SSX1 synovial sarcoma, X breakpoint 1 3.47288
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.47288
FGF16 fibroblast growth factor 16 3.47288
APOL1 apolipoprotein L, 1 3.47288
NLRP5 NLR family, pyrin domain containing 5 3.47288
HEPACAM hepatic and glial cell adhesion molecule 3.47288
FOXP3 forkhead box P3 3.47288
TGM6 transglutaminase 6 3.47288
TTC34 tetratricopeptide repeat domain 34 3.47288
AGBL4 ATP/GTP binding protein-like 4 3.47288
ZBED6 zinc finger, BED-type containing 6 3.47288
ANGPTL3 angiopoietin-like 3 3.47288
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.47288
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.47288
KIF12 kinesin family member 12 3.47288
NUTM2F NUT family member 2F 3.47288
LHB luteinizing hormone beta polypeptide 3.47288
PAGE2B P antigen family, member 2B 3.47288
GGN gametogenetin 3.47288
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.47288
CD80 CD80 molecule 3.47288
PPP1R3C protein phosphatase 1, regulatory subunit 3C 3.41739
GLRB glycine receptor, beta 3.41739
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.41739
DEGS1 delta(4)-desaturase, sphingolipid 1 2.98444
GOLGA6C golgin A6 family, member C 2.966
BRWD1 bromodomain and WD repeat domain containing 1 2.8369
SLC16A11 solute carrier family 16, member 11 2.7494
SIRPA signal-regulatory protein alpha 2.67629
CUEDC2 CUE domain containing 2 2.65312
CEP70 centrosomal protein 70kDa 2.61064
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 2.57832
BRI3BP BRI3 binding protein 2.56612
AARD alanine and arginine rich domain containing protein 2.56155
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.49798
TMEM151A transmembrane protein 151A 2.48126
TFB1M transcription factor B1, mitochondrial 2.48126
TDRD1 tudor domain containing 1 2.48126
TMEM106B transmembrane protein 106B 2.47042
KSR1 kinase suppressor of ras 1 2.47042
XPA xeroderma pigmentosum, complementation group A 2.47013
MED17 mediator complex subunit 17 2.46475
PLAGL1 pleiomorphic adenoma gene-like 1 2.45629
CCNA2 cyclin A2 2.45191
ZDHHC21 zinc finger, DHHC-type containing 21 2.43441
SPX spexin hormone 2.41822
NSG2 neuronal vesicle trafficking associated 2 2.41822
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.41822
PCDHGC3 protocadherin gamma subfamily C, 3 2.41822
FAM86B2 family with sequence similarity 86, member B2 2.41822
OPRL1 opiate receptor-like 1 2.41822
TWIST1 twist family bHLH transcription factor 1 2.41822
C2ORF92 chromosome 2 open reading frame 92 2.41822
HSPA1L heat shock 70kDa protein 1-like 2.41822
SPACDR sperm acrosome developmental regulator 2.41822
CATSPERT catsper channel auxiliary subunit tau 2.41822
ZC3H11C zinc finger CCCH-type containing 11C 2.41822
KEAP1 kelch-like ECH-associated protein 1 2.41376
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.40943
LRRC56 leucine rich repeat containing 56 2.40943
SFXN3 sideroflexin 3 2.38639
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.38241
GDE1 glycerophosphodiester phosphodiesterase 1 2.36997
SLFNL1 schlafen-like 1 2.36514
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.35445
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.34061
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.31265
AGTR1 angiotensin II receptor, type 1 2.31265
FGF8 fibroblast growth factor 8 (androgen-induced) 2.31265
GDA guanine deaminase 2.31265
NRXN3 neurexin 3 2.30809
C10ORF88 chromosome 10 open reading frame 88 2.27564
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.26635
RORA RAR-related orphan receptor A 2.25659
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.25009
ZNF500 zinc finger protein 500 2.25009
TMEM74B transmembrane protein 74B 2.24787
RRAGD Ras-related GTP binding D 2.23694
HAUS1 HAUS augmin-like complex, subunit 1 2.23384
PCDHB2 protocadherin beta 2 2.23384
ZSWIM4 zinc finger, SWIM-type containing 4 2.23384
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.22542
ALAS1 5'-aminolevulinate synthase 1 2.19878
CCNT1 cyclin T1 2.19657
ABI2 abl-interactor 2 2.19463
C19ORF25 chromosome 19 open reading frame 25 2.18808
FBXO2 F-box protein 2 2.12528
RILP Rab interacting lysosomal protein 2.12528
TMEM245 transmembrane protein 245 2.12527
ZFP2 ZFP2 zinc finger protein 2.11849
MARCHF1 membrane associated ring-CH-type finger 1 2.11517
C14ORF39 chromosome 14 open reading frame 39 2.10962
YY1 YY1 transcription factor 2.10367
ALKBH5 AlkB family member 5, RNA demethylase 2.09414
DUSP3 dual specificity phosphatase 3 2.08927
AGER advanced glycosylation end product-specific receptor 2.08875
GUCA1B guanylate cyclase activator 1B (retina) 2.07494
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.05356
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.04653
ZMYND8 zinc finger, MYND-type containing 8 2.03302
FGFR2 fibroblast growth factor receptor 2 2.02877
MMRN2 multimerin 2 2.02716
EPN3 epsin 3 2.0217
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 2.01541

decreased expression

Symbol Name Standardized Value
PTH2 parathyroid hormone 2 -3.47288
HAO2 hydroxyacid oxidase 2 (long chain) -3.47288
DYDC1 DPY30 domain containing 1 -3.47288
WNT9B wingless-type MMTV integration site family, member 9B -3.47288
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -3.47288
IZUMO4 IZUMO family member 4 -3.47288
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -3.47288
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -3.47288
A1CF APOBEC1 complementation factor -3.47288
GJA5 gap junction protein, alpha 5, 40kDa -3.47288
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -3.47288
TMPRSS11D transmembrane protease, serine 11D -3.47288
ARHGAP30 Rho GTPase activating protein 30 -3.47288
COL20A1 collagen, type XX, alpha 1 -3.47288
PRR29 proline rich 29 -3.47288
GCOM1 GRINL1A complex locus 1 -3.47288
CLEC4C C-type lectin domain family 4, member C -3.47288
ITGB7 integrin, beta 7 -3.47288
LRRC8C-DT LRRC8C divergent transcript -3.47288
FAM229A family with sequence similarity 229, member A -3.47288
EPHA10 EPH receptor A10 -3.47288
PCDHAC1 protocadherin alpha subfamily C, 1 -3.47288
APP-DT APP divergent transcript -3.47288
EVI2A ecotropic viral integration site 2A -3.47288
KCNK9 potassium channel, two pore domain subfamily K, member 9 -3.47288
VAV1 vav 1 guanine nucleotide exchange factor -3.47288
C22ORF42 chromosome 22 open reading frame 42 -3.47288
TAS2R31 taste receptor, type 2, member 31 -3.38311
SOS2 son of sevenless homolog 2 (Drosophila) -3.37203
TUSC2 tumor suppressor candidate 2 -3.09377
LRRN3 leucine rich repeat neuronal 3 -3.09377
NLRC4 NLR family, CARD domain containing 4 -3.08216
SANBR SANT and BTB domain regulator of CSR -3.05855
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -3.01558
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.91274
GBA2 glucosidase, beta (bile acid) 2 -2.8791
GCK glucokinase (hexokinase 4) -2.75243
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.6394
LACTB lactamase, beta -2.61859
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.59353
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.59353
FBLN5 fibulin 5 -2.59353
SBK1 SH3 domain binding kinase 1 -2.54762
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.51012
C8ORF34 chromosome 8 open reading frame 34 -2.47673
GRM3 glutamate receptor, metabotropic 3 -2.46413
UBXN11 UBX domain protein 11 -2.44897
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.42013
CMKLR2 chemerin chemokine-like receptor 2 -2.41027
CLDN23 claudin 23 -2.41027
FER1L6 fer-1-like family member 6 -2.41027
RBM34 RNA binding motif protein 34 -2.40943
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 -2.40624
PIBF1 progesterone immunomodulatory binding factor 1 -2.38919
LRP11 low density lipoprotein receptor-related protein 11 -2.38244
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -2.38241
CALHM2 calcium homeostasis modulator 2 -2.38241
FOXK1 forkhead box K1 -2.38241
TTLL9 tubulin tyrosine ligase-like family member 9 -2.38241
HRH1 histamine receptor H1 -2.38241
NPB neuropeptide B -2.38241
UGDH UDP-glucose 6-dehydrogenase -2.34061
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.31812
CYCS cytochrome c, somatic -2.31291
MAOB monoamine oxidase B -2.30826
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.30809
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.30809
CCND2 cyclin D2 -2.29425
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa -2.28492
TMEM179 transmembrane protein 179 -2.27564
SHOX short stature homeobox -2.27564
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.27564
TMEM147 transmembrane protein 147 -2.27294
CEP162 centrosomal protein 162kDa -2.27054
DOHH deoxyhypusine hydroxylase/monooxygenase -2.23694
LRRC7 leucine rich repeat containing 7 -2.23694
TICRR TOPBP1-interacting checkpoint and replication regulator -2.23513
GRK6 G protein-coupled receptor kinase 6 -2.234
STARD10 StAR-related lipid transfer (START) domain containing 10 -2.23384
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.21027
ZNF865 zinc finger protein 865 -2.20148
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.19463
NRIP1 nuclear receptor interacting protein 1 -2.18921
PPP4C protein phosphatase 4, catalytic subunit -2.18838
ANGPT4 angiopoietin 4 -2.1731
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -2.13938
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.13894
DHRS1 dehydrogenase/reductase (SDR family) member 1 -2.13063
MSN moesin -2.12793
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -2.12527
CDKL4 cyclin-dependent kinase-like 4 -2.10216
NOS3 nitric oxide synthase 3 (endothelial cell) -2.10216
TOR1A torsin family 1, member A (torsin A) -2.07494
IRAK1 interleukin-1 receptor-associated kinase 1 -2.07117
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.07117
DUS2 dihydrouridine synthase 2 -2.07117
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.07117
LRRC34 leucine rich repeat containing 34 -2.06044
WEE1 WEE1 G2 checkpoint kinase -2.05356
CTH cystathionine gamma-lyase -2.04575
EFCAB8 EF-hand calcium binding domain 8 -2.04575
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.03302