VEGF_A_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/VEGF_A_UP.V1_UP
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Genes

386 genes differentially expressed following the VEGF_A_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABHD3 abhydrolase domain containing 3
ADARB1 adenosine deaminase, RNA-specific, B1
ADORA2A adenosine A2a receptor
AKAP3 A kinase (PRKA) anchor protein 3
AKAP5 A kinase (PRKA) anchor protein 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
AMOT angiomotin
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARC activity-regulated cytoskeleton-associated protein
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BMP8A bone morphogenetic protein 8a
C21ORF2 chromosome 21 open reading frame 2
CABP1 calcium binding protein 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CAMP cathelicidin antimicrobial peptide
CCDC22 coiled-coil domain containing 22
CCDC57 coiled-coil domain containing 57
CCL2 chemokine (C-C motif) ligand 2
CCL7 chemokine (C-C motif) ligand 7
CCS copper chaperone for superoxide dismutase
CD19 CD19 molecule
CD5 CD5 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CIC capicua transcriptional repressor
CLCN6 chloride channel, voltage-sensitive 6
CLIP2 CAP-GLY domain containing linker protein 2
CLIP3 CAP-GLY domain containing linker protein 3
COL11A2 collagen, type XI, alpha 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CORO2B coronin, actin binding protein, 2B
CPA1 carboxypeptidase A1 (pancreatic)
CRYGC crystallin, gamma C
CRYGD crystallin, gamma D
CSHL1 chorionic somatomammotropin hormone-like 1
CXCL11 chemokine (C-X-C motif) ligand 11
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCX doublecortin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND3 DENN/MADD domain containing 3
DLG2 discs, large homolog 2 (Drosophila)
DSG2 desmoglein 2
DTX4 deltex 4, E3 ubiquitin ligase
DUSP8 dual specificity phosphatase 8
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ECM1 extracellular matrix protein 1
EMILIN1 elastin microfibril interfacer 1
ENO2 enolase 2 (gamma, neuronal)
ENO3 enolase 3 (beta, muscle)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETFB electron-transfer-flavoprotein, beta polypeptide
ETV2 ets variant 2
EVX1 even-skipped homeobox 1
FAM189A2 family with sequence similarity 189, member A2
FBP2 fructose-1,6-bisphosphatase 2
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEV FEV (ETS oncogene family)
FGA fibrinogen alpha chain
FKBP6 FK506 binding protein 6, 36kDa
FMO4 flavin containing monooxygenase 4
FMO5 flavin containing monooxygenase 5
FPGS folylpolyglutamate synthase
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GDF11 growth differentiation factor 11
GLI1 GLI family zinc finger 1
GRIK2 glutamate receptor, ionotropic, kainate 2
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HDAC5 histone deacetylase 5
HLA-DMA major histocompatibility complex, class II, DM alpha
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific
HOXB5 homeobox B5
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFT140 intraflagellar transport 140
IL32 interleukin 32
INPP5J inositol polyphosphate-5-phosphatase J
IQCK IQ motif containing K
IRF5 interferon regulatory factor 5
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
ITM2A integral membrane protein 2A
KANK3 KN motif and ankyrin repeat domains 3
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIAA0556 KIAA0556
KIAA0930 KIAA0930
KIAA1462 KIAA1462
LCAT lecithin-cholesterol acyltransferase
LHX2 LIM homeobox 2
LMOD1 leiomodin 1 (smooth muscle)
LOC730101 uncharacterized LOC730101
LONP2 lon peptidase 2, peroxisomal
LTB lymphotoxin beta (TNF superfamily, member 3)
LY6E lymphocyte antigen 6 complex, locus E
LYRM9 LYR motif containing 9
MATN2 matrilin 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MERTK MER proto-oncogene, tyrosine kinase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIA melanoma inhibitory activity
MMP2 matrix metallopeptidase 2
MN1 meningioma (disrupted in balanced translocation) 1
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MYL9 myosin, light chain 9, regulatory
MYO1A myosin IA
MYO1F myosin IF
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCF2 neutrophil cytosolic factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NKG7 natural killer cell granule protein 7
OPRD1 opioid receptor, delta 1
OPTN optineurin
OR7E24 olfactory receptor, family 7, subfamily E, member 24
OVOL1 ovo-like zinc finger 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PAX1 paired box 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLTP phospholipid transfer protein
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPL periplakin
PPP6R2 protein phosphatase 6, regulatory subunit 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGFR prostaglandin F receptor (FP)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
PYY peptide YY
RAB40AL RAB40A, member RAS oncogene family-like
RBMX2 RNA binding motif protein, X-linked 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFPL1 ret finger protein-like 1
RGS3 regulator of G-protein signaling 3
RHBDD3 rhomboid domain containing 3
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
SDC4 syndecan 4
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP2 SH3-domain binding protein 2
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHH sonic hedgehog
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SMG6 SMG6 nonsense mediated mRNA decay factor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAGLN transgelin
TCEA2 transcription elongation factor A (SII), 2
TCL1A T-cell leukemia/lymphoma 1A
THY1 Thy-1 cell surface antigen
TKTL1 transketolase-like 1
TLL2 tolloid-like 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM8B transmembrane protein 8B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNNC2 troponin C type 2 (fast)
TNS2 tensin 2
TP53I11 tumor protein p53 inducible protein 11
TPTEP1 transmembrane phosphatase with tensin homology pseudogene 1
TRAF1 TNF receptor-associated factor 1
TRAF5 TNF receptor-associated factor 5
TUB tubby bipartite transcription factor
TXNIP thioredoxin interacting protein
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2L6 ubiquitin-conjugating enzyme E2L 6
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF205 zinc finger protein 205
ZNF76 zinc finger protein 76
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACE angiotensin I converting enzyme
ADAM9 ADAM metallopeptidase domain 9
ADTRP androgen-dependent TFPI-regulating protein
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AMD1 adenosylmethionine decarboxylase 1
AMPH amphiphysin
ANGPT2 angiopoietin 2
AQP8 aquaporin 8
ARHGAP29 Rho GTPase activating protein 29
ARMC6 armadillo repeat containing 6
ASPH aspartate beta-hydroxylase
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP13A3 ATPase type 13A3
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BAK1 BCL2-antagonist/killer 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C5ORF30 chromosome 5 open reading frame 30
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC86 coiled-coil domain containing 86
CCL23 chemokine (C-C motif) ligand 23
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNH cyclin H
CD8B CD8b molecule
CDC27 cell division cycle 27
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDC45 cell division cycle 45
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP131 centrosomal protein 131kDa
CEP170 centrosomal protein 170kDa
CHM choroideremia (Rab escort protein 1)
CKS2 CDC28 protein kinase regulatory subunit 2
CNTFR ciliary neurotrophic factor receptor
CPA3 carboxypeptidase A3 (mast cell)
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYB561D2 cytochrome b561 family, member D2
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHFR dihydrofolate reductase
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPM2AIP1 EPM2A (laforin) interacting protein 1
EXO1 exonuclease 1
FABP4 fatty acid binding protein 4, adipocyte
FKBP5 FK506 binding protein 5
FLT1 fms-related tyrosine kinase 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATA6 GATA binding protein 6
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR4 G protein-coupled receptor 4
HIRA histone cell cycle regulator
HIST1H2BN histone cluster 1, H2bn
HMMR hyaluronan-mediated motility receptor (RHAMM)
IL1RL1 interleukin 1 receptor-like 1
IL6 interleukin 6
INHBB inhibin, beta B
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIAA0020 KIAA0020
KIF11 kinesin family member 11
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KLF9 Kruppel-like factor 9
LMNB1 lamin B1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC17 leucine rich repeat containing 17
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAP1B microtubule-associated protein 1B
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK6 mitogen-activated protein kinase 6
MBD4 methyl-CpG binding domain protein 4
MCM4 minichromosome maintenance complex component 4
MDN1 MDN1, midasin homolog (yeast)
MEST mesoderm specific transcript
MFAP3 microfibrillar-associated protein 3
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMRN1 multimerin 1
MPHOSPH6 M-phase phosphoprotein 6
MRPL19 mitochondrial ribosomal protein L19
MT1X metallothionein 1X
MYO5A myosin VA (heavy chain 12, myoxin)
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NDC80 NDC80 kinetochore complex component
NEK7 NIMA-related kinase 7
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRP1 neuropilin 1
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUP155 nucleoporin 155kDa
NUP50 nucleoporin 50kDa
ORC2 origin recognition complex, subunit 2
OSTF1 osteoclast stimulating factor 1
PAPOLA poly(A) polymerase alpha
PCDH7 protocadherin 7
PGAP1 post-GPI attachment to proteins 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLCL1 phospholipase C-like 1
PLK4 polo-like kinase 4
PNN pinin, desmosome associated protein
PNO1 partner of NOB1 homolog (S. cerevisiae)
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRMT3 protein arginine methyltransferase 3
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSD3 pleckstrin and Sec7 domain containing 3
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRE protein tyrosine phosphatase, receptor type, E
RAB3B RAB3B, member RAS oncogene family
RAP1A RAP1A, member of RAS oncogene family
RASA2 RAS p21 protein activator 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RECQL RecQ helicase-like
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RIF1 replication timing regulatory factor 1
RND3 Rho family GTPase 3
RNF6 ring finger protein (C3H2C3 type) 6
ROM1 retinal outer segment membrane protein 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPGR retinitis pigmentosa GTPase regulator
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF11 SR-related CTD-associated factor 11
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETBP1 SET binding protein 1
SLC30A9 solute carrier family 30 (zinc transporter), member 9
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TFAM transcription factor A, mitochondrial
TGFBI transforming growth factor, beta-induced, 68kDa
THOC2 THO complex 2
TLE3 transducin-like enhancer of split 3
TMEM259 transmembrane protein 259
TMPO thymopoietin
TNP1 transition protein 1 (during histone to protamine replacement)
TRAPPC8 trafficking protein particle complex 8
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN8 tetraspanin 8
TTC37 tetratricopeptide repeat domain 37
TTK TTK protein kinase
TWF1 twinfilin actin binding protein 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UFL1 UFM1-specific ligase 1
UGP2 UDP-glucose pyrophosphorylase 2
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VEGFC vascular endothelial growth factor C
VRK1 vaccinia related kinase 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZC3H15 zinc finger CCCH-type containing 15
ZNF117 zinc finger protein 117
ZNF124 zinc finger protein 124
ZNF253 zinc finger protein 253