Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
Category | transcriptomics |
Type | gene perturbation |
Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
External Link | http://www.broadinstitute.org/gsea/msigdb/cards/VEGF_A_UP.V1_UP |
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386 genes differentially expressed following the VEGF_A_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Symbol | Name |
---|---|
ABCA4 | ATP-binding cassette, sub-family A (ABC1), member 4 |
ABCB10 | ATP-binding cassette, sub-family B (MDR/TAP), member 10 |
ABHD3 | abhydrolase domain containing 3 |
ADARB1 | adenosine deaminase, RNA-specific, B1 |
ADORA2A | adenosine A2a receptor |
AKAP3 | A kinase (PRKA) anchor protein 3 |
AKAP5 | A kinase (PRKA) anchor protein 5 |
AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
ALDOB | aldolase B, fructose-bisphosphate |
AMOT | angiomotin |
APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G |
ARC | activity-regulated cytoskeleton-associated protein |
ARL4C | ADP-ribosylation factor-like 4C |
ATF3 | activating transcription factor 3 |
BMP8A | bone morphogenetic protein 8a |
C21ORF2 | chromosome 21 open reading frame 2 |
CABP1 | calcium binding protein 1 |
CACNB1 | calcium channel, voltage-dependent, beta 1 subunit |
CALCOCO1 | calcium binding and coiled-coil domain 1 |
CAMP | cathelicidin antimicrobial peptide |
CCDC22 | coiled-coil domain containing 22 |
CCDC57 | coiled-coil domain containing 57 |
CCL2 | chemokine (C-C motif) ligand 2 |
CCL7 | chemokine (C-C motif) ligand 7 |
CCS | copper chaperone for superoxide dismutase |
CD19 | CD19 molecule |
CD5 | CD5 molecule |
CD79A | CD79a molecule, immunoglobulin-associated alpha |
CHRNA1 | cholinergic receptor, nicotinic, alpha 1 (muscle) |
CIC | capicua transcriptional repressor |
CLCN6 | chloride channel, voltage-sensitive 6 |
CLIP2 | CAP-GLY domain containing linker protein 2 |
CLIP3 | CAP-GLY domain containing linker protein 3 |
COL11A2 | collagen, type XI, alpha 2 |
COLQ | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase |
CORO2B | coronin, actin binding protein, 2B |
CPA1 | carboxypeptidase A1 (pancreatic) |
CRYGC | crystallin, gamma C |
CRYGD | crystallin, gamma D |
CSHL1 | chorionic somatomammotropin hormone-like 1 |
CXCL11 | chemokine (C-X-C motif) ligand 11 |
DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
DCX | doublecortin |
DDIT3 | DNA-damage-inducible transcript 3 |
DDIT4 | DNA-damage-inducible transcript 4 |
DENND3 | DENN/MADD domain containing 3 |
DLG2 | discs, large homolog 2 (Drosophila) |
DSG2 | desmoglein 2 |
DTX4 | deltex 4, E3 ubiquitin ligase |
DUSP8 | dual specificity phosphatase 8 |
DYRK1B | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B |
ECM1 | extracellular matrix protein 1 |
EMILIN1 | elastin microfibril interfacer 1 |
ENO2 | enolase 2 (gamma, neuronal) |
ENO3 | enolase 3 (beta, muscle) |
ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
ETFB | electron-transfer-flavoprotein, beta polypeptide |
ETV2 | ets variant 2 |
EVX1 | even-skipped homeobox 1 |
FAM189A2 | family with sequence similarity 189, member A2 |
FBP2 | fructose-1,6-bisphosphatase 2 |
FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
FEV | FEV (ETS oncogene family) |
FGA | fibrinogen alpha chain |
FKBP6 | FK506 binding protein 6, 36kDa |
FMO4 | flavin containing monooxygenase 4 |
FMO5 | flavin containing monooxygenase 5 |
FPGS | folylpolyglutamate synthase |
GABRA5 | gamma-aminobutyric acid (GABA) A receptor, alpha 5 |
GDF11 | growth differentiation factor 11 |
GLI1 | GLI family zinc finger 1 |
GRIK2 | glutamate receptor, ionotropic, kainate 2 |
GUCY2D | guanylate cyclase 2D, membrane (retina-specific) |
HDAC5 | histone deacetylase 5 |
HLA-DMA | major histocompatibility complex, class II, DM alpha |
HMCES | 5-hydroxymethylcytosine (hmC) binding, ES cell-specific |
HOXB5 | homeobox B5 |
HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 |
HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 |
HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
HTT | huntingtin |
ICAM1 | intercellular adhesion molecule 1 |
ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
IFT140 | intraflagellar transport 140 |
IL32 | interleukin 32 |
INPP5J | inositol polyphosphate-5-phosphatase J |
IQCK | IQ motif containing K |
IRF5 | interferon regulatory factor 5 |
IRF9 | interferon regulatory factor 9 |
IRS2 | insulin receptor substrate 2 |
ISG20 | interferon stimulated exonuclease gene 20kDa |
ITGB4 | integrin, beta 4 |
ITIH4 | inter-alpha-trypsin inhibitor heavy chain family, member 4 |
ITM2A | integral membrane protein 2A |
KANK3 | KN motif and ankyrin repeat domains 3 |
KCNC3 | potassium channel, voltage gated Shaw related subfamily C, member 3 |
KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 |
KIAA0556 | KIAA0556 |
KIAA0930 | KIAA0930 |
KIAA1462 | KIAA1462 |
LCAT | lecithin-cholesterol acyltransferase |
LHX2 | LIM homeobox 2 |
LMOD1 | leiomodin 1 (smooth muscle) |
LOC730101 | uncharacterized LOC730101 |
LONP2 | lon peptidase 2, peroxisomal |
LTB | lymphotoxin beta (TNF superfamily, member 3) |
LY6E | lymphocyte antigen 6 complex, locus E |
LYRM9 | LYR motif containing 9 |
MATN2 | matrilin 2 |
ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial |
MERTK | MER proto-oncogene, tyrosine kinase |
MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase |
MIA | melanoma inhibitory activity |
MMP2 | matrix metallopeptidase 2 |
MN1 | meningioma (disrupted in balanced translocation) 1 |
MTMR11 | myotubularin related protein 11 |
MTSS1 | metastasis suppressor 1 |
MYL9 | myosin, light chain 9, regulatory |
MYO1A | myosin IA |
MYO1F | myosin IF |
NAT8 | N-acetyltransferase 8 (GCN5-related, putative) |
NCF2 | neutrophil cytosolic factor 2 |
NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 |
NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
NINJ1 | ninjurin 1 |
NKG7 | natural killer cell granule protein 7 |
OPRD1 | opioid receptor, delta 1 |
OPTN | optineurin |
OR7E24 | olfactory receptor, family 7, subfamily E, member 24 |
OVOL1 | ovo-like zinc finger 1 |
P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 |
PART1 | prostate androgen-regulated transcript 1 (non-protein coding) |
PAX1 | paired box 1 |
PER2 | period circadian clock 2 |
PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
PIN4 | peptidylprolyl cis/trans isomerase, NIMA-interacting 4 |
PKD1 | polycystic kidney disease 1 (autosomal dominant) |
PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) |
PLTP | phospholipid transfer protein |
PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 |
PPL | periplakin |
PPP6R2 | protein phosphatase 6, regulatory subunit 2 |
PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 |
PTGFR | prostaglandin F receptor (FP) |
PTPRC | protein tyrosine phosphatase, receptor type, C |
PTPRJ | protein tyrosine phosphatase, receptor type, J |
PYY | peptide YY |
RAB40AL | RAB40A, member RAS oncogene family-like |
RBMX2 | RNA binding motif protein, X-linked 2 |
RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B |
RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
RFPL1 | ret finger protein-like 1 |
RGS3 | regulator of G-protein signaling 3 |
RHBDD3 | rhomboid domain containing 3 |
RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) |
SDC4 | syndecan 4 |
SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
SH3BP2 | SH3-domain binding protein 2 |
SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 |
SHH | sonic hedgehog |
SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
SLC22A2 | solute carrier family 22 (organic cation transporter), member 2 |
SMG6 | SMG6 nonsense mediated mRNA decay factor |
SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) |
SPOCK3 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 |
SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) |
TAGLN | transgelin |
TCEA2 | transcription elongation factor A (SII), 2 |
TCL1A | T-cell leukemia/lymphoma 1A |
THY1 | Thy-1 cell surface antigen |
TKTL1 | transketolase-like 1 |
TLL2 | tolloid-like 2 |
TM7SF2 | transmembrane 7 superfamily member 2 |
TMEM8B | transmembrane protein 8B |
TNFSF12 | tumor necrosis factor (ligand) superfamily, member 12 |
TNNC2 | troponin C type 2 (fast) |
TNS2 | tensin 2 |
TP53I11 | tumor protein p53 inducible protein 11 |
TPTEP1 | transmembrane phosphatase with tensin homology pseudogene 1 |
TRAF1 | TNF receptor-associated factor 1 |
TRAF5 | TNF receptor-associated factor 5 |
TUB | tubby bipartite transcription factor |
TXNIP | thioredoxin interacting protein |
UBA7 | ubiquitin-like modifier activating enzyme 7 |
UBE2L6 | ubiquitin-conjugating enzyme E2L 6 |
ZC3H7B | zinc finger CCCH-type containing 7B |
ZCCHC24 | zinc finger, CCHC domain containing 24 |
ZNF205 | zinc finger protein 205 |
ZNF76 | zinc finger protein 76 |
ZNRF4 | zinc and ring finger 4 |
Symbol | Name |
---|---|
AASS | aminoadipate-semialdehyde synthase |
ACADM | acyl-CoA dehydrogenase, C-4 to C-12 straight chain |
ACE | angiotensin I converting enzyme |
ADAM9 | ADAM metallopeptidase domain 9 |
ADTRP | androgen-dependent TFPI-regulating protein |
AIMP1 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
AMD1 | adenosylmethionine decarboxylase 1 |
AMPH | amphiphysin |
ANGPT2 | angiopoietin 2 |
AQP8 | aquaporin 8 |
ARHGAP29 | Rho GTPase activating protein 29 |
ARMC6 | armadillo repeat containing 6 |
ASPH | aspartate beta-hydroxylase |
ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
ATP13A3 | ATPase type 13A3 |
ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 |
B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 |
BAK1 | BCL2-antagonist/killer 1 |
BAZ1A | bromodomain adjacent to zinc finger domain, 1A |
BCL10 | B-cell CLL/lymphoma 10 |
BCLAF1 | BCL2-associated transcription factor 1 |
BIRC5 | baculoviral IAP repeat containing 5 |
BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B |
C5ORF30 | chromosome 5 open reading frame 30 |
CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 |
CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase |
CCDC86 | coiled-coil domain containing 86 |
CCL23 | chemokine (C-C motif) ligand 23 |
CCNB1 | cyclin B1 |
CCNB2 | cyclin B2 |
CCNE1 | cyclin E1 |
CCNH | cyclin H |
CD8B | CD8b molecule |
CDC27 | cell division cycle 27 |
CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 |
CDC45 | cell division cycle 45 |
CDKN3 | cyclin-dependent kinase inhibitor 3 |
CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta |
CENPA | centromere protein A |
CENPE | centromere protein E, 312kDa |
CEP131 | centrosomal protein 131kDa |
CEP170 | centrosomal protein 170kDa |
CHM | choroideremia (Rab escort protein 1) |
CKS2 | CDC28 protein kinase regulatory subunit 2 |
CNTFR | ciliary neurotrophic factor receptor |
CPA3 | carboxypeptidase A3 (mast cell) |
CRYZ | crystallin, zeta (quinone reductase) |
CSE1L | CSE1 chromosome segregation 1-like (yeast) |
CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 |
CYB561D2 | cytochrome b561 family, member D2 |
DBF4 | DBF4 zinc finger |
DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 |
DHFR | dihydrofolate reductase |
DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 |
DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) |
DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
DNAJC13 | DnaJ (Hsp40) homolog, subfamily C, member 13 |
EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
EPM2AIP1 | EPM2A (laforin) interacting protein 1 |
EXO1 | exonuclease 1 |
FABP4 | fatty acid binding protein 4, adipocyte |
FKBP5 | FK506 binding protein 5 |
FLT1 | fms-related tyrosine kinase 1 |
GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
GATA6 | GATA binding protein 6 |
GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) |
GPR4 | G protein-coupled receptor 4 |
HIRA | histone cell cycle regulator |
HIST1H2BN | histone cluster 1, H2bn |
HMMR | hyaluronan-mediated motility receptor (RHAMM) |
IL1RL1 | interleukin 1 receptor-like 1 |
IL6 | interleukin 6 |
INHBB | inhibin, beta B |
ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
KIAA0020 | KIAA0020 |
KIF11 | kinesin family member 11 |
KIF22 | kinesin family member 22 |
KIF23 | kinesin family member 23 |
KLF9 | Kruppel-like factor 9 |
LMNB1 | lamin B1 |
LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
LRRC17 | leucine rich repeat containing 17 |
LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 |
MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K |
MAP1B | microtubule-associated protein 1B |
MAP3K7 | mitogen-activated protein kinase kinase kinase 7 |
MAPK6 | mitogen-activated protein kinase 6 |
MBD4 | methyl-CpG binding domain protein 4 |
MCM4 | minichromosome maintenance complex component 4 |
MDN1 | MDN1, midasin homolog (yeast) |
MEST | mesoderm specific transcript |
MFAP3 | microfibrillar-associated protein 3 |
MKLN1 | muskelin 1, intracellular mediator containing kelch motifs |
MMP14 | matrix metallopeptidase 14 (membrane-inserted) |
MMRN1 | multimerin 1 |
MPHOSPH6 | M-phase phosphoprotein 6 |
MRPL19 | mitochondrial ribosomal protein L19 |
MT1X | metallothionein 1X |
MYO5A | myosin VA (heavy chain 12, myoxin) |
NBN | nibrin |
NCOA3 | nuclear receptor coactivator 3 |
NDC80 | NDC80 kinetochore complex component |
NEK7 | NIMA-related kinase 7 |
NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) |
NR2F1 | nuclear receptor subfamily 2, group F, member 1 |
NRP1 | neuropilin 1 |
NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 |
NUP155 | nucleoporin 155kDa |
NUP50 | nucleoporin 50kDa |
ORC2 | origin recognition complex, subunit 2 |
OSTF1 | osteoclast stimulating factor 1 |
PAPOLA | poly(A) polymerase alpha |
PCDH7 | protocadherin 7 |
PGAP1 | post-GPI attachment to proteins 1 |
PHKA1 | phosphorylase kinase, alpha 1 (muscle) |
PLCL1 | phospholipase C-like 1 |
PLK4 | polo-like kinase 4 |
PNN | pinin, desmosome associated protein |
PNO1 | partner of NOB1 homolog (S. cerevisiae) |
POP1 | processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) |
POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) |
PPIG | peptidylprolyl isomerase G (cyclophilin G) |
PRKACB | protein kinase, cAMP-dependent, catalytic, beta |
PRMT3 | protein arginine methyltransferase 3 |
PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) |
PSD3 | pleckstrin and Sec7 domain containing 3 |
PTPRD | protein tyrosine phosphatase, receptor type, D |
PTPRE | protein tyrosine phosphatase, receptor type, E |
RAB3B | RAB3B, member RAS oncogene family |
RAP1A | RAP1A, member of RAS oncogene family |
RASA2 | RAS p21 protein activator 2 |
RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) |
RECQL | RecQ helicase-like |
RFC4 | replication factor C (activator 1) 4, 37kDa |
RGS2 | regulator of G-protein signaling 2 |
RGS4 | regulator of G-protein signaling 4 |
RGS5 | regulator of G-protein signaling 5 |
RIF1 | replication timing regulatory factor 1 |
RND3 | Rho family GTPase 3 |
RNF6 | ring finger protein (C3H2C3 type) 6 |
ROM1 | retinal outer segment membrane protein 1 |
RP2 | retinitis pigmentosa 2 (X-linked recessive) |
RPGR | retinitis pigmentosa GTPase regulator |
RRM2 | ribonucleotide reductase M2 |
RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) |
RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
SACS | sacsin molecular chaperone |
SAT1 | spermidine/spermine N1-acetyltransferase 1 |
SCAF11 | SR-related CTD-associated factor 11 |
SEL1L | sel-1 suppressor of lin-12-like (C. elegans) |
SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
SETBP1 | SET binding protein 1 |
SLC30A9 | solute carrier family 30 (zinc transporter), member 9 |
SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 |
SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
SMC4 | structural maintenance of chromosomes 4 |
SPAG5 | sperm associated antigen 5 |
SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 |
ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
SULT1B1 | sulfotransferase family, cytosolic, 1B, member 1 |
TFAM | transcription factor A, mitochondrial |
TGFBI | transforming growth factor, beta-induced, 68kDa |
THOC2 | THO complex 2 |
TLE3 | transducin-like enhancer of split 3 |
TMEM259 | transmembrane protein 259 |
TMPO | thymopoietin |
TNP1 | transition protein 1 (during histone to protamine replacement) |
TRAPPC8 | trafficking protein particle complex 8 |
TRIM25 | tripartite motif containing 25 |
TRMU | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase |
TSPAN8 | tetraspanin 8 |
TTC37 | tetratricopeptide repeat domain 37 |
TTK | TTK protein kinase |
TWF1 | twinfilin actin binding protein 1 |
UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
UFL1 | UFM1-specific ligase 1 |
UGP2 | UDP-glucose pyrophosphorylase 2 |
USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) |
VEGFC | vascular endothelial growth factor C |
VRK1 | vaccinia related kinase 1 |
XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 |
YES1 | YES proto-oncogene 1, Src family tyrosine kinase |
ZC3H15 | zinc finger CCCH-type containing 15 |
ZNF117 | zinc finger protein 117 |
ZNF124 | zinc finger protein 124 |
ZNF253 | zinc finger protein 253 |