VHL Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase|Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7428)
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Genes

695 genes differentially expressed following the VHL gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 3.85273
FAM13A family with sequence similarity 13, member A 3.38638
PGK1 phosphoglycerate kinase 1 3.38638
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 3.38638
STC1 stanniocalcin 1 3.38638
LDHA lactate dehydrogenase A 3.38638
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.38638
GPI glucose-6-phosphate isomerase 3.26676
TAS2R31 taste receptor, type 2, member 31 3.25787
GAPDH glyceraldehyde-3-phosphate dehydrogenase 3.25787
ENO1 enolase 1, (alpha) 3.25787
PRELID2 PRELI domain containing 2 3.21911
NMBR neuromedin B receptor 3.19578
OR56A1 olfactory receptor, family 56, subfamily A, member 1 3.19578
CFAP96 cilia and flagella associated protein 96 3.19578
NRN1 neuritin 1 3.18692
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 3.14547
FAM162A family with sequence similarity 162, member A 3.08759
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 3.08759
S100A10 S100 calcium binding protein A10 3.08759
PDK1 pyruvate dehydrogenase kinase, isozyme 1 3.03958
ADGRE3 adhesion G protein-coupled receptor E3 3.03958
COL17A1 collagen, type XVII, alpha 1 3.03958
DNAH11 dynein, axonemal, heavy chain 11 3.0173
TPI1 triosephosphate isomerase 1 3.0173
WSB1 WD repeat and SOCS box containing 1 3.0173
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 3.0173
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.99795
PTK6 protein tyrosine kinase 6 2.99795
CCDC152 coiled-coil domain containing 152 2.99795
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.99795
KISS1 KiSS-1 metastasis-suppressor 2.99795
ZCCHC12 zinc finger, CCHC domain containing 12 2.99795
EFCAB3 EF-hand calcium binding domain 3 2.99795
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.99795
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.99795
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.99795
NMUR2 neuromedin U receptor 2 2.99795
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.99795
PKM pyruvate kinase, muscle 2.99795
MST1 macrophage stimulating 1 2.99795
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.99795
CA9 carbonic anhydrase IX 2.99795
ADGB androglobin 2.99795
COL11A1 collagen, type XI, alpha 1 2.99795
TUBB8 tubulin, beta 8 class VIII 2.99795
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.99795
UNC13C unc-13 homolog C (C. elegans) 2.99795
TNRC6C trinucleotide repeat containing 6C 2.99795
IRX3 iroquois homeobox 3 2.99795
DDIT4 DNA-damage-inducible transcript 4 2.99795
HAO2 hydroxyacid oxidase 2 (long chain) 2.99795
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.99795
KDM4B lysine (K)-specific demethylase 4B 2.99795
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.99795
PNLIPRP1 pancreatic lipase-related protein 1 2.99795
PAM peptidylglycine alpha-amidating monooxygenase 2.99795
CA5A carbonic anhydrase VA, mitochondrial 2.99795
DTNA dystrobrevin, alpha 2.92701
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.92234
HK2 hexokinase 2 2.92234
BHLHE41 basic helix-loop-helix family, member e41 2.92188
GLIS3 GLIS family zinc finger 3 2.91931
RPS4X ribosomal protein S4, X-linked 2.91931
HILPDA hypoxia inducible lipid droplet-associated 2.89603
LYPLAL1 lysophospholipase-like 1 2.88604
POFUT4 protein O-fucosyltransferase 4 2.85818
EPHA6 EPH receptor A6 2.85709
ADCY8 adenylate cyclase 8 (brain) 2.83792
INSIG2 insulin induced gene 2 2.83124
PCED1B PC-esterase domain containing 1B 2.79468
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 2.76329
TMEM45A transmembrane protein 45A 2.76329
MT1H metallothionein 1H 2.76329
SLC15A5 solute carrier family 15, member 5 2.70521
NUP58 nucleoporin 58 2.70521
LCN10 lipocalin 10 2.70521
FABP4 fatty acid binding protein 4, adipocyte 2.70521
VSIR V-set immunoregulatory receptor 2.70521
C1ORF141 chromosome 1 open reading frame 141 2.70521
OPRM1 opioid receptor, mu 1 2.70521
GIPC3 GIPC PDZ domain containing family, member 3 2.70521
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.70521
TCAF2 TRPM8 channel-associated factor 2 2.70521
PGAM1 phosphoglycerate mutase 1 (brain) 2.70521
CXCL9 chemokine (C-X-C motif) ligand 9 2.70521
CXCL2 chemokine (C-X-C motif) ligand 2 2.70521
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.70521
GBP2 guanylate binding protein 2, interferon-inducible 2.70521
PCDHGA9 protocadherin gamma subfamily A, 9 2.70521
PCDH8 protocadherin 8 2.70521
AVPR1A arginine vasopressin receptor 1A 2.70521
RSPO1 R-spondin 1 2.70521
TMPRSS7 transmembrane protease, serine 7 2.70521
WASHC4 WASH complex subunit 4 2.70521
DUSP29 dual specificity phosphatase 29 2.70521
SPDYE12 speedy/RINGO cell cycle regulator family member E12 2.70521
HIC1 hypermethylated in cancer 1 2.70521
EVPL envoplakin 2.70521
STEAP4 STEAP family member 4 2.70521
FAM9B family with sequence similarity 9, member B 2.70521
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.70521
C17ORF113 chromosome 17 open reading frame 113 2.70521
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.70521
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.70521
DCST1 DC-STAMP domain containing 1 2.70521
DUT-AS1 DUT antisense RNA 1 2.70521
ZBTB26 zinc finger and BTB domain containing 26 2.70521
KDM5B lysine (K)-specific demethylase 5B 2.70521
LOC112694756 uncharaterized LOC112694756 2.70521
TFRC transferrin receptor 2.70521
SOWAHB sosondowah ankyrin repeat domain family member B 2.70521
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.70521
NPIPA8 nuclear pore complex interacting protein family, member A8 2.70521
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.70521
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.70521
BHMT2 betaine--homocysteine S-methyltransferase 2 2.70521
IL2RB interleukin 2 receptor, beta 2.70521
MCPH1 microcephalin 1 2.70521
ASGR2 asialoglycoprotein receptor 2 2.70521
CBLIF cobalamin binding intrinsic factor 2.70521
IRX4 iroquois homeobox 4 2.70521
GATA2 GATA binding protein 2 2.70521
ULBP3 UL16 binding protein 3 2.70521
ASB8 ankyrin repeat and SOCS box containing 8 2.70521
ASB9 ankyrin repeat and SOCS box containing 9 2.70521
CBLN3 cerebellin 3 precursor 2.70521
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.70521
PCDHA3 protocadherin alpha 3 2.70521
RS1 retinoschisin 1 2.70521
ISM2 isthmin 2 2.70521
OR52K2 olfactory receptor, family 52, subfamily K, member 2 2.70521
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.70521
GPR4 G protein-coupled receptor 4 2.70521
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.70521
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.70521
RPL10 ribosomal protein L10 2.70521
ASB5 ankyrin repeat and SOCS box containing 5 2.70521
PRG4 proteoglycan 4 2.70521
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.70521
COX8C cytochrome c oxidase subunit VIIIC 2.70521
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.70521
CCR4 chemokine (C-C motif) receptor 4 2.70521
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.70521
ERVH48-1 endogenous retrovirus group 48, member 1 2.70521
LY6K lymphocyte antigen 6 complex, locus K 2.70521
C6ORF118 chromosome 6 open reading frame 118 2.70521
TBX5 T-box 5 2.70521
TBX3 T-box 3 2.70521
MIA melanoma inhibitory activity 2.70521
KDM3A lysine (K)-specific demethylase 3A 2.70521
GJA9 gap junction protein, alpha 9, 59kDa 2.70521
CABP4 calcium binding protein 4 2.70521
MUC6 mucin 6, oligomeric mucus/gel-forming 2.70521
TSGA13 testis specific, 13 2.70521
PDYN prodynorphin 2.70521
OVOL3 ovo-like zinc finger 3 2.70521
AANAT aralkylamine N-acetyltransferase 2.70521
MYBPC1 myosin binding protein C, slow type 2.70521
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.70521
CLDN16 claudin 16 2.70521
CXORF65 chromosome X open reading frame 65 2.70521
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.70521
RAP2A RAP2A, member of RAS oncogene family 2.70521
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.70521
CCER2 coiled-coil glutamate-rich protein 2 2.70521
XAF1 XIAP associated factor 1 2.70521
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.70521
IQCF1 IQ motif containing F1 2.70521
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.70521
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.70521
COL20A1 collagen, type XX, alpha 1 2.70521
GRID2 glutamate receptor, ionotropic, delta 2 2.70521
TXLNB taxilin beta 2.70521
PARP3 poly (ADP-ribose) polymerase family, member 3 2.70521
MLN motilin 2.70521
TMEM106C transmembrane protein 106C 2.70521
ACER1 alkaline ceramidase 1 2.70521
NPPC natriuretic peptide C 2.70521
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.70521
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.70521
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.70521
WFDC6 WAP four-disulfide core domain 6 2.70521
WFDC8 WAP four-disulfide core domain 8 2.70521
FITM1 fat storage-inducing transmembrane protein 1 2.70521
POTEJ POTE ankyrin domain family, member J 2.70521
PKDREJ polycystin (PKD) family receptor for egg jelly 2.70521
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.70521
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.70521
CHI3L2 chitinase 3-like 2 2.70521
PCDH10 protocadherin 10 2.70521
FOXP2 forkhead box P2 2.70521
CLCNKB chloride channel, voltage-sensitive Kb 2.70521
LIN7A lin-7 homolog A (C. elegans) 2.70521
SAMD7 sterile alpha motif domain containing 7 2.70521
UTS2B urotensin 2B 2.70521
POU3F2 POU class 3 homeobox 2 2.70521
GLOD5 glyoxalase domain containing 5 2.70521
GAL3ST2 galactose-3-O-sulfotransferase 2 2.70521
EFCAB8 EF-hand calcium binding domain 8 2.70521
NSUN6 NOP2/Sun domain family, member 6 2.70521
PLA2G4E phospholipase A2, group IVE 2.70521
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.70521
FBXO39 F-box protein 39 2.70521
CIDEC cell death-inducing DFFA-like effector c 2.70521
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.70521
CTAGE15 CTAGE family, member 15 2.70521
YEATS2 YEATS domain containing 2 2.70521
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.70521
C9ORF57 chromosome 9 open reading frame 57 2.70521
RETNLB resistin like beta 2.70521
C9ORF64 chromosome 9 open reading frame 64 2.70521
TECRL trans-2,3-enoyl-CoA reductase-like 2.70521
FGR FGR proto-oncogene, Src family tyrosine kinase 2.70521
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.70521
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.70521
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.70521
KCNK18 potassium channel, two pore domain subfamily K, member 18 2.70521
TEX29 testis expressed 29 2.70521
GPC6 glypican 6 2.70521
IGIP IgA-inducing protein 2.70521
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 2.70521
C1ORF105 chromosome 1 open reading frame 105 2.70521
CLEC18B C-type lectin domain family 18, member B 2.70521
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.70521
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.70521
KIF11 kinesin family member 11 2.70521
NLRP3 NLR family, pyrin domain containing 3 2.70521
SOS1 son of sevenless homolog 1 (Drosophila) 2.70521
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.70521
TP63 tumor protein p63 2.70521
UBXN10 UBX domain protein 10 2.70521
NXF2 nuclear RNA export factor 2 2.70521
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.70521
LHX5 LIM homeobox 5 2.70521
TGM4 transglutaminase 4 2.70521
GREM1 gremlin 1, DAN family BMP antagonist 2.70521
P3H2 prolyl 3-hydroxylase 2 2.70521
FBXO42 F-box protein 42 2.70016
CCDC192 coiled-coil domain containing 192 2.69859
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.69549
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.69342
RIMKLA ribosomal modification protein rimK-like family member A 2.6932
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.68637
EGLN1 egl-9 family hypoxia-inducible factor 1 2.68593
CELF2 CUGBP, Elav-like family member 2 2.68593
RHOQ ras homolog family member Q 2.67587
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.6664
BEND4 BEN domain containing 4 2.65964
NCALD neurocalcin delta 2.65555
LYN LYN proto-oncogene, Src family tyrosine kinase 2.65555
DZIP1L DAZ interacting zinc finger protein 1-like 2.65555
RNASET2 ribonuclease T2 2.65555
LHX1 LIM homeobox 1 2.65555
NAT10 N-acetyltransferase 10 (GCN5-related) 2.65555
INHBE inhibin, beta E 2.65555
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.65412
CPO carboxypeptidase O 2.65412
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.64435
FBXO17 F-box protein 17 2.64099
INTS6L integrator complex subunit 6 like 2.63298
FNTB farnesyltransferase, CAAX box, beta 2.6286
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2.62048
GOLGA8A golgin A8 family, member A 2.61706
CD19 CD19 molecule 2.60551
ZNF638 zinc finger protein 638 2.60551
C1QL3 complement component 1, q subcomponent-like 3 2.60551
MYO1E myosin IE 2.60454
FAM222A family with sequence similarity 222, member A 2.59079
SUN1 Sad1 and UNC84 domain containing 1 2.59079
DYNC2I1 dynein 2 intermediate chain 1 2.5899
LAMA3 laminin, alpha 3 2.58292
POU5F1 POU class 5 homeobox 1 2.5804
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.57655
ARL1 ADP-ribosylation factor-like 1 2.57055
ENTREP1 endosomal transmembrane epsin interactor 1 2.55678
LRRC58 leucine rich repeat containing 58 2.55423
NREP neuronal regeneration related protein 2.54352
FNBP1 formin binding protein 1 2.54336
STK17B serine/threonine kinase 17b 2.53366
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.52209
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.50996
NELL1 NEL-like 1 (chicken) 2.50996
RYBP RING1 and YY1 binding protein 2.50996
GLIS2 GLIS family zinc finger 2 2.50352
FOXN3 forkhead box N3 2.49537
PRPH peripherin 2.49537
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 2.49325
SACK1B scaffolding CK1 anchoring protein B 2.49221
CDCA7L cell division cycle associated 7-like 2.49139
LNPK lunapark, ER junction formation factor 2.47648
GLG1 golgi glycoprotein 1 2.47648
WDR54 WD repeat domain 54 2.46065
PCDH19 protocadherin 19 2.45356
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.4514
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.45113
LUC7L3 LUC7-like 3 (S. cerevisiae) 2.45113
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 2.44898
MT3 metallothionein 3 2.43988
FAM117B family with sequence similarity 117, member B 2.43417
C3 complement component 3 2.41694
ADAM2 ADAM metallopeptidase domain 2 2.41635
TIFA TRAF-interacting protein with forkhead-associated domain 2.41635
RLF rearranged L-myc fusion 2.4134
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.39459
UBE2O ubiquitin-conjugating enzyme E2O 2.37898
CD9 CD9 molecule 2.37801
DPP6 dipeptidyl-peptidase 6 2.37801
PDE4B phosphodiesterase 4B, cAMP-specific 2.37801
WDR26 WD repeat domain 26 2.37801
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 2.36935
TMEM200A transmembrane protein 200A 2.36751
KCTD18 potassium channel tetramerization domain containing 18 2.36647
CAPZB capping protein (actin filament) muscle Z-line, beta 2.35137
THADA thyroid adenoma associated 2.35086
ARHGAP32 Rho GTPase activating protein 32 2.34639
MIMS1 mitochondrial inner membrane scaffold 1 2.34366
LMBRD2 LMBR1 domain containing 2 2.34066
ZNF724 zinc finger protein 724 2.33551
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.32768
ATP11A ATPase, class VI, type 11A 2.32768
VIPR2 vasoactive intestinal peptide receptor 2 2.32767
IFITM1 interferon induced transmembrane protein 1 2.32335
TET1 tet methylcytosine dioxygenase 1 2.32335
ZMIZ2 zinc finger, MIZ-type containing 2 2.32335
ZNF654 zinc finger protein 654 2.3217
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.31187
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.31187
PARP8 poly (ADP-ribose) polymerase family, member 8 2.30482
NOL4 nucleolar protein 4 2.30392
NEFL neurofilament, light polypeptide 2.30258
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.29308
ZNF395 zinc finger protein 395 2.29308
CCL26 chemokine (C-C motif) ligand 26 2.29274
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.29274
ALKBH5 AlkB family member 5, RNA demethylase 2.29274
SAV1 salvador family WW domain containing protein 1 2.28961
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.27744
ENOSF1 enolase superfamily member 1 2.27665
DST dystonin 2.27532
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.27332
TNIP1 TNFAIP3 interacting protein 1 2.27332
UNC13D unc-13 homolog D (C. elegans) 2.27259
ALDOC aldolase C, fructose-bisphosphate 2.27133
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.27133
ADRA2A adrenoceptor alpha 2A 2.26574
EPC1 enhancer of polycomb homolog 1 (Drosophila) 2.26523
CLDN11 claudin 11 2.26515
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.25425
FYCO1 FYVE and coiled-coil domain containing 1 2.25276
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.25276
HELZ helicase with zinc finger 2.25276
CCNG2 cyclin G2 2.251
COL6A1 collagen, type VI, alpha 1 2.24901
ARLN allregulin 2.2482
JAK1 Janus kinase 1 2.24623
AIF1 allograft inflammatory factor 1 2.24487
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.24487
IGLON5 IgLON family member 5 2.24404
SF3B2 splicing factor 3b, subunit 2, 145kDa 2.24239
ANKRD12 ankyrin repeat domain 12 2.22854
IER3 immediate early response 3 2.22706
ZDHHC4 zinc finger, DHHC-type containing 4 2.22706
TGIF2 TGFB-induced factor homeobox 2 2.22048
FTH1 ferritin, heavy polypeptide 1 2.21733
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.20838
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa 2.20838
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 2.20627
CNOT2 CCR4-NOT transcription complex, subunit 2 2.20344
CHPF chondroitin polymerizing factor 2.20187
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 2.20071
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.2005
ZNF43 zinc finger protein 43 2.19927
RWDD3 RWD domain containing 3 2.1973
PLIN2 perilipin 2 2.19644
VIM vimentin 2.19521
NEFM neurofilament, medium polypeptide 2.19262
ANXA2 annexin A2 2.18686
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 2.18686
SDK1 sidekick cell adhesion molecule 1 2.18578
CLASP1 cytoplasmic linker associated protein 1 2.18578
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.18578
BCO1 beta-carotene oxygenase 1 2.18577
MXI1 MAX interactor 1, dimerization protein 2.18577
TERT telomerase reverse transcriptase 2.18081
HSPA4L heat shock 70kDa protein 4-like 2.18081
AASS aminoadipate-semialdehyde synthase 2.18081
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 2.17502
PPME1 protein phosphatase methylesterase 1 2.17399
PFKP phosphofructokinase, platelet 2.16719
ELL2 elongation factor, RNA polymerase II, 2 2.1658
APP amyloid beta (A4) precursor protein 2.16421
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.15525
SNTA1 syntrophin, alpha 1 2.15525
AK4 adenylate kinase 4 2.1528
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.1528
CA3 carbonic anhydrase III 2.15209
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.15209
DDT D-dopachrome tautomerase 2.14444
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 2.14316
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.14316
GCHFR GTP cyclohydrolase I feedback regulator 2.14192
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 2.14184
CNMD chondromodulin 2.13769
LOXL1 lysyl oxidase-like 1 2.13381
IFITM3 interferon induced transmembrane protein 3 2.13188
TMTC2 transmembrane and tetratricopeptide repeat containing 2 2.1294
PEMT phosphatidylethanolamine N-methyltransferase 2.12669
GSTCD glutathione S-transferase, C-terminal domain containing 2.12562
RIOK3 RIO kinase 3 2.12331
MTARC2 mitochondrial amidoxime reducing component 2 2.11893
PIAS2 protein inhibitor of activated STAT, 2 2.11767
FSCN1 fascin actin-bundling protein 1 2.11601
TMT1A thiol methyltransferase 1A 2.11298
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 2.11142
RSRC1 arginine/serine-rich coiled-coil 1 2.11017
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 2.11017
SP5 Sp5 transcription factor 2.10817
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.10817
ONECUT1 one cut homeobox 1 2.10571
CTCFL CCCTC-binding factor (zinc finger protein)-like 2.1057
POMK protein-O-mannose kinase 2.10249
SMN2 survival of motor neuron 2, centromeric 2.10152
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 2.10147
MTMR10 myotubularin related protein 10 2.0891
PHIP pleckstrin homology domain interacting protein 2.0862
TRIOBP TRIO and F-actin binding protein 2.08572
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.084
GPAT4 glycerol-3-phosphate acyltransferase 4 2.0825
DDHD1 DDHD domain containing 1 2.07691
CCN2 cellular communication network factor 2 2.07524
TM9SF3 transmembrane 9 superfamily member 3 2.07318
FLT4 fms-related tyrosine kinase 4 2.07146
SEC61G Sec61 gamma subunit 2.07146
ADM adrenomedullin 2.07146
CDKL4 cyclin-dependent kinase-like 4 2.07069
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.06984
UHMK1 U2AF homology motif (UHM) kinase 1 2.06877
ESRP1 epithelial splicing regulatory protein 1 2.06877
FGF11 fibroblast growth factor 11 2.06834
ZNF212 zinc finger protein 212 2.06672
TRIM33 tripartite motif containing 33 2.05746
CDK19 cyclin-dependent kinase 19 2.0516
ZNF148 zinc finger protein 148 2.03418
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.0318
SEPHS1 selenophosphate synthetase 1 2.03059
DPY19L2 dpy-19-like 2 (C. elegans) 2.02833
KCNK12 potassium channel, two pore domain subfamily K, member 12 2.02459
ZSWIM5 zinc finger, SWIM-type containing 5 2.02286
LONP1 lon peptidase 1, mitochondrial 2.02286
DOK3 docking protein 3 2.02273
NPAS2 neuronal PAS domain protein 2 2.01193
ALCAM activated leukocyte cell adhesion molecule 2.01019
RPS8 ribosomal protein S8 2.00813
GRB7 growth factor receptor-bound protein 7 2.00813
RCAN1 regulator of calcineurin 1 2.00813
TGFA transforming growth factor, alpha 2.00813
ZNF184 zinc finger protein 184 2.00813
EEF1AKMT4 EEF1A lysine methyltransferase 4 2.00813
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.00813
ICA1 islet cell autoantigen 1, 69kDa 2.00813
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 2.00813
CCNI cyclin I 2.00813
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2.00363

decreased expression

Symbol Name Standardized Value
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.99795
SOX13 SRY (sex determining region Y)-box 13 -2.99795
PM20D1 peptidase M20 domain containing 1 -2.99795
SOX10 SRY (sex determining region Y)-box 10 -2.99795
ZNF837 zinc finger protein 837 -2.91236
FAM24B family with sequence similarity 24, member B -2.91236
LYG1 lysozyme G-like 1 -2.91236
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) -2.85232
LRRC27 leucine rich repeat containing 27 -2.8465
DCXR dicarbonyl/L-xylulose reductase -2.83124
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.79785
PRDX1 peroxiredoxin 1 -2.79732
CYB5A cytochrome b5 type A (microsomal) -2.78865
ANKRD49 ankyrin repeat domain 49 -2.78556
FRMD5 FERM domain containing 5 -2.77631
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.72283
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.70521
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -2.70521
H2AZ1 H2A.Z variant histone 1 -2.70521
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.70521
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -2.70521
FBXL18 F-box and leucine-rich repeat protein 18 -2.70521
AARS1 alanyl-tRNA synthetase 1 -2.70521
CCND1 cyclin D1 -2.70521
ZNF316 zinc finger protein 316 -2.70521
TNPO3 transportin 3 -2.70521
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.69859
MYORG myogenesis regulating glycosidase (putative) -2.68637
KIF1C-AS1 KIF1C antisense RNA 1 -2.68637
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.68593
PMM2 phosphomannomutase 2 -2.67152
FKBPL FK506 binding protein like -2.66172
WNT3A wingless-type MMTV integration site family, member 3A -2.65555
LRRC32 leucine rich repeat containing 32 -2.65555
MUC1 mucin 1, cell surface associated -2.65555
CLEC4G C-type lectin domain family 4, member G -2.65555
RSPO3 R-spondin 3 -2.65555
TTLL2 tubulin tyrosine ligase-like family member 2 -2.65555
F2 coagulation factor II (thrombin) -2.65555
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.65555
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.65555
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -2.65555
TGM2 transglutaminase 2 -2.65555
TRIM73 tripartite motif containing 73 -2.65555
SLC26A9 solute carrier family 26 (anion exchanger), member 9 -2.65555
EVI2A ecotropic viral integration site 2A -2.65555
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -2.65555
LGSN lengsin, lens protein with glutamine synthetase domain -2.65555
SDS serine dehydratase -2.65555
ARHGAP40 Rho GTPase activating protein 40 -2.65555
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -2.65555
MYLK2 myosin light chain kinase 2 -2.65555
SYT15 synaptotagmin XV -2.65555
SMIM43 small integral membrane protein 43 -2.65555
RAG2 recombination activating gene 2 -2.65555
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.65555
CCR6 chemokine (C-C motif) receptor 6 -2.65555
ANGPT4 angiopoietin 4 -2.65555
COL7A1 collagen, type VII, alpha 1 -2.65555
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.65555
GTF2A1L general transcription factor IIA, 1-like -2.65555
PTPRQ protein tyrosine phosphatase, receptor type, Q -2.65555
PSAT1 phosphoserine aminotransferase 1 -2.64435
HSPE1 heat shock 10kDa protein 1 -2.64028
PRICKLE1 prickle homolog 1 (Drosophila) -2.64028
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 -2.62144
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.60454
INSIG1 insulin induced gene 1 -2.59008
TNNC2 troponin C type 2 (fast) -2.58292
MRPL35 mitochondrial ribosomal protein L35 -2.58292
CALM1 calmodulin 1 (phosphorylase kinase, delta) -2.5817
CDH3 cadherin 3, type 1, P-cadherin (placental) -2.5817
AAMDC adipogenesis associated, Mth938 domain containing -2.57655
ZNF3 zinc finger protein 3 -2.56985
ANKRD33B ankyrin repeat domain 33B -2.56826
CUX2 cut-like homeobox 2 -2.55678
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.55095
PTPRS protein tyrosine phosphatase, receptor type, S -2.54352
OAT ornithine aminotransferase -2.54336
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -2.53295
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.53132
DOCK4 dedicator of cytokinesis 4 -2.51885
CCDC28A coiled-coil domain containing 28A -2.51488
HID1 HID1 domain containing -2.5128
ABR active BCR-related -2.49365
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.47648
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.46229
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.46065
MCF2 MCF.2 cell line derived transforming sequence -2.43988
CENATAC centrosomal AT-AC splicing factor -2.43988
NUDC nudC nuclear distribution protein -2.43629
UNC5B unc-5 homolog B (C. elegans) -2.43417
PCLAF PCNA clamp associated factor -2.43417
TXLNG taxilin gamma -2.43322
GGCT gamma-glutamylcyclotransferase -2.41694
RNF187 ring finger protein 187 -2.41635
MRPL47 mitochondrial ribosomal protein L47 -2.4134
RPL27 ribosomal protein L27 -2.41194
RINT1 RAD50 interactor 1 -2.41191
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.40047
FBXW2 F-box and WD repeat domain containing 2 -2.38482
SBK1 SH3 domain binding kinase 1 -2.37898
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.37801
MSL1 male-specific lethal 1 homolog (Drosophila) -2.37801
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.37581
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.36935
BEX1 brain expressed, X-linked 1 -2.36647
EDNRA endothelin receptor type A -2.36647
FBXW11 F-box and WD repeat domain containing 11 -2.36627
NCOA3 nuclear receptor coactivator 3 -2.36468
IFFO2 intermediate filament family orphan 2 -2.35551
TCEA1 transcription elongation factor A (SII), 1 -2.35348
H4C13 H4 clustered histone 13 -2.32837
STK33 serine/threonine kinase 33 -2.32755
ENTR1 endosome associated trafficking regulator 1 -2.32323
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.31654
GFM1 G elongation factor, mitochondrial 1 -2.31542
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.30424
CRACDL CRACD like -2.30424
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.29722
CCDC66 coiled-coil domain containing 66 -2.29274
RFXANK regulatory factor X-associated ankyrin-containing protein -2.28985
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.2861
ADCY1 adenylate cyclase 1 (brain) -2.27896
EMD emerin -2.2774
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -2.2774
ABHD17B abhydrolase domain containing 17B -2.2774
BBC3 BCL2 binding component 3 -2.27365
HCFC2 host cell factor C2 -2.27332
DLC1 DLC1 Rho GTPase activating protein -2.27259
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.27202
BCAN brevican -2.27202
HDLBP high density lipoprotein binding protein -2.27133
RGMB repulsive guidance molecule family member b -2.27107
FBXL6 F-box and leucine-rich repeat protein 6 -2.26657
PNN pinin, desmosome associated protein -2.26574
RNPS1 RNA binding protein S1, serine-rich domain -2.25902
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -2.25891
ZYG11B zyg-11 family member B, cell cycle regulator -2.25276
AIF1L allograft inflammatory factor 1-like -2.25276
FBXO22 F-box protein 22 -2.25276
ASTN2 astrotactin 2 -2.25236
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.25005
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.25005
DNM2 dynamin 2 -2.24404
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.24404
SH3BP2 SH3-domain binding protein 2 -2.24404
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.24268
TARDBP TAR DNA binding protein -2.24268
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.23778
S100A13 S100 calcium binding protein A13 -2.23212
CNTN1 contactin 1 -2.22956
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.22878
CYCS cytochrome c, somatic -2.22706
CLMP CXADR-like membrane protein -2.22706
ZNF674 zinc finger protein 674 -2.22706
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -2.22706
DEDD2 death effector domain containing 2 -2.22048
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -2.2187
SLC25A39 solute carrier family 25, member 39 -2.2153
ATCAY ataxia, cerebellar, Cayman type -2.21448
H4C1 H4 clustered histone 1 -2.20838
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.20765
HLA-E major histocompatibility complex, class I, E -2.20751
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -2.20546
NFE2L2 nuclear factor, erythroid 2-like 2 -2.20187
TEP1 telomerase-associated protein 1 -2.20187
SCAF4 SR-related CTD-associated factor 4 -2.20071
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.20071
LMO4 LIM domain only 4 -2.1973
PA2G4 proliferation-associated 2G4, 38kDa -2.1973
WNK2 WNK lysine deficient protein kinase 2 -2.1973
MED14 mediator complex subunit 14 -2.19565
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.18577
C3ORF38 chromosome 3 open reading frame 38 -2.18494
MRPS11 mitochondrial ribosomal protein S11 -2.18081
CLN3 ceroid-lipofuscinosis, neuronal 3 -2.18081
ORC2 origin recognition complex, subunit 2 -2.17502
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 -2.17436
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.17436
TUBA1C tubulin, alpha 1c -2.17436
ECD ecdysoneless homolog (Drosophila) -2.17399
C19ORF33 chromosome 19 open reading frame 33 -2.16306
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.16063
DCTPP1 dCTP pyrophosphatase 1 -2.15581
TXN thioredoxin -2.15525
SARAF store-operated calcium entry-associated regulatory factor -2.15525
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -2.1528
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) -2.15023
DNAL1 dynein, axonemal, light chain 1 -2.14539
TMEM53 transmembrane protein 53 -2.14444
DDR2 discoidin domain receptor tyrosine kinase 2 -2.13794
CIAO1 cytosolic iron-sulfur assembly component 1 -2.1294
PLIN5 perilipin 5 -2.1294
RNF212 ring finger protein 212 -2.1294
RUSC1 RUN and SH3 domain containing 1 -2.12331
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.11767
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.11298
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.11017
TMEM220 transmembrane protein 220 -2.11017
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.11017
KLRG2 killer cell lectin-like receptor subfamily G, member 2 -2.10817
AKT2 v-akt murine thymoma viral oncogene homolog 2 -2.10817
TNS3 tensin 3 -2.10468
KLHL32 kelch-like family member 32 -2.10152
PLD5 phospholipase D family, member 5 -2.09758
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B -2.09159
GJA1 gap junction protein, alpha 1, 43kDa -2.08816
PHF5A PHD finger protein 5A -2.08637
AXL AXL receptor tyrosine kinase -2.0862
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -2.0862
RNF152 ring finger protein 152 -2.0862
RPGR retinitis pigmentosa GTPase regulator -2.08572
MPST mercaptopyruvate sulfurtransferase -2.07779
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.06877
HMGB1 high mobility group box 1 -2.06831
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) -2.05201
CCBE1 collagen and calcium binding EGF domains 1 -2.05201
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.0506
KRI1 KRI1 homolog (S. cerevisiae) -2.04883
CMC2 C-x(9)-C motif containing 2 -2.04519
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.03619
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -2.03418
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.03418
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -2.03296
CTSL cathepsin L -2.01727
HTT huntingtin -2.01501
SOCS1 suppressor of cytokine signaling 1 -2.00813
IFT57 intraflagellar transport 57 -2.00417
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -2.00363
CPNE7 copine VII -2.00363