VORAPAXAR Gene Set

Dataset DGIdb Drug Targets 2026
Category physical interactions
Type drug
Description A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethynyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation. (Chemical Entities of Biological Interest Ontology, CHEBI_82702)
External Link https://dgidb.org/results?searchType=drug&searchTerms=VORAPAXAR
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Genes

3 interacting proteins for the VORAPAXAR drug from theDGIdb Drug Targets 2026 dataset.

Symbol Name Standardized Value
F2RL2 coagulation factor II (thrombin) receptor-like 2 8.822
F2R coagulation factor II (thrombin) receptor 1.96044
F2RL3 coagulation factor II (thrombin) receptor-like 3 1.47033