Vacuole Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. (Gene Ontology, GO_0005773)
External Link http://amigo.geneontology.org/amigo/term/GO:0005773
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Genes

1000 proteins co-occuring with the Vacuole cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
BECN1 beclin 1, autophagy related 3.979
LAMP1 lysosomal-associated membrane protein 1 3.907
ATG5 autophagy related 5 3.864
MTOR mechanistic target of rapamycin (serine/threonine kinase) 3.839
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 3.798
SQSTM1 sequestosome 1 3.784
ATG7 autophagy related 7 3.744
CTSB cathepsin B 3.739
CTSS cathepsin S 3.712
CTSD cathepsin D 3.703
ULK1 unc-51 like autophagy activating kinase 1 3.695
GABARAPL1 GABA(A) receptor-associated protein like 1 3.616
ATG12 autophagy related 12 3.6
GABARAPL2 GABA(A) receptor-associated protein-like 2 3.599
TFEB transcription factor EB 3.598
LAMP2 lysosomal-associated membrane protein 2 3.593
DNAH8 dynein, axonemal, heavy chain 8 3.588
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.586
IL1B interleukin 1, beta 3.565
TNF tumor necrosis factor 3.517
FBF1 Fas (TNFRSF6) binding factor 1 3.496
IL6 interleukin 6 3.493
CASP3 caspase 3, apoptosis-related cysteine peptidase 3.469
IFNG interferon, gamma 3.454
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 3.448
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.447
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 3.442
RAB5A RAB5A, member RAS oncogene family 3.438
MAP1S microtubule-associated protein 1S 3.435
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 3.433
GAPDH glyceraldehyde-3-phosphate dehydrogenase 3.415
BCL2 B-cell CLL/lymphoma 2 3.411
CD8A CD8a molecule 3.405
CD4 CD4 molecule 3.4
CTSL cathepsin L 3.395
TP53 tumor protein p53 3.387
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 3.38
PINK1 PTEN induced putative kinase 1 3.371
ATG3 autophagy related 3 3.364
MAP1B microtubule-associated protein 1B 3.354
INS insulin 3.337
EEA1 early endosome antigen 1 3.321
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 3.31
NPC1 Niemann-Pick disease, type C1 3.302
ATG14 autophagy related 14 3.29
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.288
ATG13 autophagy related 13 3.282
EGFR epidermal growth factor receptor 3.28
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 3.279
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 3.278
TGFB1 transforming growth factor, beta 1 3.277
TLR4 toll-like receptor 4 3.262
CASP1 caspase 1, apoptosis-related cysteine peptidase 3.261
RB1CC1 RB1-inducible coiled-coil 1 3.259
PXDNL peroxidasin-like 3.251
IL10 interleukin 10 3.245
GABARAP GABA(A) receptor-associated protein 3.224
APP amyloid beta (A4) precursor protein 3.223
ANXA5 annexin A5 3.195
GBA1 glucosylceramidase beta 1 3.195
RAB11A RAB11A, member RAS oncogene family 3.186
TFRC transferrin receptor 3.183
PRKN parkin RBR E3 ubiquitin protein ligase 3.183
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 3.169
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 3.169
CD300C CD300c molecule 3.155
CD63 CD63 molecule 3.153
IL18 interleukin 18 3.152
HSPA4 heat shock 70kDa protein 4 3.148
CYCS cytochrome c, somatic 3.138
NBR1 neighbor of BRCA1 gene 1 3.136
EGF epidermal growth factor 3.134
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.124
CALCOCO2 calcium binding and coiled-coil domain 2 3.116
CD68 CD68 molecule 3.116
APOE apolipoprotein E 3.113
NPC2 Niemann-Pick disease, type C2 3.106
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.105
HSPA8 heat shock 70kDa protein 8 3.105
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 3.101
OGA O-GlcNAcase 3.098
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 3.097
BAX BCL2-associated X protein 3.096
MCOLN1 mucolipin 1 3.094
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3.09
CCL2 chemokine (C-C motif) ligand 2 3.088
TLR2 toll-like receptor 2 3.084
TLR9 toll-like receptor 9 3.083
IL1A interleukin 1, alpha 3.072
UVRAG UV radiation resistance associated 3.07
ERBB2 erb-b2 receptor tyrosine kinase 2 3.068
CXCL8 chemokine (C-X-C motif) ligand 8 3.058
ATG10 autophagy related 10 3.054
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 3.046
WIPI1 WD repeat domain, phosphoinositide interacting 1 3.045
RHEB Ras homolog enriched in brain 3.043
ATG4B autophagy related 4B, cysteine peptidase 3.043
GLB1 galactosidase, beta 1 3.042
IL4 interleukin 4 3.034
SCARB2 scavenger receptor class B, member 2 3.033
SIRT1 sirtuin 1 3.032
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 3.031
IL2 interleukin 2 3.031
RPTOR regulatory associated protein of MTOR, complex 1 3.027
OPTN optineurin 3.025
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 3.024
PTEN phosphatase and tensin homolog 3.016
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 3.009
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.006
CD44 CD44 molecule (Indian blood group) 3.001
IGF2R insulin-like growth factor 2 receptor 2.997
CASP8 caspase 8, apoptosis-related cysteine peptidase 2.996
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.996
TLR7 toll-like receptor 7 2.988
ATG101 autophagy related 101 2.986
MYD88 myeloid differentiation primary response 88 2.986
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.984
MAPK3 mitogen-activated protein kinase 3 2.984
CD274 CD274 molecule 2.981
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.977
IFNB1 interferon, beta 1, fibroblast 2.975
STX17 syntaxin 17 2.973
PTPRC protein tyrosine phosphatase, receptor type, C 2.964
SCARB1 scavenger receptor class B, member 1 2.963
IDUA iduronidase, alpha-L- 2.958
MGAM maltase-glucoamylase 2.957
JUN jun proto-oncogene 2.956
TLR3 toll-like receptor 3 2.956
CTSK cathepsin K 2.953
IGF1 insulin-like growth factor 1 (somatomedin C) 2.944
MMP9 matrix metallopeptidase 9 2.944
BCL2L1 BCL2-like 1 2.943
AMBRA1 autophagy/beclin-1 regulator 1 2.935
TSC2 tuberous sclerosis 2 2.932
SCGB1D1 secretoglobin, family 1D, member 1 2.929
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.924
IFNA1 interferon, alpha 1 2.924
ACE2 angiotensin I converting enzyme 2 2.924
CD86 CD86 molecule 2.92
FOXO3 forkhead box O3 2.92
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.916
FN1 fibronectin 1 2.915
LRRK2 leucine-rich repeat kinase 2 2.912
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.91
WIPI2 WD repeat domain, phosphoinositide interacting 2 2.908
TARDBP TAR DNA binding protein 2.907
TBK1 TANK-binding kinase 1 2.903
CANX calnexin 2.903
GUSB glucuronidase, beta 2.9
PPARG peroxisome proliferator-activated receptor gamma 2.896
RAB7A RAB7A, member RAS oncogene family 2.894
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.891
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.887
MPO myeloperoxidase 2.882
ATP13A2 ATPase type 13A2 2.88
MFN2 mitofusin 2 2.877
PARP1 poly (ADP-ribose) polymerase 1 2.875
GSK3B glycogen synthase kinase 3 beta 2.872
TFE3 transcription factor binding to IGHM enhancer 3 2.869
TSG101 tumor susceptibility 101 2.867
HMOX1 heme oxygenase 1 2.866
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.864
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.864
DNM1L dynamin 1-like 2.859
CD36 CD36 molecule (thrombospondin receptor) 2.856
PPT1 palmitoyl-protein thioesterase 1 2.855
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 2.853
FUNDC1 FUN14 domain containing 1 2.85
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.848
PPA1 pyrophosphatase (inorganic) 1 2.847
PCSK9 proprotein convertase subtilisin/kexin type 9 2.846
RRAGC Ras-related GTP binding C 2.843
ICAM1 intercellular adhesion molecule 1 2.841
AIF1 allograft inflammatory factor 1 2.838
CD80 CD80 molecule 2.838
RIGI RNA sensor RIG-I 2.838
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.837
CTSC cathepsin C 2.833
NFE2L2 nuclear factor, erythroid 2-like 2 2.832
IRF3 interferon regulatory factor 3 2.831
MAPT microtubule-associated protein tau 2.828
SOD1 superoxide dismutase 1, soluble 2.825
BACE1 beta-site APP-cleaving enzyme 1 2.824
CD34 CD34 molecule 2.823
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.819
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.818
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.817
CAV1 caveolin 1, caveolae protein, 22kDa 2.817
RAB27A RAB27A, member RAS oncogene family 2.815
KEAP1 kelch-like ECH-associated protein 1 2.815
CALR calreticulin 2.814
CTSA cathepsin A 2.813
VAMP8 vesicle-associated membrane protein 8 2.813
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.811
ERVW-1 endogenous retrovirus group W, member 1 2.811
RUBCN rubicon autophagy regulator 2.81
GSDMD gasdermin D 2.808
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.807
STAT1 signal transducer and activator of transcription 1, 91kDa 2.807
LGMN legumain 2.804
FOXO1 forkhead box O1 2.801
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.799
ULK2 unc-51 like autophagy activating kinase 2 2.798
HMGB1 high mobility group box 1 2.798
CLN3 ceroid-lipofuscinosis, neuronal 3 2.798
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.798
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.795
NCOA4 nuclear receptor coactivator 4 2.793
CD40 CD40 molecule, TNF receptor superfamily member 5 2.788
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B 2.787
CCL5 chemokine (C-C motif) ligand 5 2.784
VCP valosin containing protein 2.781
RAB4A RAB4A, member RAS oncogene family 2.781
CXCR4 chemokine (C-X-C motif) receptor 4 2.779
ESR1 estrogen receptor 1 2.779
CD9 CD9 molecule 2.778
CTSG cathepsin G 2.777
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.777
ATG9A autophagy related 9A 2.775
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.773
CYBB cytochrome b-245, beta polypeptide 2.77
RRAGA Ras-related GTP binding A 2.769
ELANE elastase, neutrophil expressed 2.763
CDKN2A cyclin-dependent kinase inhibitor 2A 2.763
VDAC1 voltage-dependent anion channel 1 2.762
FASLG Fas ligand (TNF superfamily, member 6) 2.758
VAMP7 vesicle-associated membrane protein 7 2.756
TREM2 triggering receptor expressed on myeloid cells 2 2.756
FURIN furin (paired basic amino acid cleaving enzyme) 2.756
CALML3 calmodulin-like 3 2.754
TPCN2 two pore segment channel 2 2.753
MYH14 myosin, heavy chain 14, non-muscle 2.753
CALML5 calmodulin-like 5 2.752
SLCO6A1 solute carrier organic anion transporter family, member 6A1 2.752
CD81 CD81 molecule 2.751
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.751
CALML4 calmodulin-like 4 2.75
CALML6 calmodulin-like 6 2.749
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.748
IL13 interleukin 13 2.747
GPX4 glutathione peroxidase 4 2.746
CGAS cyclic GMP-AMP synthase 2.742
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.741
SORT1 sortilin 1 2.741
STK11 serine/threonine kinase 11 2.74
BDNF brain-derived neurotrophic factor 2.739
CCND1 cyclin D1 2.737
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.735
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.735
LTF lactotransferrin 2.735
GPX3 glutathione peroxidase 3 2.735
MRC1 mannose receptor, C type 1 2.734
SNAP29 synaptosomal-associated protein, 29kDa 2.734
CSF1 colony stimulating factor 1 (macrophage) 2.734
AIM2 absent in melanoma 2 2.734
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.733
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 2.733
PECAM1 platelet/endothelial cell adhesion molecule 1 2.732
GPX2 glutathione peroxidase 2 2.731
PSEN1 presenilin 1 2.727
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.725
CCL3 chemokine (C-C motif) ligand 3 2.725
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.725
PARK7 parkinson protein 7 2.724
FBXO32 F-box protein 32 2.721
HDAC6 histone deacetylase 6 2.72
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.719
ERV3-1 endogenous retrovirus group 3, member 1 2.719
GPX7 glutathione peroxidase 7 2.719
GPX8 glutathione peroxidase 8 (putative) 2.716
IRGM immunity-related GTPase family, M 2.715
NOD2 nucleotide-binding oligomerization domain containing 2 2.714
GPX5 glutathione peroxidase 5 2.714
CDC42 cell division cycle 42 2.713
GPX6 glutathione peroxidase 6 2.713
BECN2 beclin 2 2.711
ATF6 activating transcription factor 6 2.706
TYRP1 tyrosinase-related protein 1 2.702
TMPRSS2 transmembrane protease, serine 2 2.701
CLCN7 chloride channel, voltage-sensitive 7 2.7
LRP2 low density lipoprotein receptor-related protein 2 2.699
GFAP glial fibrillary acidic protein 2.699
ERN1 endoplasmic reticulum to nucleus signaling 1 2.699
PPARA peroxisome proliferator-activated receptor alpha 2.699
ZFYVE1 zinc finger, FYVE domain containing 1 2.698
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.696
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.695
TLR8 toll-like receptor 8 2.694
INSR insulin receptor 2.692
MT1E metallothionein 1E 2.692
ARSA arylsulfatase A 2.687
XBP1 X-box binding protein 1 2.686
MFN1 mitofusin 1 2.686
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.686
MMP2 matrix metallopeptidase 2 2.685
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.682
MAPK8 mitogen-activated protein kinase 8 2.681
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 2.68
RAB8A RAB8A, member RAS oncogene family 2.678
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.677
CTRL chymotrypsin-like 2.675
FOXP3 forkhead box P3 2.674
CD19 CD19 molecule 2.672
MYB v-myb avian myeloblastosis viral oncogene homolog 2.672
CTNS cystinosin, lysosomal cystine transporter 2.671
GALNS galactosamine (N-acetyl)-6-sulfatase 2.669
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.669
SLC38A9 solute carrier family 38, member 9 2.668
RAB10 RAB10, member RAS oncogene family 2.668
GALC galactosylceramidase 2.667
RABIF RAB interacting factor 2.666
AGFG1 ArfGAP with FG repeats 1 2.664
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.664
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 2.663
MCL1 myeloid cell leukemia 1 2.662
DNTT DNA nucleotidylexotransferase 2.662
NLRC4 NLR family, CARD domain containing 4 2.662
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.662
FTH1 ferritin, heavy polypeptide 1 2.661
ARF1 ADP-ribosylation factor 1 2.658
IDS iduronate 2-sulfatase 2.658
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.658
RHOA ras homolog family member A 2.657
ATG4A autophagy related 4A, cysteine peptidase 2.657
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.655
GRN granulin 2.654
ARF6 ADP-ribosylation factor 6 2.651
SGSH N-sulfoglucosamine sulfohydrolase 2.65
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.648
RRAGB Ras-related GTP binding B 2.647
TGOLN2 trans-golgi network protein 2 2.645
RIPK3 receptor-interacting serine-threonine kinase 3 2.643
MLKL mixed lineage kinase domain-like 2.641
CTSZ cathepsin Z 2.639
SNX1 sorting nexin 1 2.637
CXCL12 chemokine (C-X-C motif) ligand 12 2.635
UGCG UDP-glucose ceramide glucosyltransferase 2.634
SREBF1 sterol regulatory element binding transcription factor 1 2.633
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.632
CTSH cathepsin H 2.631
CREB1 cAMP responsive element binding protein 1 2.63
NAGLU N-acetylglucosaminidase, alpha 2.626
RRAGD Ras-related GTP binding D 2.626
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.626
IGF1R insulin-like growth factor 1 receptor 2.625
MAVS mitochondrial antiviral signaling protein 2.624
ATM ATM serine/threonine kinase 2.623
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.621
CD163 CD163 molecule 2.621
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.621
ACE angiotensin I converting enzyme 2.62
THY1 Thy-1 cell surface antigen 2.62
DRAM1 DNA-damage regulated autophagy modulator 1 2.618
LEP leptin 2.616
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.615
APOB apolipoprotein B 2.613
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.611
CSF3 colony stimulating factor 3 (granulocyte) 2.611
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.608
C1D C1D nuclear receptor corepressor 2.607
IRF7 interferon regulatory factor 7 2.607
GCG glucagon 2.607
CLEC7A C-type lectin domain family 7, member A 2.606
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.606
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.605
GOLGA2 golgin A2 2.605
PKM pyruvate kinase, muscle 2.602
ATG4D autophagy related 4D, cysteine peptidase 2.602
CDPF1 cysteine-rich, DPF motif domain containing 1 2.599
JAK2 Janus kinase 2 2.599
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.599
PRTN3 proteinase 3 2.597
NGF nerve growth factor (beta polypeptide) 2.596
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.596
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.596
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 2.596
CD28 CD28 molecule 2.595
CD209 CD209 molecule 2.595
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.593
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2.593
SYK spleen tyrosine kinase 2.591
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.59
RAB1A RAB1A, member RAS oncogene family 2.59
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.589
BCL2L11 BCL2-like 11 (apoptosis facilitator) 2.588
CCL4 chemokine (C-C motif) ligand 4 2.587
VTI1B vesicle transport through interaction with t-SNAREs 1B 2.586
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.585
UBA1 ubiquitin-like modifier activating enzyme 1 2.582
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.582
VCAM1 vascular cell adhesion molecule 1 2.581
IFIH1 interferon induced with helicase C domain 1 2.579
SPI1 Spi-1 proto-oncogene 2.578
BIRC5 baculoviral IAP repeat containing 5 2.577
CCR2 chemokine (C-C motif) receptor 2 2.577
RAB35 RAB35, member RAS oncogene family 2.575
CSF1R colony stimulating factor 1 receptor 2.572
ATG4C autophagy related 4C, cysteine peptidase 2.572
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.57
LGALS4 lectin, galactoside-binding, soluble, 4 2.57
C3 complement component 3 2.569
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.568
TLR1 toll-like receptor 1 2.566
CD47 CD47 molecule 2.565
TPCN1 two pore segment channel 1 2.564
NCAM1 neural cell adhesion molecule 1 2.562
LCN2 lipocalin 2 2.56
SESN2 sestrin 2 2.56
ZUP1 zinc finger containing ubiquitin peptidase 1 2.559
BAG3 BCL2-associated athanogene 3 2.558
MITF microphthalmia-associated transcription factor 2.558
CLTC clathrin, heavy chain (Hc) 2.558
B2M beta-2-microglobulin 2.557
SREBF2 sterol regulatory element binding transcription factor 2 2.555
HDAC9 histone deacetylase 9 2.554
RICTOR RPTOR independent companion of MTOR, complex 2 2.553
PDCD1 programmed cell death 1 2.549
KDR kinase insert domain receptor 2.549
IFI30 interferon, gamma-inducible protein 30 2.548
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 2.548
TMEM106B transmembrane protein 106B 2.547
HAMP hepcidin antimicrobial peptide 2.546
CD1D CD1d molecule 2.546
LYST lysosomal trafficking regulator 2.543
PLEK pleckstrin 2.543
IDO1 indoleamine 2,3-dioxygenase 1 2.543
ANKRD44 ankyrin repeat domain 44 2.54
GSR glutathione reductase 2.539
NT5E 5'-nucleotidase, ecto (CD73) 2.534
VMP1 vacuole membrane protein 1 2.533
M6PR mannose-6-phosphate receptor (cation dependent) 2.533
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.533
PLEK2 pleckstrin 2 2.533
IGF2 insulin-like growth factor 2 2.532
ACP5 acid phosphatase 5, tartrate resistant 2.531
CDK4 cyclin-dependent kinase 4 2.531
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.53
CKM creatine kinase, muscle 2.53
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.53
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.529
IRS1 insulin receptor substrate 1 2.529
SIRT3 sirtuin 3 2.529
FLCN folliculin 2.527
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.527
PNPLA2 patatin-like phospholipase domain containing 2 2.527
TJP1 tight junction protein 1 2.526
IL5 interleukin 5 2.524
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.523
LGALS8 lectin, galactoside-binding, soluble, 8 2.523
H3-4 H3.4 histone, cluster member 2.523
CKB creatine kinase, brain 2.522
H3-5 H3.5 histone 2.522
H3-7 H3.7 histone (putative) 2.522
IL15 interleukin 15 2.521
PLIN2 perilipin 2 2.521
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.52
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 2.52
CHIT1 chitinase 1 (chitotriosidase) 2.519
GAA glucosidase, alpha; acid 2.519
TLR5 toll-like receptor 5 2.519
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 2.518
HSPB3 heat shock 27kDa protein 3 2.515
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.514
ARRB1 arrestin, beta 1 2.513
CKMT1B creatine kinase, mitochondrial 1B 2.512
USP8 ubiquitin specific peptidase 8 2.512
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.511
LAPTM4B lysosomal protein transmembrane 4 beta 2.511
ATG2A autophagy related 2A 2.511
MAN2B1 mannosidase, alpha, class 2B, member 1 2.51
CD40LG CD40 ligand 2.51
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 2.51
MAPK1 mitogen-activated protein kinase 1 2.509
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.507
CHMP2B charged multivesicular body protein 2B 2.506
DNM2 dynamin 2 2.505
CLN5 ceroid-lipofuscinosis, neuronal 5 2.503
NLRP1 NLR family, pyrin domain containing 1 2.503
ENG endoglin 2.503
NOD1 nucleotide-binding oligomerization domain containing 1 2.503
CTRB1 chymotrypsinogen B1 2.502
CST3 cystatin C 2.502
APAF1 apoptotic peptidase activating factor 1 2.501
RETREG1 reticulophagy regulator 1 2.501
SOD2 superoxide dismutase 2, mitochondrial 2.5
CLTCL1 clathrin, heavy chain-like 1 2.5
ARRB2 arrestin, beta 2 2.5
CD38 CD38 molecule 2.498
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.498
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.497
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.496
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.496
FGF7 fibroblast growth factor 7 2.495
FADD Fas (TNFRSF6)-associated via death domain 2.494
TFAM transcription factor A, mitochondrial 2.494
CTRB2 chymotrypsinogen B2 2.494
SPHK1 sphingosine kinase 1 2.494
CLU clusterin 2.494
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.492
FOS FBJ murine osteosarcoma viral oncogene homolog 2.492
MCOLN3 mucolipin 3 2.491
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.49
PCNA proliferating cell nuclear antigen 2.489
ADIPOQ adiponectin, C1Q and collagen domain containing 2.488
DDIT3 DNA-damage-inducible transcript 3 2.487
PYCARD PYD and CARD domain containing 2.485
HPGDS hematopoietic prostaglandin D synthase 2.483
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.483
LOX lysyl oxidase 2.482
APOA1 apolipoprotein A-I 2.481
ISG15 ISG15 ubiquitin-like modifier 2.481
SOX2 SRY (sex determining region Y)-box 2 2.479
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.479
IL1R1 interleukin 1 receptor, type I 2.479
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2.478
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 2.477
FUS FUS RNA binding protein 2.477
DPP4 dipeptidyl-peptidase 4 2.477
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.476
ERLN endoregulin 2.476
ATF4 activating transcription factor 4 2.475
CTSF cathepsin F 2.474
NQO1 NAD(P)H dehydrogenase, quinone 1 2.473
RPS6 ribosomal protein S6 2.471
SNAP23 synaptosomal-associated protein, 23kDa 2.469
RAB32 RAB32, member RAS oncogene family 2.469
PGK1 phosphoglycerate kinase 1 2.468
POTEF POTE ankyrin domain family, member F 2.468
TXNIP thioredoxin interacting protein 2.467
EFNA5 ephrin-A5 2.467
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 2.467
HSPB1 heat shock 27kDa protein 1 2.466
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 2.465
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.465
AKT1S1 AKT1 substrate 1 (proline-rich) 2.465
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.464
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 2.463
DEPTOR DEP domain containing MTOR-interacting protein 2.463
CD33 CD33 molecule 2.462
ESX1 ESX homeobox 1 2.462
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.462
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 2.461
MAP2K1 mitogen-activated protein kinase kinase 1 2.46
VWF von Willebrand factor 2.459
OSBP oxysterol binding protein 2.459
ARL8B ADP-ribosylation factor-like 8B 2.458
AXL AXL receptor tyrosine kinase 2.457
FGF10 fibroblast growth factor 10 2.455
RUNX2 runt-related transcription factor 2 2.455
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.454
IL3 interleukin 3 2.454
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.453
ANXA2 annexin A2 2.452
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.451
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.451
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 2.451
CD276 CD276 molecule 2.451
JAK1 Janus kinase 1 2.448
CCR7 chemokine (C-C motif) receptor 7 2.447
PI3 peptidase inhibitor 3, skin-derived 2.446
FGF4 fibroblast growth factor 4 2.446
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.445
TYR tyrosinase 2.443
FGF8 fibroblast growth factor 8 (androgen-induced) 2.443
EIF4E eukaryotic translation initiation factor 4E 2.44
PLG plasminogen 2.44
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.439
WDR45 WD repeat domain 45 2.439
FGF9 fibroblast growth factor 9 2.439
FGF18 fibroblast growth factor 18 2.438
IFITM3 interferon induced transmembrane protein 3 2.438
RAB29 RAB29, member RAS oncogene family 2.436
SMAD2 SMAD family member 2 2.436
FGF5 fibroblast growth factor 5 2.436
VAMP3 vesicle-associated membrane protein 3 2.436
UBQLN2 ubiquilin 2 2.435
BRCA1 breast cancer 1, early onset 2.435
NOTCH1 notch 1 2.434
ADAM10 ADAM metallopeptidase domain 10 2.433
EPS15 epidermal growth factor receptor pathway substrate 15 2.433
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.432
FGF20 fibroblast growth factor 20 2.431
FGF17 fibroblast growth factor 17 2.429
SNAI1 snail family zinc finger 1 2.429
CXCL9 chemokine (C-X-C motif) ligand 9 2.429
TMEM175 transmembrane protein 175 2.429
FGF16 fibroblast growth factor 16 2.428
MFF mitochondrial fission factor 2.428
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.428
CDK2 cyclin-dependent kinase 2 2.427
MAN2C1 mannosidase, alpha, class 2C, member 1 2.427
IL33 interleukin 33 2.426
FGF6 fibroblast growth factor 6 2.426
TCHP trichoplein, keratin filament binding 2.426
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.425
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.425
FGF3 fibroblast growth factor 3 2.424
SDC1 syndecan 1 2.424
SYP synaptophysin 2.423
BST2 bone marrow stromal cell antigen 2 2.423
DHFR dihydrofolate reductase 2.423
SYT7 synaptotagmin VII 2.422
TH tyrosine hydroxylase 2.422
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.422
FGF22 fibroblast growth factor 22 2.422
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.422
POMC proopiomelanocortin 2.422
CUL3 cullin 3 2.422
GM2A GM2 ganglioside activator 2.422
UNC93B1 unc-93 homolog B1 (C. elegans) 2.421
FASN fatty acid synthase 2.42
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.42
ANPEP alanyl (membrane) aminopeptidase 2.417
TLR6 toll-like receptor 6 2.417
RAB27B RAB27B, member RAS oncogene family 2.415
CD69 CD69 molecule 2.415
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.414
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.414
MUC1 mucin 1, cell surface associated 2.414
FUCA1 fucosidase, alpha-L- 1, tissue 2.414
TYROBP TYRO protein tyrosine kinase binding protein 2.414
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 2.412
CDK1 cyclin-dependent kinase 1 2.41
NSF N-ethylmaleimide-sensitive factor 2.408
GBA2 glucosidase, beta (bile acid) 2 2.407
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.407
IRF1 interferon regulatory factor 1 2.407
TIMP1 TIMP metallopeptidase inhibitor 1 2.406
RAB6A RAB6A, member RAS oncogene family 2.406
PSEN2 presenilin 2 2.405
RAB2A RAB2A, member RAS oncogene family 2.405
CD1C CD1c molecule 2.405
ATG2B autophagy related 2B 2.405
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.404
MMP3 matrix metallopeptidase 3 2.402
BIN1 bridging integrator 1 2.401
STX7 syntaxin 7 2.401
PROM1 prominin 1 2.401
FOLR2 folate receptor 2 (fetal) 2.4
SELL selectin L 2.4
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 2.399
GJA1 gap junction protein, alpha 1, 43kDa 2.399
FTL ferritin, light polypeptide 2.396
IL22 interleukin 22 2.396
PARL presenilin associated, rhomboid-like 2.395
PLIN1 perilipin 1 2.395
ADAM17 ADAM metallopeptidase domain 17 2.393
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.393
TRAF3 TNF receptor-associated factor 3 2.392
ATP7A ATPase, Cu++ transporting, alpha polypeptide 2.391
DAPK1 death-associated protein kinase 1 2.391
MCOLN2 mucolipin 2 2.39
LAP3 leucine aminopeptidase 3 2.389
AGER advanced glycosylation end product-specific receptor 2.388
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 2.387
WDFY3 WD repeat and FYVE domain containing 3 2.387
CFLAR CASP8 and FADD-like apoptosis regulator 2.387
ATG9B autophagy related 9B 2.387
IDE insulin-degrading enzyme 2.387
POU5F1 POU class 5 homeobox 1 2.386
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.385
ASGR1 asialoglycoprotein receptor 1 2.384
PTK2 protein tyrosine kinase 2 2.384
XPR1 xenotropic and polytropic retrovirus receptor 1 2.383
SMAD3 SMAD family member 3 2.382
ACSL4 acyl-CoA synthetase long-chain family member 4 2.382
STX6 syntaxin 6 2.381
IRAK1 interleukin-1 receptor-associated kinase 1 2.381
BSG basigin (Ok blood group) 2.38
EPAS1 endothelial PAS domain protein 1 2.38
MERTK MER proto-oncogene, tyrosine kinase 2.38
CTSE cathepsin E 2.379
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.379
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.379
ERBB3 erb-b2 receptor tyrosine kinase 3 2.378
GRB2 growth factor receptor-bound protein 2 2.377
OCLN occludin 2.376
TBC1D15 TBC1 domain family, member 15 2.375
LDHA lactate dehydrogenase A 2.375
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.372
DICER1 dicer 1, ribonuclease type III 2.372
FYN FYN proto-oncogene, Src family tyrosine kinase 2.372
IL7 interleukin 7 2.372
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.371
FIG4 FIG4 phosphoinositide 5-phosphatase 2.369
TRIM21 tripartite motif containing 21 2.368
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.368
LMNB1 lamin B1 2.367
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 2.367
DDIT4 DNA-damage-inducible transcript 4 2.366
HAVCR2 hepatitis A virus cellular receptor 2 2.366
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2.366
EPCAM epithelial cell adhesion molecule 2.365
EDN1 endothelin 1 2.364
ADRB2 adrenoceptor beta 2, surface 2.364
CDK5 cyclin-dependent kinase 5 2.364
CHUK conserved helix-loop-helix ubiquitous kinase 2.364
CCNL2 cyclin L2 2.364
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.363
NOX4 NADPH oxidase 4 2.362
HSPA1B heat shock 70kDa protein 1B 2.362
DIABLO diablo, IAP-binding mitochondrial protein 2.362
KNG1 kininogen 1 2.362
KLF4 Kruppel-like factor 4 (gut) 2.36
PMEL premelanosome protein 2.36
ARL5B ADP-ribosylation factor-like 5B 2.36
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.36
HLA-DMA major histocompatibility complex, class II, DM alpha 2.359
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.359
HSPB8 heat shock 22kDa protein 8 2.358
ANXA1 annexin A1 2.358
CHMP2A charged multivesicular body protein 2A 2.357
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 2.357
SELE selectin E 2.356
HSPB2 heat shock 27kDa protein 2 2.355
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.355
ARG2 arginase 2 2.354
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.354
LPL lipoprotein lipase 2.354
CAPN1 calpain 1, (mu/I) large subunit 2.353
PRKCA protein kinase C, alpha 2.352
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.351
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 2.351
DNM1 dynamin 1 2.349
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.347
ADCY10 adenylate cyclase 10 (soluble) 2.347
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.347
STAT5A signal transducer and activator of transcription 5A 2.345
PPIG peptidylprolyl isomerase G (cyclophilin G) 2.344
TRAT1 T cell receptor associated transmembrane adaptor 1 2.344
NANOG Nanog homeobox 2.343
ACO1 aconitase 1, soluble 2.343
BAG1 BCL2-associated athanogene 2.343
MAPK14 mitogen-activated protein kinase 14 2.342
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 2.342
CXCR2 chemokine (C-X-C motif) receptor 2 2.341
CIDEB cell death-inducing DFFA-like effector b 2.341
STAT5B signal transducer and activator of transcription 5B 2.34
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 2.34
FOLR3 folate receptor 3 (gamma) 2.339
VAC14 Vac14 homolog (S. cerevisiae) 2.338
SDCBP syndecan binding protein (syntenin) 2.338
SOCS3 suppressor of cytokine signaling 3 2.338
SIRPA signal-regulatory protein alpha 2.336
SKP1 S-phase kinase-associated protein 1 2.336
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.335
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.335
LCK LCK proto-oncogene, Src family tyrosine kinase 2.335
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.334
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.334
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.333
FLOT1 flotillin 1 2.332
SHH sonic hedgehog 2.332
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.332
SMAD4 SMAD family member 4 2.331
LAG3 lymphocyte-activation gene 3 2.33
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.33
MMP14 matrix metallopeptidase 14 (membrane-inserted) 2.329
BCR breakpoint cluster region 2.329
TBL1X transducin (beta)-like 1X-linked 2.328
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.327
CXCL2 chemokine (C-X-C motif) ligand 2 2.327
MSTN myostatin 2.326
LAMP3 lysosomal-associated membrane protein 3 2.326
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.325
IZUMO1R IZUMO1 receptor, JUNO 2.324
SUMF1 sulfatase modifying factor 1 2.324
BGLAP bone gamma-carboxyglutamate (gla) protein 2.324
GNLY granulysin 2.324
GBP1 guanylate binding protein 1, interferon-inducible 2.322
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.321
CMA1 chymase 1, mast cell 2.321
LMLN leishmanolysin-like (metallopeptidase M8 family) 2.319
SIRT2 sirtuin 2 2.319
CCNB1 cyclin B1 2.319
A2M alpha-2-macroglobulin 2.319
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 2.318
HRAS Harvey rat sarcoma viral oncogene homolog 2.317
LOC102724560 cystathionine beta-synthase 2.317
APOL1 apolipoprotein L, 1 2.316
SPHK2 sphingosine kinase 2 2.316
COL1A1 collagen, type I, alpha 1 2.316
PDCD6IP programmed cell death 6 interacting protein 2.316
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 2.315
GOLGB1 golgin B1 2.314
WAS Wiskott-Aldrich syndrome 2.314
PGR progesterone receptor 2.313
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.313
ALK anaplastic lymphoma receptor tyrosine kinase 2.313
TFEC transcription factor EC 2.313
CDH5 cadherin 5, type 2 (vascular endothelium) 2.312
HAVCR1 hepatitis A virus cellular receptor 1 2.311
HDAC1 histone deacetylase 1 2.311
CD83 CD83 molecule 2.31
MMUT methylmalonyl-CoA mutase 2.31
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.309
CD1B CD1b molecule 2.309
F3 coagulation factor III (thromboplastin, tissue factor) 2.308
STEAP3 STEAP family member 3, metalloreductase 2.307
STX4 syntaxin 4 2.307
CXCR3 chemokine (C-X-C motif) receptor 3 2.306
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 2.305
PLAU plasminogen activator, urokinase 2.305
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.305
SGK1 serum/glucocorticoid regulated kinase 1 2.305
IREB2 iron-responsive element binding protein 2 2.304
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.304
FLT3 fms-related tyrosine kinase 3 2.304
E2F1 E2F transcription factor 1 2.303
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.302
LY75-CD302 LY75-CD302 readthrough 2.301
EP300 E1A binding protein p300 2.301
MMEL1 membrane metallo-endopeptidase-like 1 2.3
HSPA9 heat shock 70kDa protein 9 (mortalin) 2.3
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 2.299
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.299
MMP13 matrix metallopeptidase 13 2.299
BTK Bruton agammaglobulinemia tyrosine kinase 2.299
IDO2 indoleamine 2,3-dioxygenase 2 2.299
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.299
CD24 CD24 molecule 2.298
NRP1 neuropilin 1 2.298
H2BC21 H2B clustered histone 21 2.298
ATXN3 ataxin 3 2.297
LAPTM5 lysosomal protein transmembrane 5 2.296
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.296
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.295
CAPN2 calpain 2, (m/II) large subunit 2.295
AGO2 argonaute RISC catalytic component 2 2.294
LYN LYN proto-oncogene, Src family tyrosine kinase 2.293
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.292
NCR1 natural cytotoxicity triggering receptor 1 2.291
FGF13 fibroblast growth factor 13 2.291
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.29
SOX9 SRY (sex determining region Y)-box 9 2.29
SNX27 sorting nexin family member 27 2.29
THBS1 thrombospondin 1 2.29
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.289
XDH xanthine dehydrogenase 2.289
FKBP1A FK506 binding protein 1A, 12kDa 2.288
TGFA transforming growth factor, alpha 2.288
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.288
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.287
STIM1 stromal interaction molecule 1 2.287
PICALM phosphatidylinositol binding clathrin assembly protein 2.286
CCN2 cellular communication network factor 2 2.285
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.284
MX1 MX dynamin-like GTPase 1 2.284
SYNJ1 synaptojanin 1 2.284
PLA2G15 phospholipase A2, group XV 2.283
ACHE acetylcholinesterase (Yt blood group) 2.283
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.282
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.282
TMEM192 transmembrane protein 192 2.282
ACAN aggrecan 2.281
CA9 carbonic anhydrase IX 2.281
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.28
CD82 CD82 molecule 2.28
AXIN1 axin 1 2.28
HLA-A major histocompatibility complex, class I, A 2.279
MFSD8 major facilitator superfamily domain containing 8 2.277
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.275
NES nestin 2.275
DNASE2 deoxyribonuclease II, lysosomal 2.275
BANF1 barrier to autointegration factor 1 2.274
CD22 CD22 molecule 2.274
VCL vinculin 2.274
TOLLIP toll interacting protein 2.273
NLRX1 NLR family member X1 2.272
KITLG KIT ligand 2.271
IFNA2 interferon, alpha 2 2.271
TMEM119 transmembrane protein 119 2.271
CCL20 chemokine (C-C motif) ligand 20 2.27
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.27
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.269
GSDMA gasdermin A 2.267
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.267
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.267
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.267
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.266
GLUL glutamate-ammonia ligase 2.266
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 2.265
LIPE lipase, hormone-sensitive 2.265
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 2.263
UNC13D unc-13 homolog D (C. elegans) 2.263
OSTM1 osteopetrosis associated transmembrane protein 1 2.262
TG thyroglobulin 2.262
LY96 lymphocyte antigen 96 2.262
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 2.262
MCU mitochondrial calcium uniporter 2.261
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.261
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2.261
CTTN cortactin 2.26
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.26
SNX2 sorting nexin 2 2.26
TERT telomerase reverse transcriptase 2.26
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.259
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.259
FABP4 fatty acid binding protein 4, adipocyte 2.257
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.257
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.257
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.257
PANX1 pannexin 1 2.256
CUL1 cullin 1 2.256
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 2.256
MEFV Mediterranean fever 2.255
SNX3 sorting nexin 3 2.255
SNAPIN SNAP-associated protein 2.255
PHB2 prohibitin 2 2.254
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.253
PCSK1 proprotein convertase subtilisin/kexin type 1 2.252
PDCD1LG2 programmed cell death 1 ligand 2 2.252
ENO2 enolase 2 (gamma, neuronal) 2.252
EGR1 early growth response 1 2.252
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.252
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.252
SOCS1 suppressor of cytokine signaling 1 2.252
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.251
UBE3A ubiquitin protein ligase E3A 2.251
UBE2S ubiquitin-conjugating enzyme E2S 2.25
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 2.25
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.249
CP ceruloplasmin (ferroxidase) 2.249
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.248
ATF3 activating transcription factor 3 2.246
FGF21 fibroblast growth factor 21 2.246
STAT2 signal transducer and activator of transcription 2, 113kDa 2.246
PLIN3 perilipin 3 2.244
RAB38 RAB38, member RAS oncogene family 2.244
NCF1 neutrophil cytosolic factor 1 2.242
CA2 carbonic anhydrase II 2.241
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 2.24
RAB7B RAB7B, member RAS oncogene family 2.24
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.239
DPP7 dipeptidyl-peptidase 7 2.239
CLCN3 chloride channel, voltage-sensitive 3 2.238
FUCA2 fucosidase, alpha-L- 2, plasma 2.237
NEU4 sialidase 4 2.236
EZR ezrin 2.235
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.235
PF4 platelet factor 4 2.234
NAGA N-acetylgalactosaminidase, alpha- 2.234
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.233
DCTN1 dynactin 1 2.232
UBQLN1 ubiquilin 1 2.232
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.232
SNX5 sorting nexin 5 2.231
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.231
ACTA1 actin, alpha 1, skeletal muscle 2.231
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.231
CXCL11 chemokine (C-X-C motif) ligand 11 2.231
HCLS1 hematopoietic cell-specific Lyn substrate 1 2.23
STX5 syntaxin 5 2.23
CCNA2 cyclin A2 2.229
FLT1 fms-related tyrosine kinase 1 2.229
PGAM5 phosphoglycerate mutase family member 5 2.229
IRF8 interferon regulatory factor 8 2.229
MAOB monoamine oxidase B 2.228
SEC13 SEC13 homolog (S. cerevisiae) 2.228
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.227
PLAT plasminogen activator, tissue 2.227
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.226
PLK1 polo-like kinase 1 2.225
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.225
SLC30A10 solute carrier family 30, member 10 2.224
TMC6 transmembrane channel-like 6 2.221
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 2.22
RAB14 RAB14, member RAS oncogene family 2.22
GBP2 guanylate binding protein 2, interferon-inducible 2.22
MSR1 macrophage scavenger receptor 1 2.219
ACLY ATP citrate lyase 2.219
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.218
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 2.217
SH2D3A SH2 domain containing 3A 2.217
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.217
CLCN5 chloride channel, voltage-sensitive 5 2.216
VTN vitronectin 2.215
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.215
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.215
ZEB1 zinc finger E-box binding homeobox 1 2.214
TRIM16 tripartite motif containing 16 2.214
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.214
CDK6 cyclin-dependent kinase 6 2.214
CST7 cystatin F (leukocystatin) 2.213
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.212
YAP1 Yes-associated protein 1 2.212
H2AX H2A.X variant histone 2.212
CCPG1 cell cycle progression 1 2.211
TBC1D7 TBC1 domain family, member 7 2.21
CHEK1 checkpoint kinase 1 2.209
SEC62 SEC62 homolog (S. cerevisiae) 2.209
SLC66A1 solute carrier family 66 member 1 2.209
LMNA lamin A/C 2.208
XPO1 exportin 1 2.207
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.207
EPHA2 EPH receptor A2 2.206
SPG11 spastic paraplegia 11 (autosomal recessive) 2.206
NEK7 NIMA-related kinase 7 2.206
STAMBP STAM binding protein 2.205
RAB22A RAB22A, member RAS oncogene family 2.205