| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Valdecoxib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Valdecoxib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.342183 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.176703 |
| APOB | apolipoprotein B | 0.146839 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0962621 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0646557 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0572083 |
| MT2A | metallothionein 2A | 0.0552625 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0540232 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0468121 |
| DSPP | dentin sialophosphoprotein | 0.0433102 |
| RPS6 | ribosomal protein S6 | 0.0429832 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0420478 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0355946 |
| AFDN | afadin, adherens junction formation factor | 0.0327541 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0324748 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0321823 |
| ENO1 | enolase 1, (alpha) | 0.0299618 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0294423 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0293112 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286084 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0285007 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0284452 |
| GOLGA4 | golgin A4 | 0.0284305 |
| JMJD1C | jumonji domain containing 1C | 0.0283959 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0283457 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0280707 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0278118 |
| KIF5B | kinesin family member 5B | 0.0277706 |
| PCBP2 | poly(rC) binding protein 2 | 0.0270605 |
| RBM25 | RNA binding motif protein 25 | 0.026279 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0261457 |
| TF | transferrin | 0.0261228 |
| GPC3 | glypican 3 | 0.0260014 |
| MATR3 | matrin 3 | 0.0258514 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0255787 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0253251 |
| FN1 | fibronectin 1 | 0.0250267 |
| LDHA | lactate dehydrogenase A | 0.0244554 |
| APOA2 | apolipoprotein A-II | 0.0243201 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0242614 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0234805 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0232458 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0232166 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0227533 |
| FTL | ferritin, light polypeptide | 0.0226097 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0225704 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0224239 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0223231 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0222927 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0221432 |
| TRIM26 | tripartite motif containing 26 | 0.021976 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0216589 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.021447 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0205864 |
| RPL11 | ribosomal protein L11 | 0.0204746 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0203892 |
| MALT1 | MALT1 paracaspase | 0.0200519 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0199422 |
| PCM1 | pericentriolar material 1 | 0.0197771 |
| YBX1 | Y box binding protein 1 | 0.0197766 |
| CPE | carboxypeptidase E | 0.0194288 |
| FOXO1 | forkhead box O1 | 0.0193909 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0190628 |
| RPS12 | ribosomal protein S12 | 0.0188133 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0183727 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0182077 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0181094 |
| C3 | complement component 3 | 0.017902 |
| TOP1 | topoisomerase (DNA) I | 0.0177622 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0177231 |
| INSIG2 | insulin induced gene 2 | 0.0175962 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0175867 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0173796 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0171915 |
| B2M | beta-2-microglobulin | 0.0171636 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0171245 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0170604 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0169238 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.016897 |
| SET | SET nuclear proto-oncogene | 0.0167155 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0166206 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0164878 |
| CFB | complement factor B | 0.0164588 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0163547 |
| RPL31 | ribosomal protein L31 | 0.016306 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0162738 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0162124 |
| FAT1 | FAT atypical cadherin 1 | 0.0161199 |
| A2M | alpha-2-macroglobulin | 0.0160634 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0160447 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0159942 |
| VMP1 | vacuole membrane protein 1 | 0.0159927 |
| RTN4 | reticulon 4 | 0.0152477 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0151738 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0150867 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0150552 |
| RPLP1 | ribosomal protein, large, P1 | 0.01499 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0149453 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.014908 |
| NCKAP1 | NCK-associated protein 1 | 0.0148301 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.752869 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.136195 |
| GPC6 | glypican 6 | -0.0730869 |
| EHBP1 | EH domain binding protein 1 | -0.0526966 |
| ASPH | aspartate beta-hydroxylase | -0.0481749 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0441867 |
| ATXN1 | ataxin 1 | -0.0417456 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0407814 |
| FRMD5 | FERM domain containing 5 | -0.0364199 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0354899 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0341383 |
| INTS6 | integrator complex subunit 6 | -0.033282 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0324395 |
| RNF213 | ring finger protein 213 | -0.0294597 |
| CP | ceruloplasmin (ferroxidase) | -0.0276189 |
| GK | glycerol kinase | -0.026978 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0269646 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0269634 |
| RIGI | RNA sensor RIG-I | -0.0261295 |
| NDRG1 | N-myc downstream regulated 1 | -0.0231529 |
| ATP10A | ATPase, class V, type 10A | -0.0223433 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0221461 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.021932 |
| HPCAL1 | hippocalcin-like 1 | -0.0216206 |
| FMNL2 | formin-like 2 | -0.0213529 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0210322 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0205184 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0204648 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0198556 |
| DTNA | dystrobrevin, alpha | -0.0198322 |
| GNAS | GNAS complex locus | -0.0195776 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0194753 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0193498 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0192755 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0184171 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0179925 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0178108 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0176798 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0176373 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0174679 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0169381 |
| PEG3 | paternally expressed 3 | -0.0168801 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0163183 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0162652 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.016265 |
| PRKCA | protein kinase C, alpha | -0.0159176 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0158038 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0157768 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0157609 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0157056 |
| PARD3 | par-3 family cell polarity regulator | -0.0153309 |
| HDAC4 | histone deacetylase 4 | -0.0152791 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.015273 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0150309 |
| TMSB10 | thymosin beta 10 | -0.0150118 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0148815 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0144904 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0142506 |
| MSI2 | musashi RNA-binding protein 2 | -0.0142066 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0140198 |
| RAD51B | RAD51 paralog B | -0.0136269 |
| SP100 | SP100 nuclear antigen | -0.0133765 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0131386 |
| NABP1 | nucleic acid binding protein 1 | -0.0130022 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0127077 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0125622 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0125217 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0125143 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0123684 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0123141 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0122948 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0121795 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0120885 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0120574 |
| PLSCR1 | phospholipid scramblase 1 | -0.0120444 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0119476 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0117671 |
| PLXDC2 | plexin domain containing 2 | -0.0115558 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0115489 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0114774 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0114736 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0114352 |
| STK17A | serine/threonine kinase 17a | -0.0113857 |
| FAM107B | family with sequence similarity 107, member B | -0.0113392 |
| KLF6 | Kruppel-like factor 6 | -0.0113364 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0113265 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0109719 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0109581 |
| FLNB | filamin B, beta | -0.0108837 |
| SEPTIN9 | septin 9 | -0.0108596 |
| RPS24 | ribosomal protein S24 | -0.0108328 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0107907 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0106746 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0106473 |
| CTSB | cathepsin B | -0.0106143 |
| SPATA13 | spermatogenesis associated 13 | -0.0105948 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0104787 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0102991 |
| DISC1 | disrupted in schizophrenia 1 | -0.0101785 |
| ANKRD10 | ankyrin repeat domain 10 | -0.00992683 |
