Valdecoxib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Valdecoxib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Valdecoxib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA6 integrin, alpha 6 0.14293
MUC6 mucin 6, oligomeric mucus/gel-forming 0.114501
TXNIP thioredoxin interacting protein 0.0988048
LMO7 LIM domain 7 0.0963157
PABPC1 poly(A) binding protein, cytoplasmic 1 0.096139
RNF145 ring finger protein 145 0.0958869
MYO1E myosin IE 0.0770637
FAT1 FAT atypical cadherin 1 0.0763641
AREG amphiregulin 0.0699644
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0656973
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0624229
WAC WW domain containing adaptor with coiled-coil 0.0588086
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0551076
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0525695
SLC38A2 solute carrier family 38, member 2 0.049739
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0488417
EPS8 epidermal growth factor receptor pathway substrate 8 0.0482097
ITPRID2 ITPR interacting domain containing 2 0.047052
VEGFA vascular endothelial growth factor A 0.0469884
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0468571
SETD5 SET domain containing 5 0.0456557
DSPP dentin sialophosphoprotein 0.0448966
LOC102724023 ES1 protein homolog, mitochondrial 0.0426223
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0415312
MED13L mediator complex subunit 13-like 0.0412443
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0408295
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.039186
PPARG peroxisome proliferator-activated receptor gamma 0.0388131
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0381794
BIRC6 baculoviral IAP repeat containing 6 0.0381092
ABHD2 abhydrolase domain containing 2 0.0380167
RCOR1 REST corepressor 1 0.0377799
UBA6 ubiquitin-like modifier activating enzyme 6 0.0372263
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0368949
PTEN phosphatase and tensin homolog 0.0367246
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0362876
ERRFI1 ERBB receptor feedback inhibitor 1 0.0355438
KMT2E lysine (K)-specific methyltransferase 2E 0.0355102
PDIA6 protein disulfide isomerase family A, member 6 0.0350921
MACF1 microtubule-actin crosslinking factor 1 0.0350867
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0349989
GPBP1 GC-rich promoter binding protein 1 0.0341611
VMP1 vacuole membrane protein 1 0.0340566
MLEC malectin 0.0340052
MBNL1 muscleblind-like splicing regulator 1 0.0329656
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0327378
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.032084
CALB1 calbindin 1, 28kDa 0.0318383
POTEF POTE ankyrin domain family, member F 0.0316726
PICALM phosphatidylinositol binding clathrin assembly protein 0.0306882
NCOR1 nuclear receptor corepressor 1 0.0304532
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0300999
RAB6A RAB6A, member RAS oncogene family 0.0298042
CLOCK clock circadian regulator 0.0298003
TC2N tandem C2 domains, nuclear 0.0297177
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0297157
SEC31A SEC31 homolog A (S. cerevisiae) 0.0297055
EIF1 eukaryotic translation initiation factor 1 0.0291868
ESYT2 extended synaptotagmin-like protein 2 0.029153
SLMAP sarcolemma associated protein 0.0290868
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0290775
LAMA4 laminin, alpha 4 0.0286513
PKM pyruvate kinase, muscle 0.0286375
PTPRK protein tyrosine phosphatase, receptor type, K 0.0285136
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0284783
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0284184
ZFC3H1 zinc finger, C3H1-type containing 0.028396
MED13 mediator complex subunit 13 0.0281435
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0277067
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0275843
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.027271
CCNY cyclin Y 0.027255
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0269553
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.026749
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0265861
TMF1 TATA element modulatory factor 1 0.0264525
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0261144
KTN1 kinectin 1 (kinesin receptor) 0.026114
AKAP9 A kinase (PRKA) anchor protein 9 0.0260505
CSDE1 cold shock domain containing E1, RNA-binding 0.0260417
RAP1B RAP1B, member of RAS oncogene family 0.0259992
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0259612
SEC23A Sec23 homolog A (S. cerevisiae) 0.025887
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0258842
SUCO SUN domain containing ossification factor 0.0258743
UBE2H ubiquitin-conjugating enzyme E2H 0.025683
GREB1L growth regulation by estrogen in breast cancer-like 0.0254923
GOLGA4 golgin A4 0.0251594
FRYL FRY-like 0.0251117
FNBP1L formin binding protein 1-like 0.0247532
ALCAM activated leukocyte cell adhesion molecule 0.024741
GLS2 glutaminase 2 (liver, mitochondrial) 0.0246632
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0245848
EREG epiregulin 0.0243849
HELZ helicase with zinc finger 0.0243741
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0243372
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0242768
YTHDC1 YTH domain containing 1 0.0241195
CCNL1 cyclin L1 0.0240966
SNX9 sorting nexin 9 0.0236775

decreased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding -0.11645
TNS4 tensin 4 -0.0932187
TPT1 tumor protein, translationally-controlled 1 -0.08714
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0857034
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0768671
ACTN4 actinin, alpha 4 -0.0670393
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0665231
FHIT fragile histidine triad -0.0608826
RNF43 ring finger protein 43 -0.0596872
RPLP1 ribosomal protein, large, P1 -0.0571228
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0569233
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0540763
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0486767
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0462143
GMDS GDP-mannose 4,6-dehydratase -0.0456246
RPS8 ribosomal protein S8 -0.0453678
KLF5 Kruppel-like factor 5 (intestinal) -0.0448758
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0446208
RPL9 ribosomal protein L9 -0.0435762
NPSR1 neuropeptide S receptor 1 -0.0431078
RPL26 ribosomal protein L26 -0.0428355
H1-0 H1.0 linker histone -0.042524
RRBP1 ribosome binding protein 1 -0.0419217
AHNAK AHNAK nucleoprotein -0.0418668
RPL35A ribosomal protein L35a -0.0413927
RPL34 ribosomal protein L34 -0.0410141
ONECUT3 one cut homeobox 3 -0.04051
RAD51B RAD51 paralog B -0.0396086
RPS19 ribosomal protein S19 -0.0394603
RPS24 ribosomal protein S24 -0.0394142
HMGB1 high mobility group box 1 -0.039273
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0392079
RPL13A ribosomal protein L13a -0.0383609
LOC112694756 uncharaterized LOC112694756 -0.0380811
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0371198
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0364527
SMYD3 SET and MYND domain containing 3 -0.0363331
NEBL nebulette -0.0362028
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0360893
RPL23 ribosomal protein L23 -0.0352804
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.034951
CD44 CD44 molecule (Indian blood group) -0.0347932
NDRG1 N-myc downstream regulated 1 -0.0345196
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0334935
PRELID2 PRELI domain containing 2 -0.0331029
ATXN1 ataxin 1 -0.0326897
ACTG1 actin gamma 1 -0.031622
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0297231
RPS12 ribosomal protein S12 -0.029539
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.029163
TFRC transferrin receptor -0.0285255
PCDHB16 protocadherin beta 16 -0.028086
MYH9 myosin, heavy chain 9, non-muscle -0.0280373
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0277708
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0276993
ZNF292 zinc finger protein 292 -0.0274176
TXNRD1 thioredoxin reductase 1 -0.0271681
PLEC plectin -0.026355
RPS20 ribosomal protein S20 -0.0258973
RPS4X ribosomal protein S4, X-linked -0.0253036
ARF1 ADP-ribosylation factor 1 -0.0251589
SHB Src homology 2 domain containing adaptor protein B -0.0250755
RPL30 ribosomal protein L30 -0.0250337
RPL5 ribosomal protein L5 -0.0248969
ARL15 ADP-ribosylation factor-like 15 -0.0247917
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0247846
RPL38 ribosomal protein L38 -0.0246512
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0243571
TUBB4B tubulin, beta 4B class IVb -0.0243382
FTH1 ferritin, heavy polypeptide 1 -0.0241816
FAF1 Fas (TNFRSF6) associated factor 1 -0.02383
BTBD9 BTB (POZ) domain containing 9 -0.0238165
RPS6 ribosomal protein S6 -0.023698
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0236109
RPL37A ribosomal protein L37a -0.0235597
RPS3 ribosomal protein S3 -0.0235396
SERINC5 serine incorporator 5 -0.0234292
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0233711
CCND1 cyclin D1 -0.0226682
KDM4B lysine (K)-specific demethylase 4B -0.0226413
RPL12 ribosomal protein L12 -0.0225777
PTPRR protein tyrosine phosphatase, receptor type, R -0.0225161
PDIA4 protein disulfide isomerase family A, member 4 -0.0224449
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0224215
ITGB4 integrin, beta 4 -0.0223823
ANKRD10 ankyrin repeat domain 10 -0.0219908
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0218592
FOSL1 FOS-like antigen 1 -0.0216709
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0213887
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0213825
ZSWIM5 zinc finger, SWIM-type containing 5 -0.021322
OGA O-GlcNAcase -0.0213054
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0212617
CADPS Ca++-dependent secretion activator -0.0212471
SEC24D SEC24 family member D -0.0211086
FOXP1 forkhead box P1 -0.0211085
LDLR low density lipoprotein receptor -0.0209675
PTMA prothymosin, alpha -0.020818
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0207139
SH3RF1 SH3 domain containing ring finger 1 -0.0205576