Valdecoxib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Valdecoxib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Valdecoxib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.148772
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.129577
AKAP12 A kinase (PRKA) anchor protein 12 0.109703
GOLGA4 golgin A4 0.0956632
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0709373
LOX lysyl oxidase 0.0648829
KMT2C lysine (K)-specific methyltransferase 2C 0.0636018
ATP13A3 ATPase type 13A3 0.0626747
PSD3 pleckstrin and Sec7 domain containing 3 0.0593073
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0559337
LMAN1 lectin, mannose-binding, 1 0.0552108
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0550151
KDM3A lysine (K)-specific demethylase 3A 0.0537373
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.053411
FAM20C family with sequence similarity 20, member C 0.052227
DSCAM Down syndrome cell adhesion molecule 0.0516269
SRP54 signal recognition particle 54kDa 0.050991
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0485638
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0474828
FAM13A family with sequence similarity 13, member A 0.0458983
BZW1 basic leucine zipper and W2 domains 1 0.0425806
PDGFA platelet-derived growth factor alpha polypeptide 0.0417261
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0401294
ARHGAP5 Rho GTPase activating protein 5 0.0396103
ZFC3H1 zinc finger, C3H1-type containing 0.0391238
DLG1 discs, large homolog 1 (Drosophila) 0.0388326
ITCH itchy E3 ubiquitin protein ligase 0.0383105
SPAG9 sperm associated antigen 9 0.0380955
NGLY1 N-glycanase 1 0.0373152
CD109 CD109 molecule 0.036402
YME1L1 YME1-like 1 ATPase 0.0359065
STRN3 striatin, calmodulin binding protein 3 0.0349968
MON2 MON2 homolog (S. cerevisiae) 0.0349764
SEC31A SEC31 homolog A (S. cerevisiae) 0.0339926
OGA O-GlcNAcase 0.0338393
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0337685
RICTOR RPTOR independent companion of MTOR, complex 2 0.0335268
KPNB1 karyopherin (importin) beta 1 0.0327358
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0325151
RIOK3 RIO kinase 3 0.0318107
AKAP9 A kinase (PRKA) anchor protein 9 0.0317236
ENO1 enolase 1, (alpha) 0.0311816
UBA6 ubiquitin-like modifier activating enzyme 6 0.0311122
SBF2 SET binding factor 2 0.0305083
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0304987
RAB8B RAB8B, member RAS oncogene family 0.029865
NF1 neurofibromin 1 0.0297405
CANX calnexin 0.0291432
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.029081
ZCCHC7 zinc finger, CCHC domain containing 7 0.0284532
RBM39 RNA binding motif protein 39 0.0284061
MARCHF6 membrane associated ring-CH-type finger 6 0.0283423
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0281957
ESYT2 extended synaptotagmin-like protein 2 0.0281622
MORF4L2 mortality factor 4 like 2 0.0277348
TTC3 tetratricopeptide repeat domain 3 0.0275544
ZEB2 zinc finger E-box binding homeobox 2 0.0275509
RAB1A RAB1A, member RAS oncogene family 0.0274301
MRPS6 mitochondrial ribosomal protein S6 0.027283
TM9SF3 transmembrane 9 superfamily member 3 0.027038
COG5 component of oligomeric golgi complex 5 0.0269983
EIF1 eukaryotic translation initiation factor 1 0.0269478
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0267128
PRELID2 PRELI domain containing 2 0.0266025
SEPTIN2 septin 2 0.0256857
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0256451
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0253942
LIMCH1 LIM and calponin homology domains 1 0.0252927
CERT1 ceramide transporter 1 0.0251268
COPA coatomer protein complex, subunit alpha 0.0248998
CEP350 centrosomal protein 350kDa 0.0248939
NBAS neuroblastoma amplified sequence 0.0243184
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.024278
ELP2 elongator acetyltransferase complex subunit 2 0.0242578
THOC2 THO complex 2 0.0241242
CSNK1A1 casein kinase 1, alpha 1 0.0240968
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0240355
FOXO3 forkhead box O3 0.0240195
FNDC3B fibronectin type III domain containing 3B 0.0237853
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0234416
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0233151
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0232062
BIRC6 baculoviral IAP repeat containing 6 0.0231446
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0230919
NPC1 Niemann-Pick disease, type C1 0.0230907
SUCO SUN domain containing ossification factor 0.0228186
INSIG2 insulin induced gene 2 0.0227573
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0225144
ABI1 abl-interactor 1 0.0223533
SERINC1 serine incorporator 1 0.022324
ANKRD17 ankyrin repeat domain 17 0.0223062
PDLIM5 PDZ and LIM domain 5 0.0222158
RAI1 retinoic acid induced 1 0.0222009
PLIN2 perilipin 2 0.0221799
YTHDC1 YTH domain containing 1 0.02216
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0221321
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0221239
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0220635
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0218186
WIPF2 WAS/WASL interacting protein family, member 2 0.0217834

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.125325
NRG1 neuregulin 1 -0.111559
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0981628
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0897443
DPYD dihydropyrimidine dehydrogenase -0.078667
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0701232
ANTXR2 anthrax toxin receptor 2 -0.0631542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0599079
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0555892
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0533997
EFNA5 ephrin-A5 -0.0526688
MTSS1 metastasis suppressor 1 -0.049512
VIM vimentin -0.0482175
ECE1 endothelin converting enzyme 1 -0.0470559
GLCCI1 glucocorticoid induced 1 -0.0465021
TMSB10 thymosin beta 10 -0.0463215
MT2A metallothionein 2A -0.0440265
RPL36 ribosomal protein L36 -0.043372
RPLP1 ribosomal protein, large, P1 -0.0431749
NRP1 neuropilin 1 -0.0421468
SMAD3 SMAD family member 3 -0.0418211
RPS6 ribosomal protein S6 -0.0416203
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0413025
ETV6 ets variant 6 -0.0402433
SEPTIN9 septin 9 -0.040181
CD44 CD44 molecule (Indian blood group) -0.0392999
CDH13 cadherin 13 -0.0388079
FTL ferritin, light polypeptide -0.0387814
BCAS3 breast carcinoma amplified sequence 3 -0.0376449
RPS21 ribosomal protein S21 -0.0370354
FTH1 ferritin, heavy polypeptide 1 -0.0364272
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0362255
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0358773
LRMDA leucine rich melanocyte differentiation associated -0.0357637
FRMD4A FERM domain containing 4A -0.0356951
IFI44L interferon-induced protein 44-like -0.034619
RPS19 ribosomal protein S19 -0.0346122
GPC6 glypican 6 -0.0344888
DST dystonin -0.0334861
ANKRD28 ankyrin repeat domain 28 -0.0330925
RPS12 ribosomal protein S12 -0.0323896
RPL28 ribosomal protein L28 -0.0318949
NDRG1 N-myc downstream regulated 1 -0.0314139
CLMP CXADR-like membrane protein -0.0314035
TFPI2 tissue factor pathway inhibitor 2 -0.0313507
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0312231
ELL2 elongation factor, RNA polymerase II, 2 -0.0306984
TBL1X transducin (beta)-like 1X-linked -0.0306602
KYNU kynureninase -0.0304808
RPL37A ribosomal protein L37a -0.029924
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0298483
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0298163
KTN1 kinectin 1 (kinesin receptor) -0.029667
RPS2 ribosomal protein S2 -0.029619
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0295648
PTK2 protein tyrosine kinase 2 -0.0294118
TRPS1 trichorhinophalangeal syndrome I -0.0293587
VEGFA vascular endothelial growth factor A -0.0291712
MAML3 mastermind-like 3 (Drosophila) -0.0290947
TGM2 transglutaminase 2 -0.0285656
MCL1 myeloid cell leukemia 1 -0.0284254
ATG7 autophagy related 7 -0.0281842
RNF213 ring finger protein 213 -0.0279792
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.02787
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0277227
PRRX1 paired related homeobox 1 -0.0276797
MECOM MDS1 and EVI1 complex locus -0.0275727
COL7A1 collagen, type VII, alpha 1 -0.0273161
BMERB1 bMERB domain containing 1 -0.0269613
RPS8 ribosomal protein S8 -0.0264626
VRK2 vaccinia related kinase 2 -0.0263946
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.026134
SKIL SKI-like proto-oncogene -0.0260774
AKAP13 A kinase (PRKA) anchor protein 13 -0.0258527
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0258118
HMGA1 high mobility group AT-hook 1 -0.0257669
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0256918
RPS13 ribosomal protein S13 -0.025634
LRRC8C leucine rich repeat containing 8 family, member C -0.0254477
ANTXR1 anthrax toxin receptor 1 -0.0248223
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.024819
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0245547
RPS16 ribosomal protein S16 -0.0244631
KIAA1217 KIAA1217 -0.0241549
DIAPH2 diaphanous-related formin 2 -0.0240431
PKM pyruvate kinase, muscle -0.0239145
ALCAM activated leukocyte cell adhesion molecule -0.0238628
RPLP2 ribosomal protein, large, P2 -0.0236564
RPL35A ribosomal protein L35a -0.0234893
RPL5 ribosomal protein L5 -0.0233903
WWC2 WW and C2 domain containing 2 -0.0232397
RPL23 ribosomal protein L23 -0.0231136
RPL38 ribosomal protein L38 -0.0230955
TPT1 tumor protein, translationally-controlled 1 -0.023051
TMEM165 transmembrane protein 165 -0.0229893
MYO10 myosin X -0.0229328
PRR16 proline rich 16 -0.0228495
SDK1 sidekick cell adhesion molecule 1 -0.0228062
CUX1 cut-like homeobox 1 -0.0227608
ATF7 activating transcription factor 7 -0.0225082