Valdecoxib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Valdecoxib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Valdecoxib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0738827
TXNRD1 thioredoxin reductase 1 0.0683456
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0680942
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0628598
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0608823
ERRFI1 ERBB receptor feedback inhibitor 1 0.0604149
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0541386
TPM3 tropomyosin 3 0.0534414
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0525017
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0462898
BIRC3 baculoviral IAP repeat containing 3 0.0452265
WDR43 WD repeat domain 43 0.0408878
ERBIN erbb2 interacting protein 0.039825
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0391635
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0372217
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0358694
VIM vimentin 0.0358405
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0347826
RBM39 RNA binding motif protein 39 0.0347017
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0333265
ECT2 epithelial cell transforming 2 0.0332266
AKAP12 A kinase (PRKA) anchor protein 12 0.0332183
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.033197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0328686
RASAL2 RAS protein activator like 2 0.0326503
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0316506
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0310406
RTN4 reticulon 4 0.0308861
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0302966
SLC38A2 solute carrier family 38, member 2 0.0298214
UBASH3B ubiquitin associated and SH3 domain containing B 0.0295072
TPD52 tumor protein D52 0.0287531
PAWR PRKC, apoptosis, WT1, regulator 0.0287393
KIF5B kinesin family member 5B 0.0284478
CHN1 chimerin 1 0.0282845
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0273687
TRIO trio Rho guanine nucleotide exchange factor 0.0271826
ACACA acetyl-CoA carboxylase alpha 0.0266429
CANX calnexin 0.0252008
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.025125
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.02504
FNBP1L formin binding protein 1-like 0.0250342
APP amyloid beta (A4) precursor protein 0.0249117
COPA coatomer protein complex, subunit alpha 0.0246899
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0246147
RAD21 RAD21 homolog (S. pombe) 0.0244079
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0243677
YME1L1 YME1-like 1 ATPase 0.0239475
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0239068
CYRIB CYFIP related Rac1 interactor B 0.0236818
COG5 component of oligomeric golgi complex 5 0.0234729
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0234088
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0227859
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0227713
ASPH aspartate beta-hydroxylase 0.022627
NTN4 netrin 4 0.022311
MARCHF6 membrane associated ring-CH-type finger 6 0.0221428
HSPA8 heat shock 70kDa protein 8 0.021538
KPNB1 karyopherin (importin) beta 1 0.0213551
RAB18 RAB18, member RAS oncogene family 0.0212591
RAB10 RAB10, member RAS oncogene family 0.0211708
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0211218
PFDN2 prefoldin subunit 2 0.0209596
FGB fibrinogen beta chain 0.0208853
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.020877
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0208035
RNF145 ring finger protein 145 0.0206378
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0205579
PRRC1 proline-rich coiled-coil 1 0.0203863
CLTC clathrin, heavy chain (Hc) 0.0202602
MAPK8 mitogen-activated protein kinase 8 0.0202441
MEMO1 mediator of cell motility 1 0.0201843
TOP1 topoisomerase (DNA) I 0.0200453
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0199357
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0199274
EIF1 eukaryotic translation initiation factor 1 0.0199237
PDIA6 protein disulfide isomerase family A, member 6 0.0196019
ARHGAP29 Rho GTPase activating protein 29 0.0195449
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0194968
CSNK1A1 casein kinase 1, alpha 1 0.0194671
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0192627
VMP1 vacuole membrane protein 1 0.0191388
SPAG9 sperm associated antigen 9 0.0191104
ANLN anillin, actin binding protein 0.0190842
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0189907
SEC23A Sec23 homolog A (S. cerevisiae) 0.0189511
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.018837
NCOR1 nuclear receptor corepressor 1 0.0188346
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0187095
ENAH enabled homolog (Drosophila) 0.0187071
ZFAND3 zinc finger, AN1-type domain 3 0.0185848
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0184756
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0183759
BZW1 basic leucine zipper and W2 domains 1 0.0182427
NCKAP1 NCK-associated protein 1 0.0182193
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.01803
ADAM17 ADAM metallopeptidase domain 17 0.0179416
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0178293
UBA6 ubiquitin-like modifier activating enzyme 6 0.0175183
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0175177

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.259071
PDE4D phosphodiesterase 4D, cAMP-specific -0.11311
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107905
GRAMD1B GRAM domain containing 1B -0.094368
FTL ferritin, light polypeptide -0.0914375
TMSB10 thymosin beta 10 -0.0912
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0800973
THSD4 thrombospondin, type I, domain containing 4 -0.0707216
FTH1 ferritin, heavy polypeptide 1 -0.0425753
DOCK4 dedicator of cytokinesis 4 -0.0422723
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0370766
RPL23 ribosomal protein L23 -0.0366692
RPLP1 ribosomal protein, large, P1 -0.0349313
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0348382
EGR1 early growth response 1 -0.0343977
WWOX WW domain containing oxidoreductase -0.0339925
RPS19 ribosomal protein S19 -0.0310934
PFN1 profilin 1 -0.0305709
IGF2 insulin-like growth factor 2 -0.0297238
RPL35A ribosomal protein L35a -0.0281466
RPL36 ribosomal protein L36 -0.026349
IER3 immediate early response 3 -0.02634
BASP1 brain abundant, membrane attached signal protein 1 -0.0261283
SMOC1 SPARC related modular calcium binding 1 -0.0257897
CMIP c-Maf inducing protein -0.0249244
ARHGAP26 Rho GTPase activating protein 26 -0.024103
RPS29 ribosomal protein S29 -0.02407
RPS21 ribosomal protein S21 -0.0235849
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0226557
IGFBP3 insulin-like growth factor binding protein 3 -0.022326
ACTG1 actin gamma 1 -0.0222109
RPL28 ribosomal protein L28 -0.0217005
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0213143
RPS16 ribosomal protein S16 -0.0210862
RPL19 ribosomal protein L19 -0.0203402
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0200301
RPL9 ribosomal protein L9 -0.019522
SAMD4A sterile alpha motif domain containing 4A -0.0193642
BICC1 BicC family RNA binding protein 1 -0.0190116
ATP5F1E ATP synthase F1 subunit epsilon -0.0186518
MAML3 mastermind-like 3 (Drosophila) -0.0186016
RAD51B RAD51 paralog B -0.018144
EFNA5 ephrin-A5 -0.0179129
RPLP2 ribosomal protein, large, P2 -0.0177927
RPS8 ribosomal protein S8 -0.0175568
RACK1 receptor for activated C kinase 1 -0.0173458
NNMT nicotinamide N-methyltransferase -0.0171936
FOXP1 forkhead box P1 -0.0171553
RAB7A RAB7A, member RAS oncogene family -0.0167841
RPS27 ribosomal protein S27 -0.0163945
FNDC3B fibronectin type III domain containing 3B -0.0163563
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0163098
ELL2 elongation factor, RNA polymerase II, 2 -0.0161458
CCL5 chemokine (C-C motif) ligand 5 -0.0156944
MCL1 myeloid cell leukemia 1 -0.015608
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0154982
LOC112694756 uncharaterized LOC112694756 -0.0154763
RPS5 ribosomal protein S5 -0.0149055
FLNA filamin A, alpha -0.0146285
RPS15 ribosomal protein S15 -0.0144133
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0143956
HMGB1 high mobility group box 1 -0.0143781
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0143427
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0142795
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0142401
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0138312
PDE10A phosphodiesterase 10A -0.0135093
RPS20 ribosomal protein S20 -0.013483
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0133851
TFPI2 tissue factor pathway inhibitor 2 -0.0132974
TPT1 tumor protein, translationally-controlled 1 -0.0131247
GRB10 growth factor receptor-bound protein 10 -0.0130677
RPS13 ribosomal protein S13 -0.0130255
INHBA inhibin, beta A -0.0129266
NDRG1 N-myc downstream regulated 1 -0.0128576
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0125277
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0124811
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0123504
ANGPTL4 angiopoietin-like 4 -0.0120315
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0120041
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0119686
FLNB filamin B, beta -0.0118888
RRM2 ribonucleotide reductase M2 -0.0118317
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0117912
PRKD1 protein kinase D1 -0.0117501
OSMR oncostatin M receptor -0.0117351
SOD2 superoxide dismutase 2, mitochondrial -0.0117184
RUNX1 runt-related transcription factor 1 -0.0117119
PRDX1 peroxiredoxin 1 -0.0117049
RPL30 ribosomal protein L30 -0.0115526
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0114794
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0114554
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0114231
SERF2 small EDRK-rich factor 2 -0.0114114
ZEB1 zinc finger E-box binding homeobox 1 -0.0113412
RPL36A ribosomal protein L36a -0.0112734
BRD2 bromodomain containing 2 -0.0111661
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.011149
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0111294
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0110979