Valdecoxib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Valdecoxib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Valdecoxib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.14395
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.112045
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0988614
FNDC3B fibronectin type III domain containing 3B 0.0918849
RNF145 ring finger protein 145 0.0810657
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0710833
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0651579
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0636404
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0624062
FXR1 fragile X mental retardation, autosomal homolog 1 0.0592811
GPBP1 GC-rich promoter binding protein 1 0.0568482
CCNL1 cyclin L1 0.055108
ADAM9 ADAM metallopeptidase domain 9 0.0521815
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0511707
PAPOLA poly(A) polymerase alpha 0.0497072
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0483124
KMT2E lysine (K)-specific methyltransferase 2E 0.0472012
YTHDC1 YTH domain containing 1 0.0460995
SLMAP sarcolemma associated protein 0.045779
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0455297
WAC WW domain containing adaptor with coiled-coil 0.045112
FAM13A family with sequence similarity 13, member A 0.0450882
GOLGA4 golgin A4 0.044537
KDM6A lysine (K)-specific demethylase 6A 0.0437563
ERBIN erbb2 interacting protein 0.0434218
MYO6 myosin VI 0.0428533
NUP58 nucleoporin 58 0.0415221
NAMPT nicotinamide phosphoribosyltransferase 0.0402242
MBNL1 muscleblind-like splicing regulator 1 0.0397492
GRB10 growth factor receptor-bound protein 10 0.0394667
TPM3 tropomyosin 3 0.0394546
CANX calnexin 0.039406
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0390334
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0384072
SPAG9 sperm associated antigen 9 0.0382137
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0379449
ZFAND3 zinc finger, AN1-type domain 3 0.0374341
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0367598
NCKAP1 NCK-associated protein 1 0.0343009
UBA6 ubiquitin-like modifier activating enzyme 6 0.0342876
ZNF292 zinc finger protein 292 0.0338569
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0338269
EPS8 epidermal growth factor receptor pathway substrate 8 0.0331165
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0329253
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0322497
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0322402
AKAP13 A kinase (PRKA) anchor protein 13 0.0321124
MEF2A myocyte enhancer factor 2A 0.0318074
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0315674
RAB1A RAB1A, member RAS oncogene family 0.0315616
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0314817
RBM39 RNA binding motif protein 39 0.0312718
FAM168A family with sequence similarity 168, member A 0.0310144
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0309203
PRRC2C proline-rich coiled-coil 2C 0.0309197
MYH9 myosin, heavy chain 9, non-muscle 0.0308623
APLP2 amyloid beta (A4) precursor-like protein 2 0.030818
TFG TRK-fused gene 0.0305841
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0301141
PDIA6 protein disulfide isomerase family A, member 6 0.0299403
RNASE3 ribonuclease, RNase A family, 3 0.0296208
SEC23A Sec23 homolog A (S. cerevisiae) 0.0296031
HDGF hepatoma-derived growth factor 0.0294451
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.029129
CUL3 cullin 3 0.029117
RICTOR RPTOR independent companion of MTOR, complex 2 0.029069
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0289608
SETD5 SET domain containing 5 0.0289197
PCBP2 poly(rC) binding protein 2 0.0287632
CERT1 ceramide transporter 1 0.0286144
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0285613
ZNF207 zinc finger protein 207 0.0284542
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0284055
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0282787
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0281519
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0280003
ATP13A3 ATPase type 13A3 0.0279915
TNPO1 transportin 1 0.0278271
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0277599
TMF1 TATA element modulatory factor 1 0.0277234
SIK3 SIK family kinase 3 0.0276899
CCNB1 cyclin B1 0.0273426
VEGFA vascular endothelial growth factor A 0.0273029
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0271201
GARS1 glycyl-tRNA synthetase 1 0.0269253
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0268203
MCU mitochondrial calcium uniporter 0.026774
DSTN destrin (actin depolymerizing factor) 0.0266117
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0264765
USP53 ubiquitin specific peptidase 53 0.0262371
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261936
TRA2A transformer 2 alpha homolog (Drosophila) 0.0259113
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0255809
ZC3H11A zinc finger CCCH-type containing 11A 0.0254183
EEF2 eukaryotic translation elongation factor 2 0.0253138
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0252558
RHEB Ras homolog enriched in brain 0.0251518
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0250429
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0249998
IRF6 interferon regulatory factor 6 0.0249118

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185517
TMSB10 thymosin beta 10 -0.132664
FN1 fibronectin 1 -0.128572
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.118047
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11578
LAMB3 laminin, beta 3 -0.111663
ACTG1 actin gamma 1 -0.093664
FTL ferritin, light polypeptide -0.0780809
NDRG1 N-myc downstream regulated 1 -0.0718926
LAMC2 laminin, gamma 2 -0.0674779
TPT1 tumor protein, translationally-controlled 1 -0.0643385
S100A6 S100 calcium binding protein A6 -0.0578715
HMGA1 high mobility group AT-hook 1 -0.0564568
S100A10 S100 calcium binding protein A10 -0.0509368
RPL34 ribosomal protein L34 -0.0490141
RPLP1 ribosomal protein, large, P1 -0.0486706
LOC112694756 uncharaterized LOC112694756 -0.0484412
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.047519
LMO7 LIM domain 7 -0.0471136
LPP LIM domain containing preferred translocation partner in lipoma -0.047022
LMNA lamin A/C -0.0447436
EFNA5 ephrin-A5 -0.0441895
MAP1B microtubule-associated protein 1B -0.0438564
CCND1 cyclin D1 -0.0434159
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0424511
IFI27 interferon, alpha-inducible protein 27 -0.0420839
NAV2 neuron navigator 2 -0.0417
AHNAK AHNAK nucleoprotein -0.0413797
KRT19 keratin 19, type I -0.0396081
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0393923
TM4SF1 transmembrane 4 L six family member 1 -0.0392143
RRBP1 ribosome binding protein 1 -0.0391271
RPL35A ribosomal protein L35a -0.0382533
ENO1 enolase 1, (alpha) -0.038226
BASP1 brain abundant, membrane attached signal protein 1 -0.0379636
TRIO trio Rho guanine nucleotide exchange factor -0.0379311
RPL12 ribosomal protein L12 -0.0377554
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0357835
MT2A metallothionein 2A -0.0357226
KRT7 keratin 7, type II -0.0355927
IFI6 interferon, alpha-inducible protein 6 -0.0347989
IFI16 interferon, gamma-inducible protein 16 -0.0347507
SAMD4A sterile alpha motif domain containing 4A -0.0345149
SDC4 syndecan 4 -0.0343318
ISG15 ISG15 ubiquitin-like modifier -0.0341514
ANXA2 annexin A2 -0.034097
CTSB cathepsin B -0.0339472
TMSB4X thymosin beta 4, X-linked -0.0312195
KLF6 Kruppel-like factor 6 -0.0308314
IFITM3 interferon induced transmembrane protein 3 -0.0306368
RPL30 ribosomal protein L30 -0.0302272
H1-0 H1.0 linker histone -0.03014
KRT18 keratin 18, type I -0.029205
DUSP6 dual specificity phosphatase 6 -0.0285056
IGFBP3 insulin-like growth factor binding protein 3 -0.0284554
RPS19 ribosomal protein S19 -0.0273958
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0273092
PLSCR1 phospholipid scramblase 1 -0.0270866
WSB1 WD repeat and SOCS box containing 1 -0.0267506
DSG2 desmoglein 2 -0.0263353
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0261044
ZBTB20 zinc finger and BTB domain containing 20 -0.0260295
FLNA filamin A, alpha -0.0259839
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0258743
GNAS GNAS complex locus -0.0248586
SOX4 SRY (sex determining region Y)-box 4 -0.0247892
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0247813
CAVIN1 caveolae associated protein 1 -0.0247453
TUBB4B tubulin, beta 4B class IVb -0.0245263
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0243369
RPL32 ribosomal protein L32 -0.0242339
GPX4 glutathione peroxidase 4 -0.0241007
FTH1 ferritin, heavy polypeptide 1 -0.0236307
IFITM1 interferon induced transmembrane protein 1 -0.0236004
LGALS1 lectin, galactoside-binding, soluble, 1 -0.023577
RUNX1 runt-related transcription factor 1 -0.0231863
HMGB1 high mobility group box 1 -0.0229406
RPL26 ribosomal protein L26 -0.0228186
PTPRF protein tyrosine phosphatase, receptor type, F -0.0226152
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0225895
MX2 MX dynamin-like GTPase 2 -0.0224784
PLEC plectin -0.0223595
RPL19 ribosomal protein L19 -0.0223435
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0218344
AHNAK2 AHNAK nucleoprotein 2 -0.0217606
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.021641
ARF1 ADP-ribosylation factor 1 -0.0215087
ALCAM activated leukocyte cell adhesion molecule -0.0212882
TUBB tubulin, beta class I -0.021215
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0210337
TPI1 triosephosphate isomerase 1 -0.0209063
RPS24 ribosomal protein S24 -0.0208602
RIGI RNA sensor RIG-I -0.0207657
MAML2 mastermind-like 2 (Drosophila) -0.0205211
SQSTM1 sequestosome 1 -0.0203794
S100A11 S100 calcium binding protein A11 -0.0202389
HLA-A major histocompatibility complex, class I, A -0.0202077
FER fer (fps/fes related) tyrosine kinase -0.0202017
LIMCH1 LIM and calponin homology domains 1 -0.0201322
SMAD3 SMAD family member 3 -0.0201318