Valdecoxib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Valdecoxib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Valdecoxib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.172289
ASPH aspartate beta-hydroxylase 0.130851
IGFBP3 insulin-like growth factor binding protein 3 0.110827
LIMCH1 LIM and calponin homology domains 1 0.102079
STC1 stanniocalcin 1 0.098219
CXCL8 chemokine (C-X-C motif) ligand 8 0.0927022
MCL1 myeloid cell leukemia 1 0.0905246
GRAMD1B GRAM domain containing 1B 0.0904228
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0807135
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0804354
CANX calnexin 0.0775866
PGK1 phosphoglycerate kinase 1 0.0748573
PYGL phosphorylase, glycogen, liver 0.0743508
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0665429
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0657185
NAMPT nicotinamide phosphoribosyltransferase 0.0634906
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0624845
ERRFI1 ERBB receptor feedback inhibitor 1 0.0617985
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0616275
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0602346
FNDC3B fibronectin type III domain containing 3B 0.0585166
COL4A6 collagen, type IV, alpha 6 0.056366
CTSL cathepsin L 0.0561092
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0554603
BZW1 basic leucine zipper and W2 domains 1 0.0522475
PDGFA platelet-derived growth factor alpha polypeptide 0.051621
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0508445
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0488823
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0480802
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0470307
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0469997
FLNB filamin B, beta 0.0465276
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0463981
TMX4 thioredoxin-related transmembrane protein 4 0.0456086
ESYT2 extended synaptotagmin-like protein 2 0.0446858
MYOF myoferlin 0.043738
PDIA3 protein disulfide isomerase family A, member 3 0.0436501
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.04361
APLP2 amyloid beta (A4) precursor-like protein 2 0.0431415
SAMD4A sterile alpha motif domain containing 4A 0.0429288
PDLIM5 PDZ and LIM domain 5 0.0426013
MFF mitochondrial fission factor 0.0418707
PSD3 pleckstrin and Sec7 domain containing 3 0.0417082
MAML3 mastermind-like 3 (Drosophila) 0.0403374
EFNA5 ephrin-A5 0.0401653
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0380814
NPAS2 neuronal PAS domain protein 2 0.0379908
FNDC3A fibronectin type III domain containing 3A 0.0365661
SDK1 sidekick cell adhesion molecule 1 0.0351023
DST dystonin 0.0349481
NEK7 NIMA-related kinase 7 0.0348206
TFPI2 tissue factor pathway inhibitor 2 0.034472
INTS6 integrator complex subunit 6 0.0344376
ITGA6 integrin, alpha 6 0.0335497
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0335004
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0333042
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0328313
PDIA6 protein disulfide isomerase family A, member 6 0.0323353
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0320388
RGS2 regulator of G-protein signaling 2 0.0316436
LDHA lactate dehydrogenase A 0.0313072
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0312908
KMT2E lysine (K)-specific methyltransferase 2E 0.0309908
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0307721
PTEN phosphatase and tensin homolog 0.0307049
PHF20 PHD finger protein 20 0.0300356
CSNK1A1 casein kinase 1, alpha 1 0.0298388
LAMB1 laminin, beta 1 0.0297273
USP9X ubiquitin specific peptidase 9, X-linked 0.0294565
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0289318
NRCAM neuronal cell adhesion molecule 0.0288367
AKAP13 A kinase (PRKA) anchor protein 13 0.0288354
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0287793
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0280588
BIRC6 baculoviral IAP repeat containing 6 0.0280426
LMAN1 lectin, mannose-binding, 1 0.0280356
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0279243
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0277048
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0275231
SBF2 SET binding factor 2 0.0272208
KTN1 kinectin 1 (kinesin receptor) 0.0271131
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0270983
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0270141
GIGYF2 GRB10 interacting GYF protein 2 0.0268148
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0264645
RAI1 retinoic acid induced 1 0.0263849
ITPRID2 ITPR interacting domain containing 2 0.0262698
ANXA1 annexin A1 0.0262507
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0261909
CARD16 caspase recruitment domain family, member 16 0.0261155
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261101
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0260725
WDFY2 WD repeat and FYVE domain containing 2 0.0260194
CXXC1 CXXC finger protein 1 0.0260026
ZNF638 zinc finger protein 638 0.0258627
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0256858
CXCL5 chemokine (C-X-C motif) ligand 5 0.0256328
GPRIN3 GPRIN family member 3 0.0256033
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.024956
TXNIP thioredoxin interacting protein 0.0246376

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.103286
RPLP1 ribosomal protein, large, P1 -0.0828522
PDE10A phosphodiesterase 10A -0.0796709
RPL26 ribosomal protein L26 -0.0683677
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0647001
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0625843
NALF1 NALCN channel auxiliary factor 1 -0.0624778
PTMA prothymosin, alpha -0.0624228
RPS6 ribosomal protein S6 -0.0607817
TMSB10 thymosin beta 10 -0.0602449
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0594449
RPS19 ribosomal protein S19 -0.0593502
RPS24 ribosomal protein S24 -0.059299
RPL35A ribosomal protein L35a -0.0588639
RPL12 ribosomal protein L12 -0.057601
RPL23 ribosomal protein L23 -0.057243
RPL9 ribosomal protein L9 -0.0562387
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0558247
RPL37A ribosomal protein L37a -0.0546395
RPS8 ribosomal protein S8 -0.0544387
RPL34 ribosomal protein L34 -0.0537399
RPS12 ribosomal protein S12 -0.0526897
TXNRD1 thioredoxin reductase 1 -0.0489574
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0486713
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0473073
LSAMP limbic system-associated membrane protein -0.0466093
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0455902
RPL35 ribosomal protein L35 -0.0452491
SMYD3 SET and MYND domain containing 3 -0.0446895
NAP1L1 nucleosome assembly protein 1-like 1 -0.0430846
RPL19 ribosomal protein L19 -0.042761
RPLP0 ribosomal protein, large, P0 -0.0421859
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0420562
CDH13 cadherin 13 -0.0415877
ACTG1 actin gamma 1 -0.0403777
RPL38 ribosomal protein L38 -0.0398279
RPLP2 ribosomal protein, large, P2 -0.0386741
RPS16 ribosomal protein S16 -0.0384352
P3H2 prolyl 3-hydroxylase 2 -0.0373048
RPS3 ribosomal protein S3 -0.0372633
FTH1 ferritin, heavy polypeptide 1 -0.036941
RPS21 ribosomal protein S21 -0.0355768
RPS23 ribosomal protein S23 -0.0345966
KIAA0825 KIAA0825 -0.0333675
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0324562
S100A10 S100 calcium binding protein A10 -0.0317982
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0306276
RPL13A ribosomal protein L13a -0.0304893
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0300634
RPS14 ribosomal protein S14 -0.0300007
RPL36 ribosomal protein L36 -0.0299617
RPL5 ribosomal protein L5 -0.0298293
HLA-B major histocompatibility complex, class I, B -0.0297504
RBM39 RNA binding motif protein 39 -0.0293868
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0290832
RPS25 ribosomal protein S25 -0.029019
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0286316
RPL31 ribosomal protein L31 -0.0285913
FTL ferritin, light polypeptide -0.0284864
WDR43 WD repeat domain 43 -0.0282739
RPL11 ribosomal protein L11 -0.0280668
RAB7A RAB7A, member RAS oncogene family -0.0272268
RPS27 ribosomal protein S27 -0.0272067
PRKN parkin RBR E3 ubiquitin protein ligase -0.0268694
RPL37 ribosomal protein L37 -0.026718
RPL36A ribosomal protein L36a -0.0264023
RPS17 ribosomal protein S17 -0.026109
RPL27 ribosomal protein L27 -0.026082
LOC112694756 uncharaterized LOC112694756 -0.0252961
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0250418
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0249036
CHD1 chromodomain helicase DNA binding protein 1 -0.0246873
NACA nascent polypeptide-associated complex alpha subunit -0.0244349
ATP5F1E ATP synthase F1 subunit epsilon -0.0242562
RPS27A ribosomal protein S27a -0.0240403
RPS4X ribosomal protein S4, X-linked -0.0238236
USP15 ubiquitin specific peptidase 15 -0.0231498
RPS28 ribosomal protein S28 -0.0230127
VIM vimentin -0.0228716
ANTXR1 anthrax toxin receptor 1 -0.0227502
CADM2 cell adhesion molecule 2 -0.0226789
FUS FUS RNA binding protein -0.0225016
PDE7B phosphodiesterase 7B -0.0223504
HMGB1 high mobility group box 1 -0.0223223
NOP58 NOP58 ribonucleoprotein -0.0220068
AGTPBP1 ATP/GTP binding protein 1 -0.0215078
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0215011
RPS29 ribosomal protein S29 -0.0214902
DNAH14 dynein, axonemal, heavy chain 14 -0.0213213
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0202368
RPL30 ribosomal protein L30 -0.0201827
PALLD palladin, cytoskeletal associated protein -0.0201022
RPS5 ribosomal protein S5 -0.0199152
IARS1 isoleucyl-tRNA synthetase 1 -0.0193996
RPS13 ribosomal protein S13 -0.0193788
TSC22D2 TSC22 domain family, member 2 -0.0191888
DIAPH3 diaphanous-related formin 3 -0.0189749
HLA-A major histocompatibility complex, class I, A -0.0188316
TBXT T-box transcription factor T -0.0186228
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0185099