Valdecoxib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Valdecoxib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Valdecoxib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBM33 RNA binding motif protein 33 0.0550942
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0509832
TBC1D12 TBC1 domain family, member 12 0.0482441
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.043037
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0429209
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0420762
TENM2 teneurin transmembrane protein 2 0.041509
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0387917
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0376246
GPC3 glypican 3 0.037138
IPO7 importin 7 0.0363054
SPAG9 sperm associated antigen 9 0.0360502
OSBPL9 oxysterol binding protein-like 9 0.0358899
CRY1 cryptochrome circadian clock 1 0.0351356
PNN pinin, desmosome associated protein 0.0345188
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.034465
IGF1R insulin-like growth factor 1 receptor 0.0333181
EGFR epidermal growth factor receptor 0.0319376
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0311248
ANLN anillin, actin binding protein 0.0306834
CANX calnexin 0.0305611
UTRN utrophin 0.029959
POTEF POTE ankyrin domain family, member F 0.0299526
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.029896
MRPS30 mitochondrial ribosomal protein S30 0.0298458
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0285441
USP15 ubiquitin specific peptidase 15 0.0280943
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.027908
SIK3 SIK family kinase 3 0.0277869
STAG2 stromal antigen 2 0.0274195
WDR43 WD repeat domain 43 0.0267799
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.026364
MORF4L1 mortality factor 4 like 1 0.0262924
FUBP1 far upstream element (FUSE) binding protein 1 0.0257737
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0255296
CSDE1 cold shock domain containing E1, RNA-binding 0.0252772
SLMAP sarcolemma associated protein 0.0252717
ARB2A ARB2 cotranscriptional regulator A 0.0249081
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0236969
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.023688
KMT2E lysine (K)-specific methyltransferase 2E 0.023647
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0222438
GPATCH8 G patch domain containing 8 0.021977
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.021752
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0215517
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0215417
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0212525
PDS5B PDS5 cohesin associated factor B 0.0212077
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0211231
THBS1 thrombospondin 1 0.0210882
MKI67 marker of proliferation Ki-67 0.0208939
ZNF280C zinc finger protein 280C 0.0208359
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0207998
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0207259
ANXA5 annexin A5 0.0206865
DSCAM Down syndrome cell adhesion molecule 0.0204127
SENP6 SUMO1/sentrin specific peptidase 6 0.0203842
RBM27 RNA binding motif protein 27 0.0202525
AKAP13 A kinase (PRKA) anchor protein 13 0.0202507
SAR1A secretion associated, Ras related GTPase 1A 0.0200399
SRSF10 serine/arginine-rich splicing factor 10 0.0196166
DMD dystrophin 0.0195787
QKI QKI, KH domain containing, RNA binding 0.0193994
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.019242
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0191109
GPC4 glypican 4 0.0190591
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0186876
SOBP sine oculis binding protein homolog (Drosophila) 0.018633
PDE8A phosphodiesterase 8A 0.0183855
MBNL2 muscleblind-like splicing regulator 2 0.0182918
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0182595
RAB30 RAB30, member RAS oncogene family 0.0181636
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0181245
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0179971
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.0178926
USP53 ubiquitin specific peptidase 53 0.0174319
SRSF7 serine/arginine-rich splicing factor 7 0.0173241
MEF2A myocyte enhancer factor 2A 0.0172828
ADAM9 ADAM metallopeptidase domain 9 0.01724
FAM168A family with sequence similarity 168, member A 0.0172331
TNPO1 transportin 1 0.0171479
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0171386
CCNL1 cyclin L1 0.0170626
KIF23 kinesin family member 23 0.0170285
VCP valosin containing protein 0.0170235
XPOT exportin, tRNA 0.016893
NOCT nocturnin 0.0166961
ATAD2 ATPase family, AAA domain containing 2 0.0166204
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0165734
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0165274
HELZ helicase with zinc finger 0.0165122
GRSF1 G-rich RNA sequence binding factor 1 0.0164634
ZFAND3 zinc finger, AN1-type domain 3 0.0164601
NMT1 N-myristoyltransferase 1 0.0164592
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0164174
FBXO11 F-box protein 11 0.0163786
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0163476
NUCB2 nucleobindin 2 0.0163263
RINT1 RAD50 interactor 1 0.0163135
GPBP1 GC-rich promoter binding protein 1 0.0162644

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.153826
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.125789
TMSB10 thymosin beta 10 -0.0996611
CADM2 cell adhesion molecule 2 -0.0982329
RPS16 ribosomal protein S16 -0.0961405
ADGRL2 adhesion G protein-coupled receptor L2 -0.0898071
COL11A1 collagen, type XI, alpha 1 -0.089678
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0716599
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0699808
RPS8 ribosomal protein S8 -0.0682631
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0663762
PARD3B par-3 family cell polarity regulator beta -0.0661133
COL5A2 collagen, type V, alpha 2 -0.0655771
PHIP pleckstrin homology domain interacting protein -0.0652095
RPS6 ribosomal protein S6 -0.0636348
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0564465
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0549841
SLIT2 slit homolog 2 (Drosophila) -0.053216
RPL23 ribosomal protein L23 -0.0518772
RPL35A ribosomal protein L35a -0.0518032
USP34 ubiquitin specific peptidase 34 -0.0516891
MDK midkine (neurite growth-promoting factor 2) -0.0516309
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0514552
RERE arginine-glutamic acid dipeptide (RE) repeats -0.050428
COL1A2 collagen, type I, alpha 2 -0.0502867
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0502778
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0500189
WSB1 WD repeat and SOCS box containing 1 -0.0472256
PGK1 phosphoglycerate kinase 1 -0.0470403
TENM3 teneurin transmembrane protein 3 -0.0464427
FNDC3B fibronectin type III domain containing 3B -0.0456312
RPS13 ribosomal protein S13 -0.041478
FTL ferritin, light polypeptide -0.0414769
RPL37A ribosomal protein L37a -0.0413272
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0406591
TRIO trio Rho guanine nucleotide exchange factor -0.0406124
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0399204
CNRIP1 cannabinoid receptor interacting protein 1 -0.0399143
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0398097
RPS12 ribosomal protein S12 -0.0398017
SMYD3 SET and MYND domain containing 3 -0.0393072
TOX thymocyte selection-associated high mobility group box -0.0391881
RPL37 ribosomal protein L37 -0.0389489
TPT1 tumor protein, translationally-controlled 1 -0.0385007
ANKRD12 ankyrin repeat domain 12 -0.0383112
CENPF centromere protein F, 350/400kDa -0.038208
SETD5 SET domain containing 5 -0.0381398
ATP5F1B ATP synthase F1 subunit beta -0.0378216
NCAM2 neural cell adhesion molecule 2 -0.037442
PCLO piccolo presynaptic cytomatrix protein -0.0373225
PEG10 paternally expressed 10 -0.037221
MEIS2 Meis homeobox 2 -0.0369236
NTM neurotrimin -0.0363239
RPL5 ribosomal protein L5 -0.0362667
CLTC clathrin, heavy chain (Hc) -0.0362433
ITGAV integrin, alpha V -0.035947
RPL19 ribosomal protein L19 -0.0359209
RAB2A RAB2A, member RAS oncogene family -0.0351297
URI1 URI1, prefoldin-like chaperone -0.0351181
ENO1 enolase 1, (alpha) -0.0341862
MED13L mediator complex subunit 13-like -0.0340968
GPHN gephyrin -0.0340952
CUX1 cut-like homeobox 1 -0.0335524
ZEB2 zinc finger E-box binding homeobox 2 -0.0335014
RPL36A ribosomal protein L36a -0.0334785
RPS25 ribosomal protein S25 -0.0322214
RACK1 receptor for activated C kinase 1 -0.0321857
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0318218
MBD5 methyl-CpG binding domain protein 5 -0.03119
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0307212
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0304674
SAMD4B sterile alpha motif domain containing 4B -0.0303651
RPL11 ribosomal protein L11 -0.0303032
FBXO17 F-box protein 17 -0.0301277
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0298375
RPLP2 ribosomal protein, large, P2 -0.0296822
FN1 fibronectin 1 -0.0295768
RASAL2 RAS protein activator like 2 -0.0295578
PBX3 pre-B-cell leukemia homeobox 3 -0.0295128
LYST lysosomal trafficking regulator -0.0291432
RPS19 ribosomal protein S19 -0.029092
PTMA prothymosin, alpha -0.0287404
RAB7A RAB7A, member RAS oncogene family -0.0284913
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0284686
CAMTA1 calmodulin binding transcription activator 1 -0.0283844
ISG15 ISG15 ubiquitin-like modifier -0.0280795
PLPP1 phospholipid phosphatase 1 -0.0280736
RPS3 ribosomal protein S3 -0.0280503
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0277775
MRPS6 mitochondrial ribosomal protein S6 -0.0275091
RPS21 ribosomal protein S21 -0.0271396
PRTG protogenin -0.0267278
RPS27A ribosomal protein S27a -0.0266243
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0265828
RAD51B RAD51 paralog B -0.0263756
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0263474
MYO10 myosin X -0.026121
NHSL1 NHS-like 1 -0.0258153
FOXJ3 forkhead box J3 -0.0254648
SNX6 sorting nexin 6 -0.0254647