Vandetanib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.118719
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.114371
AKAP12 A kinase (PRKA) anchor protein 12 0.113954
DLG1 discs, large homolog 1 (Drosophila) 0.113535
TRIO trio Rho guanine nucleotide exchange factor 0.103076
LOX lysyl oxidase 0.0949362
FBN1 fibrillin 1 0.0920246
COL3A1 collagen, type III, alpha 1 0.0784073
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0744201
LOXL2 lysyl oxidase-like 2 0.0742725
SOD2 superoxide dismutase 2, mitochondrial 0.0649193
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0615642
UBC ubiquitin C 0.0606341
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0584238
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0584015
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0579316
CANX calnexin 0.0576164
PLAT plasminogen activator, tissue 0.0552645
COL8A1 collagen, type VIII, alpha 1 0.0550313
STC1 stanniocalcin 1 0.0506683
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0478464
PGK1 phosphoglycerate kinase 1 0.0476405
FNDC3B fibronectin type III domain containing 3B 0.0467156
TNIP1 TNFAIP3 interacting protein 1 0.0456595
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0440599
ELL2 elongation factor, RNA polymerase II, 2 0.0423835
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0423427
COL1A2 collagen, type I, alpha 2 0.0418264
ATP13A3 ATPase type 13A3 0.039198
OGA O-GlcNAcase 0.0391918
USP34 ubiquitin specific peptidase 34 0.0383327
IQGAP1 IQ motif containing GTPase activating protein 1 0.0377495
CALR calreticulin 0.0375703
OPTN optineurin 0.0374961
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0372455
ARRDC3 arrestin domain containing 3 0.0367952
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0366656
NDRG1 N-myc downstream regulated 1 0.0353173
LDHA lactate dehydrogenase A 0.0346651
SBF2 SET binding factor 2 0.0346144
CYLD cylindromatosis (turban tumor syndrome) 0.0339535
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0335414
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0332525
ZEB1 zinc finger E-box binding homeobox 1 0.0330629
APP amyloid beta (A4) precursor protein 0.0328142
COL5A2 collagen, type V, alpha 2 0.0327022
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0326599
SQSTM1 sequestosome 1 0.0326457
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0324868
GOLGA4 golgin A4 0.032348
WDFY1 WD repeat and FYVE domain containing 1 0.0322548
INSIG2 insulin induced gene 2 0.0318977
TAOK1 TAO kinase 1 0.0318416
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0315579
ANXA2 annexin A2 0.0308919
FLNB filamin B, beta 0.0306112
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0303271
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0297176
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0296783
AHNAK AHNAK nucleoprotein 0.0295512
RICTOR RPTOR independent companion of MTOR, complex 2 0.0294127
DST dystonin 0.0292773
HELZ helicase with zinc finger 0.0292354
ESYT2 extended synaptotagmin-like protein 2 0.0290503
MYOF myoferlin 0.0289203
PSD3 pleckstrin and Sec7 domain containing 3 0.028834
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0287486
CD109 CD109 molecule 0.0286901
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0284858
ZBTB20 zinc finger and BTB domain containing 20 0.0282758
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0280128
AUTS2 autism susceptibility candidate 2 0.0278329
DENND5A DENN/MADD domain containing 5A 0.0277141
SUCO SUN domain containing ossification factor 0.0275844
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0272898
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0272538
KIFAP3 kinesin-associated protein 3 0.0270828
CD99 CD99 molecule 0.0269652
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0268747
AFF4 AF4/FMR2 family, member 4 0.0268574
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262059
THBS2 thrombospondin 2 0.0261613
NGLY1 N-glycanase 1 0.0258812
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0258295
KMT2C lysine (K)-specific methyltransferase 2C 0.025802
DCAF6 DDB1 and CUL4 associated factor 6 0.0257188
LMAN1 lectin, mannose-binding, 1 0.0257016
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0256924
HLA-E major histocompatibility complex, class I, E 0.0255263
FAM107B family with sequence similarity 107, member B 0.0252355
RAB6A RAB6A, member RAS oncogene family 0.0250571
BACE2 beta-site APP-cleaving enzyme 2 0.0248857
SSBP2 single-stranded DNA binding protein 2 0.0247641
SEPTIN2 septin 2 0.0246607
PICALM phosphatidylinositol binding clathrin assembly protein 0.0245678
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0245588
NAV2 neuron navigator 2 0.0244868
NAP1L1 nucleosome assembly protein 1-like 1 0.024483
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0244694
PDIA6 protein disulfide isomerase family A, member 6 0.0244087

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.122433
MAP1B microtubule-associated protein 1B -0.0677418
PODXL podocalyxin-like -0.0565524
CDH13 cadherin 13 -0.0457969
IFITM3 interferon induced transmembrane protein 3 -0.0445709
ANKRD11 ankyrin repeat domain 11 -0.0394418
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0364685
COL5A1 collagen, type V, alpha 1 -0.0317064
FN1 fibronectin 1 -0.0301817
RPS6 ribosomal protein S6 -0.0301127
POTEF POTE ankyrin domain family, member F -0.0296826
ABI3BP ABI family, member 3 (NESH) binding protein -0.0288915
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0287349
RPL35A ribosomal protein L35a -0.0280843
ISG15 ISG15 ubiquitin-like modifier -0.0273522
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0269154
MT2A metallothionein 2A -0.0268927
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0267666
IGFBP3 insulin-like growth factor binding protein 3 -0.0245072
EFNA5 ephrin-A5 -0.0238256
SUCNR1 succinate receptor 1 -0.0237891
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0236878
IFI16 interferon, gamma-inducible protein 16 -0.0231826
SAMD9 sterile alpha motif domain containing 9 -0.0231475
PLXNA2 plexin A2 -0.0230866
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0229621
IFITM1 interferon induced transmembrane protein 1 -0.0222453
RPL35 ribosomal protein L35 -0.0221569
RPL28 ribosomal protein L28 -0.0221251
IL7R interleukin 7 receptor -0.0221217
CAVIN1 caveolae associated protein 1 -0.0219659
RPL36 ribosomal protein L36 -0.0218126
RPL34 ribosomal protein L34 -0.0211574
SEC61G Sec61 gamma subunit -0.0208982
RPLP1 ribosomal protein, large, P1 -0.0207681
S100A10 S100 calcium binding protein A10 -0.0207281
RPL37A ribosomal protein L37a -0.0203344
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0201454
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0197015
SLC38A1 solute carrier family 38, member 1 -0.0196554
HSPB1 heat shock 27kDa protein 1 -0.0195831
RPLP2 ribosomal protein, large, P2 -0.0192129
RNF213 ring finger protein 213 -0.0191832
RPS27 ribosomal protein S27 -0.0188429
FLNA filamin A, alpha -0.0186089
RIGI RNA sensor RIG-I -0.0184451
HLA-C major histocompatibility complex, class I, C -0.0183566
DCLK2 doublecortin-like kinase 2 -0.0180103
ASPH aspartate beta-hydroxylase -0.0179273
HMGB1 high mobility group box 1 -0.0178732
SORBS2 sorbin and SH3 domain containing 2 -0.017771
OASL 2'-5'-oligoadenylate synthetase-like -0.017725
TUBB4B tubulin, beta 4B class IVb -0.017706
SMC4 structural maintenance of chromosomes 4 -0.0176528
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.017651
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0175621
RRBP1 ribosome binding protein 1 -0.017481
FTL ferritin, light polypeptide -0.0172913
LRRC17 leucine rich repeat containing 17 -0.0172761
LMNA lamin A/C -0.0165674
ADAR adenosine deaminase, RNA-specific -0.0164395
RPL23 ribosomal protein L23 -0.0161753
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0157592
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0156577
IFI6 interferon, alpha-inducible protein 6 -0.0156348
GSE1 Gse1 coiled-coil protein -0.0155232
CEP112 centrosomal protein 112kDa -0.015364
CENPF centromere protein F, 350/400kDa -0.0152138
RPS17 ribosomal protein S17 -0.0150291
PLSCR1 phospholipid scramblase 1 -0.0149762
ECM1 extracellular matrix protein 1 -0.0149273
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0149
TUBB tubulin, beta class I -0.0147873
PFN1 profilin 1 -0.0147258
PCDH7 protocadherin 7 -0.014705
KIAA1549L KIAA1549-like -0.0146337
DGKG diacylglycerol kinase, gamma 90kDa -0.0146119
TNS3 tensin 3 -0.0141885
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0140281
DIAPH3 diaphanous-related formin 3 -0.0139967
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0137325
S100A9 S100 calcium binding protein A9 -0.0136828
FLT1 fms-related tyrosine kinase 1 -0.0136505
RSAD2 radical S-adenosyl methionine domain containing 2 -0.013615
TPI1 triosephosphate isomerase 1 -0.0135198
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0134759
RPS19 ribosomal protein S19 -0.0133948
RPS16 ribosomal protein S16 -0.0131581
FMN2 formin 2 -0.0131425
RPS14 ribosomal protein S14 -0.0131168
WARS1 tryptophanyl-tRNA synthetase 1 -0.013104
IFI27 interferon, alpha-inducible protein 27 -0.0125339
SPDL1 spindle apparatus coiled-coil protein 1 -0.0124858
OCIAD2 OCIA domain containing 2 -0.0124766
AHNAK2 AHNAK nucleoprotein 2 -0.0124458
EIF5B eukaryotic translation initiation factor 5B -0.0123954
OAZ1 ornithine decarboxylase antizyme 1 -0.0122442
RPL37 ribosomal protein L37 -0.0122361
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0122336
ANLN anillin, actin binding protein -0.0121967