Vandetanib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.11238
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0861921
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0818255
VMP1 vacuole membrane protein 1 0.0594342
TOP2A topoisomerase (DNA) II alpha 170kDa 0.046835
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0453939
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0450167
FXR1 fragile X mental retardation, autosomal homolog 1 0.0448297
MMP12 matrix metallopeptidase 12 0.0403268
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0383129
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0380559
ERRFI1 ERBB receptor feedback inhibitor 1 0.036715
KIF5B kinesin family member 5B 0.0341138
XPO1 exportin 1 0.0339783
PCBP2 poly(rC) binding protein 2 0.03106
BIRC6 baculoviral IAP repeat containing 6 0.0309694
PICALM phosphatidylinositol binding clathrin assembly protein 0.0286318
CPOX coproporphyrinogen oxidase 0.0266404
ECT2 epithelial cell transforming 2 0.0265473
GPBP1 GC-rich promoter binding protein 1 0.0242588
AKAP9 A kinase (PRKA) anchor protein 9 0.0238704
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0228796
PUM2 pumilio RNA-binding family member 2 0.0226684
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0224448
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0223364
SEC31A SEC31 homolog A (S. cerevisiae) 0.0221278
BRWD1 bromodomain and WD repeat domain containing 1 0.0213021
OGA O-GlcNAcase 0.0207924
KDM4C lysine (K)-specific demethylase 4C 0.0206398
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0205422
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0204134
ARB2A ARB2 cotranscriptional regulator A 0.02036
USP9X ubiquitin specific peptidase 9, X-linked 0.0203575
ZCCHC7 zinc finger, CCHC domain containing 7 0.0203267
CDK19 cyclin-dependent kinase 19 0.0203095
SPAG9 sperm associated antigen 9 0.020289
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0200941
KDM2A lysine (K)-specific demethylase 2A 0.0200897
EPHA6 EPH receptor A6 0.0198208
ETNK1 ethanolamine kinase 1 0.0197113
TXNRD1 thioredoxin reductase 1 0.01967
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0193713
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0192673
CCNL1 cyclin L1 0.0188112
EIF4A2 eukaryotic translation initiation factor 4A2 0.0187751
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0187419
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0187387
DCAF6 DDB1 and CUL4 associated factor 6 0.0185736
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0185275
NF1 neurofibromin 1 0.0185047
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0184942
ADAM17 ADAM metallopeptidase domain 17 0.0183774
PRKCI protein kinase C, iota 0.0183716
IPO7 importin 7 0.0182589
HELZ helicase with zinc finger 0.018207
HSPA4 heat shock 70kDa protein 4 0.0177982
OXR1 oxidation resistance 1 0.0176503
IL6ST interleukin 6 signal transducer 0.0175047
CKAP5 cytoskeleton associated protein 5 0.0174931
TMEM41B transmembrane protein 41B 0.0174095
CLDND1 claudin domain containing 1 0.0173883
ANXA1 annexin A1 0.01728
KDM6A lysine (K)-specific demethylase 6A 0.0172588
CEP192 centrosomal protein 192kDa 0.0169218
TNPO1 transportin 1 0.0169184
LEMD3 LEM domain containing 3 0.0168556
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0167519
AFTPH aftiphilin 0.0167356
CAMKMT calmodulin-lysine N-methyltransferase 0.0165228
CARD16 caspase recruitment domain family, member 16 0.0164997
PLK2 polo-like kinase 2 0.016459
NIPBL Nipped-B homolog (Drosophila) 0.0164432
CEP70 centrosomal protein 70kDa 0.0162498
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0161158
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0160684
THOC2 THO complex 2 0.0158972
CDC27 cell division cycle 27 0.015819
ANKRD17 ankyrin repeat domain 17 0.0156428
CKAP2 cytoskeleton associated protein 2 0.015467
TAOK1 TAO kinase 1 0.0153225
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0151892
ATP11B ATPase, class VI, type 11B 0.0151675
KLHL24 kelch-like family member 24 0.015084
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0150119
PTEN phosphatase and tensin homolog 0.0149903
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0149746
TTC3 tetratricopeptide repeat domain 3 0.0149557
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0146898
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0146692
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.014599
GIGYF2 GRB10 interacting GYF protein 2 0.0145397
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.014413
TBC1D32 TBC1 domain family, member 32 0.0144036
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0143766
KMT2C lysine (K)-specific methyltransferase 2C 0.0142871
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0142704
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0141698
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0139307
RAB10 RAB10, member RAS oncogene family 0.013822
KDM3A lysine (K)-specific demethylase 3A 0.0137967

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.218325
NLGN1 neuroligin 1 -0.150922
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.12578
PDE4D phosphodiesterase 4D, cAMP-specific -0.110957
VIM vimentin -0.0887951
CELF2 CUGBP, Elav-like family member 2 -0.086423
RPL35A ribosomal protein L35a -0.0809055
RPS8 ribosomal protein S8 -0.0606662
PCDH7 protocadherin 7 -0.0594618
RPS6 ribosomal protein S6 -0.0576202
RPL37A ribosomal protein L37a -0.057333
RPLP1 ribosomal protein, large, P1 -0.0567934
FTL ferritin, light polypeptide -0.0559062
RPS19 ribosomal protein S19 -0.0552583
RPLP2 ribosomal protein, large, P2 -0.053912
RPL26 ribosomal protein L26 -0.0538442
CNRIP1 cannabinoid receptor interacting protein 1 -0.0502547
ACTG1 actin gamma 1 -0.0490576
TPT1 tumor protein, translationally-controlled 1 -0.0485889
RPL23 ribosomal protein L23 -0.0479427
HMGA2 high mobility group AT-hook 2 -0.0474151
RPS13 ribosomal protein S13 -0.0466667
RPL34 ribosomal protein L34 -0.0451944
RPL37 ribosomal protein L37 -0.0438715
PTMA prothymosin, alpha -0.042771
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0427681
RPS27A ribosomal protein S27a -0.0422264
RPL36 ribosomal protein L36 -0.0412712
RPL5 ribosomal protein L5 -0.0396513
RPL38 ribosomal protein L38 -0.0392641
RPL11 ribosomal protein L11 -0.0382333
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0381596
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0379238
RPS12 ribosomal protein S12 -0.0363453
RPL19 ribosomal protein L19 -0.0343217
HMGA1 high mobility group AT-hook 1 -0.0314414
RIMS2 regulating synaptic membrane exocytosis 2 -0.0313803
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0313638
RPL12 ribosomal protein L12 -0.0313188
RPS29 ribosomal protein S29 -0.0312474
RPL9 ribosomal protein L9 -0.0296784
RPS2 ribosomal protein S2 -0.029334
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.029306
EIF1 eukaryotic translation initiation factor 1 -0.0292879
MACF1 microtubule-actin crosslinking factor 1 -0.0292844
RPS21 ribosomal protein S21 -0.0288291
RPS16 ribosomal protein S16 -0.0276018
MYL12B myosin, light chain 12B, regulatory -0.0272293
TRA2B transformer 2 beta homolog (Drosophila) -0.0270064
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0257907
RPS27 ribosomal protein S27 -0.0254267
RPS17 ribosomal protein S17 -0.0254149
YBX3 Y box binding protein 3 -0.0253661
RPS23 ribosomal protein S23 -0.0250114
HMGB1 high mobility group box 1 -0.0248484
ZNF804A zinc finger protein 804A -0.0248397
CCND1 cyclin D1 -0.0248224
RAB7A RAB7A, member RAS oncogene family -0.0247847
RPS3 ribosomal protein S3 -0.0245512
RPL31 ribosomal protein L31 -0.0244448
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0243833
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0241827
RACK1 receptor for activated C kinase 1 -0.0239749
RPS10 ribosomal protein S10 -0.0230988
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0229443
AHNAK AHNAK nucleoprotein -0.0228956
DPYD dihydropyrimidine dehydrogenase -0.0228347
FUS FUS RNA binding protein -0.0227974
RPS14 ribosomal protein S14 -0.0226044
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0225513
RPS5 ribosomal protein S5 -0.0223293
RPL36A ribosomal protein L36a -0.0222159
RPS20 ribosomal protein S20 -0.0221926
DNAH14 dynein, axonemal, heavy chain 14 -0.0218185
PDGFC platelet derived growth factor C -0.0216412
BIRC3 baculoviral IAP repeat containing 3 -0.0215367
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0212368
RPS25 ribosomal protein S25 -0.0212021
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0210044
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0209245
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0208895
PRRC2C proline-rich coiled-coil 2C -0.0208371
RPL27 ribosomal protein L27 -0.0208214
SQSTM1 sequestosome 1 -0.0207954
MTAP methylthioadenosine phosphorylase -0.0206883
RPS26 ribosomal protein S26 -0.0204967
DLC1 DLC1 Rho GTPase activating protein -0.0204552
RSL24D1 ribosomal L24 domain containing 1 -0.0204454
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0204329
MGAT4C MGAT4 family, member C -0.0198661
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.019825
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0193885
RPS24 ribosomal protein S24 -0.0193564
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.0190569
RPL30 ribosomal protein L30 -0.0189685
NAP1L1 nucleosome assembly protein 1-like 1 -0.018828
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0187636
GNAS GNAS complex locus -0.0186637
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0186141
NABP1 nucleic acid binding protein 1 -0.0180229