Vandetanib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.133107
ATP13A3 ATPase type 13A3 0.0996167
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0987026
NDRG1 N-myc downstream regulated 1 0.0703786
TRIO trio Rho guanine nucleotide exchange factor 0.0652081
LOX lysyl oxidase 0.0512348
COL1A2 collagen, type I, alpha 2 0.0486155
CADM1 cell adhesion molecule 1 0.0478769
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0447777
ELL2 elongation factor, RNA polymerase II, 2 0.0444648
SPAG9 sperm associated antigen 9 0.0429495
GOLGA4 golgin A4 0.0416785
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0412144
PDE10A phosphodiesterase 10A 0.0395814
FMNL2 formin-like 2 0.0379656
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0372983
CALR calreticulin 0.036795
STC1 stanniocalcin 1 0.035575
RASA2 RAS p21 protein activator 2 0.0340078
TTC3 tetratricopeptide repeat domain 3 0.033516
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0322231
SQLE squalene epoxidase 0.031199
MRTFA myocardin related transcription factor A 0.0303551
CANX calnexin 0.0299361
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0295194
ADAM17 ADAM metallopeptidase domain 17 0.0294053
HIP1 huntingtin interacting protein 1 0.0292355
ARRDC3 arrestin domain containing 3 0.0288792
UBA6 ubiquitin-like modifier activating enzyme 6 0.0286105
ZCCHC7 zinc finger, CCHC domain containing 7 0.028243
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0279954
RAB6A RAB6A, member RAS oncogene family 0.0279251
MTDH metadherin 0.0275419
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0274076
UGCG UDP-glucose ceramide glucosyltransferase 0.0272679
TFG TRK-fused gene 0.0267321
PRRC1 proline-rich coiled-coil 1 0.0261258
COG5 component of oligomeric golgi complex 5 0.0260456
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0253008
TRAM1 translocation associated membrane protein 1 0.0250547
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0241787
ITCH itchy E3 ubiquitin protein ligase 0.0235914
OGA O-GlcNAcase 0.0233658
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0233148
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0232928
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0232708
ESYT2 extended synaptotagmin-like protein 2 0.0230361
COPA coatomer protein complex, subunit alpha 0.0228605
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0226169
HILPDA hypoxia inducible lipid droplet-associated 0.022571
KIF1B kinesin family member 1B 0.0224407
KMT2C lysine (K)-specific methyltransferase 2C 0.022148
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0216611
NGLY1 N-glycanase 1 0.0214063
F3 coagulation factor III (thromboplastin, tissue factor) 0.0213489
PDIA6 protein disulfide isomerase family A, member 6 0.0208387
ZNF148 zinc finger protein 148 0.0205883
TBC1D23 TBC1 domain family, member 23 0.0204411
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0201858
FAM13B family with sequence similarity 13, member B 0.0201577
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0200931
SRP54 signal recognition particle 54kDa 0.019959
MATR3 matrin 3 0.0199151
PICALM phosphatidylinositol binding clathrin assembly protein 0.0198783
RYK receptor-like tyrosine kinase 0.0196912
LMAN1 lectin, mannose-binding, 1 0.0196758
DLG1 discs, large homolog 1 (Drosophila) 0.0194969
WASF2 WAS protein family, member 2 0.0194283
CHD1 chromodomain helicase DNA binding protein 1 0.019354
ERRFI1 ERBB receptor feedback inhibitor 1 0.019152
CTNND1 catenin (cadherin-associated protein), delta 1 0.0190038
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0187935
WRN Werner syndrome, RecQ helicase-like 0.018528
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0184144
ZNF292 zinc finger protein 292 0.0182377
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0179319
RICTOR RPTOR independent companion of MTOR, complex 2 0.0177763
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0176452
TRA2A transformer 2 alpha homolog (Drosophila) 0.017338
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.017324
SEPTIN2 septin 2 0.0172265
VIRMA vir like m6A methyltransferase associated 0.0171369
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0170848
CCNY cyclin Y 0.0170307
TAOK1 TAO kinase 1 0.0169546
FBN1 fibrillin 1 0.0168238
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0167319
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0166916
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.016675
ERBIN erbb2 interacting protein 0.0166669
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0164759
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.016387
RNF24 ring finger protein 24 0.0162299
DCAF13 DDB1 and CUL4 associated factor 13 0.0161632
MLEC malectin 0.0161379
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0159954
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.01594
MYO9B myosin IXB 0.0159138
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0158675
BRWD1 bromodomain and WD repeat domain containing 1 0.0158541

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.130685
MT2A metallothionein 2A -0.112022
VIM vimentin -0.0982148
CD44 CD44 molecule (Indian blood group) -0.0980819
TMSB10 thymosin beta 10 -0.0827307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0747545
COL1A1 collagen, type I, alpha 1 -0.0622783
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0613635
CDH13 cadherin 13 -0.0584846
RPL35A ribosomal protein L35a -0.0577569
RPS8 ribosomal protein S8 -0.0480844
ZBTB20 zinc finger and BTB domain containing 20 -0.0461236
FTL ferritin, light polypeptide -0.0457323
IER3 immediate early response 3 -0.0431237
PSD3 pleckstrin and Sec7 domain containing 3 -0.0380258
RPS6 ribosomal protein S6 -0.0379862
ALCAM activated leukocyte cell adhesion molecule -0.0370735
DPYD dihydropyrimidine dehydrogenase -0.0362095
RPLP1 ribosomal protein, large, P1 -0.036125
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0356369
RPL12 ribosomal protein L12 -0.035623
ASPH aspartate beta-hydroxylase -0.0347677
RPL23 ribosomal protein L23 -0.0342343
TRPS1 trichorhinophalangeal syndrome I -0.0338458
S100A9 S100 calcium binding protein A9 -0.0335488
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0317257
RRBP1 ribosome binding protein 1 -0.0310603
CALD1 caldesmon 1 -0.0309142
ACTG1 actin gamma 1 -0.0308398
RPL26 ribosomal protein L26 -0.0301978
WWTR1 WW domain containing transcription regulator 1 -0.0300229
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0291827
RPL19 ribosomal protein L19 -0.0287048
RPL11 ribosomal protein L11 -0.0284776
DST dystonin -0.0262454
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0260591
RPL36 ribosomal protein L36 -0.0255596
RPS3 ribosomal protein S3 -0.0254023
RPS19 ribosomal protein S19 -0.0252048
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0245858
ATXN1 ataxin 1 -0.0245683
COL6A3 collagen, type VI, alpha 3 -0.0239888
HMGA2 high mobility group AT-hook 2 -0.0236557
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0236054
RPL28 ribosomal protein L28 -0.0235935
RPS17 ribosomal protein S17 -0.0233956
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.023325
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0232294
RPL34 ribosomal protein L34 -0.0229679
CNTN5 contactin 5 -0.0229295
RIGI RNA sensor RIG-I -0.0228595
PRELID2 PRELI domain containing 2 -0.02268
AHNAK AHNAK nucleoprotein -0.0222289
COL5A1 collagen, type V, alpha 1 -0.022082
EIF1 eukaryotic translation initiation factor 1 -0.0220541
STAT1 signal transducer and activator of transcription 1, 91kDa -0.021867
HLA-B major histocompatibility complex, class I, B -0.0217375
FBXL7 F-box and leucine-rich repeat protein 7 -0.0216232
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0213495
RPL37A ribosomal protein L37a -0.0211077
IFI16 interferon, gamma-inducible protein 16 -0.0207157
RPL30 ribosomal protein L30 -0.0204928
SQSTM1 sequestosome 1 -0.0204183
RPS27A ribosomal protein S27a -0.0202868
RPS12 ribosomal protein S12 -0.0200751
NAV2 neuron navigator 2 -0.0200155
RPL13A ribosomal protein L13a -0.019988
RPLP2 ribosomal protein, large, P2 -0.0198171
TPM1 tropomyosin 1 (alpha) -0.0195087
TPT1 tumor protein, translationally-controlled 1 -0.0191325
POTEF POTE ankyrin domain family, member F -0.0190775
RPS20 ribosomal protein S20 -0.0185835
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0184804
RPL18 ribosomal protein L18 -0.0183823
MYH9 myosin, heavy chain 9, non-muscle -0.0183137
SP100 SP100 nuclear antigen -0.0182913
MAML2 mastermind-like 2 (Drosophila) -0.0181597
PDE4D phosphodiesterase 4D, cAMP-specific -0.0179897
S100A10 S100 calcium binding protein A10 -0.0179433
RPL37 ribosomal protein L37 -0.0177515
RPS2 ribosomal protein S2 -0.0176629
RPS21 ribosomal protein S21 -0.01764
ANKRD12 ankyrin repeat domain 12 -0.0176152
RPS5 ribosomal protein S5 -0.0175541
RPL32 ribosomal protein L32 -0.0173648
ZFPM2 zinc finger protein, FOG family member 2 -0.0170889
EHBP1 EH domain binding protein 1 -0.0170444
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0169223
MAP1B microtubule-associated protein 1B -0.0168773
PLSCR1 phospholipid scramblase 1 -0.0167908
PFN1 profilin 1 -0.0166833
LMNA lamin A/C -0.0165007
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0164435
GNAS GNAS complex locus -0.0163866
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0163602
RPL27 ribosomal protein L27 -0.0162762
RPL35 ribosomal protein L35 -0.0162508
GPC6 glypican 6 -0.0161489
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0160257
COL7A1 collagen, type VII, alpha 1 -0.0160002