Vandetanib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.195839
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.1492
ENO1 enolase 1, (alpha) 0.0966419
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0844251
FNDC3B fibronectin type III domain containing 3B 0.0824829
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0817048
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.077958
AKAP12 A kinase (PRKA) anchor protein 12 0.0767449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0635399
SLC38A2 solute carrier family 38, member 2 0.0622625
CPE carboxypeptidase E 0.0592842
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0572634
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0565849
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0561577
FBF1 Fas (TNFRSF6) binding factor 1 0.0548337
INSIG2 insulin induced gene 2 0.0536297
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0527325
FMNL2 formin-like 2 0.0518651
AHSG alpha-2-HS-glycoprotein 0.0468809
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0442483
EML4 echinoderm microtubule associated protein like 4 0.0415366
PLIN2 perilipin 2 0.0411671
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0409457
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0388334
CCL20 chemokine (C-C motif) ligand 20 0.0387171
SPDYA speedy/RINGO cell cycle regulator family member A 0.0384704
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0380446
DDIT4 DNA-damage-inducible transcript 4 0.0378038
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0371843
WDR45B WD repeat domain 45B 0.0369406
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0369399
KIF1B kinesin family member 1B 0.0367333
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0361173
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0360183
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0357037
CANX calnexin 0.0348503
CALR calreticulin 0.034327
QKI QKI, KH domain containing, RNA binding 0.0328212
NGLY1 N-glycanase 1 0.0323408
KDM7A lysine (K)-specific demethylase 7A 0.0319575
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0319184
WNK1 WNK lysine deficient protein kinase 1 0.0318524
APLP2 amyloid beta (A4) precursor-like protein 2 0.0317375
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0315224
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0309098
ARFGEF3 ARFGEF family member 3 0.0296456
AFDN afadin, adherens junction formation factor 0.0294968
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0291655
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0290669
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0290219
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0289784
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0281404
STRN3 striatin, calmodulin binding protein 3 0.0277075
TF transferrin 0.0276587
DSCAM Down syndrome cell adhesion molecule 0.0275827
KTN1 kinectin 1 (kinesin receptor) 0.027557
ITGA6 integrin, alpha 6 0.0275222
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0269873
PEG3 paternally expressed 3 0.0269751
PERP PERP, TP53 apoptosis effector 0.0266723
ZNF292 zinc finger protein 292 0.0266506
MACF1 microtubule-actin crosslinking factor 1 0.0265931
SET SET nuclear proto-oncogene 0.0262649
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0261519
KPNB1 karyopherin (importin) beta 1 0.0261218
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.025826
KDM3A lysine (K)-specific demethylase 3A 0.025746
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0257363
MXI1 MAX interactor 1, dimerization protein 0.0256222
RAB6A RAB6A, member RAS oncogene family 0.0253622
ADGRG6 adhesion G protein-coupled receptor G6 0.025173
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0247205
NBR1 neighbor of BRCA1 gene 1 0.0246083
DARS1 aspartyl-tRNA synthetase 1 0.024397
MATR3 matrin 3 0.0243204
ARRDC3 arrestin domain containing 3 0.0239496
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0239299
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0238407
ASPH aspartate beta-hydroxylase 0.0237472
ESYT2 extended synaptotagmin-like protein 2 0.0237078
PKM pyruvate kinase, muscle 0.023546
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0233483
MBNL3 muscleblind-like splicing regulator 3 0.0230888
PDIA6 protein disulfide isomerase family A, member 6 0.0226924
BBX bobby sox homolog (Drosophila) 0.0226398
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0226195
ADAM17 ADAM metallopeptidase domain 17 0.022602
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0226002
WAC WW domain containing adaptor with coiled-coil 0.0224708
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0224011
CCNL1 cyclin L1 0.0222209
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0219779
TXNIP thioredoxin interacting protein 0.0218411
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0217674
SESTD1 SEC14 and spectrin domains 1 0.0216603
ELL2 elongation factor, RNA polymerase II, 2 0.0216502
OGA O-GlcNAcase 0.0216338
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0215406
LDHA lactate dehydrogenase A 0.0215228
TNIP1 TNFAIP3 interacting protein 1 0.021389

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -0.100033
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0828115
GPC6 glypican 6 -0.0773689
NKD1 naked cuticle homolog 1 (Drosophila) -0.069513
IGFBP1 insulin-like growth factor binding protein 1 -0.0551847
DNAH17 dynein, axonemal, heavy chain 17 -0.0476794
RPLP1 ribosomal protein, large, P1 -0.0410882
RPS19 ribosomal protein S19 -0.0385677
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0352257
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0346132
RPL35A ribosomal protein L35a -0.0336569
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0335294
PARD3 par-3 family cell polarity regulator -0.0322779
LRMDA leucine rich melanocyte differentiation associated -0.0319232
RRBP1 ribosome binding protein 1 -0.0313634
VCL vinculin -0.030824
BCL2L1 BCL2-like 1 -0.0294822
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.02844
TMSB10 thymosin beta 10 -0.028358
NRIP1 nuclear receptor interacting protein 1 -0.0265287
MRTFA myocardin related transcription factor A -0.0257632
ZFHX3 zinc finger homeobox 3 -0.0252761
PTCHD4 patched domain containing 4 -0.0248347
ZNF644 zinc finger protein 644 -0.0248001
CHD6 chromodomain helicase DNA binding protein 6 -0.0244082
C3 complement component 3 -0.0241345
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0239945
ZFAND3 zinc finger, AN1-type domain 3 -0.0237543
RPL37A ribosomal protein L37a -0.0234443
RNF213 ring finger protein 213 -0.0230758
ZEB1 zinc finger E-box binding homeobox 1 -0.022852
LMO7 LIM domain 7 -0.0227997
DLC1 DLC1 Rho GTPase activating protein -0.022758
FRMD5 FERM domain containing 5 -0.0226531
ITGAV integrin, alpha V -0.0225615
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0224119
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0223666
LMCD1 LIM and cysteine-rich domains 1 -0.0223572
RAB7A RAB7A, member RAS oncogene family -0.0222815
RPL36 ribosomal protein L36 -0.0221293
EHBP1 EH domain binding protein 1 -0.0220806
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.021623
RPL18 ribosomal protein L18 -0.0212918
RPL12 ribosomal protein L12 -0.0210949
RBM39 RNA binding motif protein 39 -0.0208494
RPL34 ribosomal protein L34 -0.0207591
TULP4 tubby like protein 4 -0.0202283
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0200583
TPM1 tropomyosin 1 (alpha) -0.0198698
RPS17 ribosomal protein S17 -0.0196737
ANKRD12 ankyrin repeat domain 12 -0.0195212
TGFBI transforming growth factor, beta-induced, 68kDa -0.0194841
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0193302
CADM1 cell adhesion molecule 1 -0.019164
PRRC2B proline-rich coiled-coil 2B -0.0187057
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0186428
RPL5 ribosomal protein L5 -0.0184073
ZBTB20 zinc finger and BTB domain containing 20 -0.0183548
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0182502
CLEC16A C-type lectin domain family 16, member A -0.0182081
RPL37 ribosomal protein L37 -0.0181818
TCF12 transcription factor 12 -0.0181045
PTPRM protein tyrosine phosphatase, receptor type, M -0.0180838
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0176162
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0175792
SKI SKI proto-oncogene -0.0175151
LMNA lamin A/C -0.0174704
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0173233
CFB complement factor B -0.0170583
RPL38 ribosomal protein L38 -0.0169823
UBASH3B ubiquitin associated and SH3 domain containing B -0.0169294
APOB apolipoprotein B -0.0168327
ENAH enabled homolog (Drosophila) -0.0167441
SYN3 synapsin III -0.0165955
RPL9 ribosomal protein L9 -0.0165479
A2M alpha-2-macroglobulin -0.016547
RPL30 ribosomal protein L30 -0.0164781
ISG15 ISG15 ubiquitin-like modifier -0.0163475
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0162524
RASA2 RAS p21 protein activator 2 -0.0162145
EGR1 early growth response 1 -0.0160608
RBP4 retinol binding protein 4, plasma -0.0160174
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.015872
FAF2 Fas associated factor family member 2 -0.015839
RPS12 ribosomal protein S12 -0.0156551
RPL35 ribosomal protein L35 -0.0156443
NPAS2 neuronal PAS domain protein 2 -0.0156072
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0155469
ACYP2 acylphosphatase 2, muscle type -0.0152965
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0151234
RPL19 ribosomal protein L19 -0.0150563
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0149518
GNAS GNAS complex locus -0.0149128
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0147503
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0147311
KRT18 keratin 18, type I -0.0146671
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0146246
FAT1 FAT atypical cadherin 1 -0.014604
BCAS3 breast carcinoma amplified sequence 3 -0.014501
BPTF bromodomain PHD finger transcription factor -0.0144951