Vandetanib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0833935
PDE4D phosphodiesterase 4D, cAMP-specific 0.0376688
AHNAK AHNAK nucleoprotein 0.0348269
PDLIM5 PDZ and LIM domain 5 0.0331915
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0327622
PRELID2 PRELI domain containing 2 0.0315384
MYOF myoferlin 0.0304004
CEMIP cell migration inducing protein, hyaluronan binding 0.0299572
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0289653
LMO7 LIM domain 7 0.0282313
FLNB filamin B, beta 0.0274288
ASPH aspartate beta-hydroxylase 0.0266072
MTSS1 metastasis suppressor 1 0.0257541
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0252269
OSMR oncostatin M receptor 0.0243951
KIAA1217 KIAA1217 0.0232059
DPYD dihydropyrimidine dehydrogenase 0.0231514
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0229983
EFNA5 ephrin-A5 0.0226457
VCL vinculin 0.0221002
EXT1 exostosin glycosyltransferase 1 0.0218307
FOXO1 forkhead box O1 0.021728
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0210341
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0208786
PSD3 pleckstrin and Sec7 domain containing 3 0.0207617
FNIP1 folliculin interacting protein 1 0.0207553
NRIP1 nuclear receptor interacting protein 1 0.0206758
PICALM phosphatidylinositol binding clathrin assembly protein 0.0192227
MACF1 microtubule-actin crosslinking factor 1 0.0192169
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.018427
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0180737
AKAP13 A kinase (PRKA) anchor protein 13 0.0180355
CUL4B cullin 4B 0.0179026
FNDC3B fibronectin type III domain containing 3B 0.017709
DOCK5 dedicator of cytokinesis 5 0.017515
RAB10 RAB10, member RAS oncogene family 0.0172881
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0172148
SLC45A4 solute carrier family 45, member 4 0.0171887
DSCAM Down syndrome cell adhesion molecule 0.0166785
VMP1 vacuole membrane protein 1 0.0164693
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0162892
AOPEP aminopeptidase O (putative) 0.0162308
NCOA3 nuclear receptor coactivator 3 0.0160447
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.015928
CANX calnexin 0.0158881
CLIC4 chloride intracellular channel 4 0.0158716
ITGA6 integrin, alpha 6 0.0157683
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0156101
NDE1 nudE neurodevelopment protein 1 0.0155291
RIN2 Ras and Rab interactor 2 0.0153746
BCAR3 breast cancer anti-estrogen resistance 3 0.0149623
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0149373
FOXP1 forkhead box P1 0.0147882
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.01461
ARHGAP21 Rho GTPase activating protein 21 0.0145952
MECOM MDS1 and EVI1 complex locus 0.0144537
ATXN1 ataxin 1 0.0143168
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0143011
SERINC3 serine incorporator 3 0.014233
SMYD3 SET and MYND domain containing 3 0.014223
EXOC4 exocyst complex component 4 0.0141874
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0141838
CTNND1 catenin (cadherin-associated protein), delta 1 0.0140645
ITCH itchy E3 ubiquitin protein ligase 0.0139325
TBC1D22A TBC1 domain family, member 22A 0.0138174
NEK7 NIMA-related kinase 7 0.0137668
SEPTIN9 septin 9 0.0137295
EGFR epidermal growth factor receptor 0.0136066
JMJD1C jumonji domain containing 1C 0.013511
RAD51B RAD51 paralog B 0.0134547
STC1 stanniocalcin 1 0.0133812
INTS6 integrator complex subunit 6 0.0133438
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0133423
ARRDC3 arrestin domain containing 3 0.013251
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0132226
SLC35F3 solute carrier family 35, member F3 0.0131904
LUZP1 leucine zipper protein 1 0.013162
ANO6 anoctamin 6 0.0130032
SMAD3 SMAD family member 3 0.0128827
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.012817
CD44 CD44 molecule (Indian blood group) 0.0126203
FN1 fibronectin 1 0.012617
KIF16B kinesin family member 16B 0.0125591
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0123918
SLC38A2 solute carrier family 38, member 2 0.0123769
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0123149
KDM6A lysine (K)-specific demethylase 6A 0.0122303
METTL15 methyltransferase like 15 0.0121129
PTK2 protein tyrosine kinase 2 0.0119651
RABGAP1L RAB GTPase activating protein 1-like 0.0118436
RAI14 retinoic acid induced 14 0.0118121
MCL1 myeloid cell leukemia 1 0.0117786
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0115755
KDM4C lysine (K)-specific demethylase 4C 0.0115736
EXOC6B exocyst complex component 6B 0.011544
ENO1 enolase 1, (alpha) 0.0115012
DGKH diacylglycerol kinase, eta 0.0114926
CDK6 cyclin-dependent kinase 6 0.011408
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0113281
N4BP2L2 NEDD4 binding protein 2-like 2 0.0113033

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0560941
MT2A metallothionein 2A -0.0496728
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0469124
NDRG1 N-myc downstream regulated 1 -0.0469112
RPS6 ribosomal protein S6 -0.0408311
PTMA prothymosin, alpha -0.0333732
POTEF POTE ankyrin domain family, member F -0.0327447
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0323504
RPS8 ribosomal protein S8 -0.0323416
ANXA1 annexin A1 -0.0296566
RPS21 ribosomal protein S21 -0.0288899
LMNA lamin A/C -0.0285529
GNAS GNAS complex locus -0.0280852
IFITM3 interferon induced transmembrane protein 3 -0.0278162
IGF2 insulin-like growth factor 2 -0.0274536
LOC112694756 uncharaterized LOC112694756 -0.0265724
S100A10 S100 calcium binding protein A10 -0.0259881
RPS19 ribosomal protein S19 -0.0255736
RPLP1 ribosomal protein, large, P1 -0.0255014
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0254238
B2M beta-2-microglobulin -0.0251107
RPS12 ribosomal protein S12 -0.0236595
RPL35A ribosomal protein L35a -0.0234595
RPL11 ribosomal protein L11 -0.0232228
FTL ferritin, light polypeptide -0.0227925
RPS3 ribosomal protein S3 -0.0222718
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0222047
RPL23 ribosomal protein L23 -0.0221704
S100A6 S100 calcium binding protein A6 -0.0209471
RPLP2 ribosomal protein, large, P2 -0.0208424
RPS13 ribosomal protein S13 -0.020686
RPL37A ribosomal protein L37a -0.0205972
S100A2 S100 calcium binding protein A2 -0.0202813
EZR ezrin -0.0202704
S100A9 S100 calcium binding protein A9 -0.0201753
YBX1 Y box binding protein 1 -0.0200626
RPS27 ribosomal protein S27 -0.019764
S100A11 S100 calcium binding protein A11 -0.0196125
RPL34 ribosomal protein L34 -0.0195252
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0193978
RPL37 ribosomal protein L37 -0.0191622
RPL5 ribosomal protein L5 -0.0191497
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0189621
IFITM1 interferon induced transmembrane protein 1 -0.0187542
RBM39 RNA binding motif protein 39 -0.0186464
RACK1 receptor for activated C kinase 1 -0.0186271
RPL36 ribosomal protein L36 -0.0186134
HLA-B major histocompatibility complex, class I, B -0.0181968
HSPG2 heparan sulfate proteoglycan 2 -0.0181715
MT1X metallothionein 1X -0.0181295
RPL12 ribosomal protein L12 -0.0180056
H1-0 H1.0 linker histone -0.0169604
DSTN destrin (actin depolymerizing factor) -0.0160711
LAMA5 laminin, alpha 5 -0.0159798
CNRIP1 cannabinoid receptor interacting protein 1 -0.0159365
RPS2 ribosomal protein S2 -0.015488
RPL35 ribosomal protein L35 -0.0153178
RPL31 ribosomal protein L31 -0.0147495
CYB5R3 cytochrome b5 reductase 3 -0.0144484
CSTB cystatin B (stefin B) -0.0143551
GUK1 guanylate kinase 1 -0.0143179
RPS14 ribosomal protein S14 -0.0142145
HMGA1 high mobility group AT-hook 1 -0.0141184
EMP1 epithelial membrane protein 1 -0.0135833
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0135796
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0135026
EFHD2 EF-hand domain family, member D2 -0.0132052
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0131793
RPL19 ribosomal protein L19 -0.0131405
RPS25 ribosomal protein S25 -0.0130749
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0126281
KRT17 keratin 17, type I -0.0124612
RPS17 ribosomal protein S17 -0.0122971
KRT14 keratin 14, type I -0.0122899
ATP5F1E ATP synthase F1 subunit epsilon -0.0121719
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0121456
RPS29 ribosomal protein S29 -0.0120181
RPS16 ribosomal protein S16 -0.0118453
SEC61G Sec61 gamma subunit -0.0117716
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0117473
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0116524
BSG basigin (Ok blood group) -0.0116059
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0114837
FTH1 ferritin, heavy polypeptide 1 -0.011448
NUCB2 nucleobindin 2 -0.0112635
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0112518
PFN1 profilin 1 -0.0112276
RPL36A ribosomal protein L36a -0.0112178
RPL28 ribosomal protein L28 -0.0110704
RPL8 ribosomal protein L8 -0.0109847
LOC102724023 ES1 protein homolog, mitochondrial -0.0106875
FSCN1 fascin actin-bundling protein 1 -0.0106303
RPL18 ribosomal protein L18 -0.0105343
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0103582
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0101425
HMGB1 high mobility group box 1 -0.00996377
RRBP1 ribosome binding protein 1 -0.00985375
TMSB4X thymosin beta 4, X-linked -0.00978824
ISG15 ISG15 ubiquitin-like modifier -0.00978348
RPN2 ribophorin II -0.00954563