Vandetanib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0868027
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0850246
NAMPT nicotinamide phosphoribosyltransferase 0.0610475
FAM13A family with sequence similarity 13, member A 0.045101
ARRDC3 arrestin domain containing 3 0.0423229
NGLY1 N-glycanase 1 0.0395394
SPAG9 sperm associated antigen 9 0.0309469
CES1 carboxylesterase 1 0.0303904
CANX calnexin 0.028526
ZC3H11A zinc finger CCCH-type containing 11A 0.0268127
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0256458
ELL2 elongation factor, RNA polymerase II, 2 0.025551
GCLC glutamate-cysteine ligase, catalytic subunit 0.0251934
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0235253
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0234364
ANO6 anoctamin 6 0.0225363
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0222451
OGA O-GlcNAcase 0.0211619
ADAM17 ADAM metallopeptidase domain 17 0.0209814
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0208308
PUM2 pumilio RNA-binding family member 2 0.0207666
AGO2 argonaute RISC catalytic component 2 0.0205035
USP9X ubiquitin specific peptidase 9, X-linked 0.0204701
BRWD3 bromodomain and WD repeat domain containing 3 0.0197887
KDM3A lysine (K)-specific demethylase 3A 0.0197344
HELZ helicase with zinc finger 0.0196231
SOD2 superoxide dismutase 2, mitochondrial 0.0194621
BIRC3 baculoviral IAP repeat containing 3 0.0191653
ZNF292 zinc finger protein 292 0.0187681
RICTOR RPTOR independent companion of MTOR, complex 2 0.0181828
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.018165
ZFC3H1 zinc finger, C3H1-type containing 0.018025
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0180234
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0176414
NCKAP1 NCK-associated protein 1 0.0173128
UBA6 ubiquitin-like modifier activating enzyme 6 0.0170266
MKI67 marker of proliferation Ki-67 0.0168681
WDR45B WD repeat domain 45B 0.0167152
ATAD2B ATPase family, AAA domain containing 2B 0.0166522
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0165227
TPD52 tumor protein D52 0.0163383
SUCO SUN domain containing ossification factor 0.016208
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0161367
SRP54 signal recognition particle 54kDa 0.0160205
ATP13A3 ATPase type 13A3 0.0156958
CLTC clathrin, heavy chain (Hc) 0.0154296
STRN3 striatin, calmodulin binding protein 3 0.0152728
JMJD1C jumonji domain containing 1C 0.0151715
RAD21 RAD21 homolog (S. pombe) 0.0150292
ECT2 epithelial cell transforming 2 0.0149902
BRWD1 bromodomain and WD repeat domain containing 1 0.0149418
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0146695
ERRFI1 ERBB receptor feedback inhibitor 1 0.0146551
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0146031
DSCAM Down syndrome cell adhesion molecule 0.0145433
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0141745
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0140594
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0138789
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0137875
WDR26 WD repeat domain 26 0.0136397
ZFR zinc finger RNA binding protein 0.0135026
PCBP2 poly(rC) binding protein 2 0.0131577
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0131447
ARL5B ADP-ribosylation factor-like 5B 0.0130974
TM9SF3 transmembrane 9 superfamily member 3 0.0130925
RNF145 ring finger protein 145 0.0130486
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0129201
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0127911
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0126178
MXI1 MAX interactor 1, dimerization protein 0.0125989
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0125448
HOOK2 hook microtubule-tethering protein 2 0.0124703
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0124041
MED13 mediator complex subunit 13 0.0121607
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.012075
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0119734
CYLD cylindromatosis (turban tumor syndrome) 0.0119177
TENT2 terminal nucleotidyltransferase 2 0.0118605
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0117986
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0116201
RAB6A RAB6A, member RAS oncogene family 0.0116178
CUL3 cullin 3 0.011501
TBK1 TANK-binding kinase 1 0.011488
KDM2A lysine (K)-specific demethylase 2A 0.011449
CREBRF CREB3 regulatory factor 0.0113509
TMF1 TATA element modulatory factor 1 0.0111646
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0111629
CHD1 chromodomain helicase DNA binding protein 1 0.0111311
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0110089
NPTN neuroplastin 0.0109847
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0109134
PGK1 phosphoglycerate kinase 1 0.0108723
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0107633
ZBTB1 zinc finger and BTB domain containing 1 0.0107378
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.010659
RLIM ring finger protein, LIM domain interacting 0.0106278
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0104906
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0104554
MYO1B myosin IB 0.0102664
NEK7 NIMA-related kinase 7 0.0102428

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.357352
EGFR epidermal growth factor receptor -0.267671
TMSB10 thymosin beta 10 -0.227096
PTMA prothymosin, alpha -0.104129
ACTG1 actin gamma 1 -0.0938729
S100A10 S100 calcium binding protein A10 -0.086513
EGR1 early growth response 1 -0.0853538
RPL35A ribosomal protein L35a -0.0852867
FTL ferritin, light polypeptide -0.0849892
TPT1 tumor protein, translationally-controlled 1 -0.0845448
PTPRM protein tyrosine phosphatase, receptor type, M -0.0742035
THSD4 thrombospondin, type I, domain containing 4 -0.0718022
CST3 cystatin C -0.0693602
RPL37A ribosomal protein L37a -0.0690292
INTS6 integrator complex subunit 6 -0.0684763
NDRG1 N-myc downstream regulated 1 -0.0676241
RPS3 ribosomal protein S3 -0.0621778
RPS25 ribosomal protein S25 -0.061728
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0616086
RPS6 ribosomal protein S6 -0.0602822
MCL1 myeloid cell leukemia 1 -0.0600189
RPS8 ribosomal protein S8 -0.0596586
RPL31 ribosomal protein L31 -0.0585143
RPLP1 ribosomal protein, large, P1 -0.0583685
MT2A metallothionein 2A -0.0535058
PKM pyruvate kinase, muscle -0.0534777
SEC61G Sec61 gamma subunit -0.053001
ASPH aspartate beta-hydroxylase -0.0500778
S100P S100 calcium binding protein P -0.0464084
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0461096
ANXA2 annexin A2 -0.0456659
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0453932
RPS12 ribosomal protein S12 -0.0444688
RPS29 ribosomal protein S29 -0.0444632
RPS17 ribosomal protein S17 -0.0430112
RPL34 ribosomal protein L34 -0.0426158
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0420672
RPL11 ribosomal protein L11 -0.0418879
IFI6 interferon, alpha-inducible protein 6 -0.0414648
FNDC3B fibronectin type III domain containing 3B -0.0412124
RPL37 ribosomal protein L37 -0.0406278
ANKRD12 ankyrin repeat domain 12 -0.0405796
RPS23 ribosomal protein S23 -0.0398446
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0392386
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0388884
CAV1 caveolin 1, caveolae protein, 22kDa -0.0379262
RPS24 ribosomal protein S24 -0.037648
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0370181
KRT7 keratin 7, type II -0.0359744
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.03575
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.035607
RPS27A ribosomal protein S27a -0.0352353
RPLP2 ribosomal protein, large, P2 -0.035221
PDLIM5 PDZ and LIM domain 5 -0.034618
HMGA1 high mobility group AT-hook 1 -0.0343776
HLA-B major histocompatibility complex, class I, B -0.0339435
B2M beta-2-microglobulin -0.0337225
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0337006
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0336019
RPS27 ribosomal protein S27 -0.0335577
IGFBP3 insulin-like growth factor binding protein 3 -0.0334805
EIF1 eukaryotic translation initiation factor 1 -0.0327646
GNAS GNAS complex locus -0.0323234
KRT18 keratin 18, type I -0.0322296
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0318383
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0315377
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0312859
RPL19 ribosomal protein L19 -0.0312728
RPL30 ribosomal protein L30 -0.031159
RPS19 ribosomal protein S19 -0.0301203
MYO1D myosin ID -0.0300428
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0298859
POTEF POTE ankyrin domain family, member F -0.0288899
RPS14 ribosomal protein S14 -0.0286018
NABP1 nucleic acid binding protein 1 -0.0285019
CUX1 cut-like homeobox 1 -0.028432
RPL36 ribosomal protein L36 -0.0280018
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0277107
IER3 immediate early response 3 -0.0274911
SCEL sciellin -0.0272253
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.027063
RPL23 ribosomal protein L23 -0.0270241
RPL5 ribosomal protein L5 -0.0269762
VCL vinculin -0.0267846
RPS13 ribosomal protein S13 -0.0265352
AREG amphiregulin -0.0264731
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0263703
LDHA lactate dehydrogenase A -0.0263659
S100A11 S100 calcium binding protein A11 -0.0263245
S100A6 S100 calcium binding protein A6 -0.0262723
S100A9 S100 calcium binding protein A9 -0.0261842
RPL9 ribosomal protein L9 -0.025814
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0251564
WASF2 WAS protein family, member 2 -0.0250475
LOC102724023 ES1 protein homolog, mitochondrial -0.0249187
SERF2 small EDRK-rich factor 2 -0.0247724
CMIP c-Maf inducing protein -0.0244511
LMO7 LIM domain 7 -0.0242925
FUS FUS RNA binding protein -0.0241875
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0239366