Vandetanib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0726993
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0717711
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0693821
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0682238
TPM3 tropomyosin 3 0.0604869
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0601767
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0584828
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0571361
WDR43 WD repeat domain 43 0.057077
ERRFI1 ERBB receptor feedback inhibitor 1 0.0561646
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0556256
ZFAND3 zinc finger, AN1-type domain 3 0.054951
ERBIN erbb2 interacting protein 0.0539228
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0530723
DENND4A DENN/MADD domain containing 4A 0.0524967
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.05186
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0509094
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0504446
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0498953
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0476381
COPA coatomer protein complex, subunit alpha 0.047514
TRA2A transformer 2 alpha homolog (Drosophila) 0.047475
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0466093
ZNF207 zinc finger protein 207 0.046368
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0462112
GLG1 golgi glycoprotein 1 0.0457605
ELL2 elongation factor, RNA polymerase II, 2 0.0456515
PDIA6 protein disulfide isomerase family A, member 6 0.0452768
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0447549
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0439658
ADAM17 ADAM metallopeptidase domain 17 0.0435347
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0428296
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0423539
PUM1 pumilio RNA-binding family member 1 0.0419798
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0419752
SEC31A SEC31 homolog A (S. cerevisiae) 0.0414513
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0397905
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0396311
TRIO trio Rho guanine nucleotide exchange factor 0.0396044
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0389096
RBM25 RNA binding motif protein 25 0.0388506
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0387097
FGB fibrinogen beta chain 0.0386664
PTMA prothymosin, alpha 0.0383653
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0373706
VMP1 vacuole membrane protein 1 0.03705
APP amyloid beta (A4) precursor protein 0.0370426
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.036917
RBM39 RNA binding motif protein 39 0.03673
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0365749
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0364699
SRP54 signal recognition particle 54kDa 0.0361833
CALR calreticulin 0.0361759
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0352163
YME1L1 YME1-like 1 ATPase 0.0327227
USP3 ubiquitin specific peptidase 3 0.0327202
PICALM phosphatidylinositol binding clathrin assembly protein 0.0324709
UBA6 ubiquitin-like modifier activating enzyme 6 0.0318592
PCBP2 poly(rC) binding protein 2 0.0317261
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0316229
SPAG9 sperm associated antigen 9 0.0315203
FMNL2 formin-like 2 0.0315116
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0310843
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0309063
BHLHE40 basic helix-loop-helix family, member e40 0.0308942
KDM3A lysine (K)-specific demethylase 3A 0.0308566
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0308203
MATR3 matrin 3 0.0305889
OSBPL9 oxysterol binding protein-like 9 0.0301799
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0301132
NOP58 NOP58 ribonucleoprotein 0.0301019
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0294552
PARD3 par-3 family cell polarity regulator 0.029303
RAB1A RAB1A, member RAS oncogene family 0.029232
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0291192
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286924
PTK2 protein tyrosine kinase 2 0.0286103
ZNF292 zinc finger protein 292 0.0282644
FUBP1 far upstream element (FUSE) binding protein 1 0.0282216
VEZT vezatin, adherens junctions transmembrane protein 0.0279893
YBX3 Y box binding protein 3 0.0277377
PLS3 plastin 3 0.0273445
CANX calnexin 0.0273041
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0271456
GOLT1B golgi transport 1B 0.0268619
CALU calumenin 0.026728
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0265979
PUM2 pumilio RNA-binding family member 2 0.0263986
RBM8A RNA binding motif protein 8A 0.0262756
SIK3 SIK family kinase 3 0.0262406
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0257814
MARCHF6 membrane associated ring-CH-type finger 6 0.0255742
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0254966
JAK1 Janus kinase 1 0.0253224
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0250552
BIRC3 baculoviral IAP repeat containing 3 0.024865
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0246931
KMT2E lysine (K)-specific methyltransferase 2E 0.0244613
YTHDC1 YTH domain containing 1 0.0243522
DSCAM Down syndrome cell adhesion molecule 0.0242067

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.144808
PDE4D phosphodiesterase 4D, cAMP-specific -0.134979
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115071
FTL ferritin, light polypeptide -0.113277
MT2A metallothionein 2A -0.0898563
TMSB10 thymosin beta 10 -0.0818527
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0812591
PM20D1 peptidase M20 domain containing 1 -0.0720709
RPLP1 ribosomal protein, large, P1 -0.0602869
RPL19 ribosomal protein L19 -0.0550177
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0396886
THSD4 thrombospondin, type I, domain containing 4 -0.0380765
RPL23 ribosomal protein L23 -0.0367089
KYNU kynureninase -0.0359991
OSMR oncostatin M receptor -0.0355247
FTH1 ferritin, heavy polypeptide 1 -0.0338298
RPL12 ribosomal protein L12 -0.0330005
IER3 immediate early response 3 -0.0324683
RPL35A ribosomal protein L35a -0.0318662
RPS29 ribosomal protein S29 -0.0315178
RPS19 ribosomal protein S19 -0.0314376
RPL31 ribosomal protein L31 -0.0304103
RPS6 ribosomal protein S6 -0.0300745
RPL11 ribosomal protein L11 -0.0292305
NNMT nicotinamide N-methyltransferase -0.0292106
SPIDR scaffolding protein involved in DNA repair -0.0253199
RPS20 ribosomal protein S20 -0.0252846
NHSL1 NHS-like 1 -0.0242703
ATP5F1E ATP synthase F1 subunit epsilon -0.0236205
TPT1 tumor protein, translationally-controlled 1 -0.0236065
ACTG1 actin gamma 1 -0.0232576
RPS8 ribosomal protein S8 -0.0229529
RPS21 ribosomal protein S21 -0.0221537
EFNA5 ephrin-A5 -0.0218293
RPL34 ribosomal protein L34 -0.0217983
RPS23 ribosomal protein S23 -0.0211569
RPL36 ribosomal protein L36 -0.0208639
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0207608
LMNA lamin A/C -0.0205026
TXNRD1 thioredoxin reductase 1 -0.0204305
PDE8A phosphodiesterase 8A -0.0200301
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0198103
ROMO1 reactive oxygen species modulator 1 -0.0197901
GNAS GNAS complex locus -0.0195619
RPS15 ribosomal protein S15 -0.0194967
RPS16 ribosomal protein S16 -0.0192273
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0191135
HMGA1 high mobility group AT-hook 1 -0.0186729
ANKRD12 ankyrin repeat domain 12 -0.0184944
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0179578
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0168989
EXOC6B exocyst complex component 6B -0.0168389
PARD3B par-3 family cell polarity regulator beta -0.016801
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0166583
RPL32 ribosomal protein L32 -0.01658
RPL26 ribosomal protein L26 -0.0160829
WWOX WW domain containing oxidoreductase -0.0158927
PTPRM protein tyrosine phosphatase, receptor type, M -0.015861
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0157716
RPS27 ribosomal protein S27 -0.015648
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.015448
RPS5 ribosomal protein S5 -0.0153976
DST dystonin -0.0152008
AGO2 argonaute RISC catalytic component 2 -0.0151361
PFN1 profilin 1 -0.0151297
RPL27 ribosomal protein L27 -0.0148007
TTC28 tetratricopeptide repeat domain 28 -0.0147727
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0146421
PRKD1 protein kinase D1 -0.0143195
HMGB1 high mobility group box 1 -0.0142899
RPL36AL ribosomal protein L36a-like -0.014247
BICC1 BicC family RNA binding protein 1 -0.0136957
RPS11 ribosomal protein S11 -0.0134533
DEK DEK proto-oncogene -0.0132927
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.013283
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0132611
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0131546
RPS14 ribosomal protein S14 -0.0130656
S100A11 S100 calcium binding protein A11 -0.0129838
RPS27A ribosomal protein S27a -0.0129802
HEBP2 heme binding protein 2 -0.0128884
ZNF638 zinc finger protein 638 -0.0128772
RPL28 ribosomal protein L28 -0.0128712
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0128418
TFPI2 tissue factor pathway inhibitor 2 -0.012624
MGST1 microsomal glutathione S-transferase 1 -0.012499
COL4A5 collagen, type IV, alpha 5 -0.0124527
RSPO3 R-spondin 3 -0.0123189
NPC1 Niemann-Pick disease, type C1 -0.0122907
PRDX1 peroxiredoxin 1 -0.0119968
JAZF1 JAZF zinc finger 1 -0.011964
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.0119485
FHIT fragile histidine triad -0.0118236
TMEM131 transmembrane protein 131 -0.0117754
CEP112 centrosomal protein 112kDa -0.0117269
NEMF nuclear export mediator factor -0.01172
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0116734
RPLP0 ribosomal protein, large, P0 -0.011618
RPL9 ribosomal protein L9 -0.0115208
S100A10 S100 calcium binding protein A10 -0.0114494