Vandetanib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vandetanib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.164261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.115495
ERRFI1 ERBB receptor feedback inhibitor 1 0.107858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.104639
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0798009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0647173
ZCCHC7 zinc finger, CCHC domain containing 7 0.0646379
CANX calnexin 0.0559473
MCL1 myeloid cell leukemia 1 0.0558481
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0555234
TPM3 tropomyosin 3 0.052048
COPA coatomer protein complex, subunit alpha 0.0474675
USP34 ubiquitin specific peptidase 34 0.0442258
KDM3A lysine (K)-specific demethylase 3A 0.043223
CSDE1 cold shock domain containing E1, RNA-binding 0.0431395
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0418938
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.041383
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0410087
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0408227
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0396483
ZNF207 zinc finger protein 207 0.0394132
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0374002
VCL vinculin 0.0363285
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0354364
KDM2A lysine (K)-specific demethylase 2A 0.0353765
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0351337
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0346285
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0342006
EXT1 exostosin glycosyltransferase 1 0.0339495
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0333263
RAD51B RAD51 paralog B 0.0332662
XPO1 exportin 1 0.0332185
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0330613
ZFC3H1 zinc finger, C3H1-type containing 0.0329698
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0327864
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0321599
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0321583
PGK1 phosphoglycerate kinase 1 0.032027
PYGL phosphorylase, glycogen, liver 0.0320185
VMP1 vacuole membrane protein 1 0.031686
BIRC6 baculoviral IAP repeat containing 6 0.0314325
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0311032
CAMTA1 calmodulin binding transcription activator 1 0.0310371
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0306403
KMT5B lysine methyltransferase 5B 0.0301673
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0299902
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0299689
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0295006
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0294783
AHNAK AHNAK nucleoprotein 0.0287799
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0280128
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0279283
SRP54 signal recognition particle 54kDa 0.0278745
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0275606
IPO7 importin 7 0.0274999
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0270188
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0266947
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0264235
PDIA4 protein disulfide isomerase family A, member 4 0.02582
PDIA6 protein disulfide isomerase family A, member 6 0.0255052
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0253223
FBXO11 F-box protein 11 0.0251781
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0251198
CLTC clathrin, heavy chain (Hc) 0.0248715
FXR1 fragile X mental retardation, autosomal homolog 1 0.024871
AFF3 AF4/FMR2 family, member 3 0.0248409
BZW1 basic leucine zipper and W2 domains 1 0.0245562
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0244947
HMGA2 high mobility group AT-hook 2 0.0243485
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.024337
RYK receptor-like tyrosine kinase 0.024219
TPM4 tropomyosin 4 0.0241741
SSR1 signal sequence receptor, alpha 0.0240862
TOP2B topoisomerase (DNA) II beta 180kDa 0.0240677
UBE2H ubiquitin-conjugating enzyme E2H 0.0240145
KPNB1 karyopherin (importin) beta 1 0.0237561
NF1 neurofibromin 1 0.0237164
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0236996
ANO6 anoctamin 6 0.023606
CALR calreticulin 0.0235099
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0234008
PATJ PATJ crumbs cell polarity complex component 0.023249
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0231292
HDLBP high density lipoprotein binding protein 0.023059
SND1 staphylococcal nuclease and tudor domain containing 1 0.0230404
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0230369
LARS1 leucyl-tRNA synthetase 1 0.0229141
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0227425
NUP58 nucleoporin 58 0.0226115
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0225257
LMAN1 lectin, mannose-binding, 1 0.0225221
CKAP5 cytoskeleton associated protein 5 0.0223639
RAD21 RAD21 homolog (S. pombe) 0.0220509
NAP1L1 nucleosome assembly protein 1-like 1 0.0220133
PTMA prothymosin, alpha 0.0219584
SERINC1 serine incorporator 1 0.0217609
NABP1 nucleic acid binding protein 1 0.0217357
UBE3C ubiquitin protein ligase E3C 0.021567
RAB1A RAB1A, member RAS oncogene family 0.0215341
COPB1 coatomer protein complex, subunit beta 1 0.021532

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.161283
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152915
TFPI2 tissue factor pathway inhibitor 2 -0.131348
YBX3 Y box binding protein 3 -0.0915924
EGR1 early growth response 1 -0.0714949
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0568585
RPLP1 ribosomal protein, large, P1 -0.0557698
RPL35A ribosomal protein L35a -0.0547262
TPI1 triosephosphate isomerase 1 -0.0544756
RPS8 ribosomal protein S8 -0.0521759
GRAMD1B GRAM domain containing 1B -0.0514445
RPL34 ribosomal protein L34 -0.0498688
RPL23 ribosomal protein L23 -0.0494225
RPL12 ribosomal protein L12 -0.0488784
EIF5B eukaryotic translation initiation factor 5B -0.0485022
RPS19 ribosomal protein S19 -0.0480112
YBX1 Y box binding protein 1 -0.0475335
RPL5 ribosomal protein L5 -0.0469898
MT2A metallothionein 2A -0.0469267
RPL36 ribosomal protein L36 -0.046832
RPL37A ribosomal protein L37a -0.0465806
RPL26 ribosomal protein L26 -0.046412
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0461147
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0452123
RPLP2 ribosomal protein, large, P2 -0.0437399
RPL19 ribosomal protein L19 -0.0433086
RPS15 ribosomal protein S15 -0.0431952
RPL38 ribosomal protein L38 -0.0417217
RPS6 ribosomal protein S6 -0.0413892
RPL31 ribosomal protein L31 -0.0399551
RPL9 ribosomal protein L9 -0.0387581
RPS21 ribosomal protein S21 -0.0382354
FTL ferritin, light polypeptide -0.0377141
RPS27 ribosomal protein S27 -0.0368995
VIM vimentin -0.0368171
TPM2 tropomyosin 2 (beta) -0.0367111
RPS10 ribosomal protein S10 -0.0358686
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0346224
RPL32 ribosomal protein L32 -0.0343691
RPL37 ribosomal protein L37 -0.0341884
PFN1 profilin 1 -0.0340823
RPL27 ribosomal protein L27 -0.0328009
ATP5F1E ATP synthase F1 subunit epsilon -0.0321701
TXNRD1 thioredoxin reductase 1 -0.0312114
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0310729
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0310029
LDHB lactate dehydrogenase B -0.0307406
TM4SF1 transmembrane 4 L six family member 1 -0.0304505
RPS29 ribosomal protein S29 -0.0303238
RPL28 ribosomal protein L28 -0.0302161
RPL8 ribosomal protein L8 -0.0290902
RPS12 ribosomal protein S12 -0.0283503
SEC61G Sec61 gamma subunit -0.0283438
NACA nascent polypeptide-associated complex alpha subunit -0.027685
RPL11 ribosomal protein L11 -0.0268193
RPS17 ribosomal protein S17 -0.0262384
RPL13A ribosomal protein L13a -0.0261466
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0257334
SEPTIN7 septin 7 -0.025706
RPS4X ribosomal protein S4, X-linked -0.0252114
ATP11A ATPase, class VI, type 11A -0.0251864
RACK1 receptor for activated C kinase 1 -0.0246086
DEK DEK proto-oncogene -0.0244911
RPL30 ribosomal protein L30 -0.0244417
S100A11 S100 calcium binding protein A11 -0.0243738
HMGA1 high mobility group AT-hook 1 -0.0238498
TUBA1B tubulin, alpha 1b -0.0236947
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0236416
SLC38A2 solute carrier family 38, member 2 -0.0234351
RPS23 ribosomal protein S23 -0.0229431
HMGB1 high mobility group box 1 -0.0227429
RPL35 ribosomal protein L35 -0.0222024
RIMS2 regulating synaptic membrane exocytosis 2 -0.0221653
MEF2D myocyte enhancer factor 2D -0.0221566
RNF145 ring finger protein 145 -0.0219816
TBK1 TANK-binding kinase 1 -0.0218312
IFI6 interferon, alpha-inducible protein 6 -0.0216577
POTEF POTE ankyrin domain family, member F -0.0215066
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.02114
RPLP0 ribosomal protein, large, P0 -0.0211103
BASP1 brain abundant, membrane attached signal protein 1 -0.021089
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0208412
RASAL2 RAS protein activator like 2 -0.0208336
EEF1G eukaryotic translation elongation factor 1 gamma -0.020816
B2M beta-2-microglobulin -0.0203068
MYL12B myosin, light chain 12B, regulatory -0.0199942
GSTP1 glutathione S-transferase pi 1 -0.0198627
PNISR PNN-interacting serine/arginine-rich protein -0.0198511
PRDX1 peroxiredoxin 1 -0.0198003
ACTG1 actin gamma 1 -0.019709
RPL18 ribosomal protein L18 -0.0196287
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0191476
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0188983
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0187807
RPS16 ribosomal protein S16 -0.0186451
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0184311
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0184154
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0183667
RPS25 ribosomal protein S25 -0.0182853
BRD2 bromodomain containing 2 -0.018051