Vandetanib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106456
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0826716
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0560991
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0540157
TMSB4X thymosin beta 4, X-linked 0.0476573
MATR3 matrin 3 0.0473861
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.046027
NCKAP1 NCK-associated protein 1 0.0427608
USP3 ubiquitin specific peptidase 3 0.0414706
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0408417
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0407698
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0402455
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0387286
PEG10 paternally expressed 10 0.0375534
NOP58 NOP58 ribonucleoprotein 0.0372752
SRP54 signal recognition particle 54kDa 0.0365373
MTF2 metal response element binding transcription factor 2 0.0360932
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0350348
SET SET nuclear proto-oncogene 0.0316461
ATAD2 ATPase family, AAA domain containing 2 0.0295352
PUM1 pumilio RNA-binding family member 1 0.0291238
PCBP2 poly(rC) binding protein 2 0.0290215
HMGB2 high mobility group box 2 0.0284259
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0280996
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0278311
ATP5F1B ATP synthase F1 subunit beta 0.0276299
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0275316
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0274318
ZNF292 zinc finger protein 292 0.0274057
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0272473
PDIA6 protein disulfide isomerase family A, member 6 0.0271954
FUBP1 far upstream element (FUSE) binding protein 1 0.0271633
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0266292
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.026505
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0263424
FAM171B family with sequence similarity 171, member B 0.0261121
PDGFC platelet derived growth factor C 0.0259498
KIF1B kinesin family member 1B 0.025776
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0257619
THBS1 thrombospondin 1 0.0257513
OLA1 Obg-like ATPase 1 0.0251644
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0249907
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0245892
BCLAF1 BCL2-associated transcription factor 1 0.0244374
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0241831
MEMO1 mediator of cell motility 1 0.0235246
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0233727
PA2G4 proliferation-associated 2G4, 38kDa 0.0232563
MRPS30 mitochondrial ribosomal protein S30 0.0232415
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0231242
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0223589
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0219448
HDAC2 histone deacetylase 2 0.0217489
YBX1 Y box binding protein 1 0.0217164
CKAP2 cytoskeleton associated protein 2 0.0215431
MYH10 myosin, heavy chain 10, non-muscle 0.0211587
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0210836
CSDE1 cold shock domain containing E1, RNA-binding 0.02104
COPB1 coatomer protein complex, subunit beta 1 0.0209523
UBE2B ubiquitin-conjugating enzyme E2B 0.0208309
TLK1 tousled-like kinase 1 0.0207718
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0207684
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0206542
KAT6A K(lysine) acetyltransferase 6A 0.0202875
SPAG9 sperm associated antigen 9 0.0199246
IWS1 IWS1 homolog (S. cerevisiae) 0.0198214
VDAC1 voltage-dependent anion channel 1 0.019642
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0192443
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0190494
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0189774
RDX radixin 0.0188665
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0187948
OSBPL8 oxysterol binding protein-like 8 0.0187136
CRY1 cryptochrome circadian clock 1 0.0186525
YAP1 Yes-associated protein 1 0.0186105
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.018585
RBM25 RNA binding motif protein 25 0.0185228
TYMS thymidylate synthetase 0.0184319
BZW1 basic leucine zipper and W2 domains 1 0.0183822
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0182071
UBQLN1 ubiquilin 1 0.0181378
UBA2 ubiquitin-like modifier activating enzyme 2 0.0180962
PAWR PRKC, apoptosis, WT1, regulator 0.0180485
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0180288
RSRC2 arginine/serine-rich coiled-coil 2 0.0180176
AFF4 AF4/FMR2 family, member 4 0.0179592
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0177554
RHEB Ras homolog enriched in brain 0.0177396
MORF4L1 mortality factor 4 like 1 0.0175261
HDAC9 histone deacetylase 9 0.0174498
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0173553
SEPTIN7 septin 7 0.0170789
FAM168A family with sequence similarity 168, member A 0.0170273
BAG4 BCL2-associated athanogene 4 0.017018
ECT2 epithelial cell transforming 2 0.0169875
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0169596
SMC3 structural maintenance of chromosomes 3 0.0169449
TLK2 tousled-like kinase 2 0.0169004
RTN4 reticulon 4 0.0168789
CKAP5 cytoskeleton associated protein 5 0.0168382

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.159044
CADM2 cell adhesion molecule 2 -0.148022
COL11A1 collagen, type XI, alpha 1 -0.120234
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.10853
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.101788
TENM3 teneurin transmembrane protein 3 -0.0745666
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0734596
PARD3B par-3 family cell polarity regulator beta -0.0698388
PTMA prothymosin, alpha -0.0677014
TMSB10 thymosin beta 10 -0.0649867
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0645424
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0643654
VIM vimentin -0.0622151
PCLO piccolo presynaptic cytomatrix protein -0.0582193
TRIO trio Rho guanine nucleotide exchange factor -0.0570789
WSB1 WD repeat and SOCS box containing 1 -0.0554624
ADGRV1 adhesion G protein-coupled receptor V1 -0.0541028
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0536723
PCDH9 protocadherin 9 -0.0517828
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0504992
SLIT2 slit homolog 2 (Drosophila) -0.0475235
FTL ferritin, light polypeptide -0.0467744
FNDC3B fibronectin type III domain containing 3B -0.0464229
MDK midkine (neurite growth-promoting factor 2) -0.0463562
NPAS3 neuronal PAS domain protein 3 -0.0423803
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0419237
RPS8 ribosomal protein S8 -0.0412385
GPC3 glypican 3 -0.0394589
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0383706
RAD51B RAD51 paralog B -0.0362569
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0361823
ADGRL2 adhesion G protein-coupled receptor L2 -0.0354225
SNX6 sorting nexin 6 -0.0346607
RPS16 ribosomal protein S16 -0.0346361
RPS6 ribosomal protein S6 -0.0326739
CSMD3 CUB and Sushi multiple domains 3 -0.0325616
RPL35A ribosomal protein L35a -0.0307318
CUX1 cut-like homeobox 1 -0.0305451
RPL37 ribosomal protein L37 -0.0304049
SAMD4A sterile alpha motif domain containing 4A -0.0300508
SHROOM3 shroom family member 3 -0.0298477
HMCN1 hemicentin 1 -0.0292712
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0290902
AHNAK AHNAK nucleoprotein -0.028385
KCTD16 potassium channel tetramerization domain containing 16 -0.0281298
NCOR2 nuclear receptor corepressor 2 -0.0280618
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0279035
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0278094
PCDH7 protocadherin 7 -0.0277574
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0270642
RPL31 ribosomal protein L31 -0.0269194
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0267108
MBD5 methyl-CpG binding domain protein 5 -0.0265668
ADGRL3 adhesion G protein-coupled receptor L3 -0.0262176
NEBL nebulette -0.026213
DOCK5 dedicator of cytokinesis 5 -0.025527
SMYD3 SET and MYND domain containing 3 -0.0255141
RAB31 RAB31, member RAS oncogene family -0.0254639
TPT1 tumor protein, translationally-controlled 1 -0.0251684
TRPS1 trichorhinophalangeal syndrome I -0.025025
RPLP1 ribosomal protein, large, P1 -0.0249597
NTM neurotrimin -0.0244965
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0244679
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0240602
ATXN1 ataxin 1 -0.0239152
LRRC4C leucine rich repeat containing 4C -0.0238757
NIPBL Nipped-B homolog (Drosophila) -0.0237911
RPL36 ribosomal protein L36 -0.0237082
TTC28 tetratricopeptide repeat domain 28 -0.0235662
NXN nucleoredoxin -0.023499
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0232824
BCAS3 breast carcinoma amplified sequence 3 -0.0232651
ANKRD33B ankyrin repeat domain 33B -0.0232133
LHFPL6 LHFPL tetraspan subfamily member 6 -0.022998
ANK2 ankyrin 2, neuronal -0.0228334
MAML2 mastermind-like 2 (Drosophila) -0.0228172
RPS21 ribosomal protein S21 -0.0227649
GSE1 Gse1 coiled-coil protein -0.0227633
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0226154
BPTF bromodomain PHD finger transcription factor -0.0225428
NRG1 neuregulin 1 -0.0223175
PRSS23 protease, serine, 23 -0.0222025
VCL vinculin -0.0221872
PBX3 pre-B-cell leukemia homeobox 3 -0.0220161
RPLP2 ribosomal protein, large, P2 -0.0220109
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0218841
RPL34 ribosomal protein L34 -0.0217563
NCAM2 neural cell adhesion molecule 2 -0.0217026
GREB1L growth regulation by estrogen in breast cancer-like -0.0216389
B2M beta-2-microglobulin -0.0215069
RASAL2 RAS protein activator like 2 -0.0211942
RPS13 ribosomal protein S13 -0.02116
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0207403
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.020655
LRMDA leucine rich melanocyte differentiation associated -0.0203582
ITSN1 intersectin 1 (SH3 domain protein) -0.0203087
NFIA nuclear factor I/A -0.0202459
FBXO17 F-box protein 17 -0.0197828
ARHGAP24 Rho GTPase activating protein 24 -0.019766
PRELID2 PRELI domain containing 2 -0.0196864