Vandetanib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.111376
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0683495
EIF4A2 eukaryotic translation initiation factor 4A2 0.0625673
GOLGA4 golgin A4 0.0569882
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0515065
NUP58 nucleoporin 58 0.0493028
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0443556
TTC3 tetratricopeptide repeat domain 3 0.0440134
ECT2 epithelial cell transforming 2 0.043568
ADAM10 ADAM metallopeptidase domain 10 0.0415284
TXNIP thioredoxin interacting protein 0.0413895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0363778
RAB6A RAB6A, member RAS oncogene family 0.036337
MATR3 matrin 3 0.0331364
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0311734
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0306275
NBAS neuroblastoma amplified sequence 0.029961
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0294578
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.02935
COG6 component of oligomeric golgi complex 6 0.0292813
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0288226
XPO1 exportin 1 0.0284607
PTBP2 polypyrimidine tract binding protein 2 0.0282641
RNMT RNA (guanine-7-) methyltransferase 0.0281335
TMSB4X thymosin beta 4, X-linked 0.027787
ENO1 enolase 1, (alpha) 0.0274285
CALU calumenin 0.027248
RNF145 ring finger protein 145 0.0271315
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0267041
COPB1 coatomer protein complex, subunit beta 1 0.0265301
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.026483
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0253479
KMT2E lysine (K)-specific methyltransferase 2E 0.0253444
PLK2 polo-like kinase 2 0.0250221
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0242985
INSIG2 insulin induced gene 2 0.0242579
CD47 CD47 molecule 0.0238334
TMF1 TATA element modulatory factor 1 0.0237164
ZCCHC7 zinc finger, CCHC domain containing 7 0.0235043
LOC112694756 uncharaterized LOC112694756 0.023375
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0232316
TMEM39A transmembrane protein 39A 0.0230995
ZMYM2 zinc finger, MYM-type 2 0.023059
SRP54 signal recognition particle 54kDa 0.022781
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0227088
TOP2B topoisomerase (DNA) II beta 180kDa 0.0226569
PRRC1 proline-rich coiled-coil 1 0.0225877
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0222767
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0220265
KDM6A lysine (K)-specific demethylase 6A 0.0219417
ARRDC3 arrestin domain containing 3 0.0212097
KIF5B kinesin family member 5B 0.0211657
UBA6 ubiquitin-like modifier activating enzyme 6 0.0209845
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0208775
HILPDA hypoxia inducible lipid droplet-associated 0.0208594
HELZ helicase with zinc finger 0.0207667
QKI QKI, KH domain containing, RNA binding 0.0205777
CASC3 cancer susceptibility candidate 3 0.0205042
ZNF292 zinc finger protein 292 0.0204332
SEC23A Sec23 homolog A (S. cerevisiae) 0.02017
SEC24A SEC24 family member A 0.0201284
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.020002
SUCO SUN domain containing ossification factor 0.0199615
LDHA lactate dehydrogenase A 0.0199338
NGLY1 N-glycanase 1 0.0198642
ACBD3 acyl-CoA binding domain containing 3 0.0196844
SCAF11 SR-related CTD-associated factor 11 0.0193943
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0192128
ARF4 ADP-ribosylation factor 4 0.0191965
PCM1 pericentriolar material 1 0.0190834
PGK1 phosphoglycerate kinase 1 0.0190648
TMEM41B transmembrane protein 41B 0.0188495
NCKAP1 NCK-associated protein 1 0.0188348
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0185849
ITCH itchy E3 ubiquitin protein ligase 0.0183612
CD164 CD164 molecule, sialomucin 0.0182753
GPR107 G protein-coupled receptor 107 0.0181939
RLF rearranged L-myc fusion 0.0180217
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0179962
PNISR PNN-interacting serine/arginine-rich protein 0.0179584
PICALM phosphatidylinositol binding clathrin assembly protein 0.0177142
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.017704
PHIP pleckstrin homology domain interacting protein 0.0176543
CDC73 cell division cycle 73 0.0176288
CSDE1 cold shock domain containing E1, RNA-binding 0.0175435
COPA coatomer protein complex, subunit alpha 0.0175363
OXSR1 oxidative stress responsive 1 0.0175127
PGM3 phosphoglucomutase 3 0.0174394
SMC3 structural maintenance of chromosomes 3 0.0173754
GDI2 GDP dissociation inhibitor 2 0.0171939
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0171497
SSR1 signal sequence receptor, alpha 0.0170419
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0169413
TP53BP1 tumor protein p53 binding protein 1 0.0168406
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.016819
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0167413
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0167179
TNRC6B trinucleotide repeat containing 6B 0.0166799
SEC63 SEC63 homolog (S. cerevisiae) 0.0166525
ADAM17 ADAM metallopeptidase domain 17 0.0165971

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.149367
RPS6 ribosomal protein S6 -0.0927189
FOXP1 forkhead box P1 -0.0800344
PDE4B phosphodiesterase 4B, cAMP-specific -0.0783354
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0772629
TPT1 tumor protein, translationally-controlled 1 -0.0755268
AHNAK AHNAK nucleoprotein -0.0718527
RPS8 ribosomal protein S8 -0.069094
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0676708
RPL35A ribosomal protein L35a -0.0669845
BMP10 bone morphogenetic protein 10 -0.0653759
RPL34 ribosomal protein L34 -0.0626945
RPL9 ribosomal protein L9 -0.0575723
RPLP1 ribosomal protein, large, P1 -0.0573299
PTMA prothymosin, alpha -0.0568905
RPL31 ribosomal protein L31 -0.0564607
RPL26 ribosomal protein L26 -0.0559518
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0538166
PKM pyruvate kinase, muscle -0.0534705
EGFR epidermal growth factor receptor -0.0531539
ACTG1 actin gamma 1 -0.0496465
NBEA neurobeachin -0.0475132
RPL23 ribosomal protein L23 -0.0446571
RPLP2 ribosomal protein, large, P2 -0.0445134
RPL37A ribosomal protein L37a -0.0441316
RPS27A ribosomal protein S27a -0.0438349
ZMYND8 zinc finger, MYND-type containing 8 -0.0430455
RPS25 ribosomal protein S25 -0.0428366
RPL36 ribosomal protein L36 -0.0427426
RPL19 ribosomal protein L19 -0.0414009
RPS19 ribosomal protein S19 -0.040438
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0389799
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.038467
RPS23 ribosomal protein S23 -0.0375706
RPL11 ribosomal protein L11 -0.0369893
RPS13 ribosomal protein S13 -0.0365928
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0364843
GLI2 GLI family zinc finger 2 -0.035011
RPS29 ribosomal protein S29 -0.0347259
FLNB filamin B, beta -0.0346391
DLG1 discs, large homolog 1 (Drosophila) -0.0335346
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0326451
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0322555
CCND1 cyclin D1 -0.0320683
TAS2R14 taste receptor, type 2, member 14 -0.0310465
RPL38 ribosomal protein L38 -0.030105
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0298273
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0297615
PDGFC platelet derived growth factor C -0.0290708
PYGB phosphorylase, glycogen; brain -0.028973
IFI16 interferon, gamma-inducible protein 16 -0.0285543
RPS3 ribosomal protein S3 -0.0276752
RPS4X ribosomal protein S4, X-linked -0.0276022
RACK1 receptor for activated C kinase 1 -0.0274905
RPS21 ribosomal protein S21 -0.0273327
GLI3 GLI family zinc finger 3 -0.0270646
RPL28 ribosomal protein L28 -0.0265548
S100A10 S100 calcium binding protein A10 -0.026418
TTC28 tetratricopeptide repeat domain 28 -0.0261054
RPL37 ribosomal protein L37 -0.0259633
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0251961
AOPEP aminopeptidase O (putative) -0.0250663
RPL18 ribosomal protein L18 -0.0247871
UBC ubiquitin C -0.0246326
ANKRD17 ankyrin repeat domain 17 -0.0245422
MYL12B myosin, light chain 12B, regulatory -0.0245291
MYO5C myosin VC -0.0244124
SOX6 SRY (sex determining region Y)-box 6 -0.0243898
EFNA5 ephrin-A5 -0.0241324
VIM vimentin -0.0241175
RPL7A ribosomal protein L7a -0.0241124
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0240322
RPL36A ribosomal protein L36a -0.0237729
GNAS GNAS complex locus -0.0237545
RPS15 ribosomal protein S15 -0.0236567
HEG1 heart development protein with EGF-like domains 1 -0.0236377
RPS27 ribosomal protein S27 -0.0236169
S100A9 S100 calcium binding protein A9 -0.0235174
RPS16 ribosomal protein S16 -0.0233932
HMGB1 high mobility group box 1 -0.0232376
RPS10 ribosomal protein S10 -0.0230581
RPS24 ribosomal protein S24 -0.0229013
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.022583
SMYD3 SET and MYND domain containing 3 -0.0223473
RPS12 ribosomal protein S12 -0.0222474
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0221341
GSE1 Gse1 coiled-coil protein -0.0218838
RPL8 ribosomal protein L8 -0.0215447
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0214106
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0211107
EXOC6B exocyst complex component 6B -0.0210649
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0209469
DUSP4 dual specificity phosphatase 4 -0.0208918
MACROD2 MACRO domain containing 2 -0.020849
RPS2 ribosomal protein S2 -0.0207663
TCF12 transcription factor 12 -0.0207303
PTPRG protein tyrosine phosphatase, receptor type, G -0.0206589
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0204748
TUBB4B tubulin, beta 4B class IVb -0.02046
DIAPH3 diaphanous-related formin 3 -0.0203388