Vandetanib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.0535236
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0494419
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0493163
ELL2 elongation factor, RNA polymerase II, 2 0.0491131
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0463345
CANX calnexin 0.0423897
NPEPPS aminopeptidase puromycin sensitive 0.039444
KDM3A lysine (K)-specific demethylase 3A 0.0394237
PGK1 phosphoglycerate kinase 1 0.0368001
TPT1 tumor protein, translationally-controlled 1 0.0365008
TMSB4X thymosin beta 4, X-linked 0.0315204
AKAP12 A kinase (PRKA) anchor protein 12 0.0294379
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0281772
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0280557
AFF4 AF4/FMR2 family, member 4 0.0277622
SERINC1 serine incorporator 1 0.0256007
COPB1 coatomer protein complex, subunit beta 1 0.0252549
THBS2 thrombospondin 2 0.0252065
MXI1 MAX interactor 1, dimerization protein 0.0245109
STAG2 stromal antigen 2 0.0242935
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0241219
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0239112
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0237825
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0237072
PDE10A phosphodiesterase 10A 0.0235892
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0234654
SRP54 signal recognition particle 54kDa 0.0232563
ESYT2 extended synaptotagmin-like protein 2 0.0232048
SPAG9 sperm associated antigen 9 0.0230921
NAP1L1 nucleosome assembly protein 1-like 1 0.0227615
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0222668
ANLN anillin, actin binding protein 0.0219327
OGA O-GlcNAcase 0.0218921
LAMP2 lysosomal-associated membrane protein 2 0.0218688
ATP13A3 ATPase type 13A3 0.0214695
NF1 neurofibromin 1 0.0213998
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.020642
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0202871
CTNND1 catenin (cadherin-associated protein), delta 1 0.0202143
VDAC1 voltage-dependent anion channel 1 0.0197441
SFTPA2 surfactant protein A2 0.019506
USP9X ubiquitin specific peptidase 9, X-linked 0.0192375
RAB6A RAB6A, member RAS oncogene family 0.0188715
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.018871
CADM1 cell adhesion molecule 1 0.018769
BZW1 basic leucine zipper and W2 domains 1 0.0184275
SNX13 sorting nexin 13 0.0181821
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0181188
ITCH itchy E3 ubiquitin protein ligase 0.0179846
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0179762
OSBPL8 oxysterol binding protein-like 8 0.0177249
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0177153
TNPO1 transportin 1 0.0176437
KPNB1 karyopherin (importin) beta 1 0.0176217
AHNAK AHNAK nucleoprotein 0.0175739
NIPBL Nipped-B homolog (Drosophila) 0.017407
WDR45B WD repeat domain 45B 0.0172991
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0172474
CREBRF CREB3 regulatory factor 0.0172345
SBF2 SET binding factor 2 0.0171562
CCDC47 coiled-coil domain containing 47 0.0169193
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0168837
CUL4B cullin 4B 0.016875
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0167984
CAVIN1 caveolae associated protein 1 0.0167664
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0166573
ARB2A ARB2 cotranscriptional regulator A 0.0166391
ERRFI1 ERBB receptor feedback inhibitor 1 0.0166115
RAD21 RAD21 homolog (S. pombe) 0.0161974
CEP350 centrosomal protein 350kDa 0.0160713
FAM20C family with sequence similarity 20, member C 0.016064
FN1 fibronectin 1 0.0160356
CD164 CD164 molecule, sialomucin 0.0160118
TGFB2 transforming growth factor, beta 2 0.0159698
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.015901
WSB1 WD repeat and SOCS box containing 1 0.0158579
HBP1 HMG-box transcription factor 1 0.0157554
FLNB filamin B, beta 0.0155346
FBXO42 F-box protein 42 0.0151467
MATR3 matrin 3 0.0150803
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0148954
BIRC6 baculoviral IAP repeat containing 6 0.0148603
SDCBP syndecan binding protein (syntenin) 0.014811
ZNF654 zinc finger protein 654 0.0147707
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0147512
STAU1 staufen double-stranded RNA binding protein 1 0.0146654
ABI1 abl-interactor 1 0.014665
ANKHD1 ankyrin repeat and KH domain containing 1 0.0146585
CD2AP CD2-associated protein 0.0145672
SEC31A SEC31 homolog A (S. cerevisiae) 0.0145489
SETD2 SET domain containing 2 0.0144143
PHF3 PHD finger protein 3 0.0142892
KMT2C lysine (K)-specific methyltransferase 2C 0.014279
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0142381
LOX lysyl oxidase 0.0142076
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0141556
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0141272
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0137323
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0137113
RIOK3 RIO kinase 3 0.0135698

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.161815
TMSB10 thymosin beta 10 -0.126956
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0829708
HLA-B major histocompatibility complex, class I, B -0.079714
VEGFA vascular endothelial growth factor A -0.0787679
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0738627
MT2A metallothionein 2A -0.0703276
RPS6 ribosomal protein S6 -0.0699259
CD44 CD44 molecule (Indian blood group) -0.0637998
FTL ferritin, light polypeptide -0.0624104
C3 complement component 3 -0.0517283
RPS12 ribosomal protein S12 -0.0482882
RPL23 ribosomal protein L23 -0.0420529
RPL37A ribosomal protein L37a -0.0418509
FRMD4A FERM domain containing 4A -0.0418072
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0417067
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0403722
B2M beta-2-microglobulin -0.0389373
MSN moesin -0.0389018
UBC ubiquitin C -0.0379
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0378155
RPS3 ribosomal protein S3 -0.0377958
TNS3 tensin 3 -0.0368369
RPLP2 ribosomal protein, large, P2 -0.0367656
RPS19 ribosomal protein S19 -0.0366307
EGR1 early growth response 1 -0.0360744
IFITM3 interferon induced transmembrane protein 3 -0.0355253
RPS27A ribosomal protein S27a -0.0355039
PKM pyruvate kinase, muscle -0.0348097
FNDC3B fibronectin type III domain containing 3B -0.0327909
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0327434
SRRM2 serine/arginine repetitive matrix 2 -0.0323296
TPM1 tropomyosin 1 (alpha) -0.0315502
LDHA lactate dehydrogenase A -0.0315042
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0300773
FTH1 ferritin, heavy polypeptide 1 -0.029937
EEF2 eukaryotic translation elongation factor 2 -0.0297771
RPS14 ribosomal protein S14 -0.0293183
HMGA1 high mobility group AT-hook 1 -0.0287963
ENO2 enolase 2 (gamma, neuronal) -0.0287712
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0287022
BICC1 BicC family RNA binding protein 1 -0.0284429
NAV1 neuron navigator 1 -0.0284369
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.028063
RPL36 ribosomal protein L36 -0.0279166
IER3 immediate early response 3 -0.0278153
RPL5 ribosomal protein L5 -0.027612
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0273752
RNF213 ring finger protein 213 -0.0271245
DST dystonin -0.0266874
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0264015
RPL19 ribosomal protein L19 -0.0262838
HDAC9 histone deacetylase 9 -0.0260878
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0259625
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0256472
HLA-A major histocompatibility complex, class I, A -0.0252723
RPS8 ribosomal protein S8 -0.0252468
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0251119
ATXN1 ataxin 1 -0.0250121
RPL9 ribosomal protein L9 -0.024825
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0248196
COL6A3 collagen, type VI, alpha 3 -0.0248166
NAV2 neuron navigator 2 -0.0247111
MX1 MX dynamin-like GTPase 1 -0.0244348
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.024367
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0242305
ANKRD11 ankyrin repeat domain 11 -0.0240945
EEF1G eukaryotic translation elongation factor 1 gamma -0.0233968
RPS23 ribosomal protein S23 -0.0233654
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0233223
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0230441
FLNA filamin A, alpha -0.022926
FRMPD4 FERM and PDZ domain containing 4 -0.0226489
NCOR2 nuclear receptor corepressor 2 -0.0218622
POTEF POTE ankyrin domain family, member F -0.021794
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0217718
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0215824
TAPBP TAP binding protein (tapasin) -0.0212761
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0210433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0209776
RPS4X ribosomal protein S4, X-linked -0.0209683
PFN1 profilin 1 -0.0209616
DEK DEK proto-oncogene -0.020818
RPS29 ribosomal protein S29 -0.0207947
RPS10 ribosomal protein S10 -0.0206936
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0201264
RPL26 ribosomal protein L26 -0.0197767
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0197694
WTAP Wilms tumor 1 associated protein -0.0196676
RPL28 ribosomal protein L28 -0.0196584
RIGI RNA sensor RIG-I -0.0194529
BRD4 bromodomain containing 4 -0.0194111
ISG15 ISG15 ubiquitin-like modifier -0.0193082
PRR16 proline rich 16 -0.0192121
EGFR epidermal growth factor receptor -0.0191362
AFF3 AF4/FMR2 family, member 3 -0.0189571
DEPP1 DEPP autophagy regulator 1 -0.0189363
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0187899
RPL27 ribosomal protein L27 -0.0187616
RPL35A ribosomal protein L35a -0.0187444