Vandetanib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vandetanib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vandetanib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0862086
CANX calnexin 0.0678129
CXCL8 chemokine (C-X-C motif) ligand 8 0.0599393
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0581232
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0522253
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.045534
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0335367
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0308294
PRRC2C proline-rich coiled-coil 2C 0.0298667
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0294659
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0293901
SUCO SUN domain containing ossification factor 0.0285815
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0276285
EXT1 exostosin glycosyltransferase 1 0.0258118
CEP350 centrosomal protein 350kDa 0.0246518
RAD21 RAD21 homolog (S. pombe) 0.024557
BIRC6 baculoviral IAP repeat containing 6 0.024365
ZC3H11A zinc finger CCCH-type containing 11A 0.0235364
VCL vinculin 0.0235155
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0234622
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0234164
UBE2K ubiquitin-conjugating enzyme E2K 0.0231311
CALU calumenin 0.0230756
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0228311
NAP1L1 nucleosome assembly protein 1-like 1 0.0225477
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0224496
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0222427
FAT1 FAT atypical cadherin 1 0.0222361
KDM3A lysine (K)-specific demethylase 3A 0.0222099
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.022078
VMP1 vacuole membrane protein 1 0.0215914
EREG epiregulin 0.0215537
TXNIP thioredoxin interacting protein 0.0208249
TRIO trio Rho guanine nucleotide exchange factor 0.0207185
SRP54 signal recognition particle 54kDa 0.0207093
CALR calreticulin 0.0205138
TTC3 tetratricopeptide repeat domain 3 0.0200466
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0199384
AHR aryl hydrocarbon receptor 0.0197908
AKAP12 A kinase (PRKA) anchor protein 12 0.0197848
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0197668
COPA coatomer protein complex, subunit alpha 0.0192924
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0192181
RNF145 ring finger protein 145 0.0192055
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.01907
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0189355
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0188099
ZCCHC7 zinc finger, CCHC domain containing 7 0.0187867
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0187427
FAM13B family with sequence similarity 13, member B 0.0186921
ITCH itchy E3 ubiquitin protein ligase 0.0185767
ELL2 elongation factor, RNA polymerase II, 2 0.0183378
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0181006
TPR translocated promoter region, nuclear basket protein 0.0178523
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0177687
SEC23A Sec23 homolog A (S. cerevisiae) 0.0177489
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0177405
KDM2A lysine (K)-specific demethylase 2A 0.0176911
SFXN1 sideroflexin 1 0.017683
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0176792
CLTC clathrin, heavy chain (Hc) 0.0175464
UBE2H ubiquitin-conjugating enzyme E2H 0.0175458
NPAS2 neuronal PAS domain protein 2 0.0173066
SMAD3 SMAD family member 3 0.0172509
PICALM phosphatidylinositol binding clathrin assembly protein 0.0170994
RAB8B RAB8B, member RAS oncogene family 0.0170835
ZSWIM6 zinc finger, SWIM-type containing 6 0.0169942
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0168755
RAB6A RAB6A, member RAS oncogene family 0.01674
BIRC3 baculoviral IAP repeat containing 3 0.0166034
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0165813
KDM5B lysine (K)-specific demethylase 5B 0.016472
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0164639
NUP58 nucleoporin 58 0.0162481
ETNK1 ethanolamine kinase 1 0.0161421
UBE2B ubiquitin-conjugating enzyme E2B 0.0160133
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.015878
CREBRF CREB3 regulatory factor 0.0158062
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0157927
SPDYA speedy/RINGO cell cycle regulator family member A 0.0157083
RAB18 RAB18, member RAS oncogene family 0.0156756
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0155764
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0155585
GOLT1B golgi transport 1B 0.0154762
RICTOR RPTOR independent companion of MTOR, complex 2 0.0154117
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.015293
SIK3 SIK family kinase 3 0.0152711
ENAH enabled homolog (Drosophila) 0.015247
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0150838
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0150291
ARF4 ADP-ribosylation factor 4 0.0148943
ZNF146 zinc finger protein 146 0.0148656
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0148625
COG5 component of oligomeric golgi complex 5 0.0147894
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0147729
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0146775
CTNND1 catenin (cadherin-associated protein), delta 1 0.0146374
AKAP9 A kinase (PRKA) anchor protein 9 0.0146213
PGK1 phosphoglycerate kinase 1 0.0145897
WDR45B WD repeat domain 45B 0.014563

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0795601
NRG1 neuregulin 1 -0.0759592
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0678042
FN1 fibronectin 1 -0.0600106
TMSB10 thymosin beta 10 -0.0559917
NDRG1 N-myc downstream regulated 1 -0.0518091
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0509644
FTL ferritin, light polypeptide -0.0464976
RPL35A ribosomal protein L35a -0.0409379
ASPH aspartate beta-hydroxylase -0.0405484
HMGA2 high mobility group AT-hook 2 -0.0380852
RPS6 ribosomal protein S6 -0.0373785
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0333324
RPL9 ribosomal protein L9 -0.0282958
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0255003
LIMCH1 LIM and calponin homology domains 1 -0.025485
IFI27 interferon, alpha-inducible protein 27 -0.0253676
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0250507
RPLP1 ribosomal protein, large, P1 -0.0242313
GLIS3 GLIS family zinc finger 3 -0.0239711
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0229428
FTH1 ferritin, heavy polypeptide 1 -0.022665
RPL12 ribosomal protein L12 -0.0223142
IER3 immediate early response 3 -0.0222403
RPL36 ribosomal protein L36 -0.0216135
RPS19 ribosomal protein S19 -0.021557
HLA-B major histocompatibility complex, class I, B -0.021063
PDE4D phosphodiesterase 4D, cAMP-specific -0.0209953
RPL11 ribosomal protein L11 -0.0207467
HMGA1 high mobility group AT-hook 1 -0.0207263
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.020613
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0200794
SYT1 synaptotagmin I -0.0200574
IFI16 interferon, gamma-inducible protein 16 -0.0193739
VIM vimentin -0.0193722
RPL34 ribosomal protein L34 -0.019363
RPS12 ribosomal protein S12 -0.0187484
RPS27 ribosomal protein S27 -0.0186052
GPC6 glypican 6 -0.0183969
GNAS GNAS complex locus -0.0180283
GRB10 growth factor receptor-bound protein 10 -0.0176297
RPL19 ribosomal protein L19 -0.0175497
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0171613
NRP1 neuropilin 1 -0.0170685
RPL37A ribosomal protein L37a -0.0169123
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0168913
RPL37 ribosomal protein L37 -0.0165656
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0164693
TPI1 triosephosphate isomerase 1 -0.0161364
RPS8 ribosomal protein S8 -0.0161006
POTEF POTE ankyrin domain family, member F -0.0159005
S100A6 S100 calcium binding protein A6 -0.0158697
PTPRD protein tyrosine phosphatase, receptor type, D -0.0158544
TTC28 tetratricopeptide repeat domain 28 -0.0157037
EFNA5 ephrin-A5 -0.0154033
RTN4 reticulon 4 -0.0153493
RPL38 ribosomal protein L38 -0.0148028
RPS25 ribosomal protein S25 -0.0147786
RPL23 ribosomal protein L23 -0.0147098
TRA2B transformer 2 beta homolog (Drosophila) -0.014571
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0143739
RAD51B RAD51 paralog B -0.0142753
BABAM2 BRISC and BRCA1 A complex member 2 -0.0142258
RNF213 ring finger protein 213 -0.0140691
TSHZ2 teashirt zinc finger homeobox 2 -0.0139122
RPL26 ribosomal protein L26 -0.0137834
ETV1 ets variant 1 -0.0137667
TOP1 topoisomerase (DNA) I -0.0135862
PTMA prothymosin, alpha -0.0135427
LRMDA leucine rich melanocyte differentiation associated -0.0134971
FBXO32 F-box protein 32 -0.0134002
PCDH7 protocadherin 7 -0.0133121
RPL30 ribosomal protein L30 -0.0132582
CENPF centromere protein F, 350/400kDa -0.0131909
RPL8 ribosomal protein L8 -0.0131115
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0130306
ITGA1 integrin, alpha 1 -0.0129379
IFI44L interferon-induced protein 44-like -0.0127858
SLC35F3 solute carrier family 35, member F3 -0.0125587
RAB7A RAB7A, member RAS oncogene family -0.0125111
TFG TRK-fused gene -0.0124446
S100A10 S100 calcium binding protein A10 -0.0124219
S100A9 S100 calcium binding protein A9 -0.0124202
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0124117
SP100 SP100 nuclear antigen -0.0123291
EXOC4 exocyst complex component 4 -0.0122158
RPS24 ribosomal protein S24 -0.0120827
RPS21 ribosomal protein S21 -0.0119859
RPS27A ribosomal protein S27a -0.0119048
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0118102
AOPEP aminopeptidase O (putative) -0.0117849
NRIP1 nuclear receptor interacting protein 1 -0.0116696
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0115777
FHIT fragile histidine triad -0.0115317
SYNJ2 synaptojanin 2 -0.0115209
ALCAM activated leukocyte cell adhesion molecule -0.0114868
RRBP1 ribosome binding protein 1 -0.0114167
RPS20 ribosomal protein S20 -0.0113023
KLHL5 kelch-like family member 5 -0.0113006
SDCCAG8 serologically defined colon cancer antigen 8 -0.0112857