| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/155815 |
| Similar Terms | |
| Downloads & Tools |
196 proteins with high or low expression in Varespladib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 2.12 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.46 |
| ZNF100 | zinc finger protein 100 | 1.18 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 1.07 |
| H1-4 | H1.4 linker histone, cluster member | 0.67 |
| H1-5 | H1.5 linker histone, cluster member | 0.61 |
| SP100 | SP100 nuclear antigen | 0.6 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | 0.59 |
| CNTNAP4 | contactin associated protein-like 4 | 0.59 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.55 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.54 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.54 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.5 |
| PCBP3 | poly(rC) binding protein 3 | 0.5 |
| HIST2H3A | histone cluster 2, H3a | 0.5 |
| CCDC112 | coiled-coil domain containing 112 | 0.5 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.5 |
| ZNF431 | zinc finger protein 431 | 0.49 |
| TUBB3 | tubulin, beta 3 class III | 0.49 |
| CCNQ | cyclin Q | 0.48 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.48 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.47 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.47 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.46 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.45 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | 0.45 |
| RPL3 | ribosomal protein L3 | 0.44 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.43 |
| STK16 | serine/threonine kinase 16 | 0.43 |
| H3C1 | H3 clustered histone 1 | 0.43 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | 0.42 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.42 |
| TBX3 | T-box 3 | 0.41 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.41 |
| ZNF451 | zinc finger protein 451 | 0.41 |
| RPS18 | ribosomal protein S18 | 0.41 |
| EPHX4 | epoxide hydrolase 4 | 0.41 |
| ANKRD13C | ankyrin repeat domain 13C | 0.41 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.4 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.4 |
| RPL10A | ribosomal protein L10a | 0.4 |
| ARHGAP11A | Rho GTPase activating protein 11A | 0.4 |
| EWSR1 | EWS RNA-binding protein 1 | 0.4 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.39 |
| HIST2H2BF | histone cluster 2, H2bf | 0.39 |
| ELOC | elongin C | 0.39 |
| CENPH | centromere protein H | 0.39 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.39 |
| IL6ST | interleukin 6 signal transducer | 0.38 |
| RPLP1 | ribosomal protein, large, P1 | 0.38 |
| RPL37A | ribosomal protein L37a | 0.37 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.36 |
| DST | dystonin | 0.36 |
| ZNF169 | zinc finger protein 169 | 0.36 |
| HSPA8 | heat shock 70kDa protein 8 | 0.36 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.35 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.35 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.35 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.35 |
| TMEM11 | transmembrane protein 11 | 0.35 |
| UBQLN1 | ubiquilin 1 | 0.35 |
| RPS21 | ribosomal protein S21 | 0.34 |
| XTBD1 | XRN2 binding domain containing 1 | 0.33 |
| BTBD11 | BTB (POZ) domain containing 11 | 0.33 |
| ZNF691 | zinc finger protein 691 | 0.33 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.32 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.32 |
| RPS20 | ribosomal protein S20 | 0.32 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.32 |
| MRM1 | mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) | 0.32 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.31 |
| H1-2 | H1.2 linker histone, cluster member | 0.31 |
| DPYSL5 | dihydropyrimidinase-like 5 | 0.31 |
| NUP62 | nucleoporin 62kDa | 0.31 |
| YBX3 | Y box binding protein 3 | 0.31 |
| ZNF696 | zinc finger protein 696 | 0.31 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.31 |
| KIF21B | kinesin family member 21B | 0.31 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.31 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.3 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.3 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | 0.3 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.3 |
| ANKRD39 | ankyrin repeat domain 39 | 0.3 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.3 |
| HMGB1 | high mobility group box 1 | 0.3 |
| LRRC20 | leucine rich repeat containing 20 | 0.3 |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.3 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.29 |
| EZR | ezrin | 0.29 |
| PLD6 | phospholipase D family, member 6 | 0.29 |
| HDAC5 | histone deacetylase 5 | 0.29 |
| ZNF302 | zinc finger protein 302 | 0.29 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | 0.29 |
| RGN | regucalcin | 0.29 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.29 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.29 |
| RPS27L | ribosomal protein S27-like | 0.29 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.29 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CLSTN3 | calsyntenin 3 | -1.06 |
| NCOR1 | nuclear receptor corepressor 1 | -0.72 |
| SUCO | SUN domain containing ossification factor | -0.72 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.67 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.66 |
| FN1 | fibronectin 1 | -0.65 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.62 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.62 |
| FTL | ferritin, light polypeptide | -0.59 |
| DAP | death-associated protein | -0.57 |
| CCDC158 | coiled-coil domain containing 158 | -0.54 |
| INHBA | inhibin, beta A | -0.54 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.51 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.5 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.49 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.48 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.45 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.45 |
| KRT222 | keratin 222, type II | -0.45 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | -0.45 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.45 |
| CAB39L | calcium binding protein 39-like | -0.44 |
| STAB1 | stabilin 1 | -0.44 |
| YIPF1 | Yip1 domain family, member 1 | -0.43 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.43 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.43 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | -0.43 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.43 |
| ANKRD44 | ankyrin repeat domain 44 | -0.42 |
| GRAMD4 | GRAM domain containing 4 | -0.42 |
| ZNF503 | zinc finger protein 503 | -0.42 |
| LAMA3 | laminin, alpha 3 | -0.42 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.42 |
| CCDC82 | coiled-coil domain containing 82 | -0.4 |
| DOLK | dolichol kinase | -0.39 |
| TANK | TRAF family member-associated NFKB activator | -0.39 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.39 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.38 |
| PRG4 | proteoglycan 4 | -0.38 |
| UBAP1 | ubiquitin associated protein 1 | -0.38 |
| DOCK3 | dedicator of cytokinesis 3 | -0.38 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.38 |
| GLMP | glycosylated lysosomal membrane protein | -0.37 |
| ZNF532 | zinc finger protein 532 | -0.37 |
| PLCB4 | phospholipase C, beta 4 | -0.37 |
| RAB5IF | RAB5 interacting factor | -0.37 |
| TPM1 | tropomyosin 1 (alpha) | -0.37 |
| WDR90 | WD repeat domain 90 | -0.37 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -0.37 |
| SNAI1 | snail family zinc finger 1 | -0.37 |
| CLTA | clathrin, light chain A | -0.37 |
| C8ORF37 | chromosome 8 open reading frame 37 | -0.37 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.37 |
| NEBL | nebulette | -0.37 |
| ZSWIM1 | zinc finger, SWIM-type containing 1 | -0.37 |
| UNC80 | unc-80 homolog (C. elegans) | -0.37 |
| KIAA0825 | KIAA0825 | -0.37 |
| NAA80 | N-alpha-acetyltransferase 80, NatH catalytic subunit | -0.36 |
| GGT2 | gamma-glutamyltransferase 2 | -0.36 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.36 |
| XIRP1 | xin actin binding repeat containing 1 | -0.36 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.36 |
| ROGDI | rogdi homolog (Drosophila) | -0.35 |
| ATG2A | autophagy related 2A | -0.35 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.35 |
| PLA2G12A | phospholipase A2, group XIIA | -0.35 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.35 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | -0.35 |
| F2 | coagulation factor II (thrombin) | -0.34 |
| C11ORF49 | chromosome 11 open reading frame 49 | -0.34 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -0.34 |
| PYGM | phosphorylase, glycogen, muscle | -0.34 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.34 |
| TCEA3 | transcription elongation factor A (SII), 3 | -0.33 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.33 |
| ACY1 | aminoacylase 1 | -0.33 |
| BAIAP2 | BAI1-associated protein 2 | -0.33 |
| MAGEA12 | melanoma antigen family A12 | -0.33 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.33 |
| PRR36 | proline rich 36 | -0.33 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -0.33 |
| BORCS6 | BLOC-1 related complex subunit 6 | -0.33 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.33 |
| ZNF195 | zinc finger protein 195 | -0.32 |
| CCN2 | cellular communication network factor 2 | -0.32 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.31 |
| ARHGAP23 | Rho GTPase activating protein 23 | -0.31 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.31 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.31 |
| ATF3 | activating transcription factor 3 | -0.31 |
| MYO1G | myosin IG | -0.31 |
| GRN | granulin | -0.31 |
| FZD7 | frizzled class receptor 7 | -0.31 |
| ABHD3 | abhydrolase domain containing 3 | -0.31 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | -0.31 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.31 |
