Vascular smooth muscle contraction Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. (Gene Ontology, GO_0014829)
External Link https://www.kegg.jp/entry/hsa04270
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Genes

131 proteins participating in the Vascular smooth muscle contraction pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADM adrenomedullin
ADM2 adrenomedullin 2
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
BRAF B-Raf proto-oncogene, serine/threonine kinase
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CALCA calcitonin-related polypeptide alpha
CALCB calcitonin-related polypeptide beta
CALCRL calcitonin receptor-like
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1
IRAG1 inositol 1,4,5-triphosphate receptor associated 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNU1 potassium channel, subfamily U, member 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
MYLK2 myosin light chain kinase 2
MYLK3 myosin light chain kinase 3
MYLK4 myosin light chain kinase family, member 4
NLRP3 NLR family, pyrin domain containing 3
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPPC natriuretic peptide C
NPR1 natriuretic peptide receptor 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PLA2G10 phospholipase A2, group X
PLA2G12A phospholipase A2, group XIIA
PLA2G12B phospholipase A2, group XIIB
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G2C phospholipase A2, group IIC
PLA2G2D phospholipase A2, group IID
PLA2G2E phospholipase A2, group IIE
PLA2G2F phospholipase A2, group IIF
PLA2G3 phospholipase A2, group III
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G4D phospholipase A2, group IVD (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLA2G4F phospholipase A2, group IVF
PLA2G5 phospholipase A2, group V
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12C protein phosphatase 1, regulatory subunit 12C
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKG1 protein kinase, cGMP-dependent, type I
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RHOA ras homolog family member A
RNASE3 ribonuclease, RNase A family, 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2