Vasopressin-regulated water reabsorption Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again. (Kyoto Encyclopedia of Genes and Genomes, hsa04962)
External Link https://www.kegg.jp/entry/hsa04962
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Genes

43 proteins participating in the Vasopressin-regulated water reabsorption pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY6 adenylate cyclase 6
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AQP2 aquaporin 2 (collecting duct)
AQP3 aquaporin 3 (Gill blood group)
AQP4 aquaporin 4
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
AVPR2 arginine vasopressin receptor 2
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DCTN4 dynactin 4 (p62)
DCTN5 dynactin 5 (p25)
DCTN6 dynactin 6
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
GNAS GNAS complex locus
NLRP3 NLR family, pyrin domain containing 3
NSF N-ethylmaleimide-sensitive factor
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
RAB11A RAB11A, member RAS oncogene family
RAB43 RAB43, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
STX4 syntaxin 4
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)