| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/42611257 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Vemurafenib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRP1 | neuropilin 1 | 2.03 |
| UPP1 | uridine phosphorylase 1 | 1.25 |
| PLAUR | plasminogen activator, urokinase receptor | 1.24 |
| TRIB3 | tribbles pseudokinase 3 | 1.19 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 1.18 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1.15 |
| DUSP4 | dual specificity phosphatase 4 | 1.12 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 1.08 |
| LAMC2 | laminin, gamma 2 | 1.03 |
| PLIN2 | perilipin 2 | 1.01 |
| FOSL1 | FOS-like antigen 1 | 1.0 |
| VGF | VGF nerve growth factor inducible | 0.95 |
| TNS4 | tensin 4 | 0.93 |
| CORO2B | coronin, actin binding protein, 2B | 0.92 |
| TMEM200A | transmembrane protein 200A | 0.9 |
| PLAU | plasminogen activator, urokinase | 0.88 |
| DUSP6 | dual specificity phosphatase 6 | 0.87 |
| EGR1 | early growth response 1 | 0.85 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.84 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.83 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.83 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.82 |
| LAMA3 | laminin, alpha 3 | 0.81 |
| AHR | aryl hydrocarbon receptor | 0.78 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.78 |
| ITPRIP | inositol 1,4,5-trisphosphate receptor interacting protein | 0.74 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.71 |
| ITGB4 | integrin, beta 4 | 0.7 |
| MYO18B | myosin XVIIIB | 0.68 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.68 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.68 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.66 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.65 |
| SLFN5 | schlafen family member 5 | 0.63 |
| SESN2 | sestrin 2 | 0.63 |
| NDRG1 | N-myc downstream regulated 1 | 0.63 |
| LAMB3 | laminin, beta 3 | 0.62 |
| AMOTL1 | angiomotin like 1 | 0.61 |
| PYGB | phosphorylase, glycogen; brain | 0.61 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.6 |
| DUSP5 | dual specificity phosphatase 5 | 0.6 |
| NIBAN1 | niban apoptosis regulator 1 | 0.6 |
| KLK7 | kallikrein-related peptidase 7 | 0.6 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.59 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.58 |
| KLK6 | kallikrein-related peptidase 6 | 0.58 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.58 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.57 |
| IFRD1 | interferon-related developmental regulator 1 | 0.57 |
| FAM110C | family with sequence similarity 110, member C | 0.57 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.56 |
| S100A16 | S100 calcium binding protein A16 | 0.56 |
| NAV2 | neuron navigator 2 | 0.55 |
| ANTXR2 | anthrax toxin receptor 2 | 0.55 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 0.55 |
| PXN | paxillin | 0.55 |
| MT2A | metallothionein 2A | 0.55 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.54 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.54 |
| ZXDB | zinc finger, X-linked, duplicated B | 0.54 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.53 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.53 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.53 |
| CDCP1 | CUB domain containing protein 1 | 0.53 |
| SESN1 | sestrin 1 | 0.52 |
| JUNB | jun B proto-oncogene | 0.52 |
| SATB2 | SATB homeobox 2 | 0.5 |
| CTSL | cathepsin L | 0.5 |
| FERMT1 | fermitin family member 1 | 0.5 |
| NAV3 | neuron navigator 3 | 0.5 |
| RREB1 | ras responsive element binding protein 1 | 0.49 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.49 |
| ULBP1 | UL16 binding protein 1 | 0.49 |
| C6ORF141 | chromosome 6 open reading frame 141 | 0.49 |
| SMTN | smoothelin | 0.48 |
| CNTNAP3 | contactin associated protein-like 3 | 0.47 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.47 |
| KIAA1191 | KIAA1191 | 0.47 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.46 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.46 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.46 |
| GAS6 | growth arrest-specific 6 | 0.46 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.46 |
| ITGA6 | integrin, alpha 6 | 0.46 |
| JAG1 | jagged 1 | 0.45 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.44 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.44 |
| ONECUT2 | one cut homeobox 2 | 0.44 |
| PRNP | prion protein | 0.43 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.43 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.43 |
| APOB | apolipoprotein B | 0.43 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.43 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.42 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 0.42 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.42 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.42 |
| PLEK2 | pleckstrin 2 | 0.42 |
| ABHD5 | abhydrolase domain containing 5 | 0.42 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -2.1 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -1.4 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -1.38 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -1.35 |
| ZBED9 | zinc finger, BED-type containing 9 | -1.08 |
| ZNF91 | zinc finger protein 91 | -1.07 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.95 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | -0.94 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.93 |
| RNF111 | ring finger protein 111 | -0.86 |
| SQLE | squalene epoxidase | -0.86 |
| CDON | cell adhesion associated, oncogene regulated | -0.85 |
| BDNF | brain-derived neurotrophic factor | -0.81 |
| BHMT | betaine--homocysteine S-methyltransferase | -0.8 |
| RND3 | Rho family GTPase 3 | -0.77 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.76 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.76 |
| ZNF628 | zinc finger protein 628 | -0.75 |
| GRAMD1A | GRAM domain containing 1A | -0.73 |
| TRIM29 | tripartite motif containing 29 | -0.71 |
| MYH16 | myosin, heavy chain 16 pseudogene | -0.71 |
| EPN3 | epsin 3 | -0.7 |
| TMEM131L | transmembrane 131 like | -0.7 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.69 |
| ZFP30 | ZFP30 zinc finger protein | -0.68 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.68 |
| CCDC85B | coiled-coil domain containing 85B | -0.67 |
| CLIC3 | chloride intracellular channel 3 | -0.66 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.66 |
| MSMO1 | methylsterol monooxygenase 1 | -0.64 |
| E2F2 | E2F transcription factor 2 | -0.64 |
| AOC1 | amine oxidase, copper containing 1 | -0.63 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.63 |
| FADS1 | fatty acid desaturase 1 | -0.63 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.63 |
| KLF2 | Kruppel-like factor 2 | -0.62 |
| ATF6B | activating transcription factor 6 beta | -0.62 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.62 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.62 |
| SYTL2 | synaptotagmin-like 2 | -0.61 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.6 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.6 |
| TMX2 | thioredoxin-related transmembrane protein 2 | -0.59 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.59 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | -0.59 |
| SDC1 | syndecan 1 | -0.58 |
| RGN | regucalcin | -0.57 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.57 |
| SORT1 | sortilin 1 | -0.57 |
| APOL2 | apolipoprotein L, 2 | -0.56 |
| FUNDC1 | FUN14 domain containing 1 | -0.56 |
| CDK6 | cyclin-dependent kinase 6 | -0.56 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.56 |
| PALM3 | paralemmin 3 | -0.56 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.55 |
| GKAP1 | G kinase anchoring protein 1 | -0.55 |
| REEP1 | receptor accessory protein 1 | -0.54 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.54 |
| NOTCH3 | notch 3 | -0.53 |
| PITX2 | paired-like homeodomain 2 | -0.53 |
| GPC1 | glypican 1 | -0.52 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.51 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.51 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.5 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.5 |
| SULF2 | sulfatase 2 | -0.5 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.5 |
| PRR36 | proline rich 36 | -0.5 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.49 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.49 |
| KITLG | KIT ligand | -0.49 |
| ABHD17C | abhydrolase domain containing 17C | -0.49 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.49 |
| PEG10 | paternally expressed 10 | -0.49 |
| CA8 | carbonic anhydrase VIII | -0.49 |
| AXIN2 | axin 2 | -0.49 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.48 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.48 |
| MYL9 | myosin, light chain 9, regulatory | -0.48 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.48 |
| NGFR | nerve growth factor receptor | -0.47 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.47 |
| ANTXR1 | anthrax toxin receptor 1 | -0.47 |
| COBL | cordon-bleu WH2 repeat protein | -0.47 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.47 |
| WLS | wntless Wnt ligand secretion mediator | -0.47 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -0.46 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.46 |
| TNS3 | tensin 3 | -0.46 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.45 |
| SDC4 | syndecan 4 | -0.45 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.45 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.45 |
| ABAT | 4-aminobutyrate aminotransferase | -0.45 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.44 |
| SLC35A4 | solute carrier family 35, member A4 | -0.44 |
| FAM124A | family with sequence similarity 124A | -0.44 |
| AGFG2 | ArfGAP with FG repeats 2 | -0.44 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.44 |
