| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vemurafenib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vemurafenib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.168445 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.153739 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.143819 |
| HDAC9 | histone deacetylase 9 | 0.118804 |
| CALR | calreticulin | 0.109528 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.108644 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.106173 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.100057 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0965613 |
| S100A10 | S100 calcium binding protein A10 | 0.0903539 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0884654 |
| ACTG1 | actin gamma 1 | 0.0840933 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0815146 |
| LDHA | lactate dehydrogenase A | 0.0810938 |
| MAP1B | microtubule-associated protein 1B | 0.0802395 |
| TMSB10 | thymosin beta 10 | 0.0787904 |
| DST | dystonin | 0.0775791 |
| CSTB | cystatin B (stefin B) | 0.0755118 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0710688 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0676127 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0674647 |
| RND3 | Rho family GTPase 3 | 0.0665684 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0648053 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.063877 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0636095 |
| L1CAM | L1 cell adhesion molecule | 0.0621621 |
| PODXL | podocalyxin-like | 0.0620478 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0618189 |
| CDH13 | cadherin 13 | 0.0594629 |
| VIM | vimentin | 0.0553056 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0546183 |
| SQSTM1 | sequestosome 1 | 0.0536772 |
| S100A6 | S100 calcium binding protein A6 | 0.0533099 |
| PTMA | prothymosin, alpha | 0.0519339 |
| POTEF | POTE ankyrin domain family, member F | 0.051596 |
| EZR | ezrin | 0.0510018 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0498672 |
| NDRG1 | N-myc downstream regulated 1 | 0.0483403 |
| CCND1 | cyclin D1 | 0.0478901 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0473378 |
| TPM4 | tropomyosin 4 | 0.0457413 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0448058 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.044573 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.043633 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0436053 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0434503 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0423834 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0412605 |
| RHOA | ras homolog family member A | 0.0404171 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0395437 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0395049 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0394097 |
| ANXA1 | annexin A1 | 0.0379054 |
| NAV2 | neuron navigator 2 | 0.0378971 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0373802 |
| PFN1 | profilin 1 | 0.0367467 |
| LMNA | lamin A/C | 0.0365621 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0362686 |
| GOLGA4 | golgin A4 | 0.0357499 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0356401 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0345451 |
| JUN | jun proto-oncogene | 0.0337813 |
| FLNA | filamin A, alpha | 0.0336339 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0334017 |
| EGFR | epidermal growth factor receptor | 0.0331493 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0330088 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0326628 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0325518 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0320076 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0306814 |
| KLF6 | Kruppel-like factor 6 | 0.0306431 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0303614 |
| RPS6 | ribosomal protein S6 | 0.0302551 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.030194 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0298161 |
| RPL12 | ribosomal protein L12 | 0.0295411 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0295208 |
| FOSL1 | FOS-like antigen 1 | 0.0293213 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0292441 |
| INSIG1 | insulin induced gene 1 | 0.0292257 |
| RASAL2 | RAS protein activator like 2 | 0.0291094 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0283489 |
| DSPP | dentin sialophosphoprotein | 0.02762 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0275864 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0273796 |
| FTL | ferritin, light polypeptide | 0.0272876 |
| TAOK1 | TAO kinase 1 | 0.0269424 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.0265215 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0261259 |
| RPLP2 | ribosomal protein, large, P2 | 0.0261066 |
| ANKRD30B | ankyrin repeat domain 30B | 0.0260213 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0259829 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0258268 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0258143 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0257923 |
| EGR1 | early growth response 1 | 0.025529 |
| C1D | C1D nuclear receptor corepressor | 0.025498 |
| CENPF | centromere protein F, 350/400kDa | 0.0251477 |
| FSTL1 | follistatin-like 1 | 0.025027 |
| RPS8 | ribosomal protein S8 | 0.0249808 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.138465 |
| FBN1 | fibrillin 1 | -0.134356 |
| PLAT | plasminogen activator, tissue | -0.129429 |
| COL5A2 | collagen, type V, alpha 2 | -0.104539 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.101912 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0972533 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0865472 |
| COL1A2 | collagen, type I, alpha 2 | -0.0859348 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0829274 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0780652 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0713666 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0688493 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0664581 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0624291 |
| NAV1 | neuron navigator 1 | -0.0624075 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0593067 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0522976 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0507352 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0480269 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0472824 |
| MT2A | metallothionein 2A | -0.0471064 |
| LOX | lysyl oxidase | -0.0452415 |
| FN1 | fibronectin 1 | -0.044068 |
| COL5A1 | collagen, type V, alpha 1 | -0.042828 |
| SP3 | Sp3 transcription factor | -0.0425426 |
| STC1 | stanniocalcin 1 | -0.0423435 |
| COL3A1 | collagen, type III, alpha 1 | -0.0422792 |
| PRSS23 | protease, serine, 23 | -0.0412642 |
| MX2 | MX dynamin-like GTPase 2 | -0.040982 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0406266 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0402275 |
| GPC6 | glypican 6 | -0.0401312 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0401114 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0400576 |
| OGA | O-GlcNAcase | -0.0393578 |
| SVIL | supervillin | -0.0375178 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0373447 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0361573 |
| SBF2 | SET binding factor 2 | -0.0358857 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0346188 |
| SUCNR1 | succinate receptor 1 | -0.0336954 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0335665 |
| AFAP1 | actin filament associated protein 1 | -0.0326689 |
| RIGI | RNA sensor RIG-I | -0.032464 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0323184 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0319889 |
| RUNX1 | runt-related transcription factor 1 | -0.0319776 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0306617 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0305718 |
| TMOD1 | tropomodulin 1 | -0.0300366 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0297706 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0295923 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0295862 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0289192 |
| FRMD5 | FERM domain containing 5 | -0.0282295 |
| GLIS3 | GLIS family zinc finger 3 | -0.0281576 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0281217 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0274183 |
| LOXL2 | lysyl oxidase-like 2 | -0.0271344 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0271248 |
| RBM25 | RNA binding motif protein 25 | -0.0268384 |
| MTSS1 | metastasis suppressor 1 | -0.0267263 |
| KIFAP3 | kinesin-associated protein 3 | -0.0266973 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0262796 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.026237 |
| XPO1 | exportin 1 | -0.0258968 |
| IFI44 | interferon-induced protein 44 | -0.0257656 |
| JAZF1 | JAZF zinc finger 1 | -0.0254615 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0250391 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.0248723 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0248371 |
| MYOF | myoferlin | -0.0248166 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0245884 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0245358 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0244716 |
| MT1X | metallothionein 1X | -0.024285 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0241531 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0239227 |
| ADAR | adenosine deaminase, RNA-specific | -0.0236131 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0234609 |
| MED13L | mediator complex subunit 13-like | -0.0230657 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0220028 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0219638 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0215907 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0215687 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0215355 |
| SDC4 | syndecan 4 | -0.0214453 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0213232 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0209148 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0208623 |
| PRKD3 | protein kinase D3 | -0.0207785 |
| ZNF217 | zinc finger protein 217 | -0.0206985 |
| FRMD4A | FERM domain containing 4A | -0.0206784 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0206462 |
| TRIM56 | tripartite motif containing 56 | -0.0203743 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0202563 |
| APAF1 | apoptotic peptidase activating factor 1 | -0.0202203 |
| TPM1 | tropomyosin 1 (alpha) | -0.0199985 |
| AUTS2 | autism susceptibility candidate 2 | -0.019988 |
| SETD5 | SET domain containing 5 | -0.0198613 |
