| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vemurafenib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vemurafenib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.117487 |
| ACTG1 | actin gamma 1 | 0.0874879 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0779627 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0707054 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0647958 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0646399 |
| CALR | calreticulin | 0.0641626 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0621586 |
| EZR | ezrin | 0.0527712 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0522868 |
| ANXA1 | annexin A1 | 0.0501771 |
| EGR1 | early growth response 1 | 0.0488105 |
| POTEF | POTE ankyrin domain family, member F | 0.048635 |
| CCN2 | cellular communication network factor 2 | 0.0482385 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0468133 |
| ZNF638 | zinc finger protein 638 | 0.044176 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0435542 |
| RPS2 | ribosomal protein S2 | 0.0421297 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0412583 |
| MKI67 | marker of proliferation Ki-67 | 0.040565 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0398087 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0383461 |
| VIM | vimentin | 0.0372096 |
| TPM3 | tropomyosin 3 | 0.0370201 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.036017 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0353198 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0348208 |
| GOLGB1 | golgin B1 | 0.0337741 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.033278 |
| YEATS2 | YEATS domain containing 2 | 0.0319411 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0314982 |
| SON | SON DNA binding protein | 0.031491 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0306516 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0305447 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0299525 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0297945 |
| BRD2 | bromodomain containing 2 | 0.0294065 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0289799 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0279886 |
| RPL3 | ribosomal protein L3 | 0.0279599 |
| RPS6 | ribosomal protein S6 | 0.0277431 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.027662 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0267719 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0267245 |
| SIK3 | SIK family kinase 3 | 0.0265687 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0263641 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0252742 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0251772 |
| BRD4 | bromodomain containing 4 | 0.0248834 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0244261 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0243841 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0243081 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0242861 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0239303 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.023765 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0237097 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0234326 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0233987 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0233607 |
| KIF5B | kinesin family member 5B | 0.0232798 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0232493 |
| MYADM | myeloid-associated differentiation marker | 0.0231065 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0230023 |
| UBXN4 | UBX domain protein 4 | 0.022999 |
| SETX | senataxin | 0.0227803 |
| FLNA | filamin A, alpha | 0.0227542 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0227266 |
| RBM25 | RNA binding motif protein 25 | 0.02268 |
| MSN | moesin | 0.0225597 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0224826 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0222463 |
| INO80 | INO80 complex subunit | 0.0218236 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 0.0214914 |
| LDHA | lactate dehydrogenase A | 0.0214184 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0213675 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0212573 |
| JUN | jun proto-oncogene | 0.0211261 |
| SLK | STE20-like kinase | 0.0210185 |
| HDGF | hepatoma-derived growth factor | 0.0209868 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0208559 |
| PKM | pyruvate kinase, muscle | 0.0207295 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0206085 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0203116 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0202408 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0197715 |
| TBK1 | TANK-binding kinase 1 | 0.0196493 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | 0.0195458 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0194811 |
| RPS12 | ribosomal protein S12 | 0.0194484 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0193289 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0190843 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.0189351 |
| PGK1 | phosphoglycerate kinase 1 | 0.0189066 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0187285 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0187014 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0185893 |
| NOP58 | NOP58 ribonucleoprotein | 0.0185207 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0184611 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0184187 |
| TCP1 | t-complex 1 | 0.0182539 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.238843 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.11436 |
| NLGN1 | neuroligin 1 | -0.101477 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0898265 |
| PCDH7 | protocadherin 7 | -0.0840844 |
| TMSB10 | thymosin beta 10 | -0.0803842 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0773019 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0771166 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0759241 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0744741 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0677721 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0629117 |
| HMGA2 | high mobility group AT-hook 2 | -0.0616763 |
| AREG | amphiregulin | -0.06133 |
| CLDN1 | claudin 1 | -0.0582233 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.056527 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0554036 |
| RPS24 | ribosomal protein S24 | -0.0552496 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0534955 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0529403 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0511536 |
| AHNAK | AHNAK nucleoprotein | -0.0497872 |
| NABP1 | nucleic acid binding protein 1 | -0.0484359 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0481709 |
| RPL23 | ribosomal protein L23 | -0.0480202 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0477847 |
| ZNF804A | zinc finger protein 804A | -0.0473738 |
| RPL19 | ribosomal protein L19 | -0.0455279 |
| MTAP | methylthioadenosine phosphorylase | -0.0454946 |
| ZNF217 | zinc finger protein 217 | -0.0451677 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.045078 |
| MED13L | mediator complex subunit 13-like | -0.044914 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0448193 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0442111 |
| RPLP0 | ribosomal protein, large, P0 | -0.0438214 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0434745 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0429016 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0426114 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0420837 |
| VCL | vinculin | -0.0417328 |
| CDK17 | cyclin-dependent kinase 17 | -0.0410293 |
| NHSL1 | NHS-like 1 | -0.040523 |
| TENM3 | teneurin transmembrane protein 3 | -0.039816 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0395192 |
| BCHE | butyrylcholinesterase | -0.0383767 |
| NEK7 | NIMA-related kinase 7 | -0.0382373 |
| H1-0 | H1.0 linker histone | -0.0380489 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0380212 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0376706 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0374158 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0373859 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0365171 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0355781 |
| RPS21 | ribosomal protein S21 | -0.0354221 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0352116 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0351424 |
| RASAL2 | RAS protein activator like 2 | -0.034164 |
| MGAT4C | MGAT4 family, member C | -0.0341014 |
| GASK1B | golgi associated kinase 1B | -0.0339177 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0337192 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0332008 |
| RPL35A | ribosomal protein L35a | -0.0328746 |
| RTN3 | reticulon 3 | -0.0315784 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0313583 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0313514 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0313079 |
| OXR1 | oxidation resistance 1 | -0.0310617 |
| LMO7 | LIM domain 7 | -0.0307422 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0305978 |
| RPS16 | ribosomal protein S16 | -0.0304965 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0301665 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0300305 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0297869 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | -0.029323 |
| AHR | aryl hydrocarbon receptor | -0.0283544 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0282134 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0275021 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0274806 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0274282 |
| PHF3 | PHD finger protein 3 | -0.0272756 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0272503 |
| RAD51B | RAD51 paralog B | -0.0271302 |
| AXIN2 | axin 2 | -0.0265775 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0263673 |
| IL6ST | interleukin 6 signal transducer | -0.0260787 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0260172 |
| POU2F1 | POU class 2 homeobox 1 | -0.0259469 |
| CDC42SE2 | CDC42 small effector 2 | -0.0256564 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0256256 |
| PDGFC | platelet derived growth factor C | -0.0255838 |
| TMEM123 | transmembrane protein 123 | -0.0252148 |
| EDARADD | EDAR-associated death domain | -0.0252015 |
| RPS3 | ribosomal protein S3 | -0.0251503 |
| RNF13 | ring finger protein 13 | -0.0251366 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0251051 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0250764 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.025042 |
| IPMK | inositol polyphosphate multikinase | -0.0248928 |
| TEAD4 | TEA domain family member 4 | -0.0248515 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0247019 |
