Vemurafenib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.128179
FMN1 formin 1 0.112678
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0519779
THSD4 thrombospondin, type I, domain containing 4 0.0518969
SLIT2 slit homolog 2 (Drosophila) 0.049533
FNDC3A fibronectin type III domain containing 3A 0.0479748
VCL vinculin 0.0477833
FLT1 fms-related tyrosine kinase 1 0.0477421
TLE4 transducin-like enhancer of split 4 0.047323
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0449561
BPTF bromodomain PHD finger transcription factor 0.043572
LPIN1 lipin 1 0.0432778
ANTXR1 anthrax toxin receptor 1 0.0429535
VMP1 vacuole membrane protein 1 0.0395536
TRIO trio Rho guanine nucleotide exchange factor 0.038579
FAM107B family with sequence similarity 107, member B 0.0364868
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0362109
BICD1 bicaudal D homolog 1 (Drosophila) 0.0359269
GPC5 glypican 5 0.0337628
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0335323
NRIP1 nuclear receptor interacting protein 1 0.0334484
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0331843
DNM3 dynamin 3 0.0330267
NCOR2 nuclear receptor corepressor 2 0.0318261
PTPRE protein tyrosine phosphatase, receptor type, E 0.0314202
ZCCHC7 zinc finger, CCHC domain containing 7 0.0310451
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0308857
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0307805
ARHGAP9 Rho GTPase activating protein 9 0.0306606
PDE10A phosphodiesterase 10A 0.030188
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.029195
PDLIM5 PDZ and LIM domain 5 0.0290499
EEF2 eukaryotic translation elongation factor 2 0.0288547
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0282936
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0276345
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0271958
GLCCI1 glucocorticoid induced 1 0.0263984
KAT6A K(lysine) acetyltransferase 6A 0.0260983
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0257695
SMAD3 SMAD family member 3 0.0254403
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0254285
SH3RF1 SH3 domain containing ring finger 1 0.0253658
CSNK1A1 casein kinase 1, alpha 1 0.025136
CEMIP2 cell migration inducing hyaluronidase 2 0.025053
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0248619
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0247262
PTPRD protein tyrosine phosphatase, receptor type, D 0.0246455
RNASEH2A ribonuclease H2, subunit A 0.024305
SLITRK6 SLIT and NTRK-like family, member 6 0.0242733
STK38L serine/threonine kinase 38 like 0.0237154
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0233712
SDC2 syndecan 2 0.0233235
RIGI RNA sensor RIG-I 0.0230481
PRKCA protein kinase C, alpha 0.0230255
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0229434
AMOTL1 angiomotin like 1 0.0229022
EGR1 early growth response 1 0.0227409
MYO9A myosin IXA 0.0226757
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.022535
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0220489
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0219956
CEMIP cell migration inducing protein, hyaluronan binding 0.0218367
DGKD diacylglycerol kinase, delta 130kDa 0.0218316
TBC1D5 TBC1 domain family, member 5 0.0214981
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0214705
DUSP10 dual specificity phosphatase 10 0.0214591
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0211709
ZNF521 zinc finger protein 521 0.0210369
MACF1 microtubule-actin crosslinking factor 1 0.0209688
TGFB1 transforming growth factor, beta 1 0.0209562
NPAS2 neuronal PAS domain protein 2 0.0209332
PSD3 pleckstrin and Sec7 domain containing 3 0.0206941
PRKCE protein kinase C, epsilon 0.0205532
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0202817
CHRM3 cholinergic receptor, muscarinic 3 0.0202765
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.0197726
BBS9 Bardet-Biedl syndrome 9 0.0196599
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0195994
CREBBP CREB binding protein 0.0195264
ATP10D ATPase, class V, type 10D 0.0194864
DAND5 DAN domain family member 5, BMP antagonist 0.0193472
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0192315
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0192014
ITCH itchy E3 ubiquitin protein ligase 0.0191399
DUSP16 dual specificity phosphatase 16 0.019084
THBS1 thrombospondin 1 0.0189282
TIMP2 TIMP metallopeptidase inhibitor 2 0.0189201
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0188935
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 0.0187644
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0187178
SETBP1 SET binding protein 1 0.0186495
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0185459
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0183786
SDCCAG8 serologically defined colon cancer antigen 8 0.0182605
FRMD4A FERM domain containing 4A 0.018239
EGFR epidermal growth factor receptor 0.018232
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0181634
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0181135
MYO1E myosin IE 0.0178801
SHB Src homology 2 domain containing adaptor protein B 0.017874

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.31326
PTMA prothymosin, alpha -0.167101
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163624
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124675
VIM vimentin -0.105452
TPT1 tumor protein, translationally-controlled 1 -0.101041
RPS24 ribosomal protein S24 -0.0942826
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0841094
RPLP1 ribosomal protein, large, P1 -0.0834061
RPL19 ribosomal protein L19 -0.0833585
COL1A1 collagen, type I, alpha 1 -0.079603
RPL35A ribosomal protein L35a -0.0774748
FAM13A family with sequence similarity 13, member A -0.0715547
COL3A1 collagen, type III, alpha 1 -0.0709993
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0697505
SYT1 synaptotagmin I -0.0681769
RPS6 ribosomal protein S6 -0.0649322
RPL31 ribosomal protein L31 -0.0645486
NAMPT nicotinamide phosphoribosyltransferase -0.0618275
RPL23 ribosomal protein L23 -0.058035
RPL34 ribosomal protein L34 -0.0573065
WDR45B WD repeat domain 45B -0.0564953
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0563753
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0536574
RPS3 ribosomal protein S3 -0.0525896
AKAP12 A kinase (PRKA) anchor protein 12 -0.0515634
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.051556
EIF1 eukaryotic translation initiation factor 1 -0.0514508
KDM3A lysine (K)-specific demethylase 3A -0.0505308
RPLP0 ribosomal protein, large, P0 -0.0500728
LMNA lamin A/C -0.0486332
HELZ helicase with zinc finger -0.0486301
FTL ferritin, light polypeptide -0.0471429
MEF2A myocyte enhancer factor 2A -0.0455762
KPNB1 karyopherin (importin) beta 1 -0.0443559
SETD5 SET domain containing 5 -0.0441863
GNAS GNAS complex locus -0.0436658
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0432021
H3-3B H3.3 histone B -0.0423267
FNDC3B fibronectin type III domain containing 3B -0.0422371
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0415886
RPS19 ribosomal protein S19 -0.0407732
RAD21 RAD21 homolog (S. pombe) -0.0405111
PKM pyruvate kinase, muscle -0.0397376
RPL38 ribosomal protein L38 -0.0395344
RPS11 ribosomal protein S11 -0.0389191
NPEPPS aminopeptidase puromycin sensitive -0.0387744
AHNAK AHNAK nucleoprotein -0.0375188
DTNA dystrobrevin, alpha -0.0373263
S100A6 S100 calcium binding protein A6 -0.0371195
NAP1L1 nucleosome assembly protein 1-like 1 -0.0369723
RPS8 ribosomal protein S8 -0.0366983
OGA O-GlcNAcase -0.0362991
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0360523
MSI2 musashi RNA-binding protein 2 -0.0359299
FAM162A family with sequence similarity 162, member A -0.0357635
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.035501
NREP neuronal regeneration related protein -0.0353752
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.034587
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0344947
CD36 CD36 molecule (thrombospondin receptor) -0.0344307
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0343354
CCNI cyclin I -0.0336551
PNRC1 proline-rich nuclear receptor coactivator 1 -0.033632
MEIS2 Meis homeobox 2 -0.0335477
RPL32 ribosomal protein L32 -0.0332849
CCDC47 coiled-coil domain containing 47 -0.0332566
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0331674
CANX calnexin -0.0325817
PDIA3 protein disulfide isomerase family A, member 3 -0.0325497
LCORL ligand dependent nuclear receptor corepressor-like -0.0324221
RIOK3 RIO kinase 3 -0.032125
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0317286
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0316805
RPS5 ribosomal protein S5 -0.0310219
ENO1 enolase 1, (alpha) -0.030956
RPS21 ribosomal protein S21 -0.0308643
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0307601
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.030443
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.030437
LIMCH1 LIM and calponin homology domains 1 -0.0303687
RBM39 RNA binding motif protein 39 -0.0303383
IER3 immediate early response 3 -0.0300855
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0300443
RPLP2 ribosomal protein, large, P2 -0.0300068
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0297636
RPL12 ribosomal protein L12 -0.0295791
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.028784
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0284352
PTK2 protein tyrosine kinase 2 -0.0281063
TRIB2 tribbles pseudokinase 2 -0.0277584
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0273533
RPL27 ribosomal protein L27 -0.0273064
RPS27A ribosomal protein S27a -0.0270927
SRP72 signal recognition particle 72kDa -0.0270589
USP3 ubiquitin specific peptidase 3 -0.0268966
RPS12 ribosomal protein S12 -0.0267287
RPS29 ribosomal protein S29 -0.0266852
HILPDA hypoxia inducible lipid droplet-associated -0.0266746
PUM2 pumilio RNA-binding family member 2 -0.0266398