Vemurafenib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.101531
SMAD3 SMAD family member 3 0.0463181
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0404706
EXT1 exostosin glycosyltransferase 1 0.0392273
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0380637
TRIM2 tripartite motif containing 2 0.0372848
DST dystonin 0.0352583
PDZD8 PDZ domain containing 8 0.034382
AKAP13 A kinase (PRKA) anchor protein 13 0.0318894
MACC1 metastasis associated in colon cancer 1 0.0312557
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272795
FNIP2 folliculin interacting protein 2 0.0253406
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0249316
MBNL2 muscleblind-like splicing regulator 2 0.0239216
DUSP10 dual specificity phosphatase 10 0.0223687
FNIP1 folliculin interacting protein 1 0.0212891
XDH xanthine dehydrogenase 0.0197671
KDM6A lysine (K)-specific demethylase 6A 0.0189851
FNDC3B fibronectin type III domain containing 3B 0.0189462
MYO5B myosin VB 0.0182147
KYNU kynureninase 0.0168159
AFF1 AF4/FMR2 family, member 1 0.0164513
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0164271
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0163583
C3ORF52 chromosome 3 open reading frame 52 0.0158208
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0153895
USP9X ubiquitin specific peptidase 9, X-linked 0.0149446
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0147466
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0144009
DPP4 dipeptidyl-peptidase 4 0.0141512
COG3 component of oligomeric golgi complex 3 0.0140188
TMEM65 transmembrane protein 65 0.0138027
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0135345
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0133358
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0132628
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0127589
TMEM39A transmembrane protein 39A 0.0127331
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0125776
ITGB8 integrin, beta 8 0.0121991
YAP1 Yes-associated protein 1 0.0120685
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0120494
SLK STE20-like kinase 0.0119034
SEC24D SEC24 family member D 0.0118885
ZNF638 zinc finger protein 638 0.011768
ASPH aspartate beta-hydroxylase 0.0116714
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0116076
SAMD4A sterile alpha motif domain containing 4A 0.0115895
DUSP16 dual specificity phosphatase 16 0.0115084
YEATS2 YEATS domain containing 2 0.0114265
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0113484
FRK fyn-related Src family tyrosine kinase 0.0112803
PLPP3 phospholipid phosphatase 3 0.0112072
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0110865
RBM33 RNA binding motif protein 33 0.0110604
SFPQ splicing factor proline/glutamine-rich 0.0110392
ATP10B ATPase, class V, type 10B 0.0109332
CEMIP2 cell migration inducing hyaluronidase 2 0.0108923
ANO6 anoctamin 6 0.0106324
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0103516
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0103336
HKDC1 hexokinase domain containing 1 0.0102831
PMM2 phosphomannomutase 2 0.0102435
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0102384
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0101575
METTL15 methyltransferase like 15 0.0101444
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0101303
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00999706
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00997579
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.00996458
RAD23B RAD23 homolog B (S. cerevisiae) 0.00991315
DIDO1 death inducer-obliterator 1 0.00990735
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.00984955
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00983799
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0097904
USPL1 ubiquitin specific peptidase like 1 0.00978736
DSCAM Down syndrome cell adhesion molecule 0.00974611
CHD1 chromodomain helicase DNA binding protein 1 0.0096981
ATXN1 ataxin 1 0.00969094
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00965174
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.00964015
ARHGAP21 Rho GTPase activating protein 21 0.00960632
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00947554
CRY1 cryptochrome circadian clock 1 0.00939038
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00937471
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.00928485
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.00923189
JMJD1C jumonji domain containing 1C 0.00921554
SPAG9 sperm associated antigen 9 0.00905361
TBC1D5 TBC1 domain family, member 5 0.00904912
PBX3 pre-B-cell leukemia homeobox 3 0.00902934
DAND5 DAN domain family member 5, BMP antagonist 0.00901844
SLTM SAFB-like, transcription modulator 0.00899097
FNDC3A fibronectin type III domain containing 3A 0.00893258
ZHX2 zinc fingers and homeoboxes 2 0.00884983
HSPA8 heat shock 70kDa protein 8 0.0087533
PTPRK protein tyrosine phosphatase, receptor type, K 0.00872362
RASEF RAS and EF-hand domain containing 0.0086854
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00864239
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0086421
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.00862023

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.236276
TPT1 tumor protein, translationally-controlled 1 -0.216356
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126919
HLA-B major histocompatibility complex, class I, B -0.116762
IFI6 interferon, alpha-inducible protein 6 -0.115514
ANXA2 annexin A2 -0.112892
PTMA prothymosin, alpha -0.109262
ZMYND8 zinc finger, MYND-type containing 8 -0.105756
EPSTI1 epithelial stromal interaction 1 (breast) -0.103762
EGR1 early growth response 1 -0.0939285
PERP PERP, TP53 apoptosis effector -0.091844
RNF213 ring finger protein 213 -0.0908203
PKM pyruvate kinase, muscle -0.082522
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0780153
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0741811
C6ORF132 chromosome 6 open reading frame 132 -0.071356
IFI27 interferon, alpha-inducible protein 27 -0.0689305
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0679994
LYZ lysozyme -0.0678456
RPL35A ribosomal protein L35a -0.0664564
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0647207
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0642608
XAF1 XIAP associated factor 1 -0.0640687
TXNIP thioredoxin interacting protein -0.0634264
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0628896
RIGI RNA sensor RIG-I -0.0618701
AREG amphiregulin -0.0614935
LOC102724023 ES1 protein homolog, mitochondrial -0.0614312
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.060769
SP100 SP100 nuclear antigen -0.0606183
FTL ferritin, light polypeptide -0.0604784
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0579882
HLA-E major histocompatibility complex, class I, E -0.0560309
EIF1 eukaryotic translation initiation factor 1 -0.0553982
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.054697
MX2 MX dynamin-like GTPase 2 -0.0532413
RPS6 ribosomal protein S6 -0.0528116
NPSR1 neuropeptide S receptor 1 -0.0518732
SLC38A1 solute carrier family 38, member 1 -0.0498447
SQSTM1 sequestosome 1 -0.0495968
RPL23 ribosomal protein L23 -0.0490699
ITGA6 integrin, alpha 6 -0.0490369
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.048851
MX1 MX dynamin-like GTPase 1 -0.0481598
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0479264
RPLP1 ribosomal protein, large, P1 -0.0478698
HLA-C major histocompatibility complex, class I, C -0.0477737
RPL34 ribosomal protein L34 -0.0477351
ENO1 enolase 1, (alpha) -0.0475839
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0474431
TMSB10 thymosin beta 10 -0.0466225
RPL19 ribosomal protein L19 -0.0459395
TM4SF19 transmembrane 4 L six family member 19 -0.0442512
LOC112694756 uncharaterized LOC112694756 -0.0419436
JUN jun proto-oncogene -0.0414865
TSHZ2 teashirt zinc finger homeobox 2 -0.0413161
EZR ezrin -0.0413082
BTBD9 BTB (POZ) domain containing 9 -0.0408922
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0406764
IGFBP3 insulin-like growth factor binding protein 3 -0.0405304
CST3 cystatin C -0.0405048
NDRG1 N-myc downstream regulated 1 -0.0403861
S100A10 S100 calcium binding protein A10 -0.0403688
GCC2 GRIP and coiled-coil domain containing 2 -0.0403028
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0398768
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0395418
RPS19 ribosomal protein S19 -0.0394024
TM4SF1 transmembrane 4 L six family member 1 -0.0389604
WSB1 WD repeat and SOCS box containing 1 -0.038868
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0383471
S100A6 S100 calcium binding protein A6 -0.0382369
HLA-A major histocompatibility complex, class I, A -0.0378487
MUC20 mucin 20, cell surface associated -0.0369417
MT2A metallothionein 2A -0.0362704
WDR45B WD repeat domain 45B -0.0350666
RHOBTB3 Rho-related BTB domain containing 3 -0.0343374
RPS8 ribosomal protein S8 -0.0343365
ACTG1 actin gamma 1 -0.0343224
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.034252
TPM4 tropomyosin 4 -0.03395
RPL31 ribosomal protein L31 -0.0336133
ABLIM1 actin binding LIM protein 1 -0.0336106
SDC4 syndecan 4 -0.0334797
LCN2 lipocalin 2 -0.0331997
IFITM3 interferon induced transmembrane protein 3 -0.032949
RPS27 ribosomal protein S27 -0.0326179
H1-0 H1.0 linker histone -0.0323553
RPS24 ribosomal protein S24 -0.0322257
RPL12 ribosomal protein L12 -0.0320588
RPL7L1 ribosomal protein L7-like 1 -0.0317428
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0315075
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0314627
RRBP1 ribosome binding protein 1 -0.0313302
UBC ubiquitin C -0.0312988
PMP22 peripheral myelin protein 22 -0.031113
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0308961
VDAC1 voltage-dependent anion channel 1 -0.0308629
TMC5 transmembrane channel-like 5 -0.030556
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0305423
IFIH1 interferon induced with helicase C domain 1 -0.0299567