Vemurafenib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.220544
NDRG1 N-myc downstream regulated 1 0.151786
MT2A metallothionein 2A 0.145766
CXCL8 chemokine (C-X-C motif) ligand 8 0.144154
VEGFA vascular endothelial growth factor A 0.129475
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.112694
CD44 CD44 molecule (Indian blood group) 0.112258
FTH1 ferritin, heavy polypeptide 1 0.0993978
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0878761
EEF2 eukaryotic translation elongation factor 2 0.0848957
RPS8 ribosomal protein S8 0.0690263
LDHA lactate dehydrogenase A 0.0681126
RPS6 ribosomal protein S6 0.0665755
CALR calreticulin 0.0658627
SOD2 superoxide dismutase 2, mitochondrial 0.0619378
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0601616
TGFBI transforming growth factor, beta-induced, 68kDa 0.0571398
VIM vimentin 0.0542613
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0530646
ACTG1 actin gamma 1 0.052659
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0525511
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0506595
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0463622
FN1 fibronectin 1 0.0443325
CADM1 cell adhesion molecule 1 0.0437444
IL6 interleukin 6 0.0428278
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0416615
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0413668
RPL5 ribosomal protein L5 0.0407617
B2M beta-2-microglobulin 0.0398919
RPS2 ribosomal protein S2 0.0398171
FNDC3B fibronectin type III domain containing 3B 0.0391875
RPL7 ribosomal protein L7 0.0368638
RPS12 ribosomal protein S12 0.0366444
UBC ubiquitin C 0.0365961
RACK1 receptor for activated C kinase 1 0.0348276
FTL ferritin, light polypeptide 0.0343425
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0342678
RPL23 ribosomal protein L23 0.0338392
LGALS1 lectin, galactoside-binding, soluble, 1 0.0337969
EIF1 eukaryotic translation initiation factor 1 0.0335167
S100A9 S100 calcium binding protein A9 0.0329706
RPS3 ribosomal protein S3 0.0327997
RPL12 ribosomal protein L12 0.0327989
RND3 Rho family GTPase 3 0.0327581
CYB5R3 cytochrome b5 reductase 3 0.03235
MLF1 myeloid leukemia factor 1 0.0321037
ADM adrenomedullin 0.0320011
ZSWIM6 zinc finger, SWIM-type containing 6 0.0317885
ARRDC3 arrestin domain containing 3 0.0310065
RPL11 ribosomal protein L11 0.0309669
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0308381
POTEF POTE ankyrin domain family, member F 0.0307412
RPL26 ribosomal protein L26 0.0297895
RPL8 ribosomal protein L8 0.0295109
ANXA1 annexin A1 0.0294677
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0293069
SFTPA2 surfactant protein A2 0.0291988
BRD2 bromodomain containing 2 0.0289487
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0285235
RPL28 ribosomal protein L28 0.0280309
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0279418
NOTCH2 notch 2 0.0278415
GOLGB1 golgin B1 0.0274913
RPL37A ribosomal protein L37a 0.0274863
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0270061
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0267789
HLA-A major histocompatibility complex, class I, A 0.0265082
RPS19 ribosomal protein S19 0.0264108
PGM3 phosphoglucomutase 3 0.0263985
SP100 SP100 nuclear antigen 0.0261445
HILPDA hypoxia inducible lipid droplet-associated 0.0261206
RPS20 ribosomal protein S20 0.0257219
TNIP1 TNFAIP3 interacting protein 1 0.025694
NFE2L1 nuclear factor, erythroid 2-like 1 0.0253829
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0250145
RPL3 ribosomal protein L3 0.0247905
ATF4 activating transcription factor 4 0.0247012
RAB2A RAB2A, member RAS oncogene family 0.0245721
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0243212
RPS13 ribosomal protein S13 0.0239815
RPS25 ribosomal protein S25 0.0238401
ALCAM activated leukocyte cell adhesion molecule 0.0238176
TMSB10 thymosin beta 10 0.0237364
MYO10 myosin X 0.0235921
HSPA8 heat shock 70kDa protein 8 0.0233493
RPL35A ribosomal protein L35a 0.0233368
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0233368
RPLP0 ribosomal protein, large, P0 0.0229659
OPTN optineurin 0.0227164
ICAM1 intercellular adhesion molecule 1 0.022716
RPL37 ribosomal protein L37 0.0226359
PDIA3 protein disulfide isomerase family A, member 3 0.022505
RPS17 ribosomal protein S17 0.0224846
APLP2 amyloid beta (A4) precursor-like protein 2 0.0224171
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0222623
RPL30 ribosomal protein L30 0.0222451
EGFR epidermal growth factor receptor 0.0219475
DPYSL2 dihydropyrimidinase-like 2 0.0218137
JARID2 jumonji, AT rich interactive domain 2 0.0217652

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.208455
PSD3 pleckstrin and Sec7 domain containing 3 -0.157826
COL1A1 collagen, type I, alpha 1 -0.156411
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144039
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.122024
IGFBP3 insulin-like growth factor binding protein 3 -0.117509
COL6A3 collagen, type VI, alpha 3 -0.111701
FBN1 fibrillin 1 -0.105124
HMGA2 high mobility group AT-hook 2 -0.101639
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.091989
DPYD dihydropyrimidine dehydrogenase -0.0908433
AHNAK AHNAK nucleoprotein -0.088654
PRELID2 PRELI domain containing 2 -0.0831203
ZBTB20 zinc finger and BTB domain containing 20 -0.0763215
CDH13 cadherin 13 -0.0720159
COL5A1 collagen, type V, alpha 1 -0.0671224
TRIO trio Rho guanine nucleotide exchange factor -0.0645472
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0639031
CANX calnexin -0.0638645
ASPH aspartate beta-hydroxylase -0.0616065
TRPS1 trichorhinophalangeal syndrome I -0.0604015
ATP13A3 ATPase type 13A3 -0.0601326
VCAN versican -0.0588621
COL1A2 collagen, type I, alpha 2 -0.057659
EXT1 exostosin glycosyltransferase 1 -0.0569676
PDE4D phosphodiesterase 4D, cAMP-specific -0.0543398
LTBP1 latent transforming growth factor beta binding protein 1 -0.0532646
SMYD3 SET and MYND domain containing 3 -0.0530615
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0510017
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0509215
DST dystonin -0.0481021
LMAN1 lectin, mannose-binding, 1 -0.0456273
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0441987
COL7A1 collagen, type VII, alpha 1 -0.0430042
F3 coagulation factor III (thromboplastin, tissue factor) -0.0418987
ANTXR2 anthrax toxin receptor 2 -0.0417077
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0407723
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0403317
CNTN5 contactin 5 -0.0401726
ERRFI1 ERBB receptor feedback inhibitor 1 -0.040172
RRBP1 ribosome binding protein 1 -0.039188
CAVIN1 caveolae associated protein 1 -0.0383788
CALD1 caldesmon 1 -0.0381265
EBF1 early B-cell factor 1 -0.0379884
GLIS3 GLIS family zinc finger 3 -0.037797
MAP1B microtubule-associated protein 1B -0.0376634
FRMD4A FERM domain containing 4A -0.0374621
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0371283
TPM4 tropomyosin 4 -0.0359067
BNC2 basonuclin 2 -0.0354638
HMCN1 hemicentin 1 -0.03491
VCL vinculin -0.0343625
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0340425
LPP LIM domain containing preferred translocation partner in lipoma -0.0339186
PRR16 proline rich 16 -0.0338663
ZFPM2 zinc finger protein, FOG family member 2 -0.0331025
SBF2 SET binding factor 2 -0.0330609
KDM3A lysine (K)-specific demethylase 3A -0.0321588
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.032032
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0315992
PRSS23 protease, serine, 23 -0.031538
GRB10 growth factor receptor-bound protein 10 -0.0315061
RAD21 RAD21 homolog (S. pombe) -0.0311829
DOCK5 dedicator of cytokinesis 5 -0.0309731
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0307408
FOXP1 forkhead box P1 -0.0305044
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0303007
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0302678
COL8A1 collagen, type VIII, alpha 1 -0.0301895
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0299244
PDE10A phosphodiesterase 10A -0.029805
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0293953
FAM20C family with sequence similarity 20, member C -0.0291984
TENM3 teneurin transmembrane protein 3 -0.0290941
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0282593
MAML2 mastermind-like 2 (Drosophila) -0.0282447
KLF12 Kruppel-like factor 12 -0.027973
BBX bobby sox homolog (Drosophila) -0.0277436
ZMYND8 zinc finger, MYND-type containing 8 -0.027601
ZEB1 zinc finger E-box binding homeobox 1 -0.0269204
NREP neuronal regeneration related protein -0.0268279
GJA1 gap junction protein, alpha 1, 43kDa -0.0259076
DLG1 discs, large homolog 1 (Drosophila) -0.0255435
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0252408
SULF1 sulfatase 1 -0.0251749
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0246833
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0246081
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0245529
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0240386
BIRC6 baculoviral IAP repeat containing 6 -0.0239679
UTRN utrophin -0.0239467
ARHGAP29 Rho GTPase activating protein 29 -0.0238149
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0237904
TNRC6B trinucleotide repeat containing 6B -0.0236771
NALF1 NALCN channel auxiliary factor 1 -0.023634
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0235842
COL4A2 collagen, type IV, alpha 2 -0.0231694
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0226509
WSB1 WD repeat and SOCS box containing 1 -0.0225913
RAI14 retinoic acid induced 14 -0.0224583