Vemurafenib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.110825
PDLIM5 PDZ and LIM domain 5 0.106014
SVIL supervillin 0.0861592
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.065978
INTS6 integrator complex subunit 6 0.0659625
SAMD4A sterile alpha motif domain containing 4A 0.0657952
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0601699
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0515127
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0514864
APOB apolipoprotein B 0.049314
DTNA dystrobrevin, alpha 0.0487458
GLS2 glutaminase 2 (liver, mitochondrial) 0.0470714
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.046432
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0460187
GMDS GDP-mannose 4,6-dehydratase 0.0453275
MBNL2 muscleblind-like splicing regulator 2 0.044676
LCOR ligand dependent nuclear receptor corepressor 0.0428003
EEF2 eukaryotic translation elongation factor 2 0.0425403
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0399857
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0395119
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.038958
CLIC4 chloride intracellular channel 4 0.0385941
TLE4 transducin-like enhancer of split 4 0.0382031
FAM107B family with sequence similarity 107, member B 0.0381545
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0378627
ATXN1 ataxin 1 0.037701
FERMT2 fermitin family member 2 0.0364956
IGFBP1 insulin-like growth factor binding protein 1 0.0352799
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0352651
QKI QKI, KH domain containing, RNA binding 0.0341625
ADARB1 adenosine deaminase, RNA-specific, B1 0.0328662
EPS8 epidermal growth factor receptor pathway substrate 8 0.0328278
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0315869
MYO1E myosin IE 0.0311794
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0306943
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0302565
AHR aryl hydrocarbon receptor 0.0296743
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0294565
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0294534
MBNL1 muscleblind-like splicing regulator 1 0.0290325
FAT1 FAT atypical cadherin 1 0.0289746
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0281081
SORBS1 sorbin and SH3 domain containing 1 0.0278771
SERTAD2 SERTA domain containing 2 0.0276672
SOD2 superoxide dismutase 2, mitochondrial 0.0274712
USP47 ubiquitin specific peptidase 47 0.0273744
JAG1 jagged 1 0.0268727
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0266909
SIK3 SIK family kinase 3 0.0264752
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0259983
HSPH1 heat shock 105kDa/110kDa protein 1 0.0259575
KIF21A kinesin family member 21A 0.0257021
MYO1B myosin IB 0.0252993
PEAK1 pseudopodium-enriched atypical kinase 1 0.0251043
PSME4 proteasome (prosome, macropain) activator subunit 4 0.025058
RPL3 ribosomal protein L3 0.0248693
ARL5B ADP-ribosylation factor-like 5B 0.0245358
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0245289
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0239812
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0239112
CRY1 cryptochrome circadian clock 1 0.0238615
EXT1 exostosin glycosyltransferase 1 0.0236802
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0236092
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0235288
VEGFA vascular endothelial growth factor A 0.0233753
CCL20 chemokine (C-C motif) ligand 20 0.0231624
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0231318
OSBPL8 oxysterol binding protein-like 8 0.022933
TOP1 topoisomerase (DNA) I 0.022886
MCU mitochondrial calcium uniporter 0.0226055
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.022359
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0223554
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0223174
DDIT4 DNA-damage-inducible transcript 4 0.0222185
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0222104
CAMTA1 calmodulin binding transcription activator 1 0.0219894
ADAM9 ADAM metallopeptidase domain 9 0.0219894
LIMS1 LIM and senescent cell antigen-like domains 1 0.0219151
BIRC3 baculoviral IAP repeat containing 3 0.0216472
KYNU kynureninase 0.0215526
EXOC6B exocyst complex component 6B 0.021512
RABGAP1L RAB GTPase activating protein 1-like 0.0213507
NRIP1 nuclear receptor interacting protein 1 0.021226
PICALM phosphatidylinositol binding clathrin assembly protein 0.021086
SDC4 syndecan 4 0.0207974
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0205987
CAPRIN2 caprin family member 2 0.0204851
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0204383
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.020247
JAK1 Janus kinase 1 0.0202176
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0201169
USP53 ubiquitin specific peptidase 53 0.0200715
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.020028
LMO7 LIM domain 7 0.019973
MACF1 microtubule-actin crosslinking factor 1 0.0198934
ZNF292 zinc finger protein 292 0.0197854
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0197371
NCKAP1 NCK-associated protein 1 0.0197358
SEPTIN9 septin 9 0.0196266
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0195996

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.195306
AKAP12 A kinase (PRKA) anchor protein 12 -0.174665
TPT1 tumor protein, translationally-controlled 1 -0.16487
ENO1 enolase 1, (alpha) -0.140067
ZMYND8 zinc finger, MYND-type containing 8 -0.131538
APOA2 apolipoprotein A-II -0.129784
CP ceruloplasmin (ferroxidase) -0.111896
GPC3 glypican 3 -0.111211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0884966
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0811072
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0809956
EHBP1 EH domain binding protein 1 -0.0764191
RPLP1 ribosomal protein, large, P1 -0.0729018
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0728737
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0711119
MT2A metallothionein 2A -0.0709956
MAML2 mastermind-like 2 (Drosophila) -0.0686382
TM4SF1 transmembrane 4 L six family member 1 -0.0675609
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0654677
MARCKS myristoylated alanine-rich protein kinase C substrate -0.063155
GPC6 glypican 6 -0.0629026
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0617986
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0616979
TMSB10 thymosin beta 10 -0.0610613
RPL35A ribosomal protein L35a -0.0609226
GNAS GNAS complex locus -0.0591922
RPL34 ribosomal protein L34 -0.0570535
EML4 echinoderm microtubule associated protein like 4 -0.056228
RPS24 ribosomal protein S24 -0.0561328
NPAS2 neuronal PAS domain protein 2 -0.0537417
TPM4 tropomyosin 4 -0.0535236
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0530684
RPS6 ribosomal protein S6 -0.0511585
RRBP1 ribosome binding protein 1 -0.0508752
RPL37A ribosomal protein L37a -0.049993
FRMD5 FERM domain containing 5 -0.0499226
FTL ferritin, light polypeptide -0.0489151
FERMT1 fermitin family member 1 -0.0486462
RNASET2 ribonuclease T2 -0.0486298
ZBTB20 zinc finger and BTB domain containing 20 -0.0483476
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0482242
RPLP0 ribosomal protein, large, P0 -0.0477918
PLIN2 perilipin 2 -0.0476885
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0475651
IGF2 insulin-like growth factor 2 -0.0467856
PEG3 paternally expressed 3 -0.0465889
OSMR oncostatin M receptor -0.0460458
GDF15 growth differentiation factor 15 -0.0455781
PDGFB platelet-derived growth factor beta polypeptide -0.0449943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.044926
IER3 immediate early response 3 -0.0448736
LOC112694756 uncharaterized LOC112694756 -0.0448668
RPS19 ribosomal protein S19 -0.0443411
RPS21 ribosomal protein S21 -0.0439298
GCC2 GRIP and coiled-coil domain containing 2 -0.0438235
APOE apolipoprotein E -0.0432157
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0424428
AMBP alpha-1-microglobulin/bikunin precursor -0.042224
PERP PERP, TP53 apoptosis effector -0.0420592
ELL2 elongation factor, RNA polymerase II, 2 -0.0416778
MALT1 MALT1 paracaspase -0.041074
DOCK4 dedicator of cytokinesis 4 -0.040779
IFITM1 interferon induced transmembrane protein 1 -0.0404891
TMEM123 transmembrane protein 123 -0.0403311
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0402169
ATP10A ATPase, class V, type 10A -0.0396198
RPS27A ribosomal protein S27a -0.0387226
NPR2 natriuretic peptide receptor 2 -0.0387012
KDM3A lysine (K)-specific demethylase 3A -0.0385667
RNF213 ring finger protein 213 -0.0380207
RPL31 ribosomal protein L31 -0.0379813
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0378071
RPL11 ribosomal protein L11 -0.0374403
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0373673
SOX5 SRY (sex determining region Y)-box 5 -0.0370426
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0362785
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0360666
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0357994
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.035189
B2M beta-2-microglobulin -0.0350046
RPS29 ribosomal protein S29 -0.0346958
SLC38A2 solute carrier family 38, member 2 -0.0346781
SOX4 SRY (sex determining region Y)-box 4 -0.0345213
RPL37 ribosomal protein L37 -0.0344908
TRIM26 tripartite motif containing 26 -0.0339384
NKD1 naked cuticle homolog 1 (Drosophila) -0.0338858
ZFHX3 zinc finger homeobox 3 -0.0338615
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.033796
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0335108
PTPRF protein tyrosine phosphatase, receptor type, F -0.0334316
RPL38 ribosomal protein L38 -0.0334126
RPS8 ribosomal protein S8 -0.0333587
MX2 MX dynamin-like GTPase 2 -0.0331365
MSI2 musashi RNA-binding protein 2 -0.0331237
ARHGAP5 Rho GTPase activating protein 5 -0.0330952
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0326961
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0325004
AHSG alpha-2-HS-glycoprotein -0.0319883
RPLP2 ribosomal protein, large, P2 -0.0319639
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0319426