Vemurafenib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.151216
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.146763
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.126325
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0747445
TXNIP thioredoxin interacting protein 0.0475085
LMO7 LIM domain 7 0.0463896
EEF2 eukaryotic translation elongation factor 2 0.0440187
GOLGA4 golgin A4 0.0435083
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0371083
RNF145 ring finger protein 145 0.0367032
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0366243
MBNL2 muscleblind-like splicing regulator 2 0.0358911
CALR calreticulin 0.0356069
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0353412
CEMIP2 cell migration inducing hyaluronidase 2 0.0351004
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0339852
FTH1 ferritin, heavy polypeptide 1 0.032422
IARS1 isoleucyl-tRNA synthetase 1 0.029738
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0296321
NEBL nebulette 0.0289896
WAC WW domain containing adaptor with coiled-coil 0.0287559
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0286833
EPS8 epidermal growth factor receptor pathway substrate 8 0.0283748
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0276878
EIF1 eukaryotic translation initiation factor 1 0.0274886
KMT2E lysine (K)-specific methyltransferase 2E 0.0259888
EXT1 exostosin glycosyltransferase 1 0.0258112
ATXN1 ataxin 1 0.0257955
PDIA4 protein disulfide isomerase family A, member 4 0.0254709
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0254499
ANKRD11 ankyrin repeat domain 11 0.0253787
HSPA8 heat shock 70kDa protein 8 0.0249948
EREG epiregulin 0.0248998
ZFAND3 zinc finger, AN1-type domain 3 0.0244265
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0240381
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0239527
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0236001
ANKRD17 ankyrin repeat domain 17 0.0233234
DSCAM Down syndrome cell adhesion molecule 0.0231004
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0229454
TFG TRK-fused gene 0.0228354
PDIA3 protein disulfide isomerase family A, member 3 0.0225453
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0222874
BRD2 bromodomain containing 2 0.0221597
GARS1 glycyl-tRNA synthetase 1 0.0218059
RNF43 ring finger protein 43 0.0214799
COG5 component of oligomeric golgi complex 5 0.0209165
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.020753
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0203204
PUM2 pumilio RNA-binding family member 2 0.0202424
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0201493
PDZD8 PDZ domain containing 8 0.0198013
SEC31A SEC31 homolog A (S. cerevisiae) 0.0194301
RBM39 RNA binding motif protein 39 0.0192062
AFF1 AF4/FMR2 family, member 1 0.0189868
KLF5 Kruppel-like factor 5 (intestinal) 0.0185425
MBNL1 muscleblind-like splicing regulator 1 0.0183936
RAB1A RAB1A, member RAS oncogene family 0.0182898
POF1B premature ovarian failure, 1B 0.0182661
ERRFI1 ERBB receptor feedback inhibitor 1 0.0180808
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0179699
DDIT4 DNA-damage-inducible transcript 4 0.0179681
ARL15 ADP-ribosylation factor-like 15 0.0178036
PHF3 PHD finger protein 3 0.017802
NUP58 nucleoporin 58 0.0177195
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.017704
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0176382
SLC38A2 solute carrier family 38, member 2 0.0175773
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0175141
HDLBP high density lipoprotein binding protein 0.0174265
LDHA lactate dehydrogenase A 0.0173115
SHROOM3 shroom family member 3 0.0172397
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0171121
KDM3A lysine (K)-specific demethylase 3A 0.0170194
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0169875
NEK7 NIMA-related kinase 7 0.0167789
RPS2 ribosomal protein S2 0.0167207
KITLG KIT ligand 0.0166342
GSK3B glycogen synthase kinase 3 beta 0.0165454
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0165021
FNDC3B fibronectin type III domain containing 3B 0.016417
ZSWIM6 zinc finger, SWIM-type containing 6 0.0164112
USP47 ubiquitin specific peptidase 47 0.0162762
JAK1 Janus kinase 1 0.0162755
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0162568
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0160743
MUC13 mucin 13, cell surface associated 0.0160479
TRA2A transformer 2 alpha homolog (Drosophila) 0.0159662
MYO5B myosin VB 0.015942
COPA coatomer protein complex, subunit alpha 0.0158662
NCKAP1 NCK-associated protein 1 0.0158615
OGA O-GlcNAcase 0.0157855
TES testin LIM domain protein 0.0156454
GDF15 growth differentiation factor 15 0.0155914
LURAP1L leucine rich adaptor protein 1-like 0.0155225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0155184
NDRG1 N-myc downstream regulated 1 0.0154993
FOXJ3 forkhead box J3 0.0154314
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0153231
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0153041

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.209255
NPSR1 neuropeptide S receptor 1 -0.207824
TMSB10 thymosin beta 10 -0.131495
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.127445
TPT1 tumor protein, translationally-controlled 1 -0.0878214
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0846582
NALF1 NALCN channel auxiliary factor 1 -0.0792464
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0707131
KRT18 keratin 18, type I -0.0676964
S100A6 S100 calcium binding protein A6 -0.0615331
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0611876
GREB1L growth regulation by estrogen in breast cancer-like -0.0600432
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0588984
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0571508
TPM4 tropomyosin 4 -0.0568019
CEMIP cell migration inducing protein, hyaluronan binding -0.0560947
ITGA6 integrin, alpha 6 -0.0549011
FLNB filamin B, beta -0.0540504
ALCAM activated leukocyte cell adhesion molecule -0.0511387
ANXA2 annexin A2 -0.050733
CALB1 calbindin 1, 28kDa -0.0475223
LAMA4 laminin, alpha 4 -0.0460614
ACTG1 actin gamma 1 -0.0433918
RPL35A ribosomal protein L35a -0.0409152
KRT8 keratin 8, type II -0.0408316
MUC17 mucin 17, cell surface associated -0.0396832
TFF1 trefoil factor 1 -0.0392509
RNF217 ring finger protein 217 -0.0383971
RPS6 ribosomal protein S6 -0.0378661
LMNA lamin A/C -0.0376488
SLC35F3 solute carrier family 35, member F3 -0.036596
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0364804
MT2A metallothionein 2A -0.0359632
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0353687
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0352562
ANTXR2 anthrax toxin receptor 2 -0.0350062
TNS4 tensin 4 -0.0347736
GCC2 GRIP and coiled-coil domain containing 2 -0.034003
ACTN4 actinin, alpha 4 -0.0337292
MAML2 mastermind-like 2 (Drosophila) -0.0335797
FERMT1 fermitin family member 1 -0.033075
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0327653
PPARG peroxisome proliferator-activated receptor gamma -0.0325079
SOX4 SRY (sex determining region Y)-box 4 -0.0316943
ONECUT3 one cut homeobox 3 -0.0311158
PSD3 pleckstrin and Sec7 domain containing 3 -0.0309529
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0308135
POTEF POTE ankyrin domain family, member F -0.0307671
TFF3 trefoil factor 3 (intestinal) -0.0287867
HMGB1 high mobility group box 1 -0.0283397
IER3 immediate early response 3 -0.0282967
EZR ezrin -0.0280049
KRT19 keratin 19, type I -0.0279187
KLK10 kallikrein-related peptidase 10 -0.0278357
F3 coagulation factor III (thromboplastin, tissue factor) -0.0273713
FHIT fragile histidine triad -0.0272465
ITGB4 integrin, beta 4 -0.0270642
SH3D19 SH3 domain containing 19 -0.0269922
AHNAK AHNAK nucleoprotein -0.0269733
FOSL1 FOS-like antigen 1 -0.0269542
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0264981
PRSS3 protease, serine, 3 -0.0264397
RPL9 ribosomal protein L9 -0.0256623
RIN2 Ras and Rab interactor 2 -0.0256375
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0248101
RPS24 ribosomal protein S24 -0.0244897
EHBP1 EH domain binding protein 1 -0.0239537
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0237873
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0237789
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0236328
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0236014
ESYT2 extended synaptotagmin-like protein 2 -0.0235794
DIAPH2 diaphanous-related formin 2 -0.0234323
LSAMP limbic system-associated membrane protein -0.0232562
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0230416
DENND1A DENN/MADD domain containing 1A -0.0215975
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0215843
HMGA1 high mobility group AT-hook 1 -0.0214289
ARHGAP6 Rho GTPase activating protein 6 -0.0211709
RPL37A ribosomal protein L37a -0.0210583
PERP PERP, TP53 apoptosis effector -0.0209012
PTPRR protein tyrosine phosphatase, receptor type, R -0.0207417
TUBA1B tubulin, alpha 1b -0.0207066
RAD51B RAD51 paralog B -0.0205819
CCND1 cyclin D1 -0.0201031
TUBB4B tubulin, beta 4B class IVb -0.0200164
CSTB cystatin B (stefin B) -0.0196393
KPNB1 karyopherin (importin) beta 1 -0.0195383
FRMD5 FERM domain containing 5 -0.0194095
SAMD5 sterile alpha motif domain containing 5 -0.0193169
RPS8 ribosomal protein S8 -0.0192292
GTF2IRD1 GTF2I repeat domain containing 1 -0.0190107
RPL34 ribosomal protein L34 -0.0189372
ASPH aspartate beta-hydroxylase -0.018822
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0187147
PTPRK protein tyrosine phosphatase, receptor type, K -0.0186723
PDE4D phosphodiesterase 4D, cAMP-specific -0.0185068
LAMB3 laminin, beta 3 -0.0184881
RPS19 ribosomal protein S19 -0.0184853
ZBTB7A zinc finger and BTB domain containing 7A -0.0184674