Vemurafenib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.094916
TP63 tumor protein p63 0.0908287
PSD3 pleckstrin and Sec7 domain containing 3 0.0900912
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0445684
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0308703
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0277447
SOD2 superoxide dismutase 2, mitochondrial 0.0267488
HDAC9 histone deacetylase 9 0.0257359
BIRC3 baculoviral IAP repeat containing 3 0.0235787
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0233722
ZSWIM6 zinc finger, SWIM-type containing 6 0.0232672
TNS3 tensin 3 0.0231347
PDE10A phosphodiesterase 10A 0.0222524
MACF1 microtubule-actin crosslinking factor 1 0.0217735
EGFR epidermal growth factor receptor 0.0213841
CAPRIN2 caprin family member 2 0.021314
RNF213 ring finger protein 213 0.0206211
GOLGB1 golgin B1 0.0205178
WARS1 tryptophanyl-tRNA synthetase 1 0.0204039
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0200852
RUNX1 runt-related transcription factor 1 0.019921
PRELID2 PRELI domain containing 2 0.0199096
SP100 SP100 nuclear antigen 0.0198948
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0196026
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0194515
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0193478
ZDHHC14 zinc finger, DHHC-type containing 14 0.0193069
CFLAR CASP8 and FADD-like apoptosis regulator 0.0183971
WWTR1 WW domain containing transcription regulator 1 0.0183196
INTS6 integrator complex subunit 6 0.0182731
DNER delta/notch-like EGF repeat containing 0.0180706
HOMER1 homer scaffolding protein 1 0.0174786
EHBP1 EH domain binding protein 1 0.0173653
NEK10 NIMA-related kinase 10 0.0169301
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0162258
ZBTB38 zinc finger and BTB domain containing 38 0.0161293
NPAS2 neuronal PAS domain protein 2 0.0155531
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0155104
COL5A2 collagen, type V, alpha 2 0.0153451
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0151757
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0148518
PLSCR1 phospholipid scramblase 1 0.0146001
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0144846
MBD5 methyl-CpG binding domain protein 5 0.0142449
MB21D2 Mab-21 domain containing 2 0.0142094
HSPA8 heat shock 70kDa protein 8 0.0140486
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0138897
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0137195
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0135589
ZNF638 zinc finger protein 638 0.0133209
LPP LIM domain containing preferred translocation partner in lipoma 0.0133047
KDM4C lysine (K)-specific demethylase 4C 0.0130936
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0129919
SDCCAG8 serologically defined colon cancer antigen 8 0.0127105
MYOF myoferlin 0.0125745
MBNL2 muscleblind-like splicing regulator 2 0.0125045
ARFGEF3 ARFGEF family member 3 0.0124105
CSMD3 CUB and Sushi multiple domains 3 0.0122189
ZBTB1 zinc finger and BTB domain containing 1 0.0121181
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0120059
LYST lysosomal trafficking regulator 0.011911
ZBTB20 zinc finger and BTB domain containing 20 0.0117247
EPHA4 EPH receptor A4 0.0116628
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0116203
RAD51B RAD51 paralog B 0.0116133
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0115288
BICD1 bicaudal D homolog 1 (Drosophila) 0.0114754
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0109335
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0105697
IFIH1 interferon induced with helicase C domain 1 0.0103035
DOCK1 dedicator of cytokinesis 1 0.0102784
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.010265
AHI1 Abelson helper integration site 1 0.0102427
APOLD1 apolipoprotein L domain containing 1 0.0100945
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0100043
RSAD2 radical S-adenosyl methionine domain containing 2 0.00997205
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.009876
TTC3 tetratricopeptide repeat domain 3 0.00983176
SPIDR scaffolding protein involved in DNA repair 0.00978328
TSC22D1 TSC22 domain family, member 1 0.00967038
ZMIZ1 zinc finger, MIZ-type containing 1 0.00966291
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.00954726
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00954118
AEBP2 AE binding protein 2 0.00950072
PRKCE protein kinase C, epsilon 0.00948012
SQSTM1 sequestosome 1 0.00947378
ASPH aspartate beta-hydroxylase 0.00942227
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0094176
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.00940651
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00932083
WDR27 WD repeat domain 27 0.00931637
EXT1 exostosin glycosyltransferase 1 0.00927166
FBXL17 F-box and leucine-rich repeat protein 17 0.00924275
BCAR3 breast cancer anti-estrogen resistance 3 0.00920029
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.00911867
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.00910792
SUMF1 sulfatase modifying factor 1 0.00902807
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.00900895
AKAP12 A kinase (PRKA) anchor protein 12 0.00870149
WNK1 WNK lysine deficient protein kinase 1 0.00866245

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.240542
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20573
PTMA prothymosin, alpha -0.185256
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127954
TMSB10 thymosin beta 10 -0.125734
MT2A metallothionein 2A -0.0930554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0911588
TMSB4X thymosin beta 4, X-linked -0.0765449
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0610655
RPL35A ribosomal protein L35a -0.0547086
RAI1 retinoic acid induced 1 -0.05206
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0483678
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0451762
FTL ferritin, light polypeptide -0.0447337
CENPF centromere protein F, 350/400kDa -0.0445374
POTEF POTE ankyrin domain family, member F -0.0438599
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0435008
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0428316
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0422205
GARS1 glycyl-tRNA synthetase 1 -0.041711
CANX calnexin -0.0379747
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0371426
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0365822
TPT1 tumor protein, translationally-controlled 1 -0.0359879
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0358422
YBX1 Y box binding protein 1 -0.0356717
WSB1 WD repeat and SOCS box containing 1 -0.0348938
RPS19 ribosomal protein S19 -0.0342143
SRGN serglycin -0.0326912
SLC38A2 solute carrier family 38, member 2 -0.0315835
TOP1 topoisomerase (DNA) I -0.0313557
LOC112694756 uncharaterized LOC112694756 -0.0311297
DLG1 discs, large homolog 1 (Drosophila) -0.0308987
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0306542
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0306158
EIF1 eukaryotic translation initiation factor 1 -0.0300456
RTN4 reticulon 4 -0.0293298
RBM25 RNA binding motif protein 25 -0.0290395
RPS24 ribosomal protein S24 -0.028627
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0285408
ACTG1 actin gamma 1 -0.0280577
SEPTIN7 septin 7 -0.0280176
RPL23 ribosomal protein L23 -0.0276919
KPNB1 karyopherin (importin) beta 1 -0.0272808
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0269345
RPS8 ribosomal protein S8 -0.0267398
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0261488
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0261423
MT1X metallothionein 1X -0.0257802
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0253073
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0253015
SMC4 structural maintenance of chromosomes 4 -0.0251806
VDAC1 voltage-dependent anion channel 1 -0.0249869
RPL19 ribosomal protein L19 -0.0246203
TPI1 triosephosphate isomerase 1 -0.0244936
WDR45B WD repeat domain 45B -0.0241213
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0239764
RPS6 ribosomal protein S6 -0.0238944
ENO1 enolase 1, (alpha) -0.0238386
MATR3 matrin 3 -0.0236159
XPO1 exportin 1 -0.0235691
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0234561
PGK1 phosphoglycerate kinase 1 -0.0233094
RPLP2 ribosomal protein, large, P2 -0.0231682
MKI67 marker of proliferation Ki-67 -0.0227226
RPLP1 ribosomal protein, large, P1 -0.0226134
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0225678
AHNAK AHNAK nucleoprotein -0.0223371
SRPK2 SRSF protein kinase 2 -0.0222683
ZNF292 zinc finger protein 292 -0.0219819
RPL8 ribosomal protein L8 -0.0218887
WASF2 WAS protein family, member 2 -0.0218546
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0217723
RPL12 ribosomal protein L12 -0.0217721
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0216598
APP amyloid beta (A4) precursor protein -0.0214016
PRRC2C proline-rich coiled-coil 2C -0.021365
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.021265
KDM3A lysine (K)-specific demethylase 3A -0.0212329
RPLP0 ribosomal protein, large, P0 -0.020993
TM4SF1 transmembrane 4 L six family member 1 -0.0209921
RPS23 ribosomal protein S23 -0.0209435
NOP58 NOP58 ribonucleoprotein -0.0209036
LDHA lactate dehydrogenase A -0.0206083
DEK DEK proto-oncogene -0.0206052
OGA O-GlcNAcase -0.0205411
S100A10 S100 calcium binding protein A10 -0.0205258
S100A6 S100 calcium binding protein A6 -0.020368
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0202675
RPS14 ribosomal protein S14 -0.0201428
TMEM41B transmembrane protein 41B -0.0200975
ANLN anillin, actin binding protein -0.0200553
OLA1 Obg-like ATPase 1 -0.0200254
TRA2A transformer 2 alpha homolog (Drosophila) -0.0200196
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0199437
CELF1 CUGBP, Elav-like family member 1 -0.0197966
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0195912
ADGRG6 adhesion G protein-coupled receptor G6 -0.0195042
S100A9 S100 calcium binding protein A9 -0.0194805
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0191987